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| 1 | Effect of tip geometry and tip clearance on aerodynamic performance of a linear compressor cascade显示文摘The tip leakage flow between a blade and a casing wall has a strong impact on compressor pressure rise capability, efficiency, and stability. Consequently, there is a strong motivation to look for means to minimize its impact on performance. This paper presents the potential of passive tip leakage flow control to increase the aerodynamic performance of highly loaded compressor blades. Experimental investigations on a linear compressor cascade equipped with blade winglets mounted to the blade tips have been carried out. Results for a variation of the tip clearance and the winglet geometry are presented. Current results indicate that the use of proper tip winglets in a compressor cascade can positively affect the local aerodynamic field by weakening the tip leakage vortex. Results also show that the suction-side winglets are aerodynamically superior to the pressure-side or combined winglets. The suction-side winglets are capable of reducing the exit total pressure loss associated with the tip leakage flow and the passage secondary flow to a significant degree. | Zhong Jingjun Han Shaobing Lu Huawei Kan Xiaoxu | 2013 | Chinese Journal of Aeronautics2013，26，3： | 12 |
| 2 | Experimental investigation on a high subsonic compressor cascade flow显示文摘With the aim of deepening the understanding of high-speed compressor cascade flow,this paper reports an experimental study on NACA-65 K48 compressor cascade with high subsonic inlet flow.With the increase of passage pressurizing ability, endwall boundary layer behavior is deteriorated, and the transition zone is extended from suction surface to the endwall as the adverse pressure gradient increases.Cross flow from endwall to midspan, mixing of corner boundary layer and the main stream, and reversal flow on the suction surface are caused by corner separation vortex structures.Passage vortex is the main corner separation vortex.During its movement downstream, the size grows bigger while the rotating direction changes, forming a limiting circle.With higher incidence, corner separation is further deteriorated, leading to higher flow loss.Meanwhile, corner separation structure, flow mixing characteristics and flow loss distribution vary a lot with the change of incidence.Compared with low aspect-ratio model, corner separation of high aspect-ratio model moves away from the endwall and is more sufficiently developed downstream the cascade.Results obtained present details of high-speed compressor cascade flow,which is rare in the relating research fields and is beneficial to mechanism analysis, aerodynamic optimization and flow control design. | Zhang Haideng Wu Yun Li Yinghong Lu Huawei | 2015 | Chinese Journal of Aeronautics2015，28，4： | 8 |
| 3 | Effectiveness and safety of Ginkgo biloba extract(GBE50)in the treatment of dizziness caused by cerebral arteriosclerosis:a multi-center,double-blind,randomized controlled trial显示文摘OBJECTIVE:To evaluate the effectiveness and safety of Ginkgo biloba extract(GBE50)in the treatment of dizziness caused by cerebral arteriosclerosis.METHODS:This was a multi-center,double-blind,double-dummy,positive-controlled,parallel randomized controlled clinical trial with 1∶1 allocation.We recruited 404 patients with dizziness caused by cerebral arteriosclerosis(blood stasis symptom pattern)in 10 hospitals in China.GBE50 group received GBE50 and Naoxinqing tablet(NXQ)of mimetic agent,control group received NXQ and GBE50 of mimetic agent.The main outcome was Traditional Chinese Medicine(TCM)symptom pattern score of blood stasis after 6 weeks.The secondary outcomes were changes in the dizziness handicap inventory(DHI)score,vertigo visual analogue scale(VAS)score,the university of California vertigo questionnaire(UCLA-DQ)score and single-item symptom score of TCM from baseline to 2,4 and 6 weeks.Safety indicators included the incidence of adverse events,severe adverse events and laboratory examination including blood routine,liver function,renal function,and so forth.RESULTS:The total effective rate of TCM symptom pattern score in the GBE50 group after 6 weeks of treatment was higher than that in the control group,the difference in rate was statistically significant(92.67%vs 83.07%,P=0.004).Compared with the control group,there was no difference in the incidence of adverse reactions(9.95%vs 14.85%,P=0.136).CONCLUSION:The treatment of dizziness caused by cerebral arteriosclerosis with GBE50 is effective,safe and reliable. | SHA Rina TANG Lu DU Yawei WU Shengxian SHI Huawei ZOU Hongxin ZHANG Xuran DONG Xinglu ZHOU Li | 2022 | Journal of Traditional Chinese Medicine2022，42，1： | 5 |
| 4 | HTDet:A Clustering Method Using Information Entropy for Hardware Trojan Detection显示文摘Hardware Trojans(HTs)have drawn increasing attention in both academia and industry because of their significant potential threat.In this paper,we propose HTDet,a novel HT detection method using information entropybased clustering.To maintain high concealment,HTs are usually inserted in the regions with low controllability and low observability,which will result in that Trojan logics have extremely low transitions during the simulation.This implies that the regions with the low transitions will provide much more abundant and more important information for HT detection.The HTDet applies information theory technology and a density-based clustering algorithm called Density-Based Spatial Clustering of Applications with Noise(DBSCAN)to detect all suspicious Trojan logics in the circuit under detection.The DBSCAN is an unsupervised learning algorithm,that can improve the applicability of HTDet.In addition,we develop a heuristic test pattern generation method using mutual information to increase the transitions of suspicious Trojan logics.Experiments on circuit benchmarks demonstrate the effectiveness of HTDet. | Renjie Lu Haihua Shen Zhihua Feng Huawei Li Wei Zhao Xiaowei Li | 2021 | Tsinghua Science and Technology2021，26，1： | 4 |
| 5 | Performance Analysis of Inter-Stage Leakage Flows at Rotating Conditions in an Axial Compressor显示文摘For the compressor with shrouded stator blades,the stator well is a rotor-stator space between the rotating drum and the stationary shroud.Due to the pressure difference,a reverse leakage flow would travel through the stator well and inject into the main flow path.Although,the labyrinth seal is commonly placed under the shroud,the rotation effect and seal clearance variation in actual operation process have great impact on the characteristics of this inter-stage leakage,as well as the compressor performance.In this paper,experiments were conducted at a compressor inter-stage seal test rig.The leakage flow rates,total temperatures and swirl ratios were obtained at different speeds and working clearances.The proportions of rotation effect and the clearance reduction effect were analyzed by data processing.Comparisons indicate that the working clearance and leakage flow reduce about 43%and 50%respectively,when the rotational speedω=8100 r/min.The proportion of reduction caused by the rotation effect is around 15%,while the influence of working clearance variation is much greater,accounting for about 35%.The windage heating coefficient and swirl ratio in the outlet cavity are almost in exponential relationship with the rotor speed.The increases in total temperature and swirl ratio generated by the rotation effect are found to be about 80%.In addition,the swirl and radial velocity profiles in the cavities were discussed by validated numerical simulations to reveal the typical flow characteristics.The data presented can provide guidance for better leakage conditions prediction as well as the inter-stage seal design enhancement. | KONG Xiaozhi LIU Yuxin LU Huawei TIAN Zhitao XIN Jianchi | 2020 | Journal of Thermal Science2020，29，6： | 2 |
| 6 | Separation and determination of flavonoids in Lamiophlomis rotata by capillary electrophoresis using borate as electrolyte显示文摘 | Luo Mina Lu Huawei Ma Huaqiao | 2007 | J Pharmaceut Biomed2007，44，4： | 1 |
| 7 | Vγ9Vδ2-T lymphocytes have impaired antiviral function in small-for-gestational-age and preterm neonates显示文摘 | Jinrong Li Hong Li Huawei Mao Meixing Yu Ting Feng Fan Yang Yingying Fan Qiao Lu Chongyang Shen Zhongwei Yin Wenwei Tu Meng Mao | 2013 | Cellular & Molecular Immunology2013，10，3： | 1 |
| 8 | The MNS16A polymorphism in the TERT gene in peri-centenarians from the Han Chinese population显示文摘MNS16A,a variable number of tandem repeats polymorphism in the TERT gene,has been suggested to regulate telomerase activity.As telomerase activity has been reported to be related to life-span,we hypothesized that this polymorphism might affect human longevity by controlling the length of the telomere.To test this hypothesis,we collected 446 unrelated pericentenarian individuals(age≥90,mean 94.45±3.45 years)and 332 normal controls(age 22-53,mean 35.0±12.0 years)from Dujiangyan,Sichuan,China.We typed the MNS16A polymorphism in both groups,and compared the allele and genotype frequencies between the peri-centenarian and control groups using the chi-squared test.There was no significant difference between the peri-centenarian and control groups.Thus,the MNS16A polymorphism in TERT might not influence human life-span,at least in the Han Chinese population studied here. | LIU LiNa WANG ChengYe LU Xiang XIAO FuHui WANG HuaWei YANG LiQin XU LiangYou KONG QingPeng | 2014 | Science China(Life Sciences)2014，57，10： | 1 |
| 9 | Cryptochrome 1 Inhibits Shoot Branching by Repressing the Self-Activated Transciption Loop of PIF4 in Arabidopsis显示文摘Cryptochrome 1(CRY1)is an important light receptor essential for de-etiolation of Arabidopsis seedlings.However,its function in regulating plant architecture remains unclear.Here,we show that mutation in CRY1 resulted in increased branching of Arabidopsis plants.To investigate the underlying mechanism,we analyzed the expression profiles of branching-related genes and found that the mRNA levels of Phytochrome Interaction Factor 4(PIF4)and PIF5 are significantly increased in the cry1 mutant.Genetic analysis showed that the pif4 or pif4pif5 mutant is epistatic to the cry1 mutant,and overexpression of PIF4 conferred increased branching.Moreover,we demonstrated that PIF4 proteins physically associate with the G-box motif within the PIF4 promoter to form a self-activated transcriptional feedback loop,while CRY1 represses this process in response to blue light.Taken together,this study suggests that the CRY1–PIF4 module regulates gene expression via forming a regulatory loop and shoot branching in response to ambient light conditions. | Huawei Zhai Lu Xiong Hongyu Li Xiangguang Lyu Guodong Yang Tao Zhao Jun Liu Bin Liu | 2020 | Plant Communications2020，1，3： | 1 |
| 10 | Separation and de-termination of flavonoids in Lamiophlomis rotata by capillary e-lectrophoresis using borate as electrolyte显示文摘 | Luo Mina Lu Huawei Ma Huaqiao | 2007 | J Pharmaceut Bi-omed2007，44，4： | 1 |
| 11 | Ethyl pyruvate inhibits proliferation and induces apoptosis of hepatocellular carcinoma via regulation of the HMGB1–RAGE and AKT pathways显示文摘 | Ping Cheng Weiqi Dai Fan Wang Jie Lu Miao Shen Kan Chen Jingjing Li Yan Zhang Chengfen Wang Jing Yang Rong Zhu Huawei Zhang Yuanyuan Zheng Chuan-Yong Guo Ling Xu | 2013 | Biochemical and Biophysical Research Communications2013，，： | 1 |
| 12 | Vortex con- trol and aerodynamic performance improvement of a highly loaded compressor cascade via inlet boundary layer suction 显示文摘 | GUO Shuang LU Huawei CHEN Fu | 2013 | Experiments in Fluids2013，54，7： | 1 |
| 13 | Diagnostic Performance of Des- γ -carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis显示文摘 | Rong Zhu Jing Yang Ling Xu Weiqi Dai Fan Wang Miao Shen Yan Zhang Huawei Zhang Kan Chen Ping Cheng Chengfen Wang Yuanyuan Zheng Jingjing Li Jie Lu Yingqun Zhou Dong Wu Chuanyong Guo Fabio Farinati | 2014 | Gastroenterology Research and Practice2014，，： | 1 |
| 14 | Protective Effect of Astaxanthin on Liver Fibrosis through Modulation of TGF- β 1 Expression and Autophagy显示文摘 | Miao Shen Kan Chen Jie Lu Ping Cheng Ling Xu Weiqi Dai Fan Wang Lei He Yan Zhang Wang Chengfen Jingjing Li Jing Yang Rong Zhu Huawei Zhang Yuanyuan Zheng Yingqun Zhou Chuanyong Guo Sunil Kumar Manna | 2014 | Mediators of Inflammation2014，，： | 1 |
| 15 | Experimental study of stator clocking effects in an axial compressor显示文摘 | CHEN Fu GU Zhonghua LU Huawei | | 0，，04： | 1 |
| 16 | Functional Mutation of SMAC / DIABLO , Encoding a Mitochondrial Proapoptotic Protein, Causes Human Progressive Hearing Loss DFNA64显示文摘 | Jing Cheng Yuhua Zhu Sudan He Yanping Lu Jing Chen Bing Han Marco Petrillo Kazimierz O. Wrzeszczynski Shiming Yang Pu Dai Suoqiang Zhai Dongyi Han Michael Q. Zhang Wei Li Xuezhong Liu Huawei Li Zheng-Yi Chen Huijun Yuan | 2011 | The American Journal of Human Genetics2011，，1： | 1 |
| 17 | Influence of Cavity Leakage flow on Corner Separation in a Shrouded Stator Cascade显示文摘The impacts of the cavity leakage flow on the shrouded stator aerodynamic performance were investigated by modelling the annular cascade mainstream with the seal cavity flow path based on the validated numerical method.Meanwhile,the interactions between the cavity leakage and the mainstream were also determined in the current study.The development of hub corner separation under the action of leakage was discussed and the total pressure loss coefficient as well as the entropy-based loss coefficient was employed to evaluate the performance changes at different seal clearances and cavity rotational speeds.The results show that the cavity leakage flow induces a new vortex near the blade leading edge and plays an important role in the development of passage vortex and the size of concentrated shedding vortex.By increasing the seal clearance with more cavity leakage flow rate,an increase in the pitchwise extent of the separation region under 15%span is significant and the total pressure loss in the separation core increases.In addition,with the increase of cavity rotating speed,the starting point of corner separation moves backward,reducing the size and depth of the hub corner separation.The mainstream loss reduction in combination with the entropy increase in the seal cavity causes the entropy-based loss coefficient to perform a trend of decreasing first and then increasing with the cavity speed. | KONG Xiaozhi HUANG Tianshuo LIU Yuxin LU Huawei WANG Long | 2023 | Journal of Thermal Science2023，32，1： | 0 |
| 18 | FgRab5 and FgRab7 are essential for endosomes biogenesis and nonredundantly recruit the retromer complex to the endosomes in Fusarium graminearum显示文摘The retromer complex,composed of the cargo-selective complex(CSC)Vps35-Vps29-Vps26 in complex with the sorting nexin dimer Vps5-Vps17,mediates the sorting and retrograde transport of cargo proteins from the endosomes to the trans-Golgi network in eukaryotic cells.Rab proteins belong to the Ras superfamily of small GTPases and regulate many trafficking events including vesicle formation,budding,transport,tethering,docking and fusion with target membranes.Herein,we investigated the potential functional relationship between the retromer complex and the 11 Rab proteins that exist in Fusarium graminearum using genetic and high-resolution laser confocal microscopic approaches.We found that only FgRab5(FgRab5A and FgRab5B)and FgRab7 associate with the retromer complex.Both FgVps35-GFP and FgVps17-GFP are mis-localized and appear diffused in the cytoplasm ofΔFgrab5A,ΔFgrab5B andΔFgrab7 mutants as compared to their punctate localization within the endosomes of the wild-type.FgRab7 and FgRab5B were found to co-localize with the retromer on endosomal membranes.Most strikingly,we found that these three Rab GTPases are indispensable for endosome biogenesis as both early and late endosomes could not be detected in the cells of the mutants after FM4-64 staining of the cells,while they were very clearly seen in the wild-type PH-1.Furthermore,FgRab7 was found to recruit FgVps35 but not FgVps17 to the endosomal membranes,whereas FgRab5B recruits both FgVps35 and FgVps17 to the membranes.Thus,we conclude that the Rab proteins FgRab5A,FgRab5B and FgRab7 play critical roles in the biogenesis of endosomes and in regulating retromer-mediated trafficking in F.graminearum. | Yakubu Saddeeq Abubakar Han Qiu Wenqin Fang Huawei Zheng Guodong Lu Jie Zhou Zonghua Wang Wenhui Zheng | 2021 | Stress Biology2021，1，1： | 0 |
| 19 | Abatacept is effective in Chinese patients with LRBA and CTLA4 deficiency显示文摘CTLA4 deficiency and LRBA deficiency are a group disorders of immune dysregula-tion that affect CTLA4 pathway.The patients mainly present with autoimmunity,antibody defi-ciency and recurrent infections.Here we reported three Chinese patients with LRBA and CTLA4 mutations.They all presented with chronic diarrhea,hypokalemia,organomegaly,recurrent in-fections,and hypogammaglobulinemia.Reduced Treg cells and increased percentage of circu-lating follicular helper T(cTfh)cells were revealed in these patients.Although steroid and immunoglobulin therapy were given,the enteropathy was persistent.Therefore,abatacept treatment was provided to these patients.They showed a marked improvement of enteropathy and gastrointestinal endoscopy showed alleviated inflammatory lesion and follicular hyperpla-sia.Furthermore,the frequency of cTfh cells was reduced after abatacept therapy.Taken together,targeted therapy with abatacept is a promising treatment modality for patients with LRBA and CTLA4 deficiency.The findings also suggest that the frequency of cTfh cells could serve as a marker for tracking disease activity and the response to abatacept therapy. | Lu Yang Xiuhong Xue Xuemei Chen Junfeng Wu Xi Yang Li Xu Xuemei Tang Mo Wang Huawei Mao Xiaodong Zhao | 2021 | Genes & Diseases2021，8，5： | 0 |
| 20 | Effect of Winglet Geometry Arrangement and Incidence on Tip Clearance Control in a Compressor Cascade显示文摘An experimental study is conducted to investigate the influences of blade tip winglet on the flow field of a compressor cascade. The tests are performed in a low speed linear cascade with stationary endwall, with three blade tip configurations, including the baseline tip, the suction-side winglet tip and the pressure-side winglet tip. The flowfield downstream of the cascade is measured using five-hole probe, from which the three-dimensional velocity field, vorticity field and pressure field are obtained. Static pressure measurements are made on the endwall above the blade row using pressure taps embedded in the plywood endwall. All measurements are made at both design and off-design conditions for tip clearance level of about 2 percent of the blade chord. The results revealed the incidence variation significantly affects the secondary flow and the associated loss field downstream of the cascade, where the tip leakage vortex and passage vortex exist as the major contributors on the field. The winglet geometry arrangements can change the trajectory of the tip leakage vortex. The suction-side winglet tip blade provides a lower overall total pressure loss coefficient when compared to the baseline tip blade and pressure-side winglet tip blade at all incidence angles. | HAN Shaobing ZHONG Jingjun LU Huawei KAN Xiaoxu YANG Ling | 2014 | Journal of Thermal Science2014，23，4： | 0 |
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