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| 1 | Resistance of Helicobacter pylori to antibiotics from 2000 to 2009 in Shanghai显示文摘AIM: To investigate the resistance of Helicobacter pylori (H. pylori ) to 6 commonly used antibiotics from 2000 to 2009 in Shanghai. METHODS: A total of 293 H. pylori strains were collected from 2000 to 2009 in Shanghai and tested for their susceptibility to metronidazole, clarithromycin, amoxicillin, furazolidone, levofloxacin and tetracycline using agar dilution. RESULTS: The resistant rates of H. pylori to clarithromycin (8.6%, 9.0% and 20.7%) and levofloxacin (10.3%, 24.0% and 32.5%) increased from 2000 to 2009 in Shanghai. The resistant rate of H. pylori to metronidazole remained stable (40%-50%). Only one strain of H. pylori isolated in 2005 was resistant to tetracycline. All strains were sensitive to amoxicillin and furazolidone.The resistant rate of H. pylori to antibiotics was not related with the sex, age and clinical outcome of patients. CONCLUSION: Resistance of H. pylori to antibiotics plays an important role in making treatment strategies against H. pylori -associated diseases. | Qin-Juan Sun Xiao Liang Qing Zheng Wei-Qi Gu WenZhong Liu Shu-Dong Xiao Hong Lu | 2010 | World Journal of Gastroenterology2010，16，40： | 90 |
| 2 | Changing patterns of colorectal cancer in China over a period of 20 years显示文摘AIM: To determine whether any changes have occurred on the patterns of colorectal cancer in China.METHODS: Data from 21 Chinese articles published from 1980 to 1999, were used to analyze the time trend of colorectal cancer according to the patients' age at diagnosis,sex, the site of the tumor, stage, and the pathology.RESULTS: From 1980s to 1990s, the mean age of the colorectal cancer patients has increased. The percentage of the female patients rose. The distribution of colorectal carcinoma shows a predominance of rectal cancer. However,the proportion of proximal colon cancer (including transverse and ascending colon) increased significantly accompanied by a decline in the percentage of rectal cancer. Similarity in the percentage of distal colon cancer between two decades was revealed. In the 1990s, statistically more Stage B patients were found than those in 1980s. In addition, databases show a significant decrease in the Stage D cases. The proportion of adenocarcinoma increased, but the mucinous adenocarcinoma decreased during two decades.CONCLUSION: These findings indicate that the patternof colorectal cancer in China has been changing. Especially,a proximal shift due to the increasing proportion of ascending and transverse colon cancer has occurred in China. | Ming Li Jin Gu | 2005 | World Journal of Gastroenterology2005，11，30： | 93 |
| 3 | The zircon SHRIMP chronology and trace elementgeochemistry of the Carboniferous volcanic rocksin western Tianshan Mountains显示文摘The genesis of the Carboniferous volcanic rocks in the Dahalajunshan group, mainly consisting of trachytes and trachy-andesites and distributing widely in western Tianshan Mountains, remains to be controversial. It has been proposed to be relevant to “rift” or “plume”. Detailed pe-trology and geochemical data presented in this paper show that these volcanic rocks represent typical continental arc magmatism. The volcanic rocks are mainly trachy-andesitic, and the magma source is enriched in LILE, Th and Pb, and depleted in HFSE and Ce. Trace element geochemical study suggests that the basalts could be modeled by 7%-11% partial melt of garnet lherzolite. The volcanic rocks in the Dahala-junshan group are neither the products of “rift” nor so-called “plume” but represent the continental island arc of the Pa-leo-Southern Tianshan Ocean. The mantle wedge had been modified by the melt generating in subduction zone during a long evolution history of this island arc. The continental crust materials (i.e. mainly sediment on ocean floor) had been added into island arc through melt in subduction zone. Volcanic rocks occurring in different regions might represent magma eruption in different time. The zircon SHRIMP dat-ing indicates that the ages of the basalt varies between 334.0 Ma and 394.9 Ma. The 13 analyses give an average age of 353.7 ±4.5 Ma (MSWD = 1.7). The apparent ages of zircons in trachy-andesite vary between 293.0 Ma and 465.4 Ma. All analyses fall on the U-Pb concordant line and are divided into two groups. 8 analyses produce an average age of 312.8±4.2 Ma (MSWD = 1.7), which represents the crystal-lizing age of zircon rims in trachy-andesite. The acquired two ages (i.e. 354 and 313 Ma) belong to the Early Carboniferous and Late Carboniferous epochs, respectively. Thus, the Da-halajunshan group would be separated into several groups with the accumulation of high-quality age dating and data of trace element and isotopic geochemistry, in our opinion. | ZHU Yongfeng ZHANG Lifei GU Libing GUO Xuan ZHOU Jing | 2005 | Chinese Science Bulletin2005，50，19： | 188 |
| 4 | Isolation and initial characterization of GW5, a major QTL associated with rice grain width and weight显示文摘谷物重量是庄稼谷物产量的一个主要决定因素并且被自然地发生的量的特点 loci (QTL ) 控制。我们更早识别了控制米饭谷物宽度和重量的主要 QTL, GW5,它在米饭染色体 5 上被印射到一个再结合热点。获得 GW5 怎么控制米饭谷物宽度的更好的理解,我们进行了这个地点的好印射并且揭开在米饭栽培变种 Asominori 与增加的谷物宽度联系的 1 212-bp 删除,与苗条谷物米饭 IR24 比较。另外, 46 米饭栽培变种的 genotyping 分析表明这删除高度与谷物宽度显型被相关,建议 GW5 删除可能在米饭驯服期间被选择了。GW5 编码对原子核局部性的 144 氨基酸的新奇原子蛋白质。而且,我们证明 GW5 身体上在酵母与 polyubiquitin 交往二混血儿的试金。一起,我们的结果建议 GW5 代表主要 QTL 内在的米饭宽度和重量,并且它多半在 ubiquitin-proteasome 小径行动在种子开发期间调整房间分割。这研究提供新奇卓见进控制米饭谷物开发的分子的机制并且建议 GW5 能为庄稼的产量很高的繁殖用作一个潜在的工具。 | Jianfeng Weng Suhai Gu Xiangyuan Wan He Gao Tao Guo Ning Su Cailin Lei Xin Zhang Zhijun Cheng Xiuping Guo Jiulin Wang Ling Jiang Huqu Zhai Jianmin Wan | 2008 | Cell Research2008，18，12： | 248 |
| 5 | 大型浅水湖泊沉积物内源营养盐释放模式及其估算方法——以太湖为例显示文摘在新的野外调查和室内试验基础上,完善了有关大型浅水湖泊沉积物内源营养盐释放的模式,并在此基础上提出了太湖内源释放的估算方法。通过在太湖开展室内释放模拟实验和风浪期间底泥悬浮及上覆水中营养盐浓度变化的野外观测,提出了静态与动态二种浅水湖泊内源释放模式。静态情况下,营养盐主要通过浓度梯度扩散从沉积物进入上覆水,其释放强度受控于沉积物~水界面的温度,氧化还原环境及营养盐浓度差;动态条件下,沉积物由于动力扰动而发生悬浮,沉积物中溶解性及颗粒态的营养盐随着沉积物的悬浮而释放。虽然动态情况下总的营养盐释放较静态条件下大,但由于湍流导致水体及水土界面充氧,铁,锰等金属元素因氧化而吸附溶解性营养盐(特别是活性磷SRP)的能力增强,所以动力扰动仅引起总的营养盐释放,而不一定导致溶解性营养盐的释放。因此,在动态条件下,营养盐总释放量受控于动力扰动强度,底泥可悬浮量及沉积物中的营养盐含量;对于可溶性的营养盐,特别是SRP,其释放还受控于动力复氧的强度,沉积物中铁的含量及沉积物间隙水与上覆水中营养盐的浓度差。在此基础上,分别估算了静态和动态二种情况下沉积物内源释放量。根据实验室模拟结果,静态条件下太湖全湖一年NH_4^+-N释放量达1万吨左右,PO_4^(3-)-P释放量达900 t左右;结合太湖2001年的风场观测记录,把太湖野外风浪过程分为风平浪静,小风浪,大风浪三种情况,分别占全年总日数的12%,82%,6%在“风平浪静”条件下,其释放量根据实验室的静态释放试验来估算,而“小风浪”和“大风浪”条件下,其释放量则根据室内水槽试验得到的释放通量来估算。结果显示太湖全年释放量为总氮8.1万吨,总磷为2.1万吨;分别为外源氮磷年输入量的2-6倍。 | 秦伯强 朱广伟 张路 罗潋葱 高光 Gu Binghe | 2005 | 中国科学:地球科学2005，39，S2： | 113 |
| 6 | Study on the prevalence of benlgn prostatic hyperplasia and prostatic cancer in China显示文摘StudyontheprevalenceofbenlgnprostatichyperplasiaandprostaticcancerinChinaGuFang-liu(顾方六)InstituteofUrology,BeijingMedicalUniv... | $$$$ Gu Fang-liu(顾方六)Institute of Urology,Beijing Medical University,Beijing 100083,China | 1994 | 生殖医学杂志1994，3，S1： | 116 |
| 7 | 利用多尺度CT成像表征致密砂岩微观孔喉结构显示文摘为全面表征致密储集层微观孔喉分布及结构特征,对鄂尔多斯盆地上三叠统延长组致密砂岩储集层样品进行纳米—微米多尺度CT三维成像研究。首先利用低分辨率微米尺度X-CT扫描获取直径为2.54 cm岩心柱内部微米级别孔喉结构特征,然后根据微孔分布特征,制备多个直径为65μm的样品进行高分辨率纳米尺度扫描,重构纳米级微孔三维结构模型,最终计算出样品的孔隙度和渗透率。在微米尺度下,孔喉大小不一,直径为5.4~26.0μm,呈孤立状,局部呈条带状;在纳米尺度下,微孔直径主要为0.4~1.5μm,纳米级微孔数量增多,孔喉为管状、球状,分布于矿物颗粒(晶体)内部或表面。纳米级球状微孔连通性较差,三维空间呈孤立状,多仅作为储集空间,而纳米级短管状微孔具有一定的连通性,与微米级管状微孔和邻近孤立球状纳米微孔具有一定连通性,兼具喉道与孔隙的双重功能。数值计算样品渗透率为0.843×10 3μm2,孔隙度为10%。 | 白斌 朱如凯 吴松涛 杨文静 Jeff Gelb Allen Gu 张响响 苏玲 | 2013 | 石油勘探与开发2013，40，3： | 165 |
| 8 | Targeted mutagenesis in rice using CRISPR-Cas system显示文摘 | Jin Miao Dongshu Guo Jinzhe Zhang Qingpei Huang Genji Qin Xin Zhang Jianmin Wan Hongya Gu Li-Jia Qu | 2013 | Cell Research2013，23，10： | 103 |
| 9 | Liver cancer incidence and mortality in China: Temporal trends and projections to 2030显示文摘Objective: Liver cancer is one of the most common cancers and major cause of cancer deaths in China,which accounts for over 50% of new cases and deaths worldwide.The systematic liver cancer statistics including of projection through 2030 could provide valuable information for prevention and control strategies in China,and experience for other countries.Methods: The burden of liver cancer in China in 2014 was estimated using 339 cancer registries' data selected from Chinese National Cancer Center(NCC).Incident cases of 22 cancer registries were applied for temporal trends from 2000 to 2014.The burden of liver cancer through 2030 was projected using age-period-cohort model.Results: About 364,800 new cases of liver cancer(268,900 males and 95,900 females) occurred in China,and about 318,800 liver cancer deaths(233,500 males and 85,300 females) in 2014.Western regions of China had the highest incidence and mortality rates.Incidence and mortality rates decreased by about 2.3% and 2.6% per year during the period of 2000-2014,respectively,and would decrease by more than 44% between 2014 and 2030 in China.The young generation,particularly for those aged under 40 years,showed a faster down trend.Conclusions: Based on the analysis,incidence and mortality rates of liver cancer are expected to decrease through 2030,but the burden of liver cancer is still serious in China,especially in rural and western areas.Most cases of liver cancer in China can be prevented through vaccination and more prevention efforts should be focused on high risk groups. | Rongshou Zheng Chunfeng Qu Siwei Zhang Hongmei Zeng Kexin Sun Xiuying Gu Changfa Xia Zhixun Yang He Li Wenqiang Wei Wanqing Chen Jie He | 2018 | Chinese Journal of Cancer Research2018，30，6： | 132 |
| 10 | Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis显示文摘 | Yan Li Qiupeng Zheng Chunyang Bao Shuyi Li Weijie Guo Jiang Zhao Di Chen Jianren Gu Xianghuo He Shenglin Huang | 2015 | Cell Research2015，25，8： | 323 |
| 11 | Clinical observation of salvianolic acid B in treatment of liver fibrosis in chronic hepatitis B显示文摘AIM: To evaluate the clinical efficacy of salvianolic acidB (SA-B) on liver fibrosis in chronic hepatitis B.METHODS: Sixty patients with definite diagnosis of liverfibrosis with hepatitis B were included in the trial.Interferon-γ (IFN-γ) was used as control drug. Thepatients took orally SA-B tablets or received muscularinjection of IFN-γ in the double blind randomized test,The complete course lasted 6 months. The histologicalchanges of liver biopsy specimen before and after thetreatment were the main evidence in evaluation, incombination with the results of contents of serum HA,LN, Ⅳ-C, P-Ⅲ-P, liver ultrasound imaging, andsymptoms and signs.RESULTS: Reverse rate of fibrotic stage was 36.67 % inSA-B group and 30.0 % in IFN-γgroup. Inflammatoryalleviating rate was 40.0 % in SA-B group and 36.67 %in IFN-γ group. The average content of HA and Ⅳ-Cwas significantly lower than that before treatment. Theabnormal rate also decreased remarkably. Overallanalysis of 4 serological fibrotic markers showedsignificant improvement in SA-B group as comparedwith the IFN-γgroup. Score of liver ultrasound imagingwas lower in SA-B group than in IFN-γgroup (HA 36.7 %vs80 %,Ⅳ-C 3.3 % vs23.2 %). Before the treatment,ALT AST activity and total bilirubin content of patientswho had regression of fibrosis after oral administrationof SA-B, were significantly lower than those of patientswho had aggravation of fibrosis after oraladministration of SA-B. IFN-γ showed certain sideeffects (fever and transient decrease of leukocytes,occurrence rates were 50 % and 3.23 %), but SA-Bshowed no side effects.CONCLUSION: SA-B could effectively reverse liverfibrosis in chronic hepatitis B. SA-B was better than IFN-γ in reduction of serum HA content, overall decrease of4 serum fibrotic markers, and decrease of ultrasoundimaging score. Liver fibrosis in chronic hepatitis B withslight liver injury was more suitable to SA-B in anti-fibrotic treatment. SA-B showed no obvious side effects. | Ping Liu Yi-Yang Hu Cheng Liu Hui-Ming Xue Zhi-Qiang Xu Lie-Ming Xu Cheng-Hai Liu Hong-Tu Gu Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China Da-Yuan Zhu Shanghai Institute of Metaria Medica,Chinese Academy of Sciences,Shanghai 200031,China Zhi-Qing Zhang the 4~(th) Hualyin City Hospital,Hualan City,223000,JiangSu Province,China | 2002 | World Journal of Gastroenterology2002，8，4： | 85 |
| 12 | Identification of a novel coronavirus causing severe pneumonia in human:a descriptive study显示文摘Background:Human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern globally.Here,we report a novel batorigin CoV causing severe and fatal pneumonia in humans.Methods:We collected clinical data and bronchoalveolar lavage(BAL)specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital,Hubei province,China.Nucleic acids of the BAL were extracted and subjected to next-generation sequencing.Virus isolation was carried out,and maximum-likelihood phylogenetic trees were constructed.Results:Five patients hospitalized from December 18 to December 29,2019 presented with fever,cough,and dyspnea accompanied by complications of acute respiratory distress syndrome.Chest radiography revealed diffuse opacities and consolidation.One of these patients died.Sequence results revealed the presence of a previously unknownβ-CoV strain in all five patients,with 99.8%to 99.9%nucleotide identities among the isolates.These isolates showed 79.0%nucleotide identity with the sequence of SARS-CoV(GenBank NC_004718)and 51.8%identity with the sequence of MERS-CoV(GenBank NC_019843).The virus is phylogenetically closest to a bat SARS-like CoV(SL-ZC45,GenBank MG772933)with 87.6%to 87.7%nucleotide identity,but is in a separate clade.Moreover,these viruses have a single intact open reading frame gene 8,as a further indicator of bat-origin CoVs.However,the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV,indicating that these viruses might use the same receptor.Conclusion:A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans. | Li-Li Ren Ye-Ming Wang Zhi-Qiang Wu Zi-Chun Xiang Li Guo Teng Xu Yong-Zhong Jiang Yan Xiong Yong-Jun Li Xing-Wang Li Hui Li Guo-Hui Fan Xiao-Ying Gu Yan Xiao Hong Gao Jiu-Yang Xu Fan Yang Xin-Ming Wang Chao Wu Lan Chen Yi-Wei Liu Bo Liu Jian Yang Xiao-Rui Wang Jie Dong Li Li Chao-Lin Huang Jian-Ping Zhao Yi Hu Zhen-Shun Cheng Un-Lin Liu Zhao-Hui Qian Chuan Qin Qi Jin Bin Cao Jian-Wei Wang | 2020 | Chinese Medical Journal2020，，9： | 99 |
| 13 | China Stroke Statistics 2019:A Report From the National Center for Healthcare Quality Management in Neurological Diseases,China National Clinical Research Center for Neurological Diseases,the Chinese Stroke Association,National Center for Chronic and Non-communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations显示文摘China faces the greatest challenge from stroke in the world.The death rate for cerebrovascular diseases in China was 149.49 per 100000,accounting for 1.57 million deaths in 2018.It ranked third among the leading causes of death behind malignant tumours and heart disease.The age-standardised prevalence and incidence of stroke in 2013 were 1114.8 per 100000 population and 246.8 per 100000 person-years,respectively.According to the Global Burden of Disease Study 2017,the years of life lost(YLLs)per 100000 population for stroke increased by 14.6%;YLLs due to stroke rose from third highest among all causes in 1990 to the highest in 2017.The absolute numbers and rates per 100000 population for all-age disability-adjusted life years(DALYs)for stroke increased substantially between 1990 and 2017,and stroke was the leading cause of all-age DALYs in 2017.The main contributors to cerebrovascular diseases include behavioural risk factors(smoking and alcohol use)and pre-existing conditions(hypertension,diabetes mellitus,dyslipidaemia and atrial fibrillation(AF)).The most prevalent risk factors among stroke survivors were hypertension(63.0%-84.2%)and smoking(31.7%-47.6%).The least prevalent was AF(2.7%-7.4%).The prevalences for major risk factors for stroke are high and most have increased over time.Based on the latest national epidemiological data,26.6%of adults aged≥15 years(307.6 million adults)smoked tobacco products.For those aged≥18 years,age-adjusted prevalence of hypertension was 25.2%;adjusted prevalence of hypercholesterolaemia was 5.8%;and the standardised prevalence of diabetes was 10.9%.For those aged≥40 years,the standardised prevalence of AF was 2.31%.Data from the Hospital Quality Monitoring System showed that 3010204 inpatients with stroke were admitted to 1853 tertiary care hospitals during 2018.Of those,2466785(81.9%)were ischaemic strokes(ISs);447609(14.9%)were intracerebral haemorrhages(ICHs);and 95810(3.2%)were subarachnoid haemorrhages(SAHs).The average age of patients admitted was 66 years old,and nearly 60%were male.A total of 1555(0.1%),2774(0.6%)and 1347(1.4%)paediatric strokes(age<18 years)were identified among IS,ICH and SAH,respectively.Over one-third(1063892(35.3%))of the patients were covered by urban resident basic medical insurance,followed by urban employee basic medical insurance(699513(23.2%))and new rural cooperative medical schema(489361(16.3%)).The leading risk factor was hypertension(67.4%for IS,77.2%for ICH and 49.1%for SAH),and the leading comorbidity was pneumonia or pulmonary infection(10.1%for IS,31.4%for ICH and 25.2%for SAH).In-hospital death/discharge against medical advice rate was 8.3%for stroke inpatients,ranging from 5.8%for IS to 19.5%for ICH.The median and IQR of length of stay was 10.0(7.0-14.0)days,ranging from 10.0(7.0-13.0)in IS to 14.0(8.0-22.0)in SAH.Data from the Chinese Stroke Center Alliance demonstrated that the composite scores of guideline-recommended key performance indicators for patients with IS,ICH and SAH were 0.77±0.21,0.72±0.28 and 0.59±0.32,respectively. | Yong-Jun Wang Zi-Xiao Li Hong-Qiu Gu Yi Zhai Yong Jiang Xing-Quan Zhao Yi-Long Wang Xin Yang Chun-Juan Wang Xia Meng Hao Li Li-Ping Liu Jing Jing Jing Wu An-Ding Xu Qiang Dong David Wang Ji-Zong Zhao On behalf of China Stroke Statistics 2019 Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 181 |
| 14 | Corrosion Resistance of Graphene-Reinforced Waterborne Epoxy Coatings显示文摘Graphene(G) was dispersed uniformly in water and used as an inhibitor in waterborne epoxy coatings.The effect of dispersed G on anticorrosion performance of epoxy coatings was evaluated.The composite coatings displayed outstanding barrier properties against H_2O molecule compared to the neat epoxy coating.Open circuit potential(OCP),Tafel and electrochemical impedance spectroscopy(EIS)analysis con-?rmed that the corrosion rate exhibited by composite coatings with 0.5 wt%G was an order of magnitude lower than that of neat epoxy coating.Salt spray test results revealed superior corrosion resistance offered by the composite coating. | Shuan Liu Lin Gu Haichao Zhao Jianmin Chen Haibin Yu | 2016 | Journal of Materials Science & Technology2016，32，5： | 67 |
| 15 | Soluble triggering receptor expressed on myeloid cell-1 (sTREM- 1): a potential biomarker for the diagnosis of infectious diseases显示文摘为传染疾病的诊断和预后的敏感、有用的 biomarkers 广泛地被开发了。这些 biomarkers 的一个例子正在触发在 myeloid cell-1 (TREM-1 ) 上表示的受体,它是在单核白血球 / 巨噬细胞和 neutrophils 上表示的房间表面受体。TREM-1 由激活 TREM-1/DAP12 小径放大发炎。这条小径被细菌的 lipopolysaccharide 被和 ligands 或刺激的 TREM-1 的相互作用触发。因而,支持 inflammatory cytokines 和 chemokines 被分泌。可溶的 TREM-1 (sTREM-1 ) 是能直接为传染疾病在人的身体液体和著名 biomarker 被测试的 TREM-1 的一种特殊形式。 sTREM-1 水平能潜在地为早诊断和一些传染疾病的预后预言被使用,包括传染肋膜的流出,肺感染,败血,细菌的脑膜炎,病毒的感染(例如,克里米亚半岛的刚果出血性的发烧和登革热发烧),真菌的感染(例如,曲霉属菌感染),并且灼伤相关的感染。sTREM-1 比传统的索引是更敏感、特定的 biomarker,例如 C 反应的蛋白质和 procalcitonin 层次,为这些传染疾病。因此, sTREM-1 是为指向的治疗和传染疾病的快速、早的诊断的可行 biomarker。 | Changlin Cao Jingxian Gu Jingyao Zhang | 2017 | Frontiers of Medicine2017，11，2： | 62 |
| 16 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 17 | Zircon SHRIMP Dating for the Weiya Pluton, Eastern Tianshan: Its Geological Implications显示文摘The timing of the emplacement of the Weiya pluton remains controversial due to the absence of systematic and precise dating. This paper reports zircon SHRIMP U-Pb dating of different lithologic phases in the Weiya pluton, and discusses the genesis and tectonic environment. The ages of gabbro, quartz syenite, diorite porphyrite and fine-grained granite are 236?6 Ma, 246?6 Ma, 233?8 Ma and 237?8 Ma, respectively. All these phases were formed in early-middle Indosinian (Triassic) in a post-orogenic environment. In addition to underplating, intraplating of mantle-derived magmas is also a substantial mechanism for magma generation and vertical accretion of the continental crust. Granitoid rocks are important products of vertical continental accretion as underplating evolves gradually to intraplating. The existence of post-orogenic Indosinian granites shows that the middle Tianshan orogenic belt underwent an important tectonic conversion from the Paleo-Asian ocean subduction-collision system to the Paleo-Tethys ocean regime. | ZHANG Zunzhong GU Lianxing WU Changzhi LI Weiqiang XI Aihua WANG Shuo | 2005 | Acta Geologica Sinica(English Edition)2005，79，4： | 53 |
| 18 | Comparative Analysis of Codon Usage Patterns Among Mitochondrion, Chloroplast and Nuclear Genes显示文摘 | Wen-Juan Zhang Jie Zhou Zuo-Feng Li Li Wang Xun Gu Yang Zhong | 2007 | Journal of Integrative Plant Biology2007，49，2： | 55 |
| 19 | Inhibitory effect of ginsenoside Rg3 combined with cyclophosphamide on growth and angiogenesis of ovarian cancer显示文摘背景人参皂甙 Rg3,从人参孤立的主要部件,禁止某些瘤生长和 angiogenesis。低剂量化疗和 antiangiogenesis 禁止者的联合比常规治疗更有效地压制试验性的瘤的生长。卵巢的癌症上的这联合的效果尚待被评估。因此,我们在人的卵巢的 cancer.Methods 的生长和 angiogenesis 上调查了人参皂甙 Rg3 和 cyclophosphamide (CTX ) 的协同 28 只女 athymic 老鼠随机被划分成 4 组 7:人参皂甙 Rg3, CTX,人参皂甙 Rg3 和 CTX 联合和控制,在与卵巢的癌症房间(SKOV-3 ) 被移植以后。老鼠为 SKOV-3cells 的 10 天后面的接种被给人参皂甙 Rg3 和 CTX 的 intraperitoneal 注射。老鼠的生活天的生活质量和数字被记录。瘤的尺寸,瘤禁止的率,生活延伸率,增殖的房间原子抗原标记索引( PCNALI ),脉管的 endothelial 房间生长因素( VEGF )和瘤纸巾的 microvessel 密度( MVD )的表示是在人参皂甙的鼠标的 estimated.Results 生活质量 Rg3 和联合治疗组更好并且比控制长生活天数。每个对待的组的平均的瘤重量是不到控制,在对待的组之中没有重要差别。对待的组的 PCNALI 比控制低。在对待的组的 MVD 价值和 VEGF 表示比控制显著地低, MVD 人参皂甙 Rg3 和联合治疗组珍视显著地比 CTX group.Conclusions 人参皂甙 Rg3 的低当独自使用了或与 CTX 结合了时,禁止了卵巢的癌症的生长和 angiogenesis。人参皂甙 Rg3 和 CTX 联合互相增强了 antitumour 效果并且与瘤改进了生活质量和老鼠的幸存时间。 | XU Tian-min XIN Ying CUI Man-hua JIANG Xin GU Li-ping | 2007 | Chinese Medical Journal2007，，7： | 59 |
| 20 | Study on effectiveness evaluation of weapon systems based on grey relational analysis and TOPSIS显示文摘To evaluate the effectiveness of weapon systems, the advantages and disadvantages of grey relational analysis and TOPSIS for multiattribute decision-making is pointed out, and an effectiveness evaluation model of weapon systems by combining grey relational analysis and TOPSIS is proposed. The model aggregates the grey relational grade and the distance to a new integrated closeness and reflects not only the trend but also the situation of the alternative. The example illuminates that the model is effective for the effectiveness evaluation of weapon systems. | Gu Hui Song Bifeng | 2009 | Journal of Systems Engineering and Electronics2009，20，1： | 53 |
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