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| 1 | 功能性消化不良、胃排空延迟和生活质量下降显示文摘功能性消化不良(FD)是一种临床上最常见的综合征,表现为慢性反复性中上腹疼痛或不适,传统的诊断检测方法不能检测出病因。许多FD患者诉说症状与饮食有关,但病理生理情况不明。25%~50%的FD患者发生胃排空延迟症状,这与胃窦部动力降低有关。其他FD的异常表现包括胃底容受性限制、胃扩张过度敏感和幽门螺杆菌(H.pylori)感染。 | Talley NJ Locke Ⅲ GR Lahr B Zinsmeister AR Tougas G Ligozio G Rojavin MA Tack J.Mayo Clinic Rochester MN 陆红 | 2006 | 胃肠病学2006，11，2： | 12 |
| 2 | Three global conditions for biodiversity conservation and sustainable use: an implementation framework显示文摘‘Nature and its vital contributions to people,which together embody biodiversity and ecosystem functions and services,are deteriorating worldwide’[1].The United Nations Convention on Biological Diversity(CBD)is intended to ensure conservation of biodiversity,its wise use,and sharing of benefits from use of genetic resources.Through it,the Strategic Plan(SP)for Biodiversity 2011-2020 was created to make progress toward a vision of humanity‘Living in Harmony with N ature’by 2050[2].W hen that vision is realized,biodiversity will be valued,conserved,restored,and wisely used,so it can maintain ecosystem services and sustain a healthy planet. | Harvey Locke Erie C.Ellis Oscar Venter Richard Schuster Keping Ma Xiaoli Shen Stephen Woodley Naomi Kingston Nina Bhola Bernardo B.N.Strassburg Axel Paulsch Brooke Williams James E.M.Watson | 2019 | National Science Review2019，6，6： | 6 |
| 3 | Social media as passive geo-participation in transportation planning-how effective are topic modeling&sentiment analysis in comparison with citizen surveys?显示文摘We live in an era of rapid urbanization as many cities are experiencing an unprecedented rate of population growth and congestion.Public transport is playing an increasingly important role in urban mobility with a need to move people and goods efficiently around the city.With such pressures on existing public transportation systems,this paper investigates the opportunities to use social media to more effectively engage with citizens and customers using such services.This research forms a case study of the use of passively collected forms of big data in cities-focusing on Sydney,Australia.Firstly,it examines social media data(Tweets)related to public transport performance.Secondly,it joins this to longitudinal big data-delay information continuously broadcast by the network over a year,thus forming hundreds of millions of data artifacts.Topics,tones,and sentiment are modeled using machine learning and Natural Language Processing(NLP)techniques.These resulting data,and models,are compared to opinions derived from a citizen survey among users.The validity of such data and models versus the intentions of users,in the context of systems that monitor and improve transport performance,are discussed.As such,key recommendations for developing Smart Cities were formed in an applied research context based on these data and techniques. | Oliver Lock Christopher Pettit | 2020 | Geo-Spatial Information Science2020，23，4： | 5 |
| 4 | 糖皮质激素对急性淋巴细胞白血病Puma表达的影响显示文摘目的糖皮质激素可通过调节某些基因的表达而诱导细胞凋亡,但在治疗白血病过程中对促凋亡蛋白Pum a表达的影响尚不清楚,该实验试探讨糖皮质激素在诱导体外培养的急性淋巴细胞白血病细胞凋亡过程中对Pum a表达的影响。方法利用人急性淋巴细胞白血病细胞移植到免疫缺陷小鼠体内建立的细胞系,地塞米松处理后MTT比色法进行药物敏感性实验、W estern印迹及实时荧光定量PCR检测Pum a蛋白及mRNA的表达。结果来源于临床疗效好的病例样本,其体外培养的白血病细胞对地塞米松敏感,来源于临床疗效差的病例样本,其体外培养的白血病细胞对地塞米松耐药,耐药组与敏感组白血病细胞间对地塞米松的体外敏感性有显著差异(P<0.05)。地塞米松处理后耐药组及敏感组均未见Pum a蛋白及mRNA的表达上调。结论糖皮质激素在诱导体外培养的白血病细胞凋亡过程中,不能引起Pum a表达的上调。 | 徐波 王保捷 李爱敏 Richard LOCK | 2006 | 中国当代儿科杂志2006，8，2： | 3 |
| 5 | Entrepreneurial motivation显示文摘 | Scott Shane Edwin A. Locke Christopher J. Collins | 2003 | Human Resource Management Review2003，，2： | 3 |
| 6 | 细胞分裂抑制剂:未来抗生素研发的新理解显示文摘对过度滥用的老抗生素所衍生的新药物的临床应用,促使抗生素耐药问题日趋严重。不控制抗生素的使用而限制抗生素的耐药性的想法是不现实的。健康组织、制药公司和研究机构已开始意识到研发新靶标药物的紧迫性。有关细菌细胞分裂途径的丰富知识可以帮助人们寻找新型抑制剂,本文将讨论抑制细菌细胞分裂的治疗潜能,并回顾在这个抗生素发现新领域中的进展。 | 温晓雪 明琰 王林 Lock RL Harry EJ | 2009 | 国际药学研究杂志2009，36，1： | 3 |
| 7 | Factors associated with marked reduction in mortality for Fontan operations in patients with single ventricle显示文摘 | Mayer JE Bridges ND Lock JE | 1992 | J Thorac Cardiovasc Surg1992，103，3： | 2 |
| 8 | Prevalence and clinical spectrum of gastroesophageal reflux: A population-based study in Olmsted County, Minnesota显示文摘 | GR Locke NJ Talley SL Fett AR Zinsmeister LJ Melton | 1997 | Gastroenterology1997，，5： | 2 |
| 9 | Endovascular stent implantation in patients with stenotic aortoarteriopathies: early and medium-term results显示文摘 | Siwik ES Perry SB Lock JE | 2003 | Catheter Cardiovasc Interv2003，59，3： | 2 |
| 10 | Seasonal variation in milk conjugated linoleic acid and Δ 9 -desaturase activity in dairy cows显示文摘 | A.L Lock P.C Garnsworthy | 2002 | Livestock Production Science2002，，1： | 2 |
| 11 | Biosynthesis of Conjugated Linoleic Acid in Ruminants and Humans显示文摘 | Donald L. Palmquist Adam L. Lock Kevin J. Shingfield Dale E. Bauman | 2005 | Advances in Food and Nutrition Research2005，，： | 2 |
| 12 | Epidemiology of IBS显示文摘 | Rok Seon Choung G. Richard Locke | 2011 | Gastroenterology Clinics of North America2011，，1： | 2 |
| 13 | Epidemiology of Eosinophilic Esophagitis Over Three Decades in Olmsted County, Minnesota显示文摘 | Ganapathy A. Prasad Jeffery A. Alexander Cathy D. Schleck Alan R. Zinsmeister Thomas C. Smyrk Richard M. Elias G. Richard Locke Nicholas J. Talley | 2009 | Clinical Gastroenterology and Hepatology2009，，10： | 2 |
| 14 | Spatial Variability of Soil Properties and Weed Population in the Mississippi Delta 显示文摘 | Gaston L A Locke M A Zablotowicz R M Reddy K N | 1999 | Soil Science Bulletin1999，44，8： | 2 |
| 15 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 16 | Functional dyspepsia, delayed gastric emptying, and impaired quality of life显示文摘 | Talley NJ Locke GR 3rd Lahr BD | 2006 | Gut2006，55，7： | 1 |
| 17 | Direct and Indirect Effects of Three Core Charismatic Leadership Components on Performance and Attitude显示文摘 | KIRKPATRICK S A LOCKE E A | 1996 | Journal of Applied Psychology1996，，1： | 1 |
| 18 | 2,4,6-Tri-ter-butylphenylphosphene-dimesitylsilene,the first phosphassilaalkene显示文摘 | Lock F M Bickelhaupt F | 1984 | Tetrahedron Lett1984，25，28： | 1 |
| 19 | Amniotic fluid concentrations of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase during pregnancy and labor 显示文摘 | Lock smith G J Clark P DuffP | 2001 | Am J Obstet Gynecol2001，184，2： | 1 |
| 20 | Do circuit breakers moderate volatility? 显示文摘 | Kuhn B A Kuserk G J Locke P | 1991 | Review of Futures Markets1991，，7： | 1 |
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