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| 1 | Using old liver grafts for liver transplantation: Where are the limits?显示文摘The scarcity of ideal liver grafts for orthotopic liver transplantation(OLT) has led transplant teams to investigate other sources of grafts in order to augment the donor liver pool. One way to get more liver grafts is to use marginal donors, a not well-defined group which includes mainly donors > 60 years, donors with hypernatremia or macrosteatosis > 30%, donors with hepatitis C virus or hepatitis B virus positive serologies, cold ischemia time > 12 h, non-heart-beating donors, and grafts from split-livers or living-related donations. Perhaps the most practical and frequent measure to increase the liver pool, and thus to reduce waiting list mortality, is to use older livers. In the past years the results of OLT with old livers have improved, mainly due to better selection and maintenance of donors, improvements in surgical techniques in donors and recipients, and intra- and post-OLT management. At the present time, sexagenarian livers are generally accepted, but there still exists some controversy regarding the use of septuagenarian and octogenarian liver grafts. The aim of this paper is to briefly review the aging process of the liver and reported experiences using old livers for OLT. Fundamentally, the series of septuagenarian and octogenarian livers will be addressed to see if there is a limit to using these aged grafts. | Carlos Jiménez-Romero Oscar Caso Maestro Félix Cambra Molero Iago Justo Alonso Cristina Alegre Torrado Alejandro Manrique Municio Jorge Calvo Pulido Carmelo Loinaz Segurola Enrique Moreno González | 2014 | World Journal of Gastroenterology2014，20，31： | 11 |
| 2 | Incidence, risk factors and outcome of de novo tumors in liver transplant recipients focusing on alcoholic cirrhosis显示文摘Orthotopic liver transplantation(OLT) is an established life-saving procedure for alcoholic cirrhotic(AC) patients, but the incidence of de novo tumors ranges between 2.6% and 15.7% and is significantly increased in comparison with patients who undergo OLT for other etiologies. Tobacco, a known carcinogen, has been reported to be between 52% and 83.3% in AC patients before OLT. Other risk factors that contribute to the development of malignancies are dose-dependent immunosuppression, advanced age, viral infections, sun exposure, and premalignant lesions(inflammatory bowel disease, Barrett's esophagus). A significantly more frequent incidence of upper aerodigestive(UAD) tract, lung, skin, and kidney-bladder tumors has been found in OLT recipients for AC in comparison with other etiologies. Liver transplant recipients who develop de novo non-skin tumors have a decreased long-term survival rate compared with controls. This significantly lower survival rate is more evident in AC recipients who develop UAD tract or lung tumors after OLT mainly because the diagnosis is usually performed at an advanced stage. All transplant candidates, especially AC patients, should be encouraged to cease smoking and alcohol consumption in the pre- and postOLT periods, use skin protection, avoid sun exposure and over-immunosuppression, and have a yearly otopharyngolaryngeal exploration and chest computed tomography scan in order to prevent or reduce the incidence of de novo malignancies. Although still under investigation, substitution of calcineurin inhibitors for sirolimus or everolimus may reduce the incidence of de novo tumors after OLT. | Carlos Jiménez-Romero Iago Justo-Alonso Félix Cambra-Molero Jorge Calvo-Pulido álvaro García-Sesma Manuel Abradelo-Usera Oscar Caso-Maestro Alejandro Manrique-Municio | 2015 | World Journal of Hepatology2015，7，7： | 6 |
| 3 | Use of a novel covered self-expandable metal stent with an anti-migration system for endoscopic ultrasound-guided drainage of a pseudocyst显示文摘The development of pseudocysts in patients with chronic pancreatitis has been reported in 23%-60% of cases and drainage is indicated when they become symptomatic. Endoscopic ultrasound-guided drainage with the placement of plastic or metallic stents to create a cystogastric anastomosis has been shown to be a reliable and efficacious maneuver. Metallic stent use appears to be a safe and effective alternative that shortens the length of time of the procedure and maintains a greater diameter in the cystogastric communication. However, important migration rates have been reported. The use of new metallic stents that are specially designed to prevent migration represents a promising development in the treatment of these group of patients that appears to be safe and effective for pseudocyst drainage and could importantly reduce migrationrates, while at the same time having the advantage of a single step procedure and a larger fistula diameter in the endoscopic cystogastric anastomosis. | Félix Ignacio Téllez-vila lvaro Villalobos-Garita Miguel ngel Ramírez-Luna | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，6： | 5 |
| 4 | Phosphorus fractions and sorption dynamics in the sediments of two Ca-SO4 water reservoirs in the central Argentine Andes显示文摘Phosphorus(P) fractionation and sorption behavior were studied in the sediments of two calcium-sulfate(Ca-SO_4: Ca^(2+)170 mg L^(-1); SO_4^(2-) 400 mg L^(-1)) water reservoirs in the southern central Argentine Andes-El Carrizal Reservoir(ECR),which stratifies in summer and El Nihuil Reservoir(ENR),which is vertically mixed throughout the year. Sediment size classes reflected the lithology of both basins and the reservoirs relative location: ECR(downstream from a valley adjacent to a mountain environment) had higher clay proportions while the sand fraction was more important in ENR(just next to a mountain environment).In both reservoirs, the chemical composition revealed low alteration and calcium enrichment. Total P content was relatively high(1.1-1.6 mg P kg^(-1) dry weight) as expected from the contribution of marine formations. P fractionation was dominated by Ca-P(ECR, 69% and ENR, 63%) followed by organic-P(23%)in summer-anoxic ECR and by iron/aluminum(Fe/Al)-P(27%) in oxic ENR. Batch experiments showed that sorption behavior in ECR had a typical Langmuir isotherm plot while in ENR that model fitted only at low dissolved P values(<5 mg PL^(-1)) and co-precipitation evidence was observed at higher P concentrations. It is proposed that lower Fe/Al-P content in anoxic(ECR) vs. oxic(ENR) sediments results from the P released from iron-bound phosphorus due to sulfate reduction-ferrous sulfide formation in an anoxic environment. This condition should enable ECR sediments to adsorb P into fresh oxidized iron,and ENR sediments to co-precipitate P with calcium due to Fe/Al-P saturation, as observed in batch experiments. This paper constitutes the first description of phosphorus content and dynamics in reservoir sediments in arid central western Argentina, where water sulfate concentrations are naturally high due to basin lithology. | José Gabriel León Fernando Luis Pedrozo Pedro Félix Temporetti | 2017 | International Journal of Sediment Research2017，32，3： | 3 |
| 5 | Functional Heterogeneity of Cancer-Associated Fibroblasts from Human Colon Tumors Shows Specific Prognostic Gene Expression Signature显示文摘 | Mercedes Herrera Abul B.M.M.K. Islam Alberto Herrera Paloma Martín Vanesa García Javier Silva Jose M. Garcia Clara Salas Ignacio Casal Antonio García de Herreros Félix Bonilla Cristina Pe?a | 2013 | Clinical Cancer Research2013，，21： | 2 |
| 6 | Environmental impact and management of phosphogypsum显示文摘 | Hanan Tayibi Mohamed Choura Félix A. López Francisco J. Alguacil Aurora López-Delgado | 2009 | Journal of Environmental Management2009，，8： | 2 |
| 7 | Optimization of room-and-pillar dimensions using automated numerical models显示文摘This paper presents an optimization methodology for the geometric configuration of a room–and–pillar mining project,considering safety and operational restrictions while maximizing ore recovery.An underground manganese mine was chosen as a case study to investigate the capabilities of the presented methodology.A software package(OPTIMINE)was implemented to address the computational demand in an automated manner.Three–dimensional finite difference analyses were performed in FLAC3D and used as implicit functions to consider safety in terms of the factor of safety and room convergence.The obtained results showed that recovery could be increased from 44%to more than 80%in a safe manner. | Gian Franco Napa-García Tais Renata Camara Vidal Félix Navarro Torres | 2019 | International Journal of Mining Science and Technology2019，29，5： | 2 |
| 8 | Molecular genetics of berry colour variation in table grape显示文摘 | Diego Lijavetzky Leonor Ruiz-García José A. Cabezas María T. Andrés Gemma Bravo Ana Ibá?ez Juan Carre?o Félix Cabello Javier Ibá?ez José M. Martínez-Zapater | 2006 | Molecular Genetics and Genomics2006，，5： | 2 |
| 9 | Analyzing predictors of graft survival in patients undergoing liver transplantation with donors aged 70 years and over显示文摘AIM To increase the number of available grafts.METHODS This is a single-center comparative analysis performed between April 1986 and May 2016. Two hundred and twelve liver transplantation(LT) were performed with donors ≥ 70 years old(study group). Then, we selected the first cases that were performed with donors < 70 years old immediately after the ones that were performed with donors ≥ 70 years old(control group).RESULTS Graft and patient survivals were similar between both groups without increasing the risk of complications, especially primary non-function, vascular complications and biliary complications. We identified 5 risk factors as independent predictors of graft survival: recipient hepatitis C virus(HCV)-positivity [hazard ratio(HR) = 2.35; 95% confidence interval(CI): 1.55-3.56; P = 0.00]; recipient age(HR = 1.04; 95%CI: 1.02-1.06; P = 0.00); donor age X model for end-stage liver disease(D-MELD)(HR = 1.00; 95%CI: 1.00-1.00; P = 0.00); donor value of serum glutamic-pyruvic transaminase(HR = 1.00; 95%CI: 1.00-1.00; P = 0.00); and donor value of serum sodium(HR = 0.96; 95%CI: 0.94-0.99; P = 0.00). After combining D-MELD and recipient age we obtained a new scoring system that we called DR-MELD(donor age X recipient age X MELD). Graft survival significantly decreased in patients with a DR-MELD score ≥ 75000, especially in HCV patients(77% vs 63% at 5 years in HCV-negative patients, P = 0.00; and 61% vs 25% at 5 years in HCV-positive patients; P = 0.00). CONCLUSION A DR-MELD ≥ 75000 must be avoided in order to obtain the best results in LT with donors ≥ 70 years old. | Oscar Caso-Maestro Carlos Jiménez-Romero Iago Justo-Alonso Jorge Calvo-Pulido David Lora-Pablos Alberto Marcacuzco-Quinto Félix Cambra-Molero Alvaro García-Sesma Marina Pérez-Flecha Carlos Munoz- Arce Carmelo Loinaz-Segurola Alejandro Manrique-Municio | 2018 | World Journal of Gastroenterology2018，24，47： | 2 |
| 10 | Software Project Management Approaches for Global Software Development: A Systematic Mapping Study显示文摘Global Software Development(GSD) is a well established field of software engineering with the benefits of a global environment. Software Project Management(SPM) plays a key role in the success of GSD. As a result, the need has arisen to study and evaluate the downsides of SPM for GSD, to thereby pave the way for the development of new methods, techniques, and tools with which to tackle them. This paper aims to identify and classify research on SPM approaches for GSD that are available in the literature, to identify their current weaknesses and strengths, and to analyze their applications in industry. We performed a Systematic Mapping Study(SMS) based on six classification criteria. Eighty-four papers were selected and analyzed. The results indicate that interest in SPM for GSD has been increasing since 2006. As a class of approaches, the most frequently reported methods(40%) are those used for coordination, planning, and monitoring, along with estimation techniques that can be used to better match a distributed project. SPM for GSD requires further investigation by researchers and practitioners, particularly with respect to cost and time estimations. These findings will help overcome the challenges that must to be considered in future SPM research for GSD, especially regarding collaboration and time-zone differences. | Manal El Bajta Ali Idri Joaquín Nicolás Ros José Luis Fernández-Alemán Juan Manuel Carrillo de Gea Félix García Ambrosio Toval | 2018 | Tsinghua Science and Technology2018，23，6： | 2 |
| 11 | Pyrolysis of solid waste in rotary kiln: influence of final pyrolysis temperature on the pyrolysis products 显示文摘 | Li AM LiX D Li S Q Ren Y Chi Y Yan J H Cen K F | 1999 | Journal of Analytical and Applied Pyrolysis1999，50，： | 1 |
| 12 | A new technique for building maps of large scientific domains based on the cocitation of classes and categories显示文摘 | Félix Moya-Anegón Benjamín Vargas-Quesada Victor Herrero-Solana Zaida Chinchilla-Rodríguez Elena Corera-álvarez Francisco J. Munoz-Fernández | 2004 | Scientometrics2004，，1： | 1 |
| 13 | Overexpression, purification, and biochemical and spectroscopic characterization of copper-containing nitrite reductase from Sinorhizobium meliloti 2011. Study of the interaction of the catalytic copper center with nitrite and NO显示文摘 | Félix M. Ferroni Sergio A. Guerrero Alberto C. Rizzi Carlos D. Brondino | 2012 | Journal of Inorganic Biochemistry2012，，： | 1 |
| 14 | A Multicenter, Randomized, Clinical Trial of Hormonal Therapy in the Prevention of Rebleeding From Gastrointestinal Angiodysplasia显示文摘 | Félix Junquera Faust Feu Michel Papo Sebastián Videla José Ramón Armengol Josep Mar??a Bordas Esteban Saperas Josep M. Piqué Juan-Ramón Malagelada | 2001 | Gastroenterology2001，，5： | 1 |
| 15 | Corrosion of 7A04 aluminum alloy under defected epoxy coating studied by localized electrochemical im- pedance spectroscopy 显示文摘 | Dong C F Sheng H An Y H LiX G Xiao K Cheng Y F | 2010 | Progress in Organic Coating2010，67，： | 1 |
| 16 | Severe aortic regurgitation and reduced left ventricular ejection fraction: Outcomes after isolated aortic valve replacement and combined surgery显示文摘 | Alessandro Sionis Ana García-Alvarez María ángeles Castel Marco Cordero Miguel Josa Félix Pérez-Villa Eulàlia Roig | 2010 | Journal of Heart and Lung Transplantation2010，，4： | 1 |
| 17 | The basic structure and dynamics of cell membranes: An update of the Singer–Nicolson model显示文摘 | Félix M. Go?i | 2014 | BBA - Biomembranes2014，，： | 1 |
| 18 | Serum S100β levels in patients with neural tube defects显示文摘 | NETTO C B PORTELA L V F(E)LIX T M | 2006 | Clin Chim Acta2006，364，12： | 1 |
| 19 | Cerebral venous thrombosis and homoeystinuria: ease report 显示文摘 | Silva GS Almeida CM F lix EP | 2001 | Arq Neuropsiquiatr2001，59，3： | 1 |
| 20 | Replantation of completely amputated thumbs with venous arterialization 显示文摘 | Tian L Tian F LiX | 2007 | J Hand Surg Am2007，32，7： | 1 |
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