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| 1 | Maintenance of remission with infliximab in inflammatory bowel disease: Effi cacy and safety long-term follow-up显示文摘AIM: To evaluate the safety and efficacy of a long- term therapy with infliximab in Crohn’s disease (CD) and ulcerative colitis (UC) patients retrospectively. METHODS: The medical charts of 50 patients (40 CD and 10 UC), who received after a loading dose of 3 infl iximab infusions scheduled re-treatments every 8 wk as a maintenance protocol, were reviewed. RESULTS: Median (range) duration of treatment was 27 (4-64) mo in CD patients and 24.5 (6-46) mo in UC patients. Overall, 32 (80%) CD and 9 (90%) UC patients showed a sustained clinical response or remission throughout the maintenance period. Three CD patients shortened the interval between infusions. Eight (20%) CD patients and 1 UC patient underwent surgery for flare up of disease. Nine out of 29 CD and 4 out of 9 UC patients, who discontinued infliximab scheduled treatment, are still relapse-free after a median of 16 (5-30) and 6.5 (4-16) mo following the last infusion, respectively. Ten CD patients (25%) and 1 UC patient required concomitant steroid therapy during maintenance period, compared to 30 (75%) and 9 (90%) patients at enrolment. Of the 50 patients, 16 (32%) experienced at least 1 adverse event and 3 patients (6%) were diagnosed with cancer during maintenance treatment. CONCLUSION: Scheduled infl iximab strategy is effective in maintaining long-term clinical remission both in CD and UC and determines a marked steroid sparing effect. Long-lasting remission was observed following infliximab withdrawal. | Renato Caviglia Mentore Ribolsi Marina Rizzi Sara Emerenziani Maria Laura Annunziata Michele Cicala | 2007 | World Journal of Gastroenterology2007，13，39： | 14 |
| 2 | Estrogen-mediated downregulation of HIF-1αsignaling in B lymphocytes influences postmenopausal bone loss显示文摘In the bone marrow, B cells and bone-resorbing osteoclasts colocalize and form a specific microenvironment. How B cells functionally influence osteoclasts and bone architecture is poorly understood. Using genetically modified mice and highthroughput analyses, we demonstrate that prolonged HIF-1α signaling in B cells leads to enhanced RANKL production and osteoclast formation. In addition, deletion of HIF-1α in B cells prevents estrogen deficiency-induced bone loss in mice.Mechanistically, estrogen controls HIF-1α protein stabilization through HSP70-mediated degradation in bone marrow B cells.The stabilization of HIF-1α protein in HSP70-deficient bone marrow B cells promotes RANKL production and osteoclastogenesis.Induction of HSP70 expression by geranylgeranylacetone(GGA) administration alleviates ovariectomy-induced osteoporosis.Moreover, RANKL gene expression has a positive correlation with HIF1 A expression in human B cells. In conclusion, HIF-1αsignaling in B cells is crucial for the control of osteoclastogenesis, and the HSP70/HIF-1α axis may serve as a new therapeutic target for osteoporosis. | Xianyi Meng Zhen Lin Shan Cao Iga Janowska Koshiro Sonomoto Darja Andreev Knab Katharina Jinming Wen Karl Xaver Knaup Michael Sean Wiesener Gerhard Krönke Marta Rizzi Georg Schett Aline Bozec | 2022 | Bone Research2022，10，2： | 6 |
| 3 | Giant splenic artery aneurysm presenting with massive upper gastrointestinal bleeding:A case report and review of literature显示文摘BACKGROUND Splenic artery aneurysm(SAA)and pseudoaneurysm are rare vessel’s lesions.Pseudoaneurysm is often symptomatic and secondary to pancreatitis or trauma.True SAA is the most common aneurysm of visceral vessels.In contrast to pseudoaneurysm,SAA is usually asymptomatic until the rupture,with high mortality rate.The clinical onset of SSA’s rupture is a massive life-threatening bleeding with hemodynamic instability,usually into the free peritoneal space and more rarely into the gastrointestinal tract.CASE SUMMARY We describe the case of a 35-year-old male patient,with negative past medical history,who presented to the emergency department for massive upper gastrointestinal bleeding,severe anemia and hypotension.An esophagogastroduodenoscopy performed in emergency showed a gastric bulging in the greater curvature/posterior wall with a small erosion on its surface,with a visible vessel,but no active bleeding.Endoscopic injection therapy with cyanoacrylate glue was performed.Urgent contrast-enhanced computed tomography was carried out due to the clinical scenario and the unclear endoscopic aspect:The radiological examination showed a giant SAA which was adherent to posterior stomach wall,and some smaller aneurysms of the left gastric and ileocolic artery.Because of the high risk of a two-stage rupture of the giant SAA with dramatic outcome,the patient underwent immediate open surgery with aneurysmectomy,splenectomy and distal pancreatectomy with a good postoperative outcome.CONCLUSION The management of a ruptured giant SAA into the stomach can be successful with surgical approach. | Francesco Panzera Riccardo Inchingolo Marina Rizzi Assunta Biscaglia Maria Grazia Schievenin Emilia Tallarico Giancarlo Pacifico Beatrice Di Venere | 2020 | World Journal of Gastroenterology2020，26，22： | 4 |
| 4 | 5-ASA in ulcerative colitis:Improving treatment compliance显示文摘5-aminosalicylic acid(5-ASA)compounds are a highly effective treatment for ulcerative colitis(UC).While UC patient compliance in clinical studies is over 90%, only 40%of patients in every day life take their prescribed therapy.Adherence to medication has been emphasized recently by a Cochrane meta-analysis that has suggested that future trials of 5-ASA in UC should look at patient compliance rather than drug efficacy. Better compliance can be obtained by reducing the number of tablets and times of administration.Given that the 5-ASA formulations have different delivery systems that split the active moiety in various regions of the intestine,it is particularly important that an adequate dose of the drug arrives at the inflamed part of the colon.5-ASA Multi matrix(MMx)is a novel,high strength(1.2 g),oral formulation designed for oncedaily dosing.It releases the active moiety throughout the colon.Different studies with this compound have shown that it is as effective as 5-ASA enema in the treatment of mild-to-moderate,left-sided UC,and is comparable to a pH-dependent,delayed release 5-ASA (Asacol ),even if given once daily.Recently,the effectiveness in the acute phase of UC has been confirmed also in maintenance.In conclusion,at present,5-ASA MMx seems theoretically the best agent for maintaining patient compliance,and consequently,treatment effectiveness. | Cosimo Prantera Marina Rizzi | 2009 | World Journal of Gastroenterology2009，15，35： | 3 |
| 5 | 针灸可改善乳腺癌患者术后患肢功能障碍显示文摘巴西圣保罗联邦大学的Giron教授等人公布了一项最新研究结果,针灸治疗对乳腺癌患者术后肢体功能障碍的恢复效果显著,具有安全、微创、耐受性好的特点,可减轻乳腺癌患者术后的身心问题,提高其生活质量。该研究共纳入50例18岁以上、术后3个月仍有肩胛带、上肢及颈胸椎疼痛,且视觉模拟评分法(VAS)≥3分的女性乳腺癌患者,排除双侧乳腺切除、转移性肿瘤、静脉炎和肢体触觉感觉障碍、 | 刘少华 王琦 Giron PS Haddad CA Lopes de Almeida Rizzi SK | 2017 | 护士进修杂志2017，32，14： | 3 |
| 6 | The ALPPS procedure for hepatocellular carcinoma显示文摘 | G. Vennarecci A. Laurenzi G.B. Levi Sandri E. Busi Rizzi M. Cristofaro M. Montalbano P. Piselli A. Andreoli G. D’Offizi G.M. Ettorre | 2014 | European Journal of Surgical Oncology2014，，： | 3 |
| 7 | 酿酒酵母3-磷酸甘油脱氢酶的诱导、提纯和性质显示文摘在YEPD培养基中添加NaCl,可以诱导酿酒酵母(Saccharomyces cerevisiae)细胞内3-磷酸甘油脱氢酶的形成,当NaCl浓度达5%时,酶比活从0.05U/mg提高0.5U/mg;若再限制培养墓中葡萄糖浓度在100mg/L以下,酶比活可达到0.89U/mg。酶比活与培养基中的NaCl浓度的函数关系式为:Sa=0.129C^3-0.038C^2+0.034C+0.063(0≤C≤5%)。粗酶液经Sephadex G-25凝胶过滤,Blue Sepharose亲和层析以及Mono Q离子交换等步骤,提纯123.6倍,得纯酶液。经SDS-凝胶电泳测得分子量为45000±2000。酶的最适温度为51℃,最适pH值为6.8。保温30分钟的半失活温度(t_(1/2))为41℃。NADH和DHAP的Km(mmol/L)值分别为:0.017和0.134。 | 蔡敬民 Markus Pietzsch Manfred Rizzi | 1996 | 真菌学报1996，15，2： | 2 |
| 8 | Undernutrition, risk of malnutrition and obesity in gastroenterological patients: A multicenter study显示文摘AIM: To investigate the prevalence of undernutrition, risk of malnutrition and obesity in the Italian gastroenterological population. METHODS: The Italian Hospital Gastroenterology Association conducted an observational, cross-sectional multicenter study. Weight, weight loss, and body mass index were evaluated. Undernutrition was defined as unintentional weight loss > 10% in the last threesix months. Values of Malnutrition Universal Screening Tool(MUST) > 2, NRS-2002 > 3, and Mini Nutritional Assessment(MNA) from 17 to 25 identified risk of malnutrition in outpatients, inpatients and elderly patients, respectively. A body mass index ≥ 30 indicated obesity. Gastrointestinal pathologies were categorized into acute, chronic and neoplastic diseases. RESULTS: A total of 513 patients participated in the study. The prevalence of undernutrition was 4.6% in outpatients and 19.6% in inpatients. Moreover, undernutrition was present in 4.3% of the gastrointestinal patients with chronic disease, 11.0% of those with acute disease, and 17.6% of those with cancer. The risk of malnutrition increased progressively and significantly in chronic, acute and neoplastic gastrointestinal diseases in inpatients and the elderly population. Logistical regression analysis confirmed that cancer was a risk factor for undernutrition(OR = 2.7; 95%CI: 1.2-6.44, P = 0.02). Obesity and overweight were more frequent in outpatients. CONCLUSION: More than 63% of outpatients and 80% of inpatients in gastroenterological centers suffered from significant changes in body composition and required specific nutritional competence and treatment. | Massimiliano Rizzi Silvia Mazzuoli Nunzia Regano Rosa Inguaggiato Margherita Bianco Gioacchino Leandro Elisabetta Bugianesi Donatella Noè Nicoletta Orzes Paolo Pallini Maria Letizia Petroni Gianni Testino Francesco William Guglielmi | 2016 | World Journal of Gastrointestinal Oncology2016，8，7： | 2 |
| 9 | Economical assessment of the impact of RFID technology and EPC system on the fast-moving consumer goods supply chain显示文摘 | Eleonora Bottani Antonio Rizzi | 2007 | International Journal of Production Economics2007，，2： | 2 |
| 10 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase, new insights into an ancient enzyme显示文摘 | Rong Grace Zhai Menico Rizzi Silvia Garavaglia | 2009 | Cellular and Molecular Life Sciences2009，，17： | 2 |
| 11 | A refined Frequency Domain Decomposition tool for structural modal monitoring in earthquake engineering显示文摘Output-only structural identification is developed by a refined Frequency Domain Decomposition(rFDD) approach, towards assessing current modal properties of heavy-damped buildings(in terms of identification challenge), under strong ground motions. Structural responses from earthquake excitations are taken as input signals for the identification algorithm. A new dedicated computational procedure, based on coupled Chebyshev Type Ⅱ bandpass filters, is outlined for the effective estimation of natural frequencies, mode shapes and modal damping ratios. The identification technique is also coupled with a Gabor Wavelet Transform, resulting in an effective and self-contained time-frequency analysis framework. Simulated response signals generated by shear-type frames(with variable structural features) are used as a necessary validation condition. In this context use is made of a complete set of seismic records taken from the FEMA P695 database, i.e. all 44 'Far-Field'(22 NS, 22 WE) earthquake signals. The modal estimates are statistically compared to their target values, proving the accuracy of the developed algorithm in providing prompt and accurate estimates of all current strong ground motion modal parameters. At this stage, such analysis tool may be employed for convenient application in the realm of Earthquake Engineering, towards potential Structural Health Monitoring and damage detection purposes. | Fabio Pioldi Egidio Rizzi | 2017 | Earthquake Engineering and Engineering Vibration2017，16，3： | 2 |
| 12 | 神经生长因子增强小胶质细胞的神经保护作用显示文摘小胶质细胞是脑组织内的防御细胞,但在病理和生理条件下,调控小胶质细胞活化的因子并不十分清楚。本研究发现,神经生长因子(NGF)可以增强小胶质细胞的神经保护和抗炎功能。在体内和体外研究中都发现,小胶质细胞表达NGF受体。原代培养小胶质细胞,给予NGF处理,转录本分析结果显示,NGF对小胶质细胞的运动、吞噬和降解吞噬物的能力均产生影响。对功能的研究显示,NGF可增加小胶质细胞的膜运动能力和胞饮作用;在体研究显示,NGF可激活小胶质细胞释放向外整流电流,调节周围谷氨酸能神经元的神经传递。既往研究提示,小胶质细胞有清除脑内Aβ肽的功能,本研究观察了NGF对小胶质细胞吞噬能力的影响。结果显示,NGF可促进小胶质细胞通过Trk A途径清除Aβ,并加速其降解。此外,NGF还可减轻由Aβ导致的炎症激活。特异性激活小胶质细胞还可以减轻由Aβ导致的神经元树突损伤和长时程增强抑制。在对离体脑片的研究中,我们也发现NGF可以促进小胶质细胞吞噬Aβ。综上所述,本研究证实NGF可以促进小胶质细胞活化,活化的小胶质细胞通过抗炎作用减轻Aβ聚集,发挥神经保护作用。 | 唐颖馨 Rizzi C Tiberi A Giustizieri M Marrone MC Gobbo F Carucci NM Meli G Arisi I D'Onofrio M Marinelli S Capsoni S Cattaneo A | 2018 | 神经损伤与功能重建2018，13，2： | 2 |
| 13 | Strain localization in fluid-saturatedanisotropic elastic-plastic porous media显示文摘 | Rizzi E Loret B | 1999 | InternationalJournal of Engineering Science1999，37，： | 2 |
| 14 | Effects of human urotensin Ⅱ in isolated vessels of various species; comparison with other vasoactive agents显示文摘 | Camarda V Rizzi A Calo G | 2002 | Naunyn Schmiedebergs Arch Phamacol2002，365，2： | 2 |
| 15 | 3D design and simulation of men garments 显示文摘 | CUGINI U RIZZI C | 2002 | Journal of Winter School of Computer Graphics2002，10，3： | 1 |
| 16 | A Computational Approach to Color Adaptation Effects显示文摘 | MARINI D RIZZI A | 2000 | Image and Vision Compu ring2000，18，13： | 1 |
| 17 | Spectral element approach to wave motion in layered solids 显示文摘 | Rizzi S A Doyle J F | 1992 | Trans ASME Journal of Vibration and Acoustics1992，114，4： | 1 |
| 18 | nociceptin-NH (2), a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor显示文摘 | Calo G Rizzi A Rizzi D | 2002 | Br J Pharmacol2002，136，2： | 1 |
| 19 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase, new insights into an ancient enzyme显示文摘 | Zhai R G Rizzi M Garavaglia S | 2009 | Cell Mol Life Sci2009，66，17： | 1 |
| 20 | Chemoprevention of hu- man prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepi- thelial neoplasia: a preliminary report from a one-year proof-of-principle study 显示文摘 | Bettuzzi S Brausi M Rizzi F | 2006 | Cancer Research2006，66，2： | 1 |
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