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| 1 | Different profile of cytokine synthesis according to the severity of acute pancreatitis显示文摘AIM: To evaluate the cellular synthetic ability of cytokines involved in pro- and anti-inflammatory reactions in patients with AP.METHODS: Sixty-seven patients with AP (16 severe,51 mild) and 10 controls were included in the study.Cultures of whole blood were performed in samples obtained within the first 72 h from the onset of pain.Serum levels of interleukins (IL) 6, 8, 10, and TNF-α were measured at baseline and in the supernatant of cultures with (functional reserve) or without stimulation with phytohemaglutinin.RESULTS: Basal levels of cytokines were significantly higher in patients with severe AP. A significant increase of all pro-inflammatory cytokines vs basal levels was observed in the supernatant after 24 h of whole blood cultures in patients, but not in controls. In contrast, IL-10 increased significantly in the supernatant of cultures only in patients with mild AP. Cells showed a statistically significant functional reserve for all IL in patients with mild, but only for pro-inflammatory cytokines in patients with severe AP.CONCLUSION: A marked activation of immune system may be observed in patients with AP, being balanced between pro- and anti-inflammatory cytokines in patients with mild but not severe AP. A reduced functional reserve for the synthesis of IL-10 may be observed in patients with severe AP, which might lead to a worst prognosis. | Raquel Laveda Juan Martínez Carlos Mu■oz Juan Carlos Penalva Jesus Sáez Germán Belda Salvador Navarro Faust Feu Anton Mas José Ma Palazón José Sánchez-Payá José Such Miguel Pérez-Mateo | 2005 | World Journal of Gastroenterology2005，11，34： | 24 |
| 2 | Surgical resection of hepatocellular carcinoma in cirrhotic patients: Prognostic value of preoperative portal pressure显示文摘 | J Bruix A Castells J Bosch F Feu J Fuster JC Garcia-Pagan J Visa C Bru J Rodes | 1996 | Gastroenterology1996，，4： | 3 |
| 3 | Effects of ethanol consumption on hepatic hemodynamics in patients with alcoholic cirrhosis显示文摘 | A Luca JC Garcia-Pagan J Bosch F Feu J Caballeria RJ Groszmann J Rodes | 1997 | Gastroenterology1997，，4： | 3 |
| 4 | Risk of developing tuberculosis under anti-TNF treatment despite latent infection screening显示文摘 | Aranzazu Jauregui-Amezaga Fanny Turon Ingrid Ordás Marta Gallego Faust Feu Elena Ricart Julián Panés | 2012 | Journal of Crohn’s and Colitis2012，，： | 2 |
| 5 | Effects of isosorbide-5-mononitrate on vertical pressure and systemic haemodynamics in patients with cirrhosis显示文摘 | Albillos A Feu F Bordas JM | 1996 | J hepatol1996，24，： | 1 |
| 6 | A multicenter,randomized,clinical trial of hormonal therapy in the prevention of rebleeding from gastrointestinal angiodysplasia显示文摘 | Junquera F Feu F Papo M | | 0，，5： | 1 |
| 7 | Wireless capsule endoscopy in patiems with obscure gastrointestinal bleeding: a comparative study with push enteroscopy 显示文摘 | Mata A Bordas JM Feu F | 2004 | Aliment Pharmacol Ther2004，20，： | 1 |
| 8 | Wireless capsule endoscopy in patients with obscure gastrointestinal bleeding: A comparative study with push enteroscopy显示文摘 | Mata A Bordas JM Feu F | 2004 | Alimentary Pharmacology & Therapeutics2004，20，2： | 1 |
| 9 | A multicenter,randomized,clinical trial of hormonal therapy in the prevention of rebleeding from gastrointestinal angiodysplasia显示文摘 | Junquera F Feu F Papo M | | Gastroenterology0，，： | 1 |
| 10 | Relation between portal pressure response to pharmacotherapy and risk of recurrent variceal haemorrhage in patients with cirrhosis 显示文摘 | Feu F Garcia-Pagan JC Bosch J | 1995 | Lancet1995，346，8982： | 1 |
| 11 | A Multicenter, Randomized, Clinical Trial of Hormonal Therapy in the Prevention of Rebleeding From Gastrointestinal Angiodysplasia显示文摘 | Félix Junquera Faust Feu Michel Papo Sebastián Videla José Ramón Armengol Josep Mar??a Bordas Esteban Saperas Josep M. Piqué Juan-Ramón Malagelada | 2001 | Gastroenterology2001，，5： | 1 |
| 12 | Metastatic breast carcinoma in axillary lymph nodes:in vitro US detection显示文摘 | Feu J Tresserra F Fabregas R | 1997 | Radiology1997，205，： | 1 |
| 13 | Circadian variations of portal pressure and variceal hemorrhage in patients with cirrhosis显示文摘 | Garcia-Pagan JC Feu F Castells A | 1994 | Hepatology1994，19，3： | 1 |
| 14 | Oral health elated quality of life and orthodontic treatment seeking 显示文摘 | Feu D De Oliveira BH | 2010 | Am J Orthod Dentofaeial Orthop2010，138，2： | 1 |
| 15 | Pathophysiology of portal hypertension显示文摘 | Bosch J Pizcueta P Feu F | | 0，，： | 1 |
| 16 | Tumor necrosis factor-a induces apoptosis via inducible nitric oxide synthase in neonatal mouse cardiomyocytes 显示文摘 | Song W Lu Y Feu Q | 2000 | Cardiovas Res2000，45，3： | 1 |
| 17 | Cardiovascular re-sponses to insertion of the laryngeal mask airway显示文摘 | WILSON IG FEU D ROBINSIONSL | 1992 | An- aes-thesia1992，47，： | 1 |
| 18 | A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal anti-inflammatory drug use 显示文摘 | Lanas A Perez-Aisa MA Feu F | 2005 | Am J Gastroenterol2005，100，8： | 1 |
| 19 | Clinical events after transjugular intrahepatic portosystemic shunt: Correlation with hemodynamic findings显示文摘 | Marta Casado Jaume Bosch Juan Carlos García-Pagán Conxita Bru Rafael Ba?ares Juan Carlos Bandi Angels Escorsell José Manuel Rodríguez-Láiz Rosa Gilabert Faust Feu Carlos Schorlemer Antonio Echenagusia Joan Rodés | 1998 | Gastroenterology1998，，6： | 1 |
| 20 | Anemia Worsens Hyperdynamic Circulation of Patients with Cirrhosis and Portal Hypertension显示文摘 | Isabel Cirera Josep I. Elizalde Josep M. Pique Faust Feu Maria Casadevall Eran Goldin Josep Teres Jaume Bosch Juan Rodes | 1997 | Digestive Diseases and Sciences1997，，8： | 1 |
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