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| 1 | An A-D-A′-D-A type unfused nonfullerene acceptor for organic solar cells with approaching 14%efficiency显示文摘In recent years,power conversion efficiency(PCE)of organic solar cells(OSCs)has made significant improvement.A large number of studies were reported to achieve high PCEs through exploring new active layer materials,especially the high efficiency fused ring acceptors(FRAs).Compared with FRAs,another type of so-called unfused-ring acceptors(UFAs),possessing some advantages such as simple synthesis and low cost,have attracted a lot of attention.Herein,a new UFA BTzO-4F,incorporating with a benzotriazole moiety and S···O intramolecular noncovalent interactions,has been successfully synthesized.The photovoltaic device based on PBDB-T:BTzO-4F achieved a record PCE of 13.8%for UFAs,which indicates that introducing the benzotriazole moiety is an effective strategy for high quality acceptors.Thus,these findings of this work demonstrate the great potential of UFAs for high performance OSCs. | Xingzheng Liu Yanan Wei Xin Zhang Linqing Qin Zhixiang Wei Hui Huang | 2021 | Science China Chemistry2021，64，2： | 7 |
| 2 | Human rhinovirus C infection is associated with asthma in children determined by x TAG respiratory viral panel FAST显示文摘Dear Editor,Cumulative evidence supports the role of early-life viral infections,especially respiratory syncytial virus(RSV)and human rhinovirus(HRV),as major antecedents of childhood asthma(Lemanske,2002;Jackson et al.,2008).In this study,the x TAG respiratory viral panel FAST(RVP FAST)assay,a multiplex polymerase chain reaction(PCR)-based method(Arens et al.,2010;BaladaLlasat et al.,2011;Gharabaghi et al.,2011;Selvaraju,2012),was used to investigate the association of infec- | Dongmei Chen Qinwei Song Runan Zhu Yuan Qian Yu Sun Jie Deng Fang Wang Yaxin Ding Run Tian Chuanhe Liu Wenjing Zhu Linqing Zhao | 2017 | Virologica Sinica2017，32，2： | 5 |
| 3 | The next detectors for gravitational wave astronomy显示文摘This paper focuses on the next detectors for gravitational wave astronomy which will be required after the current ground based detectors have completed their initial observations, and probably achieved the first direct detection of gravitational waves. The next detectors will need to have greater sensitivity, while also enabling the world array of detectors to have improved angular resolution to allow localisation of signal sources. Sect. 1 of this paper begins by reviewing proposals for the next ground based detectors,and presents an analysis of the sensitivity of an 8 km armlength detector, which is proposed as a safe and cost-effective means to attain a 4-fold improvement in sensitivity. The scientific benefits of creating a pair of such detectors in China and Australia is emphasised. Sect. 2 of this paper discusses the high performance suspension systems for test masses that will be an essential component for future detectors, while sect. 3 discusses solutions to the problem of Newtonian noise which arise from fluctuations in gravity gradient forces acting on test masses. Such gravitational perturbations cannot be shielded, and set limits to low frequency sensitivity unless measured and suppressed. Sects. 4 and 5 address critical operational technologies that will be ongoing issues in future detectors. Sect. 4 addresses the design of thermal compensation systems needed in all high optical power interferometers operating at room temperature. Parametric instability control is addressed in sect. 5. Only recently proven to occur in Advanced LIGO, parametric instability phenomenon brings both risks and opportunities for future detectors. The path to future enhancements of detectors will come from quantum measurement technologies. Sect. 6 focuses on the use of optomechanical devices for obtaining enhanced sensitivity, while sect. 7 reviews a range of quantum measurement options. | BLAIR David JU Li ZHAO ChunNong WEN LinQing MIAO HaiXing CAI RongGen GAO JiangRui LIN XueChun LIU Dong WU Ling-An ZHU ZongHong HAMMOND Giles PAIK Ho Jung FAFONE Viviana ROCCHI Alessio BLAIR Carl MA YiQiu QIN JiaYi PAGE Michael | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，12： | 3 |
| 4 | Where are the Volcanic Calderas in the Xiangshan Volcanic Basin of Jiangxi? Implications from Anisotropy of Magnetic Susceptibility显示文摘Objective As the world's third largest volcanic type uranium ore field,the Xiangshan volcanic basin has attracted much attention for its large industrial value.The ore hosting rocks are mainly the early Cretaceous rhyodacite and porphyroclastic lava,as well as small amounts of high level intrusive acidic rocks and metamorphic rocks.The vertical alteration of polymetallic | GUO Fusheng LI Guangrong LIU Linqing WU Zhichun YANG Qingkun XIE Caifu | 2017 | Acta Geologica Sinica(English Edition)2017，91，1： | 2 |
| 5 | Visual comfort is affected by urban colorscape tones in hazy weather显示文摘 | Yang Liu Jian Kang Ying Zhang Dehua Wang Linqing Mao | 2016 | Frontiers of Architectural Research2016，5，4： | 2 |
| 6 | Sulfur vs. tellurium: the heteroatom effects on the nonfullerene acceptors显示文摘The effect of chalcogen heteroatom variation on donor materials has been systematically investigated. However, this effect on acceptors has rarely been explored. Herein, nonfullerene acceptors BFPSP and BFPTP were reported by simply changing the chalcogen atoms from S to Te. The differences between BFPSP and BFPTP in light absorption, energy levels, excited-state lifetimes, energy loss, charge mobilities, morphology, and photovoltaic properties were systematically investigated to understand the heteroatom effects. More importantly, the electroluminescence spectra, external quantum efficiency of photovoltaics and TDDFTcalculations revealed that the triplet excited state(T1) in energy of BFPTP equals to the charge transfer(CT) state in PBDBT:BFPTP, which allows T1 excitons, generated by intersystem crossing, to split into free charges to contribute to the efficiency.This contribution provides a strategy for tuning the photophysical properties of nonfullerene acceptors and designing high performance triplet materials for OSCs. | Lei Yang Linqing Qin Yunxiao Xu Huotian Zhang Lei Lv Kepeng Chen Xinyu Sui Yangguang Zhong Yuan Guo Feng Gao Jianzhang Zhao Yuhao Li Xinfeng Liu Yuanping Yi Xinhui Lu Aidong Peng Hui Huang | 2019 | Science China Chemistry2019，62，7： | 1 |
| 7 | Combination of classifiers with incomplete frames of discernment显示文摘The methods for combining multiple classifiers based on belief functions require to work with a common and complete(closed)Frame of Discernment(Fo D)on which the belief functions are defined before making their combination.This theoretical requirement is however difficult to satisfy in practice because some abnormal(or unknown)objects that do not belong to any predefined class of the Fo D can appear in real classification applications.The classifiers learnt using different attributes information can provide complementary knowledge which is very useful for making the classification but they are usually based on different Fo Ds.In order to clearly identify the specific class of the abnormal objects,we propose a new method for combination of classifiers working with incomplete frames of discernment,named CCIF for short.This is a progressive detection method that select and add the detected abnormal objects to the training data set.Because one pattern can be considered as an abnormal object by one classifier and be committed to a specific class by another one,a weighted evidence combination method is proposed to fuse the classification results of multiple classifiers.This new method offers the advantage to make a refined classification of abnormal objects,and to improve the classification accuracy thanks to the complementarity of the classifiers.Some experimental results are given to validate the effectiveness of the proposed method using real data sets. | Zhunga LIU Jingfei DUAN Linqing HUANG Jean DEZERT Yongqiang ZHAO | 2022 | Chinese Journal of Aeronautics2022，35，5： | 1 |
| 8 | Evidential combination of augmented multi-source of information based on domain adaptation显示文摘In the applications of domain adaptation(DA),there may exist multiple source domains,and each source domain usually provides some auxiliary information for object classification.The combination of such complementary knowledge from different source domains is helpful for improving the accuracy.We propose an evidential combination of augmented multi-source of information(ECAMI)method.The information sources are augmented at first by merging several randomly selected source domains to generate extra auxiliary information.We can obtain one piece of classification result with the assistance of each information source based on DA.Then these multiple classification results are combined by belief functions theory,which is expert at dealing with the uncertain information.Nevertheless,the classification results derived from different information sources may have different weights.The optimal weights are calculated by minimizing an given error criteria defined by the distance between the combination result and the ground truth using some training data.For each object,the augmented information sources will produce multiple classification results that will be discounted by the learnt weights under the belief functions framework.Then the combination of these discounted results is employed to make the final class decision.The effectiveness of ECAMI is evaluated with respect to some related methods based on several real data sets,and the experimental results show that ECAMI can significantly improve the classification accuracy. | Linqing HUANG Zhunga LIU Quan PAN Jean DEZERT | 2020 | Science China(Information Sciences)2020，63，11： | 1 |
| 9 | Consolidation treatment needed for sustained HBsAg-negative response induced by interferon-alpha in HBeAg positive chronic hepatitis B patients显示文摘Hepatitis B surface antigen(HBsAg)clearance is considered as functional cure in patients with chronic hepatitis B(CHB).This study aimed to assess the durability of HBsAg clearance achieved by interferon-based therapies in patients with CHB who were originally positive for hepatitis B envelope antigen(HBeAg).In this prospective study,HBeAg-positive CHB patients with confirmed HBsAg loss under interferon-based therapies were enrolled within 12 weeks from end of treatment and followed up for 48 weeks.Virological markers,biochemical indicators,and liver imaging examinations were observed every 3–6 months.Sustained functional cure was analysed as primary outcome.Factor associated with sustained HBsAg loss or reversion was also investigated.The rate of HBsAg loss sustainability was 91.8%(212/231).Patients receiving consolidation treatment for 12–24weeks or≥24 weeks had higher rates of sustained HBsAg negativity than those receiving consolidation treatment for<12 weeks(98.3%and 91.2%vs.86.7%,P=0.068),and the former groups had significantly higher anti-HBs levels than the later(P<0.05).The cumulative incidence of HBsAg reversion and HBV DNA reversion was 8.2%and 3.9%,respectively.Consolidation treatment of≥12 weeks[odd ratio(OR)3.318,95%confidence interval(CI)1.077–10.224,P=0.037)was a predictor of sustained functional cure,and HBeAg-positivity at cessation of treatment(OR 12.271,95%CI 1.076–139.919,P=0.043)was a predictor of HBsAg reversion.Interferon-alpha induced functional cure was durable and a consolidation treatment of≥12–24 weeks was needed after HBsAg loss in HBeAg-positive CHB patients. | Minghui Li Fangfang Sun Xiaoyue Bi Yanjie Lin Liu Yang Yao Lu Lu Zhang Gang Wan Wei Yi Linqing Zhao Yao Xie | 2022 | Virologica Sinica2022，37，3： | 1 |
| 10 | Gravitational wave astronomy: the current status显示文摘In the centenary year of Einstein's General Theory of Relativity, this paper reviews the current status of gravitational wave astronomy across a spectrum which stretches from attohertz to kilohertz frequencies. Sect. 1 of this paper reviews the historical development of gravitational wave astronomy from Einstein's first prediction to our current understanding the spectrum. It is shown that detection of signals in the audio frequency spectrum can be expected very soon, and that a north-south pair of next generation detectors would provide large scientific benefits. Sect. 2 reviews the theory of gravitational waves and the principles of detection using laser interferometry. The state of the art Advanced LIGO detectors are then described. These detectors have a high chance of detecting the first events in the near future. Sect. 3 reviews the KAGRA detector currently under development in Japan,which will be the first laser interferometer detector to use cryogenic test masses. Sect. 4 of this paper reviews gravitational wave detection in the nanohertz frequency band using the technique of pulsar timing. Sect. 5 reviews the status of gravitational wave detection in the attohertz frequency band, detectable in the polarisation of the cosmic microwave background, and discusses the prospects for detection of primordial waves from the big bang. The techniques described in sects. 1–5 have already placed significant limits on the strength of gravitational wave sources. Sects. 6 and 7 review ambitious plans for future space based gravitational wave detectors in the millihertz frequency band. Sect. 6 presents a roadmap for development of space based gravitational wave detectors by China while sect. 7 discusses a key enabling technology for space interferometry known as time delay interferometry. | BLAIR David JU Li ZHAO ChunNong WEN LinQing CHU Qi FANG Qi CAI RongGen GAO JiangRui LIN XueChun LIU Dong WU Ling-An ZHU ZongHong REITZE David H. ARAI Koji ZHANG Fan FLAMINIO Raffaele ZHU XingJiang HOBBS George MANCHESTER Richard N. SHANNON Ryan M. BACCIGALUPI Carlo GAO Wei XU Peng BIAN Xing CAO ZhouJian CHANG ZiJing DONG Peng GONG XueFei HUANG ShuangLin JU Peng LUO ZiRen QIANG Li'E TANG WenLin WAN XiaoYun WANG Yue XU ShengNian ZANG YunLong ZHANG HaiPeng LAU Yun-Kau NI Wei-Tou | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，12： | 1 |
| 11 | The forecast model to carbonation depth of prestressed track beam of light rail显示文摘 | Chen Mingzheng Liu Xianfeng Huang Linqing | 2013 | Applied Mechanics and Materi- als2013，，275277： | 1 |
| 12 | Genotypic evolution and antigenic drift of H9N2 influenza viruses in China from 1994 to 2008显示文摘 | Yipeng Sun Juan Pu Zhanlei Jiang Tao Guan Yingju Xia Qi Xu Linqing Liu Bo Ma Fulin Tian E.G. Brown Jinhua Liu | 2010 | Veterinary Microbiology2010，，3： | 1 |
| 13 | Prevalence analysis of different human bocavirus genotypes in pediatric patients revealed intra-genotype recombination显示文摘 | Min Zhao Runan Zhu Yuan Qian Jie Deng Fang Wang Yu Sun Huijin Dong Liying Liu Liping Jia Linqing Zhao | 2014 | Infection, Genetics and Evolution2014，，： | 1 |
| 14 | Variant rs8400 enhances ALKBH5 expression through disrupting miR-186 binding and promotes neuroblastoma progression显示文摘Objective:AlkB homolog 5(ALKBH5)has been proven to be closely related to tumors.However,the role and molecular mechanism of ALKBH5 in neuroblastomas have rarely been reported.Methods:The potential functional single-nucleotide polymorphisms(SNPs)in ALKBH5 were identified by National Center for Biotechnology Information(NCBI)dbSNP screening and SNPinfo software.TaqMan probes were used for genotyping.A multiple logistic regression model was used to evaluate the effects of different SNP loci on the risk of neuroblastoma.The expression of ALKBH5 in neuroblastoma was evaluated by Western blotting and immunohistochemistry(IHC).Cell counting kit-8(CCK-8),plate colony formation and 5-ethynyl-2'-deoxyuridine(EdU)incorporation assays were used to evaluate cell proliferation.Wound healing and Transwell assays were used to compare cell migration and invasion.Thermodynamic modelling was performed to predict the ability of miRNAs to bind to ALKBH5 with the rs8400 G/A polymorphism.RNA sequencing,N6-methyladenosine(mA)sequencing,mA methylated RNA immunoprecipitation(MeRIP)and a luciferase assay were used to identify the targeting effect of ALKBH5 on SPP1.Results:ALKBH5 was highly expressed in neuroblastoma.Knocking down ALKBH5 inhibited the proliferation,migration and invasion of cancer cells.miR-186-3p negatively regulates the expression of ALKBH5,and this ability is affected by the rs8400 polymorphism.When the G nucleotide was mutated to A,the ability of miR-186-3p to bind to the 3'-UTR of ALKBH5 decreased,resulting in upregulation of ALKBH5.SPPI is the downstream target gene of the ALKBH5 oncogene.Knocking down SPP1 partially restored the inhibitory effect of ALKBH5 downregulation on neuroblastoma.Downregulation of ALKBH5 can improve the therapeutic efficacy of carboplatin and etoposide in neuroblastoma.Conclusions:We first found that the rs8400 G>A polymorphism in the m6A demethylase-encoding gene ALKBH5 increases neuroblastoma susceptibility and determines the related mechanisms.The aberrant regulation of ALKBH5 by miR-186-3p caused by this genetic variation in ALKBH5 promotes the occurrence and development of neuroblastoma through the ALKBH5-SPP1 axis. | Qian Guan Huiran Lin Wenfeng Hua Lei Lin Jiabin Liu Linqing Deng Jiao Zhang Jiwen Cheng Zhonghua Yang Yong Li Jun Bian Haixia Zhou Suhong Li Li Li Lei Miao Huimin Xia Jing He Zhenjian Zhuo | 2023 | Chinese Journal of Cancer Research2023，35，2： | 0 |
| 15 | Epidemiological Characteristics of Human Parainfluenza Viruses Infections-China,2019-2023显示文摘Introduction:A retrospective study based on sentinel surveillance was conducted in 10 provinciallevel administrative divisions(PLADs)in China to enhance the understanding of the epidemiological characteristics of human parainfluenza viruses(HPIVs).Methods:From January 2019 to June 2023,respiratory specimens were collected from individuals with acute respiratory infections(ARIs)and screened for four HPIVs serotypes and other common respiratory viruses using multiplex real-time polymerase chain reaction(PCR).This study analyzed the association of HPIVs infections with seasonal patterns,geographical distribution,demographic profiles,clinical features,and co-infection status.Results:During the study period,a total of 12,866 ARIs were included.The overall detection rate of HPIVs was 6.15%,varying from 5.04%in 2022 to 9.70%in 2020.The median age of HPIVs-infected patients was 3 years.HPIV2 was more prevalent among individuals aged 5–17 years(42.57%),while HPIV4 was more common in those over 65 years(12.24%).HPIV3(54.16%)and HPIV1(27.18%)were the predominant serotypes,and their prevalence exhibited significant seasonal fluctuations postcoronavirus disease 2019(COVID-19)pandemic.The peak of HPIV3 shifted three months later in 2020 compared to 2019 and returned to a summer peak thereafter.Two peaks of HPIV1 were observed in 2021 following the peak of HPIV3.Additionally,coinfections were frequent in HPIVs cases(overall rate:22.12%),with human rhinovirus being the most common co-infecting virus.Conclusions:The prevalence of HPIVs in China was predominantly due to HPIV3 and HPIV1,and their seasonal patterns were altered by pandemic restrictions.Hence,continuous surveillance of HPIVs is essential. | Yixuan Gao Yingwei Ma Daxing Feng Feng Zhang Biao Wang Xiaoqing Liu Bing Zhu Hui Xie Linqing Zhao Xiaoru Long Ying Chen Bing Wang Jie Jiang Zhen Zhu Yan Zhang Aili Cui Baicheng Xia Naiying Mao | 2024 | China CDC weekly2024，6，12： | 0 |
| 16 | Interfacial Characteristics and Formation Mechanisms of Copper–steel Multimaterial Structures Fabricated via Laser Powder Bed Fusion Using Different Building Strategies显示文摘Laser powder bed fusion(LPBF)is an innovative method for manufacturing multimaterial components with high geometrical resolution.The LPBF-printing sequences of materials may be diverse in the actual design and application of multimaterial components.In this study,multimaterial copper(CuSn10)–steel(316 L)structures are printed using different building strategies(printing 316 L on CuSn10 and printing CuSn10 on 316 L)via LPBF,and the characteristics of two interfaces(the 316 L/CuSn10 or“L/C”and CuSn10/316 L or“C/L”interfaces)are investigated.Subsequently,the interfacial melting mode and formation mechanisms are discussed.At the L/C interface,the keyhole melting mode induced by the high volumetric energy density(EL/C=319.4 J/mm3)results in a large penetration depth in the pre-solidified layer and enhances laser energy absorption,thus promoting the extensive migration of materials and intense intermixing of elements to form a wide diffusion zone(∼400μm).At the C/L interface,the conduction mode induced by the low volumetric energy density(EC/L=74.1 J/mm3)results in a narrow diffusion zone(∼160μm).The interfacial defects observed are primarily cracks and pores.More cracks appeared at the C/L interface,which is attributable to the weak bonding strength of the narrow diffusion zone.This study provides guidance and reference for the design and manufacturing of multimaterial components via LPBF using different building strategies. | Linqing Liu Di Wang Guowei Deng Yongqiang Yang Jie Chen Jinrong Tang Yonggang Wang Yang Liu Xusheng Yang Yicha Zhang | 2022 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2022，1，3： | 0 |
| 17 | Influence Mechanism of Process Parameters on Relative Density, Influence Mechanism of Process Parameters on Relative Density, Microstructure, and Mechanical Properties of Low Sc-Content Al-Mg-Sc-Zr Alloy Fabricated by Selective Laser Melting显示文摘Additive manufacturing of Al-Mg-Sc-Zr alloys is a promising technique for the fabrication of lightweight components with complex shapes.In this study,the effect of the process parameters of selective laser melting(SLM)on the surface morphology,relative density,microstructure,and mechanical properties of Al-Mg-Sc-Zr high-strength aluminum alloys with low Sc content was systematically investigated.The results show that the energy density has an important effect on the surface quality and densification behavior of the Al-Mg-Sc-Zr alloy during the SLM process.As the energy density increased,the surface quality and the number of internal pores increased.However,the area of the fine-grained region at the boundary of the molten pool gradually decreased.When the laser energy density was set to 151.52 J/mm3,a low-defect sample with a relative density of 99.2%was obtained.After heat treatment,the area of the fine grains at the boundary increased significantly,thereby contributing to the excellent mechanical properties.The microstructure was characterized by a unique“fan-shaped”heterogeneous structure.As the energy density increased,the microhardness first increased and then decreased,reaching a maximum value of 122 HV0.3.With the optimized process parameters,the yield strength(YS),ultimate tensile strength(UTS),and elongation of the as-built Al-Mg-Sc-Zr alloys were 346.8±3.0 MPa,451.1±5.2 MPa,14.6%±0.8%,respectively.After heat treatment at 325°C for 8 h,the hardness increased by 38.5%to 169 HV0.3,and the YS and UTS increased by 41.3%and 18.1%,respectively,to 490.0±9.0 MPa and 532.7±7.8 MPa,respectively,while the elongation slightly decreased to 13.1%±0.7%. | Di Wang Yongwei Feng Linqing Liu Xiongmian Wei Yongqiang Yang Pan Yuan Yang Liu Changjun Han Yuchao Bai | 2022 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2022，1，4： | 0 |
| 18 | simple and effective aerosol pathogen disinfection test for a flowing air disinfector显示文摘Aerosol transmission is an important disease transmission route and has been especially pertinent to hospital and biosafety laboratories during the SARS-CoV-2 pandemic.The thermal resistance of airborne SARS-CoV-2 is lower than that of Bacillus subtilis spores,which are often used to test the effectiveness of SARS-CoV-2 and other pathogen disinfection methods.Herein,we propose a new method to test the disinfection ability of a flowing air disinfector(a digital electromagnetic induction air heater)using B.subtilis spores.The study provides an alternative air disinfection test method.The new test system combined an aerosol generator and a respiratory filter designed in-house and could effectively recover spores on the filter membrane at the air outlet after passing through the flowing air disinfector.The total number of bacterial spores used in the test was within the range of 5×10^(5)–5×10^(6)colony-forming units(CFUs)specified in the technical standard for disinfection.The calculation was based on the calculation method in Air Disinfection Effect Appraisal Test in Technical Standard for Disinfection(2002 Edition).At an air speed of 3.5 m/s,we used a digital electromagnetic induction air heater to disinfect flowing air containing 4.100×10^(6)CFUs of B.subtilis spores and determined that the minimum disinfection temperature was 350℃for a killing rate of 99.99%.At 400℃,additional experiments using higher spore concentrations(4.700×10^(6)±1.871×10^(5)CFU)and a higher airspeed(4 m/s)showed that the killing rate remained>99.99%.B.subtilis spores,as a biological indicator for testing the efficiency of dry-heat sterilization,were killed by the high temperatures used in this system.The proposed method used to test the flowing air disinfector is simple,stable,and effective.This study provides a reference for the development of test systems that can assess the disinfection ability of flowing air disinfectors. | Xuling Liu Zhiran Qin Linqing Wang Xiaoting Xie Yifang Fu Jianhai Yu Zuxin Liang Xiaoen He Jingshu Li Hong Dai Jinxiu Yao Qinghua Wu Weiwei Xiao Li Zhu Chengsong Wan Bao Zhang Wei Zhao | 2023 | Journal of Biosafety and Biosecurity2023，5，1： | 0 |
| 19 | More common RNAemia in the early stage of severe SARS-CoV-2 BF.7.14 infections in pediatric patients显示文摘The risk factors of severe infections in children during the severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2)outbreak in Beijing remain elusive.SARS‐CoV‐2‐positive children admitted to the intensive care unit(ICU)with collected plasma specimens were enrolled and screened for common pathogens using capillary electrophoresis‐based multiplex PCR from December 12,2022,to January 24,2023.The SARS‐CoV‐2 subvariants were identified using next‐generation sequencing.Plasma was positive for two(positive;P),one(suspicious;S),or no(negative;N)SARS‐CoV‐2 genes were classified as plasmatic RNA‐positive(RNAemia;P+S)or without RNAemia(N).Clinical and laboratory data of the enrolled cases were then collected and analyzed.The 34 enrolled children included 26 males and 24 younger than three years.All were negative for other respiratory pathogens.BF.7.14(18/29)was the predominant subvariant.Viral loads in respiratory specimens,hours from symptom onset to the first respiratory specimen collection(time‐variable),with comorbidities and BF.7.14 and BA.5.2 distributions were significantly different in P vs.N and RNAemia vs.without RNAemia group.Among most cases,the T lymphocyte ratios decreased,while the cytokine level and the B lymphocyte ratio increased.The time variables were 2.22±2.05 and 4.00±2.49 days in BF.7.14 and BA.5.2 infections,respectively.In conclusion,SARS‐CoV‐2 was more likely to cause severe infections among males aged≤3 years old with comorbidities during the SARS‐CoV‐2 outbreak in Beijing,while RNAemia is more common in children at the early stage of severe BF.7.14 infections,and most had high cytokine levels and B‐cell activation. | Yu Sun Runan Zhu Yang Pan Ri De Shuang Liu Liping Jia Bing Lv Xiaoyun Li Dongmei Chen Yao Yao Dong Qu Daitao Zhang Linqing Zhao | 2024 | Biosafety and Health2024，6，1： | 0 |
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