|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Epidemiological characteristics and disease burden of infectious mononucleosis in hospitalized children in China:A nationwide retrospective study显示文摘Epstein-Barr virus(EBV)is very common,with the infection rate in adults over 90%worldwide.Infectious mononucleosis(IM)is caused by primary infection with EBV.Most IM patients are generally considered to have a favorable prognosis,but a few patients will also develop complications.Children with severe symptoms will require hospitalization.However,the disease burden of children hospitalized with IM in China has been rarely described.In this study,we included the Face sheets of discharge medical records from 27 member children's hospitals of Futang Research Center of Pediatric Development from Jan 1st,2016 to Dec 31st,2020,and medical information such as gender,age,region,time of admission,length of stay and expenditure were extracted.There were 24,120 IM cases,which accounted for 0.42%(24,120/5,693,262)of all hospitalized cases during this period.The ratio of male to female was 1.48:1.Hospitalization for IM in the 4-6 years age group was the highest among inpatients of all age groups.Case numbers increased year by year between 2016 and 2020,and the monthly hospitalization was generally high from Jul to Sep but reduced from Jan to Feb per year.Bronchitis/pneumonia and hepatic dysfunction were two common complications in hospitalized IM patients.The median length of stay was 8 days,and the median cost of hospitalization was 970.59 US dollars.This study will help understand the epidemiological characteristics and disease burden of hospitalized children with IM in China. | Mengjia Liu Xinyu Wang Linlin Zhang Guoshuang Feng Yueping Zeng Ran Wang Zhengde Xie | 2022 | Virologica Sinica2022，37，5： | 10 |
| 2 | Progress in small-molecule luminescent materials for organic light-emitting diodes显示文摘Organic light-emitting diodes(OLEDs) have been extensively studied since the first efficient device based on small molecular luminescent materials was reported by Tang. Organic electroluminescent material, one of the centerpieces of OLEDs, has been the focus of studies by many material scientists. To obtain high luminosity and to keep material costs low, a few remarkable design concepts have been developed. Aggregation-induced emission(AIE) materials were invented to overcome the common fluorescence-quenching problem, and cross-dipole stacking of fluorescent molecules was shown to be an effective method to get high solid-state luminescence. To exceed the limit of internal quantum efficiency of conventional fluorescent materials, phosphorescent materials were successfully applied in highly efficient electroluminescent devices. Most recently, delayed fluorescent materials via reverse-intersystem crossing(RISC) from triplet to singlet and the 'hot exciton' materials based on hybridized local and charge-transfer(HLCT) states were developed to be a new generation of low-cost luminescent materials as efficient as phosphorescent materials. In terms of the device-fabrication process, solution-processible small molecular luminescent materials possess the advantages of high purity(vs. polymers) and low procession cost(vs. vacuum deposition), which are garnering them increasing attention. Herein, we review the progress of the development of small-molecule luminescent materials with different design concepts and features, and also briefly examine future development tendencies of luminescent materials. | Tiancheng Yu Linlin Liu Zengqi Xie Yuguang Ma | 2015 | Science China Chemistry2015，58，6： | 7 |
| 3 | Resilience-based retrofitting of existing urban RC-frame buildings using seismic isolation显示文摘The improvement of the seismic resilience of existing reinforced-concrete(RC) frame buildings, which is essential for the seismic resilience of a city, has become a critical issue. Although seismic isolation is an effective method for improving the resilient performance of such buildings, target-oriented quantitative improvements of the resilient performance of these buildings have been reported rarely. To address this gap, the seismic resilience of two existing RC frame buildings located in a high seismic intensity region of China were assessed based on the Chinese Standard for Seismic Resilience Assessment of Buildings. The critical engineering demand parameters(EDPs) affecting the seismic resilience of such buildings were identified. Subsequently, the seismic resilience of buildings retrofitted with different isolation schemes(i.e., yield ratios) were evaluated and compared, with emphasis on the relationships among yield ratios, EDPs, and levels of seismic resilience. Accordingly, to achieve the highest level of seismic resilience with respect to the Chinese standard, a yield ratio of 3% was recommended and successfully applied to the target-oriented design for the seismic-resilience improvement of an existing RC frame building. The research outcome can provide an important reference for the resilience-based retrofitting of existing RC frame buildings using seismic isolation in urban cities. | Yang Cantian Xie Linlin Li Aiqun Zeng Demin Jia Junbo Chen Xi Chen Min | 2020 | Earthquake Engineering and Engineering Vibration2020，19，4： | 7 |
| 4 | Histone deacetylase 6 and cytoplasmic linker protein 170 function together to regulate the motility of pancreatic cancer cells显示文摘胰腺的癌症是有在所有主要人的恶意之中的最糟的预后的破坏疾病。很快转移的倾向显著地作出贡献到胰腺的癌症的高度好攻击的特征。位于这下面的分子的机制留下逃犯,并且涉及胰腺的癌症房间活动性的控制的蛋白质充分没被描绘。在这研究,我们发现那 histone deacetylase 6 (HDAC6 ) ,班 II HDAC 家庭的一个成员,高度在人的胰腺的癌症纸巾在蛋白质和 mRNA 层次被表示。HDAC6 显然不影响胰腺的癌症房间增长或房间周期前进。相反,它显著地支持胰腺的癌症房间的活动性。进一步的研究表明 HDAC6 与细胞质的连接器蛋白质 170 交往(CLIP-170 ) 并且这二蛋白质一起工作刺激胰腺的癌症房间的迁居。这些调查结果提供机械学的卓见进胰腺的癌症的前进并且为这恶意的管理作为一个潜在的目标建议 HDAC6。 | Dengwen Li Xiaodong Sun Linlin Zhang Bing Yan Songbo Xie Ruming Liu Min Liu Jun Zhou | 2014 | Protein & Cell2014，5，3： | 5 |
| 5 | Activated carbon enhanced ozonation of oxalate attributed to HO·oxidation in bulk solution and surface oxidation: Effect of activated carbon dosage and pH显示文摘Ozonation of oxalate in aqueous phase was performed with a commercial activated carbon(AC)in this work. The effect of AC dosage and solution pH on the contribution of hydroxyl radicals(HOU) in bulk solution and oxidation on the AC surface to the removal of oxalate was studied. We found that the removal of oxalate was reduced by tert-butyl alcohol(tBA) with low dosages of AC,while it was hardly affected by tBA when the AC dosage was greater than 0.3 g/L. tBA also inhibited ozone decomposition when the AC dosage was no more than 0.05 g/L, but it did not work when the AC dosage was no less than 0.1 g/L. These observations indicate that HOUin bulk solution and oxidation on the AC surface both contribute to the removal of oxalate. HOU oxidation in bulk solution is significant when the dosage of AC is low, whereas surface oxidation is dominant when the dosage of AC is high. The oxalate removal decreased with increasing pH of the solution with an AC dosage of 0.5 g/L. The degradation of oxalate occurs mainly through surface oxidation in acid and neutral solution, but through HOUoxidation in basic bulk solution. A mechanism involving both HOUoxidation in bulk solution and surface oxidation was proposed for AC enhanced ozonation of oxalate. | Linlin Xing Yongbing Xie Daisuke Minakata Hongbin Cao Jiadong Xiao Yi Zhang John C. Crittenden | 2014 | Journal of Environmental Sciences2014，26，10： | 5 |
| 6 | The LRXs-RALFs-FER module controls plant growth and salt stress responses by modulating multiple plant hormones显示文摘Salt stress is a major environmental factor limiting plant growth and productivity.We recently discovered an important new salt tolerance pathway,where the cell wall leucine-rich repeat extensins LRX3/4/5,the RAPID ALKALINIZATION FACTOR(RALF)peptides RALF22/23 and receptor-like kinase FERONIA(FER)function as a module to simultaneously regulate plant growth and salt stress tolerance.However,the intracellular signaling pathways that are regulated by the extracellular LRX3/4/5-RALF22/23-FER module to coordinate growth,cell wall integrity and salt stress responses are still unknown.Here,we report that the LRX3/4/5-RALF22/23-FER module negatively regulates the levels of jasmonic acid(JA),salicylic acid(SA)and abscisic acid(ABA).Blocking JA pathway rescues the dwarf phenotype of the lrx345 and fer-4mutants,while disruption of ABA biosynthesis suppresses the salt-hypersensitivity of these mutants.Many salt stress-responsive genes display abnormal expression patterns in the lrx345 and fer-4 mutants,as well as in the wild type plants treated with epigallocatechin gallate(EGCG),an inhibitor of pectin methylesterases,suggesting cell wall integrity as a critical factor that determines the expression pattern of stress-responsive genes.Production of reactive oxygen species(ROS)is constitutively increased in the lrx345 and fer-4mutants,and inhibition of ROS accumulation suppresses the salt-hypersensitivity of these mutants.Together,our work provides strong evidence that the LRX3/4/5-RALF22/23-FER module controls plant growth and salt stress responses by regulating hormonal homeostasis and ROS accumulation. | Chunzhao Zhao Wei Jiang Omar Zayed Xin Liu Kai Tang Wenfeng Nie Yali Li Shaojun Xie Yuan Li Tiandan Long Linlin Liu Yingfang Zhu Yang Zhao Jian-Kang Zhu | 2021 | National Science Review2021，8，1： | 3 |
| 7 | Changes in dendritic cells and dendritic cell subpopulations in peripheral blood of recipients during acute rejection after kidney transplantation显示文摘 | Ma Linlin Liu Yong Wu Junjie Xu Xiuhong Liu Fen Feng Lang Xie Zelin Tang Yawang Sun Wen Guo Hongbo Zhang Lei Lin Jun Tian Ye | 2014 | Chinese Medical Journal2014，，8： | 3 |
| 8 | Effects ofβ-alanine on intestinal development and immune performance of weaned piglets显示文摘Beta-alanine is an important amino acid involved in several metabolic reactions in the body.The study aimed to investigate the effect ofβ-alanine supplementation on intestinal development and the immune performance of weaned piglets.Thirty-two 21-day-old healthy weaned piglets(half female and half male;Duroc×Landrace×Yorkshire)with an initial body weight of 8.11±0.21 kg were randomly divided into 4 groups with 8 replicates of 1 pig each.The control group was fed a basal diet and the three experimental treatment groups were fed diets supplemented with 300,600 and 1,200 mg/kgβ-alanine,respectively.The trial lasted 28 days and the diets fed were divided into 2 phases:the late lactation period(day 1 to 14)and the nursery period(day 15 to 28),during which the weaned piglets had free access to food and water.The regulatory effects ofβ-alanine were further investigated in vitro using organoids obtained from the jejunum of piglets.In vivo,the addition ofβ-alanine to the diet had no significant effect on the growth performance of weaned piglets(P>0.05),but significantly reduced serum levels of immunoglobulin G(IgG)(P<0.01),immunoglobulin M(IgM)(P=0.005),and complement 3(C3)(P=0.017).The serum interleukin-6(IL-6)levels(P<0.01)were significantly reduced in the 1,200 mg/kg treatment group.The addition ofβ-alanine increased ileal villus height,with the most significant effect at a concentration of 300 mg/kg(P=0.041).The addition of 600 mg/kgβ-alanine significantly up-regulated the expression of superoxide dismutase(SOD)activity(P=0.020)and the zonula occludens-1(ZO-1)gene(P=0.049)in the jejunum.Diets supplemented with 300 mg/kgβ-alanine significantly increased the number of Ki67 positive cells in the jejunal crypts(P<0.01).In vitro,β-alanine increased the organoid budding rates(P=0.001)and the budding height of the crypt significantly(P=0.004).In conclusion,β-alanine can improve intestinal morphology and barrier function,reduce inflammatory responses and alleviate the adverse effects of weaning stress on piglet intestinal health. | Linlin Chen Yan Zhong Xiangqin Ouyang Chunfeng Wang Lanmei Yin Jing Huang Yali Li Qiye Wang Junyan Xie Pengfei Huang Huansheng Yang Yulong Yin | 2023 | Animal Nutrition2023，，1： | 2 |
| 9 | Isolation and genetic analysis revealed no predominant new strains of avian infectious bronchitis virus circulating in South China during 2004–2008显示文摘 | Linlin Li Chunyi Xue Feng Chen Jianping Qin Qingmei Xie Yingzuo Bi Yongchang Cao | 2009 | Veterinary Microbiology2009，，2： | 2 |
| 10 | Three-dimensional ATUM-SEM reconstruction and analysis of hepatic endoplasmic reticulum-organelle interactions显示文摘The endoplasmic reticulum(ER)is a contiguous and complicated membrane network in eukaryotic cells,and membrane contact sites(MCSs)between the ER and other organelles perform vital cellular functions,including lipid homeostasis,metabolite exchange,calcium level regulation,and organelle division.Here,we establish a whole pipeline to reconstruct all ER,mitochondria,lipid droplets,lysosomes,peroxisomes,and nuclei by automated tape-collecting ultramicrotome scanning electron microscopy and deep learning techniques,which generates an unprecedented 3D model for mapping liver samples.Furthermore,the morphology of various organelles and the MCSs between the ER and other organelles are systematically analyzed.We found that the ER presents with predominantly flat cisternae and is knitted tightly all throughout the intracellular space and around other organelles.In addition,the ER has a smaller volume-to-membrane surface area ratio than other organelles,which suggests that the ER could be more suited for functions that require a large membrane surface area.Our data also indicate that ER-mitochondria contacts are particularly abundant,especially for branched mitochondria.Our study provides 3D reconstructions of various organelles in liver samples together with important fundamental information for biochemical and functional studies in the liver. | Yi Jiang Linlin Li Xi Chen Jiazheng Liu Jingbin Yuan Qiwei Xie Hua Han | 2021 | Journal of Molecular Cell Biology2021，13，9： | 2 |
| 11 | A Role for Transmembrane Protein 16C/Slack Impairment in Excitatory Nociceptive Synaptic Plasticity in the Pathogenesis of Remifentanil-induced Hyperalgesia in Rats显示文摘Remifentanil is widely used to control intraoperative pain. However, its analgesic effect is limited by the generation of postoperative hyperalgesia. In this study, we investigated whether the impairment of transmembrane protein 16C(TMEM16C)/Slack is required for a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic receptor(AMPAR) activation in remifentanil-induced postoperative hyperalgesia. Remifentanil anesthesia reduced the paw withdrawal threshold from 2 h to 48 h postoperatively,with a decrease in the expression of TMEM16C and Slack in the dorsal root ganglia(DRG) and spinal cord.Knockdown of TMEM16C in the DRG reduced the expression of Slack and elevated the basal peripheral sensitivity and AMPAR expression and function. Overexpression of TMEM16C in the DRG impaired remifentanilinduced ERK1/2 phosphorylation and behavioral hyperalgesia. AMPAR-mediated current and neuronal excitability were downregulated by TMEM16C overexpression in the spinal cord. Taken together, these findings suggest that TMEM16C/Slack regulation of excitatory synaptic plasticity via GluA1-containing AMPARs is critical in the pathogenesis of remifentanil-induced postoperative hyperalgesia in rats. | Yize Li Linlin Zhang Jing Li Chunyan Wang Yi Chen Yuan Yuan Keliang Xie Guolin Wang Yonghao Yu | 2021 | Neuroscience Bulletin2021，37，5： | 2 |
| 12 | Uniform composition film of hydrophilic colloidal gold nanoparticles and hydrophobic carbazole functionalized fluorene trimers for enhanced fluorescence and stability显示文摘Compositing gold nanoparticles into conjugated molecules have been developed to be one of the most important approaches to increase stability, since degradation of conjugated materials is now one of the biggest bottle-necks to be conquered before industrialization application. Big-size colloidal gold nanoparticles with strong surface plasma resonance are designed to composite with conjugated molecules, in order to realize effective fluorescence enhancement and stabilization. The uniform composition film of hydrophilic colloidal gold nanoparticles (particle diameter of 30 nm) and hydrophobic carbazole functionalized fluorene trimers has been obtained by direct mixing of their aqueous and THF solutions, which is determined by AFM. By the comparison of composition based on fluorene trimers with similar structures, we have found that peripheral carbazole group and molecular size of fluorene trimers play an important role in the balance of incompatible solubility, which is regarded as increasing solubility of fluorene trimers in mixed solvent, connecting AuNP and peripheral carbazole groups, and restraining aggregate of gold nanoparticle. This allows facile hydrophilic gold nanoparticle to disperse uniformly in hydrophobic-conjugated host. Our investigations show that fluorescence intensity of composition film is enhanced by 4 folds, and heat treatment (200°C for 4h) for the composition film does not induce the degradation of conjugated backbone without the appearance of low-energy emission band, demonstrating the prominent potency of gold nanoparticles in enhanced fluorescence and stability of conjugated molecules and polymers. | LIU LinLin XIE ZengQi MA YuGuang | 2013 | Chinese Science Bulletin2013，58，22： | 1 |
| 13 | An investigation of the dispersion of CuCl on γ-Al2O3 surface and the adsorption of ethylene on CuC1 / y -Al2O3 and other supported transition metal salts显示文摘 | Gui Linlin Guo Qinlin Xie Youchang | 1984 | Scientia Sinica(series B)1984，27，5： | 1 |
| 14 | Simultaneous red-green-blue electroluminescent enhancement directed by surface plasmonic "far-field" of facile gold nanospheres显示文摘基于表面血浆回声的远地的效果,由灵巧的综合金 nanospheres 的同时的 red-green-blue electroluminescence 改进在这个工作被认识到,它将困难、复杂用选择波长的局部性的表面血浆回声到达。远地的效果能同时提高的 plasmonic 在白轻范围的整个排放区域,因为到红排放的从蓝色的提高的区域大部分被重叠。由做嵌入在的金 nanospheres 一 poly (3,4乙烯 dioxythiophene ):聚苯乙烯酸性硫酸基的酸( PEDOT : PSS )层,收益改进与60%的最好的提高比率和国际 de LEclairage ( CIE )坐标是的委员会在超过95%设备被完成在稳定近似( 0.33 , 0.36 )。plasmonic 远地的效果在 picomolar 大小要求 Au NP 的极端低的工作集中,并且在电子进程并且轻散布上显示出小否定效果,它在认识到在新窗户中射出 diodes.Open | Xiaoyan Wu Yiqi Zhuang Zhongtao Feng Xuehong Zhou Yuzhao Yang Linlin Liu Zengqi Xie Xudong Chen Yuguang Ma | 2018 | Nano Research2018，11，1： | 1 |
| 15 | Nicotinamide mononucleotide improves spermatogenic function in streptozotocin-induced diabetic mice via modulating the glycolysis pathway显示文摘Spermatogenic dysfunction is one of the major secondary complications of diabetes;however,the underlying mechanisms remain ill-defined,and there is no available drug or strategy for the radical treatment of diabetic spermatogenic dysfunction.Therefore,the objective of this study is to investigate the protective effects of nicotinamide mononucleotide(NMN)on testicular spermatogenic function in streptozotocin(STZ)-induced diabetic mice.The results show that oral administration of NMN significantly increases the body and testis weight and the number of sperms.Moreover,the abnormal sperm count and the rate of sperm malformation are significantly decreased compared with the saline-treated diabetic mice.Histological analysis reveals that NMN treatment significantly increases the area and diameter of seminiferous tubules,accompanied by an increased number of spermatogenic cells and sperms.Immunohistochemistry and qRT-PCR results show that NMN increases Bcl-2 expression and decreases Bax expression in the testis.NMN also increases the protein expression of Vimentin and the mRNA expressions of WT1 and GATA4.In addition,qRT-PCR,western blot analysis and immunohistochemistry results also show that NMN increases the expressions of glycolysis-related rate-limiting enzymes including HK2,PKM2,and LDHA.In summary,this study demonstrates the protective effects of NMN on the testis in an STZ-induced diabetic mice model.NMN exerts its protective effects via reducing spermatogenic cell apoptosis by regulating glycolysis of Sertoli cells in diabetic mice.This study provides an experimental basis for the future clinical application of NMN in diabetes-induced spermatogenicdysfunction. | Duo Ma Linlin Hu Jinyuan Wang Min Luo Aihong Liang Xiaocan Lei Biyun Liao Meixiang Li Ming Xie Haicheng Li Yiwei Gong Dan Zi Xiangrun Li Xi Chen Xucai Liao | 2022 | Acta Biochimica et Biophysica Sinica2022，54，9： | 1 |
| 16 | Study of bonding wire failure effects on external measurable signals of IGBT module显示文摘 | Wei Kexin Du Mingxing Xie Linlin | 2014 | IEEE Journals Magazines2014，14，1： | 1 |
| 17 | Preparation and antibacterial activity of quaternizod chitosan with iodine 显示文摘 | Yang Tang Linlin Xie Mingze Sai | 2015 | Mater Sci Eng C2015，48，： | 1 |
| 18 | Studies of the impedance models and water transport behaviors of cathodically polarized coating显示文摘 | Chengfei Zhu Rui Xie Jinhua Xue Linlin Song | 2011 | Electrochimica Acta2011，，16： | 1 |
| 19 | Roles of PFKFB3 in cancer显示文摘The understanding of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(PFK-2/FBPase 3,PFKFB3)has advanced considerably since its initial identification in human macrophages in the mid-1990s.As a vital regulator of glycolysis,accumulating studies have suggested that PFKFB3 is associated with many aspects of cancer,including carcinogenesis,cancer cell proliferation,vessel aggressiveness,drug resistance and tumor microenvironment.In this review,we summarize current knowledge of PFKFB3 regulation by several signal pathways and its function in cancer development in different cell types in cancer tissues.Ubiquitous PFKFB3 has emerged as a potential target for anti-neoplastic therapy. | Linlin Shi Hongming Pan Zhen Liu Jiansheng Xie Weidong Han | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 1 |
| 20 | A study on structure and mechanism of high activity catalyst 显示文摘 | Xie Youchang Gui Linlin Bu Naiyu | 1979 | Scientia Sinica1979，124，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员