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| 1 | Osteoarthritis:toward a comprehensive understanding of pathological mechanism显示文摘Osteoarthritis(OA) is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the detailed molecular mechanisms of OA initiation and progression remain poorly understood and, currently,there are no interventions available to restore degraded cartilage or decelerate disease progression. The diathrodial joint is a complicated organ and its function is to bear weight, perform physical activity and exhibit a joint-specific range of motion during movement. During OA development, the entire joint organ is affected, including articular cartilage, subchondral bone, synovial tissue and meniscus. A full understanding of the pathological mechanism of OA development relies on the discovery of the interplaying mechanisms among different OA symptoms, including articular cartilage degradation, osteophyte formation, subchondral sclerosis and synovial hyperplasia, and the signaling pathway(s) controlling these pathological processes. | Di Chen Jie Shen Weiwei Zhao Tingyu Wang Lin Han John L Hamilton Hee-Jeong Im | 2017 | Bone Research2017，5，1： | 121 |
| 2 | Automated X-ray recognition of solder bump defects based on ensemble-ELM显示文摘Solder bumps realize the mechanical and electrical interconnection between chips and substrates in surface mount components,such as flip chip, wafer level packaging and three-dimensional integration. With the trend to smaller and lighter electronics,solder bumps decrease in dimension and pitch in order to achieve higher I/O density. Automated and nondestructive defect inspection of solder bumps becomes more difficult. Machine learning is a way to recognize the solder bump defects online and overcome the effect caused by the human eye-fatigue. In this paper, we proposed an automated and nondestructive X-ray recognition method for defect inspection of solder bumps. The X-ray system captured the images of the samples and the solder bump images were segmented from the sample images. Seven features including four geometric features, one texture feature and two frequency-domain features were extracted. The ensemble-ELM was established to recognize the defects intelligently. The results demonstrated the high recognition rate compared to the single-ELM. Therefore, this method has high potentiality for automated X-ray recognition of solder bump defects online and reliable. | SU Lei WANG LingYu LI Ke WU JingJing LIAO GuangLan SHI TieLin LIN TingYu | 2019 | Science China(Technological Sciences)2019，62，9： | 5 |
| 3 | Diffusion mechanism simulation of cloud manufacturing complex network based on cooperative game theory显示文摘Cloud manufacturing is a specific implementation form of the 'Internet + manufacturing' strategy. Why and how to develop cloud manufacturing platform(CMP), however, remains the key concern of both platform operators and users. A microscopic model is proposed to investigate advantages and diffusion forces of CMP through exploration of its diffusion process and mechanism. Specifically, a three-stage basic evolution process of CMP is innovatively proposed. Then, based on this basic process, a more complex CMP evolution model has been established in virtue of complex network theory, with five diffusion forces identified. Thereafter, simulations on CMP diffusion have been conducted. The results indicate that, CMP possesses better resource utilization,user satisfaction, and enterprise utility. Results of simulation on impacts of different diffusion forces show that both the time required for CMP to reach an equilibrium state and the final network size are affected simultaneously by the five diffusion forces. All these analyses indicate that CMP could create an open online cooperation environment and turns out to be an effective implementation of the 'Internet + manufacturing' strategy. | GENG Chao QU Shiyou XIAO Yingying WANG Mei SHI Guoqiang LIN Tingyu XUE Junjie JIA Zhengxuan | 2018 | Journal of Systems Engineering and Electronics2018，29，2： | 4 |
| 4 | Heterogeneous nanocomposites consisting of Pt_(3)Co alloy particles and CoP_(2) nanorods towards high-efficiency methanol electro-oxidation显示文摘Heterogeneous nanocomposites comprising chemically distinct constituents are particularly promising in electrocatalysis.We herein report a synthetic strategy that combines the reduction of Pt and Co ionic precursors at an appropriate ratio with the subsequent phosphating at an elevated temperature for forming heterogeneous nanocomposites consisting of quasi-spherical Pt_(3)Co alloy domains and rod-like CoP_(2) domains for high-efficiency methanol electrooxidation.The strong electronic coupling between Pt_(3)Co and CoP_(2) domains in the nanocomposites render the electron density around Pt atoms to decrease,which is favorable for reducing the adsorption of poisoning CO-like intermediates on the catalyst surfaces.Accordingly,the as-prepared heterogeneous Pt_(3)Co–CoP_(2) nanocomposites show good performance for methanol electrooxidation both in acidic and alkaline media.In specific,at a Pt loading of only 6.4%on a common carbon substrate,the mass-based activity of Pt_(3)Co–CoP_(2) nanocomposites in an acidic medium is about 2 and 1.5 times as high as that of commercial Pt/C catalyst(20%mass loading)and home-made Pt_(3)Co alloy nanoparticles(8.0%mass loading),while in the alkaline medium,these values are 3 and 2,respectively. | Niuwa Yang Dong Chen Penglei Cui Tingyu Lu Hui Liu Chaoquan Hu Lin Xu Jun Yang | 2021 | SmartMat2021，2，2： | 3 |
| 5 | In situ establishment of Co/MoS_(2) heterostructures onto inverse opal‐structured N,S‐doped carbon hollow nanospheres:Interfacial and architectural dual engineering for efficient hydrogen evolution reaction显示文摘Rational design of low‐cost and high‐efficiency non‐precious metal‐based catalysts toward the hydrogen evolution reaction(HER)is of paramount significance for the sustainable development of the hydrogen economy.Interfacial manipulationinduced electronic modulation represents a sophisticated strategy to enhance the intrinsic activity of a non‐precious electrocatalyst.Herein,we demonstrate the straightforward construction of Co/MoS_(2) hetero‐nanoparticles anchored on inverse opal‐structured N,S‐doped carbon hollow nanospheres with an ordered macroporous framework(denoted as Co/MoS_(2)@N,S-CHNSs hereafter)via a templateassisted method.Systematic experimental evidence and theoretical calculations reveal that the formation of Co/MoS_(2) heterojunctions can effectively modulate the electronic configuration of active sites and optimize the reaction pathways,remarkably boosting the intrinsic activity.Moreover,the inverse opal‐structured carbon substrate with an ordered porous framework is favorable to enlarge the accessible surface area and provide multidimensional mass transport channels,dramatically expediting the reaction kinetics.Thanks to the compositional synergy and structural superiority,the fabricated Co/MoS_(2)@N,S-CHNSs exhibit excellent HER activity with a low overpotential of 105mV to afford a current density of 10 mA/cm^(2).The rationale of interface manipulation and architectural design herein is anticipated to be inspirable for the future development of efficient and earth‐abundant electrocatalysts for a variety of energy conversion systems. | Tingyu Lu Tongfei Li Desheng Shi Jialin Sun Huan Pang Lin Xu Jun Yang Yawen Tang | 2021 | SmartMat2021，2，4： | 3 |
| 6 | Top-level modeling theory of multi-discipline virtual prototype显示文摘Multi-disciplinary virtual prototypes of complex products are increasingly and widely used in modern advanced manufacturing.How to effectively address the problems of unified modeling,composition and reuse based on the multi-disciplinary heterogeneous models has brought great challenges to the modeling and simulation(M&S) science and technology.This paper presents a top-level modeling theory based on the meta modeling framework(M2F) of the COllaborative SIMulation(COSIM) theory of virtual prototyping to solve the problems.Firstly the fundamental principles of the top-level modeling theory are decribed to expound the premise,assumptions,basic conventions and special requirements in the description of complex heterogeneous systems.Next the formalized definitions for each factor in top level modeling are proposed and the hierarchical nature of them is illustrated.After demonstrating that they are self-closing,this paper divides the toplevel modeling into two views,static structural graph and dynamic behavioral graph.Finally,a case study is discussed to demonstrate the feasibility of the theory. | Tingyu Lin Xudong Chai Bohu Li | 2012 | Journal of Systems Engineering and Electronics2012，23，3： | 2 |
| 7 | Extraction optimization of insecticidal compounds from Lysurus mokusin by response surface methodology显示文摘We optimized the extraction process of Lysurus mokusin(L.)Fr.insecticidal compound(LMIC)using response surface methodology with ultrasonic extraction(UE).The surface morphologies of maceration extract(ME)and UE residues were compared by scanning electron microscopy,and then the activity of LMIC on Lymantria dispar(Asian gypsy moths)larvae was determined.Results showed that the optimal condition of UE was followed by 80 min of extraction time,60%of ethanol concentration and 80 mL g^-1 of liquid–solid ratio.The surface morphologies of UE residue were looser and rougher than ME residue.The corrected mortalities of LMIC on L.dispar larvae was 59.77%.This result indicated that L.mokusin was a good candidate as pesticide for pest management. | Liannan Lin Jing Yang Guocai Zhang Xiaobo Zhang Chuanshan Zou Tingyu Wang Jianyong Zeng | 2020 | Journal of Forestry Research2020，31，5： | 2 |
| 8 | Hemocompatibility of polyacrylon-itriledialysis membrane immobilized with chitosan and heparin conjugate显示文摘 | Lin Wenching Liu Tingyu Yang Mingchien | 2004 | Biomaterials2004，25，10： | 1 |
| 9 | Optimizing warpage analysis for an optical housing显示文摘 | N.R. Subramanian Lin Tingyu (Leon) Yak Aik Seng | 2004 | Mechatronics2004，，1： | 1 |
| 10 | Biofunctional ZnO nanorod arrays grown on flexible substrates 显示文摘 | Liu Tingyu Liao Hungchou Lin Chinching | 2006 | Langmuir2006，22，13： | 1 |
| 11 | Determination of Opti- mum Design Spaces for Topology Optimization显示文摘 | Chen Tingyu Lin Chiayang | 2000 | Fi- nite Elements in Analysis and Design2000，，： | 1 |
| 12 | Determination of opt-imum design spaces for topology optimization显示文摘 | Chen Tingyu Lin Chiayang | 2000 | Finite Elements in Analysis and Design2000，36，1： | 1 |
| 13 | Oral bio availabilily of curcumin in rats and the herbal analysis from Curcuma longa by LC-MS/MS显示文摘 | Yang KuoYi Lin LeiChwen Tseng TingYu | 2007 | J Chromatogr B Analyt Technol Biomed Life Sei2007，853，12： | 1 |
| 14 | CoSMSOL:Complex system modeling,simulation and optimization language显示文摘Complex System Modeling,Simulation and Optimization Language(CoSMSOL)is problem-oriented and designed to run on multi-core computers.This paper provides the system environment of CoSMSOL and proposes the modeling methods of complex system,language text specification,function library,algorithm library,parallel simulation algorithms and intelligent optimization algorithms which support continuous system,discrete system and agent systems.Also,we developed a simulation language compiler of CoSMSOL,which is employed in two case studies generating a multi-entity war gaming system and an aerodynamic spacecraft model.The two cases illustrate main functions and implementation processes of CoSMSOL.The results validate that CoSMSOL is useful to model agent-based system and aerospace system. | Bo Hu Li Xiao Song Lin Zhang Jing Liu Peng Chi Tingyu Lin Xing Zhang Yuanjun Laili Fei Tao Tan Li | 2017 | International Journal of Modeling, Simulation, and Scientific Computing2017，8，2： | 0 |
| 15 | 组蛋白H3泛素化通过影响H3K9甲基化进而调控肝脏发育相关基因表达的机制显示文摘文章简介肝脏的发育是一个多步骤并且受到严格调控的过程。过去的研究主要集中在个体出生前肝细胞如何分裂分化,并且多以转录因子和信号通路为研究对象。相比之下,肝脏在个体出生后直至成熟的过程中,虽然肝脏的发育并未停止,但是研究资料相对匮乏。 | Gaofeng Li Tong Ji Jiang Chen Yufei Fu Lidan Hou Yan Feng Tingyue Zhang Tianyu Song Jie Zhao Yoko Endo Hui Lin 蔡秀军 仓勇 | 2018 | 科学新闻2018，0，4： | 0 |
| 16 | A Survey of Output Feedback Robust MPC for Linear Parameter Varying Systems显示文摘For constrained linear parameter varying(LPV)systems,this survey comprehensively reviews the literatures on output feedback robust model predictive control(OFRMPC)over the past two decades from the aspects on motivations,main contributions,and the related techniques.According to the types of state observer systems and scheduling parameters of LPV systems,different kinds of OFRMPC approaches are summarized and compared.The extensions of OFRMPC for LPV systems to other related uncertain systems are also investigated.The methods of dealing with system uncertainties and constraints in different kinds of OFRMPC optimizations are given.Key issues on OFRMPC optimizations for LPV systems are discussed.Furthermore,the future research directions on OFRMPC for LPV systems are suggested. | Xubin Ping Jianchen Hu Tingyu Lin Baocang Ding Peng Wang Zhiwu Li | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，10： | 0 |
| 17 | Deep Segmentation Feature-Based Radiomics Improves Recurrence Prediction of Hepatocellular Carcinoma显示文摘Objective and Impact Statement.This study developed and validated a deep semantic segmentation feature-based radiomics(DSFR)model based on preoperative contrast-enhanced computed tomography(CECT)combined with clinical information to predict early recurrence(ER)of single hepatocellular carcinoma(HCC)after curative resection.ER prediction is of great significance to the therapeutic decision-making and surveillance strategy of HCC.Introduction.ER prediction is important for HCC.However,it cannot currently be adequately determined.Methods.Totally,208 patients with single HCC after curative resection were retrospectively recruited into a model-development cohort(n=180)and an independent validation cohort(n=28).DSFR models based on different CT phases were developed.The optimal DSFR model was incorporated with clinical information to establish a DSFR-C model.An integrated nomogram based on the Cox regression was established.The DSFR signature was used to stratify high-and low-risk ER groups.Results.A portal phase-based DSFR model was selected as the optimal model(area under receiver operating characteristic curve(AUC):development cohort,0.740;validation cohort,0.717).The DSFR-C model achieved AUCs of 0.782 and 0.744 in the development and validation cohorts,respectively.In the development and validation cohorts,the integrated nomogram achieved C-index of 0.748 and 0.741 and time-dependent AUCs of 0.823 and 0.822,respectively,for recurrence-free survival(RFS)prediction.The RFS difference between the risk groups was statistically significant(P<0.0001 and P=0.045 in the development and validation cohorts,respectively).Conclusion.CECT-based DSFR can predict ER in single HCC after curative resection,and its combination with clinical information further improved the performance for ER prediction. | Jifei Wang Dasheng Wu Meili Sun Zhenpeng Peng Yingyu Lin Hongxin Lin Jiazhao Chen Tingyu Long Zi-Ping Li Chuanmiao Xie Bingsheng Huang Shi-Ting Feng | 2022 | Biomedical Engineering Frontiers2022，3，1： | 0 |
| 18 | Ultrathin curved PdNiRu nanosheets as bifunctional catalysts for oxygen reduction and ethylene glycol oxidation显示文摘Pd-based metallic nanosheets with advanced physicochemical properties have been widely prepared and employed in various electrocatalytic reactions.However,few concerns were focused on their multiple performances in different electrocatalysis.Here,highly curved and ultrathin PdNiRu nanosheets(NSs)are developed by facile wet-chemistry strategy and exhibit excellent electrocatalytic performance toward both oxygen reduction reaction(ORR)and ethylene glycol oxidation reaction(EGOR).Owing to the synergistically structural(e.g.,ultrathin,curved,defects/steps-rich)and compositional(ternary alloy)advantages,PdNiRu NSs exhibited enhanced ORR and EGOR specific/mass activities and better stability/durability than control electrocatalysts.The specific activity(5.52 mA·cm^(−2))and mass activity(1.13 A·mg_(Pd)^(−1))of the PdNiRu NSs in ORR are 4.8 and 3.4 times as the ones of commercial Pt/C,respectively.The mass activity of PdNiRu NSs(3.86 A·mg_(Pd)^(−1))in EGOR is 2.6 times as commercial Pd/C(1.51 A·mg_(Pd)^(−1)).This study is helpful for the development of desired electrocatalysts with multi-functional application in practical fuel cells. | Xianzeng Li Tingyu Lu Huan Pang Mingyi Zhang Dongdong Xu Lin Xu Min Han Jun Yang | 2024 | Nano Research2024，17，5： | 0 |
| 19 | Energy-efficient removal of carbamazepine in solution by electrocoagulation-electrofenton using a novel P-rGO cathode显示文摘In this study,carbamazepine(CBZ)decay in solution has been studied by coupling electro-coagulation with electro-Fenton(EC-EF)with a novel P-rGO/carbon felt(CF)cathode,aiming to accelerate the in-situ generation of·OH,instead of adding Fe2+and H2O2.Firstly,the fabri-cated P-rGO and its derived cathode were characterized by XRD,SEM,AFM,XPS and electro-chemical test(EIS,CV and LSV).Secondly,it was confirmed that the performance in removal efficiency and electric energy consumption(EEC)by EC-EF(kobs=0.124 min^(-1),EEC=43.98 kWh/kg CBZ)was better than EF(kobs=0.069 min^(-1),EEC=61.04 kWh/kg CBZ).Then,P-rGO/CF(kobs=0.248 min^(-1),EEC=29.47 kWh/kg CBZ,CE=61.04%)showed the best performance in EC-EF,among all studied heteroatom-doped graphene/CF.This superior performance may be associated with its largest layer spacing and richest C=C,which can promote the electron transfer rate and conductivity of the cathode.Thus,more H2O2 and·OH could be produced to degrade CBZ,and almost 100%CBZ was removed with kobs being 0.337 min^(-1) and the EEC was only 24.18 kWh/kg CBZ,under the optimal conditions(P-rGO loading was 6.0 mg/cm^(2),the current density was 10.0 mA/cm^(2),the gap between electrode was 2.0 cm).Additionally,no matter the influent is acidic,neutral or alkaline,no additional pH adjustment is required for the effluent of EC-EF.At last,an inconsecutive empirical kinetic model was firstly estab-lished to predict the effect of operating parameters on CBZ removal. | Zhihui Xiao Tingyu Cui Zhenbei Wang Yan Dang Meijie Zheng Yixinfei Lin Zilong Song YipingWang Chao Liu Bingbing Xu Amir Ikhlaq Jolanta Kumirska Ewa Maria Siedlecka Fei Qi | 2022 | Journal of Environmental Sciences2022，34，5： | 0 |
| 20 | The effects of pressure, temperature, and depth/diameter ratio on the microvia filling performance of Ag-coated Cu micro-nanoparticles for advanced electronic packaging显示文摘Conductive fillers made from metal nanoparticles offer many advan-tages for the fabrication of a variety of electronic devices,but when they have a porous structure,their poor conductivity limits their adoption in many applications.In this study,an Ag-coated Cu micro-nanoparticle paste is used to achieve compact filling of blind vias on flexible copper clad polyimide laminates through a multistep filling and sintering tech-nique.The filled blind vias achieve a resistivity as low as 6.2μΩ·cm,which is comparable that of electroplated blind vias.Higher sintering pressure and temperature promote the filling performance,while the conductivity deteriorates at a via depth/diameter ratio greater than 1:1.Finite element simulations reveal a stress inhomogeneity in vias with large depth/diameter ratios,which is the key to understanding the evolution of the conductive properties of a paste-filled via.This study provides an effective method for high-performance microvia filling as well as insights into the mechanism that influences its performance. | Guannan Yang Shaogen Luo Bo Luo Yan Zuo Shiwo Ta Tingyu Lin Zhaohui Zhao Yu Zhang Chengqiang Cui | 2022 | International Journal of Smart and Nano Materials2022，13，4： | 0 |
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