|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Bionic optimization research of soil cultivating component design显示文摘The basic biomechanical laws that apply to the clawed toes of animals with powerful digging abilities and the optimal bionic design of curved soil cultivating components with an analogous contour were researched in a novel way. First, the curvature and profile of the inside contour line of a field mouse’s clawed toe were analyzed. The finite element method (FEM) was then used to simulate the working process in order to study the changing characteristics of the working resistance of bionic soil- engag- ing surfaces and the stress field of the processed soil. A straight-line cultivating component was used for comparative analysis. In accordance with the simulation results, a series of soil cultivating com- ponents of varying design were manufactured. An indoor soil bin experiment was carried out to meas- ure their working resistance and validate the results of the FEM analysis. The results of this research would have important values in the optimization design of cultivating components for energy and cost savings. | GUO ZhiJun ZHOU ZhiLi ZHANG Yi LI ZhongLi | 2009 | Science China(Technological Sciences)2009，52，4： | 11 |
| 3 | Effect of tempering temperature on microstructure and mechanical properties of high boron white cast iron显示文摘The effect of different tempering temperatures on the microstructure and mechanical properties of airquenched high boron white cast iron was studied.The results indicate that the high boron white cast iron comprises dendritic matrix and inter-dendritic M 2 B boride;and the matrix comprises martensite and pearlite.After quenching in the air,the matrix is changed into lath martensite;but only 1-μm-size second phase exists in the matrix.After tempering,another second phase of several tens of nanometers is found in the matrix,and the size and quantity increase with an increase in tempering temperature.The two kinds of second precipitation phase with different sizes in the matrix have the same chemical formula,but their forming stages are different.The precipitation phase with larger size forms during the austenitizing process,while the precipitation phase with smaller size forms during the tempering process.When tempered at different temperatures after quenching,the hardness decreases with an increase in the tempering temperature,but it increases a little at 450 ℃ due to the precipitation strengthening effect of the second phase,and it decreases greatly due to the martensite decomposition above 450 ℃.The impact toughness increases a little when tempered below 300 ℃,but it then decreases continuously owing to the increase in size and quantity of the secondary precipitate above 300 ℃.Considered comprehensively,the optimum tempering temperature is suggested at 300 ℃ to obtain a good combination of hardness and toughness. | Liu Zhongli Li Yanxiang Chen Xiang | 2012 | China Foundry2012，9，4： | 10 |
| 4 | High performance columnar-like Fe2O3@carbon composite anode via yolk@shell structural design显示文摘Conversion-type reaction anode materials with high specific capacity are attractive candidates to improve lithium ion batteries(LIBs), yet the rapid capacity fading and poor rate capability caused by drastic volume change and low electronic conductivity greatly hinder their practical applications. To circumvent these issues, the successful design of yolk@shell Fe2 O3@C hybrid composed of a columnar-like Fe2O3 core within a hollow cavity completely surrounded by a thin, self-supported carbon(C) shell is presented as an anode for high-performance LIBs. This yolk@shell structure allows each Fe2O3 core to swell upon lithiation without deforming the carbon shell. This preserves the structural and electrical integrity against pulverization, as revealed by in situ transmission electron microscopy(TEM) measurement. Benefiting from these structural advantages, the resulting electrode exhibits a high reversible capacity(1013 m Ah g-1 after80 cycles at 0.2 A g-1), outstanding rate capability(710 m Ah g-1 at 8 A g-1) and superior cycling stability(800 m Ah g-1 after 300 cycles at 4 A g-1). A Li-ion full cell using prelithiated yolk@shell Fe2 O3@C hybrid as the anode and commercial Li CoO2(LCO) as the cathode demonstrates impressive cycling stability with a capacity retention of 84.5% after 100 cycles at 1 C rate, holding great promise for future practical applications. | Zhiming Zheng Pei Li Jason Huang Haodong Liu Yi Zao Zhongli Hu Li Zhang Huixin Chen Ming-Sheng Wang Dong-Liang Peng Qiaobao Zhang | 2020 | Journal of Energy Chemistry2020，29，2： | 7 |
| 5 | Classification of Magmatic Sulphide Deposits in China and Mineralization of Small Intrusions显示文摘许多重要金属资源,例如 Ni (Cu,公司) , PGE,在 magmaticsulfide 存款存在,是在地质的研究的一个热点。我们根据他们的构造背景在中国把 magmatic 硫醚存款划分成四种类型,侵入模式,矿床模式, mainmetallogenic 元素。四种类型如下:(1 ) 小侵入的存款 inpaleo 大陆;(2 ) 在大陆人的小侵入的存款充满暗岩;(3 ) 在 orogenic 的 Small-intrusiondeposits;并且(4 ) 存款与 ophiolites 联系了。根据分类,我们提出了在中国的主要 magmatic metallogenic 类型是 small-intrusionmetallogeny,并且从小侵入描述它的特征,这联系了概念,三个地质的背景,三个暴烈恼人的集合和 metallogenic 钥匙因素。根据国内外勘探的经验,我们指出在勘探小侵入的存款有大潜力,它需要进一步的学习。最后,我们不仅广泛地显示 thatsmall 侵入矿床成因论在 mafic-ultramafic 散布侵入,而且在中间酸的侵入有重要经济价值和科学意义。 | TANG Zhongli YAN Haiqing JIAO Jiangang LI Xiaohu | 2006 | Acta Geologica Sinica(English Edition)2006，80，3： | 6 |
| 6 | Bridging peripheral nerves using a deacetyl chitin conduit combined with short-term electrical stimulation显示文摘Previous studies have demonstrated that deacetyl chitin conduit nerve bridging or electrical stimulation can effectively promote the regeneration of the injured peripheral nerve.We hypothesized that the combination of these two approaches could result in enhanced regeneration.Rats with right sciatic nerve injury were subjected to deacetyl chitin conduit bridging combined with electrical stimulation(0.1 ms,3 V,20 Hz,for 1 hour).At 6 and 12 weeks after treatment,nerve conduction velocity,myelinated axon number,fiber diameter,axon diameter and the thickness of the myelin sheath in the stimulation group were better than in the non-stimulation group.The results indicate that deacetyl chitin conduit bridging combined with temporary electrical stimulation can promote peripheral nerve repair. | Zhongli Zhang Xin Li Songjie Zuo Jie Xin Peixun Zhang | 2014 | Neural Regeneration Research2014，9，10： | 5 |
| 7 | Corrosion protection properties of vanadium films formed on zinc surfaces显示文摘Vanadium films were prepared on zinc surfaces by using a solution containing vanadate.Corrosion protection properties of vanadium-treated (V-treated),chromium-treated (Cr-treated),and untreated zinc surfaces in contact with a 3.5 wt.% NaCl solution were studied using potentiodynamic polarization,electrochemical impedance spectroscopy (EIS),and neutral salt spray (NSS) tests.According to these results,the V-treated layer significantly improved the corrosion resistance of zinc surfaces.In comparison with the Cr-treated layer,the V-treated layer exhibited a better corrosion resistance.The composition of the V-treated layer was studied using X-ray photoelectron spectroscopy (XPS).XPS measurements indicated that the vanadium layer formed on zinc surfaces and the vanadium-rich coating was a hydrated oxide with a composition of V2O5,VO2,and its hydrates such as V2O5·nH2O and VO(OH)2. | ZOU Zhongli LINing LI Deyu | 2011 | Rare Metals2011，30，2： | 4 |
| 8 | HEIHE WATERSHED ALLIED TELEMETRY EXPERIMENTAL RESEARCH (HiWATER): Scientific Objectives and Experimental Design显示文摘 | Li Xin Cheng Guodong Liu Shaomin Xiao Qing Ma Mingguo Jin Rui Che Tao Liu Qinhuo Wang Weizhen Qi Yuan Wen Jianguang Li Hongyi Zhu Gaofeng Guo Jianwen Ran Youhua Wang Shuoguo Zhu Zhongli Zhou Jian Hu Xiaoli Xu Ziwei | 2013 | Bulletin of the American Meteorological Society2013，，8： | 3 |
| 9 | A Hydrogen Sensor Using SrCe_(0.95)Yb_(0.05)O_(3-α) as Proton Conductor and YH_x+YH_(2-z) as Reference Electrode for Determining Hydrogen Pressure in Solid Steel显示文摘The steel contains a small amount of hydrogen which will escape during the heat treatment.The hydrogen pressure in 16MnRE steel was investigated with a hydrogen sensor,which used SrCe0.95Yb0.05O3-α proton conductor as a solid electrolyte,YHx+YH2z as a solid state reference electrode and Ni wire as electrode constructing a hydrogen concentration cell,shown as Ni|YHx+YH2z |SrCe0.95Yb0.05O3-α |[H] steel |Ni.The response time of sensor is less than 10s.The relational expression of hydrogen partial pressure with temperatures was determined using two shape proton conductors.The results showed the regularity in experimental temperature range,and the hydrogen partial pressure increased as its temperature was raised. | Ying Li Changzhen Wang Zhongli Zhang Jiangxin Wang | 2010 | Journal of Materials Science & Technology2010，26，10： | 3 |
| 10 | Complete mitochondrial genome of the Japanese snapping shrimp Alpheus japonicus(Crustacea:Decapoda:Caridea):Gene rearrangement and phylogeny within Caridea显示文摘The complete sequence of the mitochondrial genome of the Japanese snapping shrimp Alpheus japonicus Miers(Crustacea:Decapoda:Caridea) is presented here.A comparative analysis based on the currently available mitochondrial genomic data revealed many previously unknown characteristics of the mitochondrial genomes of caridean shrimps.The A.japonicus mitochondrial genome is 16487 bp long and contains the typical set of 37 metazoan genes.The gene arrangements in the mitochondrial genomes of four previously studied carideans(Macrobrachium rosenbergii,M.nipponense,M.lanchesteri and Halocaridina rubra) were found to be identical to the pancrustacean ground pattern;thus,it was considered that gene rearrangements probably did not occur in the suborder Caridea.In the present study,a translocation of the trnE gene involving inversion was found in Alpheus mitochondrial genomes.This phenomenon has not been reported in any other crustacean mitochondrial genome that has been studied so far;however,the translocation of one transfer RNA gene(trnP or trnT) was reported in the mitochondrial genome of Exopalaemon carinicauda.When the ratios of the nonsynonymous and synonymous substitutions rates(Ka/Ks) for the 13 protein coding genes from two Alpheus species(A.japonicus and A.distinguendus) and three Macrobrachium species(M.rosenbergii,M.nipponense,M.lanchesteri) were calculated,the Ka/Ks values for all the protein coding genes in Alpheus and Macrobrachium mitochondrial genomes were found to be less than 1(between 0.0048 and 0.2057),indicating that a strong purification selection had occurred.The phylogenetic tree that was constructed based on the mitochondrial protein coding genes in the genomes of nine related species indicated that Palaemonidae and Alpheidae formed a monophyly and shared a statistically significant relationship,(Palaemonidae+Alpheidae)+Atyidae,at the family level. | SHEN Xin LI Xiao SHA ZhongLi YAN BinLun XU QiHua | 2012 | Science China(Life Sciences)2012，55，7： | 3 |
| 11 | Puerarin accelerates neural regeneration after sciatic nerve injury显示文摘Puerarin is a natural isoflavone isolated from plants of the genus Pueraria and functions as a protector against cerebral ischemia. We hypothesized that puerarin can be involved in the repair of peripheral nerve injuries. To test this hypothesis, doses of 10, 5, or 2.5 mg/kg per day puerarin(8-(β-D-Glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) were injected intraperitoneally into mouse models of sciatic nerve injury. Puerarin at the middle and high doses significantly up-regulated the expression of growth-associated protein 43 in the L4–6 segments of the spinal cord from mice at 1, 2, and 4 weeks after modeling, and reduced the atrophy of the triceps surae on the affected side and promoted the regeneration of nerve fibers of the damaged spinal cord at 8 weeks after injury. We conclude that puerarin exerts an ongoing role to activate growth-associated protein 43 in the corresponding segment of the spinal cord after sciatic nerve injury, thus contributing to neural regeneration after sciatic nerve injuries. | Minfei Wu Guanjie Zhao Xiaoyu Yang Chuangang Peng Jianwu Zhao Jun Liu Rui Li Zhongli Gao | 2014 | Neural Regeneration Research2014，9，6： | 3 |
| 12 | Inhibition of free radical induced oxidative hemolysis of red blood cells by green tea polyphenols显示文摘The in vitro oxidative hemolysis of human red blood cells (RBC) was used as a model to study the free radical induced damage of biological membranes and the inhibitory effect of natural antioxidants. The hemolysis was induced by a water-soluble free radical initiator 2,2’-azo(2-asmidinopropane)dihydrochloride (AAPH) and inhibited by the principal polyphenolic components extracted from green tea leaves, i.e. (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicat-echin gallate (ECG), (-)-epigallocatechin gallate (EGCG) and gallic acid (GA). Addition of AAPH at 37℃ caused fast hemolysis after a short period of inhibition period, while addition of the green tea polyphenols efficiently suppressed the hemolysis in the activity sequence of EGCG > EGC> ECG ≈EC>GA, demonstrating that these green tea polyphenols are effective antioxidants which could protect biological membranes from free radical induced oxidative damage. | Lanping Ma Zaiqun Liu Bo Zhou Li Yang Zhongli Liu | 2000 | Chinese Science Bulletin2000，45，22： | 3 |
| 13 | ANALYSIS SOLUTION OF BULGING CONVEXITY OF THE HYDRAULIC ELASTIC BULGING ROLL显示文摘ANALYSISSOLUTIONOFBULGINGCONVEXITYOFTHEHYDRAULICELASTICBULGINGROLLANALYSISSOLUTIONOFBULGINGCONVEXITYOFTHEHYDRAULICELASTICBULG... | Li Benli Wang Bingru Liu Zhubai Liu Guohui (Northeast Heavy Machinery institute)Li Yunquan Li Zhongli(Xi’an Heavy Machine Plant) | 1994 | Chinese Journal of Mechanical Engineering1994，7，3： | 2 |
| 14 | Regulation of Glucose Oxidase Activity through Interaction with Fullerene Derivatives显示文摘2-(hydroxymethyl ) pyridine 修改了 C60 (PY-C60 ) , methoxydiglycol 修改了 C60 (MDG-C60 ) 用 Bingel-Hirsch 反应被综合并且由原子磁性的回声(NMR ) 和集体系列描绘了。PY-C60 和 MDG-C60 能绑在葡萄糖 oxidase (GOx ) 并且熄灭色氨酸(Trp ) 的荧光在通过静态的机制的 GOx 的残余。GOx 的符合构造与这些 fullerene 衍生物在建筑群的形成以后被扰乱。运动分析显示 PY-C60 和 MDG-C60 可以与部分混合类型抑制机制影响 GOx 的催化活动。在血浆葡萄糖集中变化(3.65.2 mmol ???????????? 吗?? | Gao,Yunyan Wang,Zhongli Ou,Zhize Li,Yi Wang,Xuesong Yang,Guoqiang | 2012 | Chinese Journal of Chemistry2012，30，2： | 2 |
| 15 | Highly integrated sulfur cathodes with strong sulfur/high-strength binder interactions enabling durable high-loading lithium-sulfur batteries显示文摘The development of high-sulfur-loading Li-S batteries is a key prerequisite for their commercial applications.This requires to surmount the huge polarization,severe polysulfide shuttling and drastic volume change caused by electrode thickening.High-strength polar binders are ideal for constructing robust and long-life high-loading sulfur cathodes but show very weak interfacial interaction with non-polar sulfur materials.To address this issue,this work devises a highly integrated sulfur@polydopamine/highstrength binder composite cathodes,targeting long-lasting and high-sulfur-loading Li-S batteries.The super-adhesion polydopamine(PD)can form a uniform nano-coating over the graphene/sulfur(G-S)surface and provide strong affinity to the cross-linked polyacrylamide(c-PAM)binder,thus tightly integrating sulfur with the binder network and greatly boosting the overall mechanical strength/conductivity of the electrode.Moreover,the PD coating and c-PAM binder rich in polar groups can form two effective blockades against the effusion of soluble polysulfides.As such,the 4.5 mg cm−2 sulfur-loaded G-S@PD-c-PAM cathode achieves a capacity of 480 mAh g−1 after 300 cycles at 1 C,while maintaining a capacity of 396 mAh g−1 after 50 cycles at 0.2 C when the sulfur loading rises to 9.1 mg cm−2.This work provides a system-wide concept for constructing high-loading sulfur cathodes through integrated structural design. | Arif Rashid Xingyu Zhu Gulian Wang Chengzhi Ke Sha Li Pengfei Sun Zhongli Hu Qiaobao Zhang Li Zhang | 2020 | Journal of Energy Chemistry2020，29，10： | 2 |
| 16 | A retrospective analysis of primary gastric diffuse large B-cell lymphoma with or without concomitant mucosa-associated lymphoid tissue (MALT) lymphoma components显示文摘 | Xiaowu Li Bing Xia Shanqi Guo Zhongli Zhan Lianyu Zhang Dandan Zhao Xiaoxiong Wu Yizhuo Zhang | 2013 | Annals of Hematology2013，，6： | 2 |
| 17 | Orchestrated cellular,biochemical,and biomechanical optimizations endow platelet-rich plasma-based engineered cartilage with structural and biomechanical recovery显示文摘Recently,biomaterials for cartilage regeneration has been intensively investigated.However,the development of scaffolds that capture regenerated cartilage with biomechanical and structural recovery has rarely been reported.To address this challenge,platelet-rich plasma(PRP)-based cartilage constructs with a well-orchestrated symphony of cellular,biochemical and biomechanical elements were prepared by simultaneously employing chondrogenic progenitor cells(CPCs)as a cell source,optimizing platelet concentration,and adding an enzyme-ion activator.It was shown that this triple-optimized PRP+CPC construct possessed increased biomechanical properties and suitable biochemical signals.The following in vitro study demonstrated that the triple-optimized PRP+CPC constructs generated cartilage-like tissue with higher expression levels of chondrogenic-specific markers,more deposition of cartilage-specific extracellular matrix(ECM),and greater biomechanical values than those of the other constructs.Twelve weeks after the construct was implanted in a cartilage defect in vivo,histological analysis,qPCR,and biomechanical tests collectively showed that the triple-optimized constructs yielded a more chondrocyte-like cell phenotype with a higher synthesis of Col-Ⅱand aggrecan.More importantly,the triple-optimized constructs facilitated cartilage regeneration with better biomechanical recovery than that of the other constructs.These results demonstrate the efficacy of the triple-optimization strategy and highlight the simplicity and potency of this PRP+CPC construct for cartilage regeneration. | Ketao Wang Ji Li Yuxing Wang Yaqiang Wang Yuanyuan Qin Fei Yang Mingzhu Zhang Heng Zhu Zhongli Li | 2021 | Bioactive Materials2021，6，11： | 2 |
| 18 | Enhanced integrin-mediated human osteoblastic adhesion to porous amorphous calcium phosphate/poly(L-lactic acid) composite显示文摘 | Huang Xin Qi Yiying Li Weixu Shi Zhongli Weng Wenjian Chen Kui He Rongxin | 2014 | Chinese Medical Journal2014，，19： | 2 |
| 19 | Positioning taxonomic research for the future显示文摘Why do taxonomists matter? The work of taxonomists is often understated if not completely misunderstood. Without taxonomists, organisms cannot be accurately identified, neither can these organisms be given universally accepted names, and reliably positioned in the phylogenetic tree of life. Thanks to the work of taxonomists over the last 269 years since Carl Linnaeus established the binomial system, we can now measure the health and wealth of our biodiversity in a refined, science-based inventory prescribed by stringent nomenclatural rules. | Deyuan Hong Wenying Zhuang Min Zhu Keping Ma Xiaoquan Wang Dawei Huang Yalin Zhang Guodong Ren Wenjun Bu Wanzhi Cai Dong Ren Ding Yang Aiping Liang Fengyan Bai Runzhi Zhang Fumin Lei Shuqiang Li Hongzhi Kong Lei Cai Yucheng Dai Chaodong Zhu Qisen Yang Jun Chen Zhongli Sha Jianping Jiang Jing Che Donghui Wu Jiatang Li Qiang Wang Xinli Wei Ming Bai Xingyue Liu Xuexin Chen Gexia Qiao | 2022 | Zoological Systematics2022，47，3： | 2 |
| 20 | Prevalence and associated metabolic factors of fatty liver disease in the elderly显示文摘 | Zhongli Wang Ming Xu Jianhong Peng Li Jiang Zhengguo Hu Hua Wang Shiqing Zhou Rui Zhou Michael Hultstr?m En Yin Lai | 2013 | Experimental Gerontology2013，，8： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员