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| 1 | 神经肌肉电刺激治疗周围神经损伤的相关研究进展显示文摘周围神经损伤(PNI)是指外周神经的轴突和(或)髓鞘发生断裂损伤,往往由直接机械性创伤所致,少部分继发于外科肿瘤切除手术。PNI可以导致神经支配区域的感觉或运动功能障碍和多种复杂病变。周围神经系统(PNS)由单个或多个神经元单位组成,具有内在的修复和再生能力,神经的再生能力受损与患者的年龄、损伤机制尤其是神经本身的周围环境有很大关联。 | 方洪伟 朱浩 王祥瑞 | 2018 | 上海医学2018，41，9： | 16 |
| 2 | 术中电刺激及肌电监测在手外科周围神经损伤诊治中的应用价值显示文摘目的:探究术中电刺激及肌电监测在手外科周围神经损伤诊治中的应用价值。方法:选取2011年5月至2016年12月我院手外科收治的周围神经损伤患者35例,给予松解手术治疗,术中给予电刺激并且通过肌电图仪监测电刺激前后受损神经的复合肌肉动作电位(CMAP)的潜伏期及波幅变化,术后3个月随访记录临床疗效。结果:与电刺激前比较,臂丛神经损伤组及尺神经损伤组CMAP潜伏期明显缩短(P<0.05),臂丛神经损伤组、正中神经损伤组及桡神经损伤组CMAP波幅明显增加(P<0.05);术后3个月随访91.42%的患者受损神经功能得到恢复。结论:术中电刺激及肌电监测可有效提高手外科周围神经损伤的临床疗效,促进受损神经再生,利于功能恢复。 | 谭润 张辉 叶放 | 2018 | 神经损伤与功能重建2018，13，3： | 12 |
| 3 | 制备坐骨神经损伤大鼠模型:脊髓与局部神经电刺激的修复效果比较显示文摘背景:周围神经损伤后,损伤远端神经纤维出现Wallerian变性,近端相应节段脊髓出现神经元凋亡,导致轴突再生困难,影响神经损伤修复后的效果。目前针对周围神经损伤的研究大都局限在对损伤局部的修复与刺激,而对近端神经元胞体的研究相对较少。目的:比较脊髓电刺激与局部电刺激治疗周围神经损伤的疗效,探讨脊髓电刺激促进周围神经损伤修复的机制。方法:建立大鼠坐骨神经损伤模型,按随机数字表法分为3组,脊髓电刺激组、局部电刺激组和对照组各15只。测定造模后不同时期3组大鼠坐骨神经功能指数、小腿三头肌湿质量、脊髓神经元计数和超微结构、再生神经纤维髓鞘厚度及传导速度。结果与结论:造模后2周,大鼠坐骨神经功能指数比较脊髓电刺激组>对照组,局部电刺激组>对照组(P<0.05);造模后4,6,8周,大鼠坐骨神经功能指数比较脊髓电刺激组>局部电刺激组>对照组(P<0.05)。造模后2周,大鼠小腿三头肌湿重测定脊髓电刺激组>对照组,局部电刺激组>对照组(P<0.05);造模后4,8周,大鼠小腿三头肌湿质量比较脊髓电刺激组>局部电刺激组>对照组(P<0.05)。造模后2,4,8周,各组大鼠脊髓前角神经元计数脊髓电刺激组>局部电刺激组>对照组(P<0.05)。造模后4,8周,各组大鼠再生神经纤维髓鞘厚度、坐骨神经传导速度比较,脊髓电刺激组>局部电刺激组>对照组(P均<0.05)。提示周围神经损伤后给予相应节段脊髓电刺激,可以有效预防中枢神经元凋亡,促进轴突再生及神经功能恢复,且效果优于局部电刺激。 | 裴保安 訾金花 吴立生 张存华 陈允震 | 2015 | 中国组织工程研究2015，19，49： | 5 |
| 4 | Myelin-associated glycoprotein combined with chitin conduit inhibits painful neuroma formation after sciatic nerve transection显示文摘Studies have shown that myelin-associated glycoprotein(MAG)can inhibit axon regeneration after nerve injury.However,the effects of MAG on neuroma formation after peripheral nerve injury remain poorly understood.In this study,local injection of MAG combined with nerve cap made of chitin conduit was used to intervene with the formation of painful neuroma after sciatic nerve transfection in rats.After 8 weeks of combined treatment,the autotomy behaviors were reduced in rats subjected to sciatic nerve transfection,the mRNA expression of nerve growth factor,a pain marker,in the proximal nerve stump was decreased,the density of regenerated axons was decreased,the thickness of the myelin sheath was increased,and the ratio of unmyelinated to myelinated axons was reduced.Moereover,the percentage of collagen fiber area and the percentage of fibrosis marker alpha-smooth muscle actin positive staining area in the proximal nerve stump were decreased.The combined treatment exhibited superior effects in these measures to chitin conduit treatment alone.These findings suggest that MAG combined with chitin conduit synergistically inhibits the formation of painful neuroma after sciatic nerve transection and alleviates neuropathic pain.This study was approved by the Animal Ethics Committee of Peking University People’s Hospital(approval No.2019PHE027)on December 5,2019. | Wei Pi Ci Li Meng Zhang Wei Zhang Pei-Xun Zhang | 2022 | Neural Regeneration Research2022，17，6： | 2 |
| 5 | Bridging larger gaps in peripheral nerves using neural prosthetics and physical therapeutic agents显示文摘Peripheral nerve injuries are relatively common and can be caused by a variety of traumatic events such as motor vehicle accidents.They can lead to long-term disability,pain,and financial burden,and contribute to poor quality of life.In this review,we systematically analyze the contemporary literature on peripheral nerve gap management using nerve prostheses in conjunction with physical therapeutic agents.The use of nerve prostheses to assist nerve regeneration across large gaps(> 30 mm) has revolutionized neural surgery.The materials used for nerve prostheses have been greatly refined,making them suitable for repairing large nerve gaps.However,research on peripheral nerve gap management using nerve prostheses reports inconsistent functional outcomes,especially when prostheses are integrated with physical therapeutic agents,and thus warrants careful investigation.This review explores the effectiveness of nerve prostheses for bridging large nerve gaps and then addresses their use in combination with physical therapeutic agents. | Muhammad Sana Ullah Sahar Matthew Barton Geoffrey Douglas Tansley | 2019 | Neural Regeneration Research2019，14，7： | 1 |
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