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| 1 | Advanced treatment of dyeing wastewater towards reuse by the combined Fenton oxidation and membrane bioreactor process显示文摘The performance of combined Fenton oxidation and membrane bioreactor (MBR) process for the advanced treatment of an effluent from an integrated dyeing wastewater treatment plant was evaluated. The experimental results revealed that under the optimum Fenton oxidation conditions (initial pH 5, H 2 O 2 dosage 17 mmol/L, and Fe 2+ 1.7 mmol/L) the average total organic carbon (TOC) and color removal ratios were 39.3% and 69.5% after 35 min of reaction, respectively. Results from Zahn-Wallens Test also represented that Fenton process was effective to enhance the biodegradability of the test wastewater. As for the further purification of MBR process, TOC removal capacity was examined at different hydraulic retention times (HRT) of 10, 18 and 25 hr. Under the optimum HRT of 18 hr, the average TOC concentration and color of the final MBR effluent were 16.8 mg/L and 2 dilution time, respectively. The sludge yield coefficient was 0.13 g MLSS/g TOC and TOC degradation rate was 0.078 kg TOC/(m 3 ·day). The final effluent of MBR can meet the reuse criteria of urban recycling water-water quality standard for miscellaneous water consumption GBT18920-2002. | Fei Feng Zhenliang XU Xiaohuan Li Wenting You Yang Zhen | 2010 | Journal of Environmental Sciences2010，22，11： | 27 |
| 2 | Indosinian isotope ages of plutons and deposits in southwestern Miaoershan-Yuechengling,northeastern Guangxi and implications on Indosinian mineralization in South China显示文摘The Miaoershan-Yuechengling complex pluton is the largest granitoid complex in the western Nanling metallogenic belt with a surface exposure of >3000 km2.The complex pluton is composed of an early stage granitoid batholith and late stage small intrusions.The early stage batholith contains mainly medium-grained porphyritic mica granite and porphyritic monzonite granite,whereas the late stage intrusions are composed of muscovite granite porphyry and muscovite monzonitic granite.There are many W-Sn-Mo-Pb-Zn-Cu ores in the contact zone between the batholith and strata,forming an ore-rich belt around the batholith.Based on zircon LA-ICP-MS U-Pb ages,the southwestern part of the early stage batholith formed at 228.7 ± 4.1 Ma(MSWD = 2.49),with slightly earlier magmatic activity at 243.0 ± 5.8 Ma(MSWD = 2.62).The Yuntoujie muscovite granite was associated with W-Mo mineralization and has a zircon LA-ICP-MS U-Pb age of 216.8 ± 4.9 Ma(MSWD = 1.44).The Re-Os isochron age of molybdenite from the Yuntoujie W-Mo ore was 216.8 ± 7.5 Ma(MSWD = 11.3).Our new isotope data suggest that the late stage intrusive stocks from the southwestern Miaoershan-Yuechengling batholith were closely associated with W-Mo mineralization from the Indosinian period.These new results together with previous isotope data,suggest that South China underwent not only the well-known Yanshanian mineralization event,but also a widespread Indosinian metallogenic event during the Mesozoic period.Therefore,South China has a greater potential for Indosinian mineralization than previously thought such that more attention should be given to the Indosinian ore prospecting in South China. | WU Jing LIANG HuaYing HUANG WenTing WANG ChunLong SUN WeiDong SUN YaLi LI Jing MO JiHai WANG XiuZhang | 2012 | Chinese Science Bulletin2012，57，9： | 28 |
| 3 | Thiolactone copolymer donor gifts organic solar cells a 16.72% efficiency显示文摘Since 1995,bulk-heterojunction organic solar cells consisting of one or two organic donors and one or two organic acceptors have been fighting for high power conversion efficiencies(PCEs)and good stability[1].Until recent years,this next-generation photovoltaic technology starts to offer decent PCEs,shedding the light on commercialization,and attracting great attention again[2-14].Compared w让h the continuously emerging highperformance nonfullerene acceptors,high-performance donors are rare. | Ji Xiong Ke Jin Yufan Jiang Jianqiang Qin Tan Wang Jinfeng Liu Qishi Liu Haili Peng Xiongfeng Li Anxin Sun Xianyi Meng Lixiu Zhang Ling Liu Wenting Li Zhimin Fang Xue Jia Zuo Xiao Yaqing Feng Xiaotao Zhang Kuan Sun Shangfeng Yang Shengwei Shi Liming Ding | 2019 | Science Bulletin2019，64，21： | 17 |
| 4 | Gold nanorods together with HSP inhibitor-VER-155008 micelles for colon cancer mild-temperature photothermal therapy显示文摘Enhancing the heat-sensitivity of tumor cells provides an alternative solution to maintaining the therapeutic outcome of photothermal therapy(PTT). In this study, we constructed a therapeutic system, which was composed of methoxy-polyethylene-glycol-coated-gold-nanorods(MPEG-AuN R) and VER-155008-micelles, to evaluate the effect of VER-155008 on the sensitivity of tumor cells to heat, and further investigate the therapeutic outcome of MPEG-AuN R mediated PTT combined with VER-155008-micelles. VER-155008-micelles downregulate the expression of heat shock proteins and attenuate the heat-resistance of tumor cell. The survival of HCT116 cells treated with VER-155008-micelles under 45 ℃ is equal to that treated with high temperature hyperthermia(55 ℃) in vitro. Furthermore, we proved either the MPEG-AuN R or VER-155008-micelles can be accumulate in the tumor site by photoacoustic imaging and fluorescent imaging. In vivo anti-cancer evaluation showed that tumor size remarkably decreased(smaller than 100 mm^3 or vanished) when treated with combing 45℃ mild PTT system, which contrasted to the tumor size when treated with individual 45℃ mild PTT(around 500nm^3) or normal saline as control(larger than 2000 nm^3). These results proved that the VER-155008-micelles can attenuate the heat-resistance of tumor cells and enhance the therapeutic outcome of mild-temperature photothermal therapy. | Xichuan Tang Liwei Tan Kun Shi Jinrong Peng Yao Xiao Wenting Li Lijuan Chen Qian Yang Zhiyong Qian | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 12 |
| 5 | CAS FGOALS-f3-L Model Datasets for CMIP6 Historical Atmospheric Model Intercomparison Project Simulation显示文摘The outputs of the Chinese Academy of Sciences(CAS) Flexible Global Ocean–Atmosphere–Land System(FGOALS-f3-L) model for the baseline experiment of the Atmospheric Model Intercomparison Project simulation in the Diagnostic,Evaluation and Characterization of Klima common experiments of phase 6 of the Coupled Model Intercomparison Project(CMIP6) are described in this paper. The CAS FGOALS-f3-L model, experiment settings, and outputs are all given. In total,there are three ensemble experiments over the period 1979–2014, which are performed with different initial states. The model outputs contain a total of 37 variables and include the required three-hourly mean, six-hourly transient, daily and monthly mean datasets. The baseline performances of the model are validated at different time scales. The preliminary evaluation suggests that the CAS FGOALS-f3-L model can capture the basic patterns of atmospheric circulation and precipitation well, including the propagation of the Madden–Julian Oscillation, activities of tropical cyclones, and the characterization of extreme precipitation. These datasets contribute to the benchmark of current model behaviors for the desired continuity of CMIP. | Bian HE Qing BAO Xiaocong WANG Linjiong ZHOU Xiaofei WU Yimin LIU Guoxiong WU Kangjun CHEN Sicheng HE Wenting HU Jiandong LI Jinxiao LI Guokui NIAN Lei WANG Jing YANG Minghua ZHANG Xiaoqi ZHANG | 2019 | Advances in Atmospheric Sciences2019，36，8： | 12 |
| 6 | Dietary supplementation with Clostridium butyricum improves growth performance of broilers by regulating intestinal microbiota and mucosal epithelial cells显示文摘Clostridium butyricum has been widely considered an antibiotic substitute in recent years.It can promote growth performance,improve the immune response and enhance the intestinal barrier function of the host.In the present study,1-d-old Arbor Acres(AA)broilers were fed C.butyricum(1×109 cfu/kg)for 28 d.The transcriptomic characteristics of epithelial cells of the cecal mucosa were determined by RNA-sequence,and the cecal microbiota composition was explored by 16 S ribosomal RNA gene sequencing.The changes in the intestinal mucosa of broilers were then analyzed by tissue staining.Gene Ontology(GO)annotations identified substance transport and processes and pathways that might participate in intestinal development and cell viability.Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis revealed that the differentially expressed genes are involved in numerous pathways related to amino acid and vitamin metabolism and antioxidant and defensive functions,among others.The relative expression of some genes associated with intestinal barrier function(claudins 2,15,19,and 23,tight junction proteins 1,2,and 3 and mucin 1)was significantly increased in the treatment group(P<0.05 or P<0.01).Moreover,the proportion of Firmicutes was higher in the C.butyricum-treated group,whereas the proportion of Proteobacteria was higher in the control group.At the genus level,the relative abundances of Butyricicoccus and Lactobacillus,among other bacteria,were increased after C.butyricum supplementation.The tissue staining analysis showed that the cecal mucosa of broilers was significantly ameliorated after the addition of C.butyricum(P<0.05 or P<0.01).These results showed that dietary supplementation with C.butyricum can enhance the antioxidant capacity,mucosal barrier function,and stabilize the cecal microbiota,resulting in improving the growth performance. | Laipeng Xu Xiangli Sun Xianhua Wan Keke Li Fuchun Jian Wenting Li Ruirui Jiang Ruili Han Hong Li Xiangtao Kang Yanbin Wang | 2021 | Animal Nutrition2021，，4： | 12 |
| 7 | Distinct element method analysis and field experiment of soil resistance applied on the subsoiler显示文摘Since the design of the subsoiler is a complex work,the interaction between the subsoiler and soil was investigated by using Distinct Element Method(DEM)in this study.Based on the traditional discrete element theory,the 3D model of soil particles and the subsoiler were established after considering the liquid bridge force between soil particles.The operating resistance curves of the subsoiler were achieved after the DEM simulation at a speed of 1 m/s,and three depths of 180 mm,220 mm and 260 mm,respectively.The simulation curves agreed well with the field experimental results based on relative errors of 2.96%,14.95%and 7.15%,respectively,at three depths.All these data proved that it was feasible and favorable to analyze the performance of the subsoiler by using the DEM and it is of important significance for studying and further optimizing the structure of the subsoiler. | Li Bo Liu Fanyi Mu Junying Chen Jun Han Wenting | 2014 | International Journal of Agricultural and Biological Engineering2014，7，1： | 9 |
| 8 | A high-quality genome sequence of alkaligrass provides insights into halophyte stress tolerance显示文摘Alkaligrass(Puccinellia tenuiflora) is a monocotyledonous halophytic forage grass widely distributed in Northern China. It belongs to the Gramineae family and shares a close phylogenetic relationship with the cereal crops, wheat and barley. Here, we present a high-quality chromosome-level genome sequence of alkaligrass assembled from Illumina, Pac Bio and 10× Genomics reads combined with genome-wide chromosome conformation capture(Hi-C) data. The ~1.50 Gb assembled alkaligrass genome encodes 38,387 protein-coding genes, and 54.9% of the assembly are transposable elements, with long terminal repeats being the most abundant. Comparative genomic analysis coupled with stress-treated transcriptome profiling uncovers a set of unique saline-and alkaline-responsive genes in alkaligrass. The high-quality genome assembly and the identified stress related genes in alkaligrass provide an important resource for evolutionary genomic studies in Gramineae and facilitate further understanding of molecular mechanisms underlying stress tolerance in monocotyledonous halophytes. The alkaligrass genome data is freely available at http://gffzz284c18d2de364501h9kf9xbvkkw9n69vb.ffgz.tsg.suse.edu.cn/data/alkaligrass.html. | Wenting Zhang Jie Liu Yongxue Zhang Jie Qiu Ying Li Baojiang Zheng Fenhong Hu Shaojun Dai Xuehui Huang | 2020 | Science China(Life Sciences)2020，63，9： | 8 |
| 9 | Automated pavement horizontal curve measurement methods based on inertial measurement unit and 3D profiling data显示文摘Pavement horizontal curve is designed to serve as a transition between straight segments,and its presence may cause a series of driving-related safety issues to motorists and drivers.As is recognized that traditional methods for curve geometry investigation are time consuming,labor intensive,and inaccurate,this study attempts to develop a method that can automatically conduct horizontal curve identification and measurement at network level.The digital highway data vehicle(DHDV) was utilized for data collection,in which three Euler angles,driving speed,and acceleration of survey vehicle were measured with an inertial measurement unit(IMU).The 3D profiling data used for cross slope calibration was obtained with PaveVision3 D Ultra technology at 1 mm resolution.In this study,the curve identification was based on the variation of heading angle,and the curve radius was calculated with kinematic method,geometry method,and lateral acceleration method.In order to verify the accuracy of the three methods,the analysis of variance(ANOVA) test was applied by using the control variable of curve radius measured by field test.Based on the measured curve radius,a curve safety analysis model was used to predict the crash rates and safe driving speeds at horizontal curves.Finally,a case study on 4.35 km road segment demonstrated that the proposed method could efficiently conduct network level analysis. | Wenting Luo Lin Li Kelvin C.P.Wang | 2016 | Journal of Traffic and Transportation Engineering(English Edition)2016，3，2： | 8 |
| 10 | GeoScope:Full 3D Geospatial Information System Case Study显示文摘Aiming at the integrative management and comprehensive applications of large-scale 3D geospatial information covering the full 3D space of a city,this paper briefly introduces the design and implementation of a full 3D GIS platform:GeoScope,which provides a professional solution for the massive full three-dimensional geospatial data integration,management,analysis,visualization,and applications.GeoScope is characterized by:(1) extendible software architecture based on the hierarchical message bus,facilitates multimodal integrative applications of 2D GIS and 3D GIS;(2) unified 3D city models,support multiscale semantic representation of outdoor & indoor and aboveground & underground 3D objects;(3) high-efficient 3D geospatial database engine,supports integrated management of massive 3D geospatial data for real-time applications;and (4) high-performance visualization engine exploiting the massively parallel computation architecture of modern GPUs,supports real-time realistic rendering of large-scale complicated 3D geospatial environments.The successful pilot application of GeoScope is also illustrated with the 3D city models of 8494 km2 of the whole Wuhan City,the largest city in middle China. | ZHANG Yeting ZHU Qing LIU Gang ZHENG Wenting LI Zhonghua DU Zhiqiang | 2011 | Geo-Spatial Information Science2011，14，2： | 7 |
| 11 | An Epidemic of Hepatitis A--Liaoning Province,2020显示文摘What is already known about this topic?Hepatitis A(HA)is caused by acute hepatitis A virus(HAV)infection and was once very common in China.Following the 2008 introduction of the HA vaccine into the national Expanded Program on Immunization(EPI),the incidence of reported HA in China decreased markedly.However,HA epidemics still occur in Liaoning Province every 3–5 years,although with far fewer cases than in the pre-HA-vaccination era.What is added by this report?Between January 1,2020 and March 18,2020,the number of reported cases of HA in Dalian and Dandong cities of Liaoning Province increased significantly compared with the same period in previous years.All cases were sporadic,and cases were seen in nearly every township.The increase in HA occurred one month after local fresh seafood became available with most cases being among adults.A casecontrol study showed that consuming raw or undercooked seafood,clams,snapping shrimp,and oysters were significantly associated with the increase in HA.What are the implications for public health practices?Strengthening health education for residents to avoid consumption of raw seafood and encouraging HAV vaccination of adults aged 20 to 54 years are important to prevent periodic HAV endemic outbreaks.Further multisectoral cooperation must be emphasized on HA surveillance in areas with a high prevalence of HA. | Jing Sun Yuanqiu Li Xing Fang Yan Wang Yinan Han Yang Liu Jingyuan Cao Wenting Zhou Hui Zheng Wenqing Yao | 2020 | China CDC weekly2020，2，30： | 7 |
| 12 | Ship detection and classification from optical remote sensing images: A survey显示文摘Considering the important applications in the military and the civilian domain, ship detection and classification based on optical remote sensing images raise considerable attention in the sea surface remote sensing filed. This article collects the methods of ship detection and classification for practically testing in optical remote sensing images, and provides their corresponding feature extraction strategies and statistical data. Basic feature extraction strategies and algorithms are analyzed associated with their performance and application in ship detection and classification.Furthermore, publicly available datasets that can be applied as the benchmarks to verify the effectiveness and the objectiveness of ship detection and classification methods are summarized in this paper. Based on the analysis, the remaining problems and future development trends are provided for ship detection and classification methods based on optical remote sensing images. | Bo LI Xiaoyang XIE Xingxing WEI Wenting TANG | 2021 | Chinese Journal of Aeronautics2021，34，3： | 7 |
| 13 | Removal of antimonite and antimonate from water using Fe-based metal-organic frameworks: The relationship between framework structure and adsorption performance显示文摘We investigated the adsorption performance of five Fe-based MOFs(Fe-BTC,MIL-100(Fe),MIL-101(Fe),MIL-53(Fe)and MIL-88 C(Fe))for removal of antimonite(Sb(Ⅲ))and antimonate(Sb(Ⅴ))from water.Among these MOFs,MIL-101(Fe)exhibited the best adsorption capacities for both Sb(Ⅲ)and Sb(Ⅴ)(151.8 and 472.8 mg/g,respectively)which were higher than those of most adsorbents previously reported.The effect of steric hindrance was evident during Sb removal using the Fe-based MOFs,and the proper diameter of the smallest cage windows/channels should be considered an important parameter during the evaluation and selection of MOFs.Additionally,the adsorption capacities of MIL-101(Fe)for Sb(Ⅴ)decreased with increasing initial p H values(from 3.0 to 8.0),while the opposite trend was observed for Sb(Ⅲ).Chloride,nitrate and sulfate ions had a negligible influence on Sb(Ⅴ)adsorption,while NO3-and SO42-improved Sb(Ⅲ)adsorption.This result implies that inner sphere complexes might form during both Sb(Ⅲ)and Sb(Ⅴ)adsorption. | Wei Zhang Na Li Ting Xiao Wenting Tang Guangli Xiu | 2019 | Journal of Environmental Sciences2019，31，12： | 7 |
| 14 | 粪菌移植应用于慢传输型便秘的临床疗效及疗效影响因素:一项前瞻性研究的长期随访结果显示文摘背景和目的肠道菌群参与结肠动力的调控,菌群失调是便秘是病因之一。粪菌移植被证实可以恢复肠道平衡。本研究旨在评估粪菌移植治疗慢传输型便秘(STC)的临床疗效和预后影响因素。方法:52例STC患者接受标准的粪菌移植入组研究,对其进行至少6个月的随访。记录入组患者的排便习惯、结肠传输时间、便秘相关的症状(PAC-SYM评分)、生活质量(PAC-QOL评分)、治疗满意度和不良反应。主要疗效指标是平均每周完全自主排便≥3次的患者比例。结果:治疗后34周、912周、2124周,每周完全自主排便≥3次患者的比例分别为50.0%、38.5%和32.7%,均较治疗前显著提高(均P<0.01)。其他排便情况、结肠传输时间、便秘相关症状和生活质量方面,治疗后亦有显著改善;但这些短期改善在治疗后12周和24周逐渐减小。治疗前排便不尽是唯一的疗效影响因素。治疗和随访期间未发现任何治疗相关的不良反应。结论:本研究显示粪菌移植治疗STC安全有效,但远期疗效有所降低。治疗前排便不尽感较少甚至没有的患者接受粪菌移植的治疗效果更佳。 | Chao Ding Wenting Fan Lili Gu Hongliang Tian Xiaolong Ge Jianfeng Gong Yongzhan Nie Ning Li | 2018 | Gastroenterology Report2018，6，2： | 7 |
| 15 | Characterization of the soybean Gm ALMT family genes and the function of Gm ALMT5 in response to phosphate starvation显示文摘A potential mechanism to enhance utilization of sparingly soluble forms of phosphorus(P) is the root secretion of malate, which is mainly mediated by the ALMT gene family in plants. In this study, a total of 34 Gm ALMT genes were identified in the soybean genome. Expression patterns diverged considerably among Gm ALMTs in response to phosphate(Pi) starvation in leaves, roots and flowers, with expression altered by P availability in 26 of the 34 Gm ALMTs. One root-specific Gm ALMT whose expression was significantly enhanced by Pi-starvation,Gm ALMT_5, was studied in more detail to determine its possible role in soybean P nutrition. Analysis of Gm ALMT_5 tissue expression patterns, subcellular localization, and malate exudation from transgenic soybean hairy rootsoverexpressing Gm ALMT_5, demonstrated that Gm ALMT_5 is a plasma membrane protein that mediates malate efflux from roots. Furthermore, both growth and P content of transgenic Arabidopsis overexpressing Gm ALMT_5 were significantly increased when sparingly soluble Ca-P was used as the external P source. Taken together, these results indicate that members of the soybean Gm ALMT gene family exhibit diverse responses to Pi starvation. One member of this family, Gm ALMT_5, might contribute to soybean P efficiency by enhancing utilization of sparingly soluble P sources under P limited conditions. | Wenting Peng Weiwei Wu Junchu Peng Jiaojiao Li Yan Lin Yanan Wang Jiang Tian Lili Sun Cuiyue Liang Hong Liao | 2018 | Journal of Integrative Plant Biology2018，60，3： | 7 |
| 16 | Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression显示文摘OBJECTIVE: To investigate the effects of Sini San and fluoxetine on the levels of central and peripheral 5-HT in a rat model of depression, and provide new insight into the treatment of depression with integrated Chinese-Western Medicine.METHODS: A rat model of depression was established by chronic mild stress(CMS). Model rats received either Sini San, fluoxetine, a combination of the two drugs, or no drug treatment. Healthy naive rats were used as controls. Open field and sucrose preference tests were used to assess depression-like behavior. ELISA and immunohistochemistry were used to determine central and peripheral levels of 5-HT.RESULTS: In the group with no drug treatment,central 5-HT expression decreased while peripheral5-HT concentrations increased as CMS continued.Four weeks after CMS, Sini San alone was less effective in reducing depression-like behavior than fluoxetine alone or in combination with Sini San,but combined use was more effective than fluoxetine alone. Eight weeks after CMS, Sini San alone or in combination with fluoxetine was more effective in reducing depression-like behavior than fluoxetine alone. Furthermore Sini San and fluoxetine used alone or in combination notably increased central 5-HT expression and decreased peripheral 5-HT levels in the rat model.CONCLUSION:The results of the present study indicate that there is a synergistic action between the two medicines in the treatment of depression. Sini San exhibited a relatively long lag before its effects were observed; however, by eight weeks the Traditional Chinese Medicine appeared at least as effective as fluoxetine. We suggest that Sini San can replace fluoxetine in the later stages of depression treatment to minimize side effects observed with long-term fluoxetine administration. | Yubo Li Yuxiu Sun Xueling Ma Xiaoxing Xue Wenting Zhang Zhiqian Wu Yulin Ouyang Jianxin Chen Weiming Wang Shuzhen Guo Wei Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 6 |
| 17 | Epigenetics in the pathogenesis of diabetic nephropathy显示文摘Diabetic nephropathy(DN),which is a common microvascular complication with a high incidence in diabetic patients,greatly increases the mortality of patients.With further study on DN,it is found that epigenetics plays a crucial role in the pathophysiological process of DN.Epigenetics has an important impact on the development of DN through a variety of mechanisms,and promotes the generation and maintenance of metabolic memory,thus ultimately leading to a poor prognosis.In this review we discuss the methylation of DNA,modification of histone,and regulation of non-coding RNA involved in the progress of cell dysfunction,inflammation and fibrosis in the kidney,which ultimately lead to the deterioration of DN. | Xue Li Lihong Lu Wenting Hou Ting Huang Xiangyuan Chen Jie Qi Yanjun Zhao Minmin Zhu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，2： | 6 |
| 18 | H2S protects PC12 cells against toxicity of corticosterone by modulation of BDNF-TrkB pathway显示文摘 | Shenglan Gao Wenting Li Wei Zou Ping Zhang Ying Tian Fan Xiao Hongfeng Gu Xiaoqing Tang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 6 |
| 19 | Solid Acid Used as Highly Efficient Catalyst for Esterification of Free Fatty Acids with Alcohols显示文摘Anovel solid acid catalyst, which was prepared from sodium alginate (SA) and metal chlorides and characterized with XRD and FT-IR spectrometry, was used for the preparation of biodiesel via esterification reaction. The study results showed that the aluminum-alginate complex prepared in a cheap and easy way exhibited high catalytic activity, and a 92.6% conversion of methyl oleate was obtained in the presence of 4m% of catalyst dosage upon refluxing for 3h of methanol and acid mixed in a molar ratio of 10:1. It should be noted that the catalyst can be applied to the esterification reaction of fatty acids with various carbon chain length on methanol or different short chain alcohols, indicating that the catalyst is suitable for the preparation of biodiesel from waste oils with a high acid value. | Zhang Qiuyun Li Hu Qin Wenting Liu Xiaofang Zhang Yuping Xue Wei Yang Song | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，1： | 6 |
| 20 | Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing显示文摘Targeting immune checkpoints such as programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for treating melanoma,gastric cancer(GC)and bladder cancer with clinical benefit.Nevertheless,many patients failed to respond to anti-PD-1/PD-L1 treatment,so it is necessary to seek an alternative strategy for traditional PD-1/PD-L1 targeting immunotherapy.Here with the data from The Cancer Genome Atlas(TCGA)and our in-house tissue library,PD-L1 expression was found to be positively correlated with the expression of ubiquitin-specific processing protease 7(USP7)in GC.Furthermore,USP7 directly interacted with PD-L1 in order to stabilize it,Gastric cancer;Immunosuppression;Cancer biologywhile abrogation of USP7 attenuated PD-L1/PD-1 interaction and sensitized cancer cells to T cell killing in vitro and in vivo.Besides,USP7 inhibitor suppressed GC cells proliferation by stabilizing P53 in vitro and in vivo.Collectively,our findings indicate that in addition to inhibiting cancer cells proliferation,USP7 inhibitor can also downregulate PD-L1 expression to enhance anti-tumor immune response simultaneously.Hence,these data posit USP7 inhibitor as an anti-proliferation agent as well as a novel therapeutic agent in PD-L1/PD-1 blockade strategy that can promote the immune response of the tumor. | Zhiru Wang Wenting Kang Ouwen Li Fengyu Qi Junwei Wang Yinghua You Pengxing He Zhenhe Suo Yichao Zheng Hong-Min Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 5 |
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