| 3 | Correlation between X-ray cross-complementing group 1 polymorphisms and the onset risk of glioma A meta-analysis显示文摘OBJECTIVE:To evaluate the association of X-ray cross-complementing group 1(XRCC1)Arg399Gln,Arg194Trp and Arg280His polymorphisms with the risk of glioma.DATA SOURCES:A systematic literature search of papers published from January 2000 to August2012 in PubMed,Embase,China National Knowledge Infrastructure database,and Wanfang database was performed.The key words used were'glioma','polymorphism',and'XRCC1 or X-ray repair cross-complementing group 1'.References cited in the retrieved articles were screened manually to identify additional eligible studies.STUDY SELECTION:Studies were identified according to the following inclusion criteria:case-control design was based on unrelated individuals;and genotype frequency was available to estimate an odds ratio(OR)and 95%confidence interval(CI).Meta-analysis was performed for the selected studies after strict screening.Dominant and recessive genetic models were used and the relationship between homozygous mutant genotype frequencies and mutant gene frequency and glioma incidence was investigated.We chose the fixed or random effect model according to the heterogeneity to calculate OR and 95%CI,and sensitivity analyses were conducted.Publication bias was examined using the inverted funnel plot and the Egger’s test using Stata 12.0 software.MAIN OUTCOME MEASURES:Association of XRCC1 Arg399Gln,Arg194Trp,and Arg280His polymorphisms with the risk of glioma,and subgroup analyses were performed according to different ethnicities of the subjects.RESULTS:Twelve articles were included in the meta-analysis.Eleven of the articles were concerned with the Arg399Gln polymorphism and glioma onset risk.Significantly increased glioma risks were found only in the dominant model(Gln/Gln+Gln/Arg versus Arg/Arg:OR=1.26,95%CI=1.03-1.54,P=0.02).In the subgroup analysis by ethnicity,significantly increased risk was found in Asian subjects in the recessive(OR=1.46,95%CI=1.04-2.45,P=0.03)and dominant models(OR=1.40,95%CI=1.10-1.78,P=0.007),and homozygote contrast(OR=1.69,95%CI=1.17-2.45,P=0.005),but not in Caucasian subjects.For association of the Arg194Trp(eight studies)and Arg280His(four studies)polymorphisms with glioma risk,the meta-analysis did not reveal a significant effect in the allele contrast,the recessive genetic model,the dominant genetic model,or homozygote contrast.CONCLUSION:The XRCC1 Arg399Gln polymorphism may be a biomarker of glioma susceptibility,especially in Asian populations.The Arg194Trp and Arg280His polymorphisms were not associated with overall glioma risk. | Xinquan Gu Hongyan Sun Liping Chang Ran Sun Hongfeng Yang Xuewen Zhang Xianling Cong | 2013 | Neural Regeneration Research2013，8，26： | 1 |
| 4 | Formaldehyde accelerates cellular senescence in HT22 cells: possible involvement of the leptin pathway显示文摘甲醛(FA ) ,一种著名环境污染物质,是在民族生活的广泛地使用的化学混合物。深刻研究证明了 FA 在中央神经系统上有有毒的效果[1 ] 。然而,位于导致 FA 的 neurotoxicity 下面的机制充分没被调查。发现一个方法阻止并且慢下来引起 FA 的 neurotoxicity 的前进也是必要的。细胞的老朽,导致永久房间周期拘捕的规划房间回答,能被象 oncogene 激活,照耀, DNA 损坏和氧化应力那样的各种各样的细胞的压力导致[2 ] 。最近的研究建议了在大脑的衰老的房间可以贡献 neurodegenerative 变化[3 ] 。有趣地,积累了 FA 在使个人变老的大脑被报导了并且贡献年龄相关的 neurodegenerative 症状[4 ] 。因此, FA 能加速细胞的老朽,这被假设并且它可以接着贡献得到 FA 的 neurotoxicity。 | Kebin Zhan Min Ning Chunyan Wang Yonghong Tang Hongfeng Gu Canqun Yan Xiaoqing Tang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，8： | 0 |
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