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| 1 | Tri-Co Robot: a Chinese robotic research initiative for enhanced robot interaction capabilities显示文摘Since the invention of the first industrial robot in 1959, the missions of robots have evolved from basic mechanical transfer or assistance to a diverse range of tasks through close interactions with environment, their human counterparts and robot peers. Through adaptation to uncertain and dynamic environments. | Han Ding Xuejun Yang Nanning Zheng Ming Li Yinan Lai Hao Wu | 2018 | National Science Review2018，5，6： | 24 |
| 2 | An Epidemic of Hepatitis A--Liaoning Province,2020显示文摘What is already known about this topic?Hepatitis A(HA)is caused by acute hepatitis A virus(HAV)infection and was once very common in China.Following the 2008 introduction of the HA vaccine into the national Expanded Program on Immunization(EPI),the incidence of reported HA in China decreased markedly.However,HA epidemics still occur in Liaoning Province every 3–5 years,although with far fewer cases than in the pre-HA-vaccination era.What is added by this report?Between January 1,2020 and March 18,2020,the number of reported cases of HA in Dalian and Dandong cities of Liaoning Province increased significantly compared with the same period in previous years.All cases were sporadic,and cases were seen in nearly every township.The increase in HA occurred one month after local fresh seafood became available with most cases being among adults.A casecontrol study showed that consuming raw or undercooked seafood,clams,snapping shrimp,and oysters were significantly associated with the increase in HA.What are the implications for public health practices?Strengthening health education for residents to avoid consumption of raw seafood and encouraging HAV vaccination of adults aged 20 to 54 years are important to prevent periodic HAV endemic outbreaks.Further multisectoral cooperation must be emphasized on HA surveillance in areas with a high prevalence of HA. | Jing Sun Yuanqiu Li Xing Fang Yan Wang Yinan Han Yang Liu Jingyuan Cao Wenting Zhou Hui Zheng Wenqing Yao | 2020 | China CDC weekly2020，2，30： | 7 |
| 3 | Effect of direct current pulse stimulating acupoints of JiaJi (T10-L3) and Ciliao (BL 32) with Han's Acupoint Nerve Stimulator on labour pain in women: a randomized controlled clinical study显示文摘OBJECTIVE: To assess the clinical effect and safety of direct current(DC) pulse produced by Han's Acupoint Nerve Stimulator in reduction(HANS) of labor pain.METHODS: Totally 120 participants were enrolled in this clinical trial, and were randomly divided into4 groups including: HANS group, patient controlled intravenous analgesia(PCIA) group, patient-controlled epidural analgesia(PCEA) group and control group. The HANS group was treated by stimulating the acupoints of Jia Ji(T10-L3) and Ciliao(BL 32)with DC pulse of 100 Hz and 15-30 m A produced by a portable battery-powered Han's Acupoint Nerve Stimulator for 30 min. The PCIA group was intravenously infused Ondansetron(8 mg) for 5 min,then tramadol injection(1.5 mg/kg) was slowly dripped by using Baxter APⅡ electronic pump with50 m L tramadol(0.70%) + ondansetron(8 mg),background infusion 2 m L/h, PCA dose of 2 m L,lockout interval of 10 min. In PCEA group, women received intrathecal injection ropivacaine(3 mg) in L2-3, and epidural catheter was connected to Baxter APⅡ electronic pump, with 100 m L Ropivacaine(0.1%) and Sufentanil(50 ug), background infusion5 m L, Patient controlled analgesia(PCA) dose of 5m L, lockout interval of 10 min. The control group was not received analgesia. The visual analogue scale(VAS), stage and manner of labor, Apgar score of newborn, neonatal weights, oxytocin dosage,postpartum hemorrhage and side effects were monitored in all groups.RESULTS: The vital signs were all stable in the four analgesic groups. After analgesia, there was statistical difference in VAS score between HANS group and control group, between PCEA group and the control group, between PCIA group and control group. The analgesic effect in the PCEA group was significantly better than that of other two groups.The second stage of labor in the PCEA group was longer than the other three groups, showing significant difference between them. The Apgar score of newborn 1min after birth in the PCIA group was slightly lower than that of the other two groups,showing significant difference between them. The neonatal weights between four groups were not significantly different. The rate of cesarean sectionin the control group was significantly higher than that of the labor analgesia group, there was statistically difference in four groups. The number of PCIA group that used oxytocin was lower than that of other three groups. There was no significant difference in postpartum hemorrhage between four groups. The side effects of the PCEA group were itching, uroschesis and neonatal asphyxia and PCIA group were nausea and vomiting and neonatal asphyxia. However, fewer side effects were observed in the HANS group.CONCLUSION: The DC pulse produced by HANS may be a non-pharmacological alternative to labor pain with fewer side effects. | Liu Ye Xu Mingjun Che Xiangming He Junqin Guo Dandan Zhao Guosheng Zhang Guogang Zhang Shuo Kang Kai Zhang Chunlei Wang Yinan Li Shan Zhang Qinglin Xu Li Zhang Ming Han Bin Jing Yumiao Zhang Ning | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 4 |
| 4 | Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice显示文摘Dear Editor,Hypercholesterolemia is the leading risk factor for cardiovascular diseases.Current evidence suggests that the heritability for blood cholesterol levels is high,with 40%-60%in different cohorts.1,2 Genome-wide association study(GWAS)is a powerful tool to ascertain the contribution of common genetic variants in population-wide disease variability.It has been performed extensively on blood lipids traits and hundreds of genome variants are associated with dyslipidemia.However,approximately 95%of these variants are located in genome noncoding regions and cluster in more than 300 loci in different populations. | Fangfang Han Xiao Liu Chuanfang Chen Yinan Liu Mingkun Du Yu Zhou Yong Liu Bao-Liang Song Housheng Hansen He Yan Wang | 2020 | Cell Research2020，30，4： | 2 |
| 5 | HIV-1 Vif suppresses antiviral immunity by targeting STING显示文摘HIV-1 infection-induced cGAS–STING–TBK1–IRF3 signaling activates innate immunity to produce type I interferon(IFN).The HIV-1 nonstructural protein viral infectivity factor(Vif)is essential in HIV-1 replication,as it degrades the host restriction factor APOBEC3G.However,whether and how it regulates the host immune response remains to be determined.In this study,we found that Vif inhibited the production of type I IFN to promote immune evasion.HIV-1 infection induced the activation of the host tyrosine kinase FRK,which subsequently phosphorylated the immunoreceptor tyrosine-based inhibitory motif(ITIM)of Vif and enhanced the interaction between Vif and the cellular tyrosine phosphatase SHP-1 to inhibit type I IFN.Mechanistically,the association of Vif with SHP-1 facilitated SHP-1 recruitment to STING and inhibited the K63-linked ubiquitination of STING at Lys337 by dephosphorylating STING at Tyr162.However,the FRK inhibitor D-65495 counteracted the phosphorylation of Vif to block the immune evasion of HIV-1 and antagonize infection.These findings reveal a previously unknown mechanism through which HIV-1 evades antiviral immunity via the ITIM-containing protein to inhibit the posttranslational modification of STING.These results provide a molecular basis for the development of new therapeutic strategies to treat HIV-1 infection. | Yu Wang Gui Qian Lingyan Zhu Zhuo Zhao Yinan Liu Wendong Han Xiaokai Zhang Yihua Zhang Tingrong Xiong Hao Zeng Xianghui Yu Xiaofang Yu Xiaoyan Zhang Jianqing Xu Quanming Zou Dapeng Yan | 2022 | Cellular & Molecular Immunology2022，19，1： | 2 |
| 6 | Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation显示文摘One major strategy to generate genetically modified mouse models is gene targeting in mouse embryonic stem(ES)cells,which is used to produce gene-targeted mice for wide applications in biomedicine.However,a major bottleneck in this approach is that the robustness of germiine transmission of gene-targeted ES cells can be significantly reduced by their genetic and epigenetic instability after long-term culturing,which impairs the efficiency and robustness of mouse model generation.Recently,we have established a new type of pluripotent cells termed extended pluripotent stem(EPS)cells,which have superior developmental potency and robust germline competence compared to conventional mouse ES cells.In this study,we demonstrate that mouse EPS cells well maintain developmental potency and genetic stability after long-term passage.Based on gene targeting in mouse EPS cells,we established a new approach to directly and rapidly generate gene-targeted mouse models through tetraploid complementation,Haibo Li and Chaoran Zhao contributed equally to this work.Electronic supplementary material The online version of this article(http://gffzzd3cc09b8251d45dfs9oxkuxw5o9vv6okw.ffgz.tsg.suse.edu.cn/10.1007/s13238-018-0556-1)contains supplementary material,which is available to authorized users.which could be accomplished in approximately 2 months.Importantly,using this approach,we successfully constructed mouse models in which the human interleukin 3(IL3)or interleukin 6(IL6)gene was knocked into its corresponding locus in the mouse genome.Our study demonstrates the feasibility of using mouse EPS cells to rapidly generate mouse models by gene targeting,which have great application potential in biomedical research. | Haibo Li Chaoran Zhao Jun Xu Yaxing Xu Chunmei Cheng Yinan Liu Ting Wang Yaqin Du Liangfu Xie Jingru Zhao Yanchuang Han Xiaobao Wang Yun Bai Hongkui Deng | 2019 | Protein & Cell2019，10，1： | 1 |
| 7 | Dammarane-type triterpenoid saponins isolated from Gynostemma pentaphyllum ameliorate liver fibrosis via agonizing PP2Cαand inhibiting deposition of extracellular matrix显示文摘Gypenosides,structurally analogous to ginsenosides and derived from a sustainable source,are recognized as the principal active compounds found in Gynostemma pentaphyllum,a Chinese medicinal plant used in the treatment of the metabolic syndrome.By bioactive tracking isolation of the plants collected from different regions across China,we obtained four new gypenosides(1−4),together with nine known gypenosides(5−13),from the methanol extract of the plant.The structures of new gypenosides were elucidated by one-dimensional(1D)and two-dimensional(2D)nuclear magnetic resonance(NMR)spectra,complemented by chemical degradation experiments.Through comprehensive evaluation involving COL1A1 promoter assays and PP2Cαactivity assays,we established a definitive structure-activity relationship for these dammarane-type triterpenoids,affirming the indispensability of the C-3 saccharide chain and C-17 lactone ring in effectively impeding extracellular matrix(ECM)deposition within hepatic stellate cells.Further in vivo study on the CCl4-induced liver damage mouse model corroborated that compound 5 significantly ameliorated the process of hepatic fibrosis by oral administration.These results underscore the potential of dammarane-type triterpenoids as prospective antifibrotic leads and highlight their prevalence as key molecular frameworks in the therapeutic intervention of chronic hepatic disorders. | LIU Yue YANG Yating WANG Hanghang LI Han LV Qi WANG Xiachang WU Dalei HU Lihong ZHANG Yinan | 2023 | Chinese Journal of Natural Medicines2023，21，8： | 1 |
| 8 | Saponins from Platycodi Radix ameliorate high fat diet-induced obesity in Mice 显示文摘 | Han Likun Zheng Yinan Xu Baojun | 2002 | J Nutr2002，132，： | 1 |
| 9 | Sapomins(Ginsenosides) from stems and leaves of Panax quinquefolium prevented high-fat diet-induced obesity in mice显示文摘 | Liu Wengcong Zheng Yinan Han Likun | | 0，，： | 1 |
| 10 | Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes显示文摘 | Han Likun Zheng Yinan Yoshikawa M | | 0，，09： | 1 |
| 11 | A new Amino Acid derivative from RedGinseng 显示文摘 | Yinan Zheng Likun Han Okuda H | 1998 | Uoumal of Chinese Pharmaceutical Sciences1998，7，1： | 1 |
| 12 | Inhibition of hydrogen sulfide synthesis provides protection for severe acute pancreatitis rats via apoptosis pathway显示文摘 | Gang Wang Bing Han Haoxin Zhou Linfeng Wu Yongwei Wang Guang Jia Jiachen Lv Zhuoxin Cheng Shangha Pan Ji Liu Yinan Zhou Bei Sun | 2013 | Apoptosis2013，，1： | 1 |
| 13 | Isoflavone Content of Soybean Cultivars from Maturity Group 0 to VI Grown in Northern and Southern China显示文摘 | Jingying Zhang Yinan Ge Fenxia Han Bin Li Shurong Yan Junming Sun Lianzheng Wang | 2014 | Journal of the American Oil Chemists’ Society2014，，6： | 1 |
| 14 | Integrative Analysis of Genome,3D Genome,and Transcriptome Alterations of Clinical Lung Cancer Samples显示文摘Genomic studies of cancer cell alterations,such as mutations,copy number variations(CNVs),and translocations,greatly promote our understanding of the genesis and development of cancers.However,the 3D genome architecture of cancers remains less studied due to the complexity of cancer genomes and technical difficulties.To explore the 3D genome structure in clinical lung cancer,we performed Hi-C experiments using paired normal and tumor cells harvested from patients with lung cancer,combining with RNA sequenceing analysis.We demonstrated the feasibility of studying 3D genome of clinical lung cancer samples with a small number of cells(1×10^(4)),compared the genome architecture between clinical samples and cell lines of lung cancer,and identified conserved and changed spatial chromatin structures between normal and cancer samples.We also showed that Hi-C data can be used to infer CNVs and point mutations in cancer.By integrating those different types of cancer alterations,we showed significant associations between CNVs,3D genome,and gene expression.We propose that 3D genome mediates the effects of cancer genomic alterations on gene expression through altering regulatory chromatin structures.Our study highlights the importance of analyzing 3D genomes of clinical cancer samples in addition to cancer cell lines and provides an integrative genomic analysis pipeline for future larger-scale studies in lung cancer and other cancers. | Tingting Li Ruifeng Li Xuan Dong Lin Shi Miao Lin Ting Peng Pengze Wu Yuting Liu Xiaoting Li Xuheng He Xu Han Bin Kang Yinan Wang Zhiheng Liu Qing Chen Yue Shen Mingxiang Feng Xiangdong Wang Duojiao Wu Jian Wang Cheng Li | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 1 |
| 15 | A graphical method of presenting property rights, building types, and residential behaviors: A case study of Xiaoxihu historic area, Nanjing显示文摘One of the main reasons for the decline of urban historic areas in China is the coexistence of multiple property rights.It also deeply affects conservation and regeneration practice.This paper aims to propose a graphical method that illustrates the association between property rights,space,and resident behavior.Based on typological maps and justified graphs,a three-step method was proposed to visualize the relationships between these three elements.The final graph and quantitative data were used to observe the evolution of the courtyard building from a diachronic perspective,as well as to compare the residential behavior in different types from a synchronic perspective.The results show that following the subdivision of property rights,the building layout become more diverse due to various illegal additions,while the residential behavior within different building types tends to be consistent.Moreover,the study observed the traditional Chinese courtyard buildings’adaptability.The findings contribute to understand the evolution of Chinese urban historic areas and internal motivation,and provide guidance for the conservation and regeneration practice. | Yinan Dong Dongqing Han Marco Trisciuoglio | 2022 | Frontiers of Architectural Research2022，11，6： | 1 |
| 16 | Decoratable hybrid-film-patch stabilized Pickering emulsions and their catalytic applications显示文摘我们表明了一个方法制作被用来形成皮克林乳剂(足) 的功能的混合电影补丁。混合补丁用碳 nanotubes 做的, Fe 3 O 4 nanoparticles, octadecyltrimethoxysilane,并且 poly (diallyldimethylammonium 氯化物) 。混合补丁的稳定的足的水的阶段能被使用一个磁场容易分开。hybrid-film-patch 稳定了足为在房间温度的八个月极其稳定、持续。而且,他们被增加乙醇容易破裂,并且在 aqueous/oil 混合物由 vortexing 改革了补丁,启用容易与金属 nanoparticles 要修改的补丁的内部吸水的方面。作为一个例子,钯 nanoparticles 被嵌进混合补丁的表面用一在里面 situ 减小方法。Pd functionalized 补丁形成了显示出的足为有 99.5% 的收益的丙酮的加氢的优秀催化表演。没有催化活动的损失, Pd functionalized 补丁的一样的批被再循环 13 次。混合补丁的形成的足在催化的域里有一个大潜力。 | Shenghua Ma Yinan Wang Kunpeng Jiang Xiaojun Han | 2015 | Nano Research2015，8，8： | 0 |
| 17 | Role of 5-hydroxytryptamine type 3 receptors in the regulation of anxiety reactions显示文摘5-Hydroxytryptamine(5-HT)type 3 receptor(5-HT_(3)R)is the only type of ligand-gated ion channel in the 5-HT receptor family.Through the high permeability of Na+,K+,and Ca2+and activation of subsequent voltage-gated calcium channels(VGCCs),5-HT_(3)R induces a rapid increase of neuronal excitability or the release of neurotransmitters from axon terminals in the central nervous system(CNS).5-HT_(3)Rs are widely expressed in the medial prefrontal cortex(mPFC),amygdala(AMYG),hippocampus(HIP),periaqueductal gray(PAG),and other brain regions closely associated with anxiety reactions.They have a bidirectional regulatory effect on anxiety reactions by acting on different types of cells in different brain regions.5-HT_(3)Rs mediate the activation of the cholecystokinin(CCK)system in the AMYG,and theγ-aminobutyric acid(GABA)“disinhibition”mechanism in the prelimbic area of the mPFC promotes anxiety by the activation of GABAergic intermediate inhibitory neurons(IINs).In contrast,a 5-HT_(3)R-induced GABA“disinhibition”mechanism in the infralimbic area of the mPFC and the ventral HIP produces anxiolytic effects.5-HT_(2)R-mediated regulation of anxiety reactions are also activated by 5-HT_(3)R-activated 5-HT release in the HIP and PAG.This provides a theoretical basis for the treatment of anxiety disorders or the production of anxiolytic drugs by targeting 5-HT_(3)Rs.However,given the circuit specific modulation of 5-HT_(3)Rs on emotion,systemic use of 5-HT_(3)R agonism or antagonism alone seems unlikely to remedy anxiety,which deeply hinders the current clinical application of 5-HT_(3)R drugs.Therefore,the exploitation of circuit targeting methods or a combined drug strategy might be a useful developmental approach in the future. | Yinan DU Zhiwei LI Yukui ZHAO Jing HAN Weiping HU Zhiqiang LIU | 2024 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2024，25，1： | 0 |
| 18 | Impact of Tropical Cyclone Avoidance on Fishing Vessel Activity over Coastal China Based on Automatic Identification System Data during 2013–2018显示文摘Tropical cyclones(TCs)may cause severe impacts on the activities of coastal fishing vessels.Due to the unavailability or unacceptability of detailed Automatic Identification System(AIS)data that are capable of differentiating fishing activity from navigation,as well as the lack of detailed models and observation data of TC winds,few studies have provided quantitative and reliable assessment of the impacts of TCs on fishing activities.In this study,we modeled snapshots for the TC winds of 52 TCs over the Northwest Pacific(NWP)basin from 2013 to 2018,as well as daily fishing hours and daily hours of presence(hereafter“vessel hours”)of fishing vessels.Based on these data,the spatiotemporal pattern of fishing vessel activity over off-shore China was first analyzed and mapped.Then,a TC wind hazard index and absolute and relative impact indices were proposed to assess the impact of the 52 TCs on fishing and vessel hours.Their relationship was then fitted with the cumulative distribution function(CDF)of the log-normal distribution.The results show that in the 2013-2018 period,the most active fishing areas were located in the South China Sea.In each instance,an increase was first observed in the initial several years;then a decrease followed in the yearly total fishing hours per vessel in the remaining years.The relative impact index was significantly correlated to the TC wind hazard index proposed in this study.Based on the quantitative relationship between the specified TC hazard index and the impact indices,it is possible to implement a pre-cyclone rapid loss assessment due to TC avoidance in the future. | Weihua Fang Cunmin Guo Yinan Han Rongfa Qing | 2022 | International Journal of Disaster Risk Science2022，13，4： | 0 |
| 19 | Engineering Saccharomyces cerevisiae to produce plant benzylisoquinoline alkaloids显示文摘Benzylisoquinoline alkaloids(BIAs)are a diverse family of plant natural products with extensive pharmacological properties,but the yield of BIAs from plant is limited.The understanding of BIA biosynthetic mechanism in plant and the development of synthetic biology enable the possibility to produce BIAs through microbial fermentation,as an alternative to agriculture-based supply chains.In this review,we discussed the engineering strategies to synthesize BIAs in Saccharomyces cerevisiae(yeast)and improve BIA production level,including heterologous pathway reconstruction,enzyme engi neering,expression regulation,host engineering and fermentation engineering.We also highlight recent meta bolic engineering advances in the production of BIAs in yeast. | Jianing Han Yinan Wu Yilun Zhou Sijin Li | 2021 | aBIOTECH2021，2，3： | 0 |
| 20 | Repurposing of Antazoline Hydrochloride as an Inhibitor of Hepatitis B Virus DNA Secretion显示文摘Hepatitis B virus(HBV) belongs to Hepadnaviridae family and mainly infects hepatocytes, which can cause acute or chronic hepatitis. Currently, two types of antiviral drugs are approved for chronic infection clinically: interferons and nucleos(t)ide analogues. However, the clinical cure for chronic infection is still rare, and it is a huge challenge for all researchers to develop high-efficiency, safe, non-tolerant, and low-toxicity anti-HBV drugs. Antazoline hydrochloride is a first-generation antihistamine with anticholinergic properties, and it is commonly used to relieve nasal congestion and in eye drops. Recently, an in vitro high-throughput evaluation system was constructed to screen nearly 800 compounds from the Food and Drug Administration(FDA)-approved Drug Library. We found that arbidol hydrochloride and antazoline hydrochloride can effectively reduce HBV DNA in the extracellular supernatant in a dose-dependent manner, with EC_(50) of4.321 lmol/L and 2.910 lmol/L in HepAD38 cells, respectively. Moreover, the antiviral effects and potential mechanism of action of antazoline hydrochloride were studied in different HBV replication systems. The results indicate that antazoline hydrochloride also has a significant inhibitory effect on HBV DNA in the extracellular supernatant of Huh7 cells,with an EC_(50) of 2.349 lmol/L. These findings provide new ideas for screening and research related to HBV agents. | Jing Li Yangyang Hu Yifei Yuan Yinan Zhao Qiqi Han Canyu Liu Xue Hu Yuan Zhou Yun Wang Yu Guo Chunchen Wu Xinwen Chen Rongjuan Pei | 2021 | Virologica Sinica2021，36，3： | 0 |
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