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| 1 | Automated pavement horizontal curve measurement methods based on inertial measurement unit and 3D profiling data显示文摘Pavement horizontal curve is designed to serve as a transition between straight segments,and its presence may cause a series of driving-related safety issues to motorists and drivers.As is recognized that traditional methods for curve geometry investigation are time consuming,labor intensive,and inaccurate,this study attempts to develop a method that can automatically conduct horizontal curve identification and measurement at network level.The digital highway data vehicle(DHDV) was utilized for data collection,in which three Euler angles,driving speed,and acceleration of survey vehicle were measured with an inertial measurement unit(IMU).The 3D profiling data used for cross slope calibration was obtained with PaveVision3 D Ultra technology at 1 mm resolution.In this study,the curve identification was based on the variation of heading angle,and the curve radius was calculated with kinematic method,geometry method,and lateral acceleration method.In order to verify the accuracy of the three methods,the analysis of variance(ANOVA) test was applied by using the control variable of curve radius measured by field test.Based on the measured curve radius,a curve safety analysis model was used to predict the crash rates and safe driving speeds at horizontal curves.Finally,a case study on 4.35 km road segment demonstrated that the proposed method could efficiently conduct network level analysis. | Wenting Luo Lin Li Kelvin C.P.Wang | 2016 | Journal of Traffic and Transportation Engineering(English Edition)2016，3，2： | 8 |
| 2 | Dendrocalamus latiflorus and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production via AKT activation显示文摘The potential medicinal value of Ma bamboo(Dendrocalamus latiflorus), one of the most popular and economically important bamboo species in China, has been underestimated. In the present study, we found that D. latiflorus leaf extract(DLE) reduced fasting blood glucose levels, body weight,and low-density lipoprotein cholesterol with low liver toxicity in db/db mice. In addition, gene expression profiling was performed and pathway enrichment analysis showed that DLE affected metabolic pathways.Importantly, DLE activated the AKT signaling pathway and reduced glucose production by downregulating glucose-6-phosphatase(G6 PC) and phosphoenolpyruvate carboxykinase 1(PCK1) expression. Moreover, network pharmacology analysis identified rutin as an active component in DLE through targeting insulin growth factor 1 receptor(IGF1 R), an upstream signaling transducer of AKT. Due to its hypoglycemic effects and low toxicity, DLE may be considered an adjuvant treatment option for type 2 diabetes patients. | Kun Luo Wenting Huang Liansheng Qiao Xiaoling Zhang Di Yan Zhiyu Ning Chengmei Ma Honglei Dang Dong Wang Hongyan Guo Lan Xie Jing Cheng | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 4 |
| 3 | A genetically encoded ratiometric calcium sensor enables quantitative measurement of the local calcium microdomain in the endoplasmic reticulum显示文摘The local Ca^2+ release from the heterogeneously distributed endoplasmic reticulum (ER) calcium store has a critical role in calcium homeostasis and cellular function. However;single fluorescent proteinbased ER calcium probes experience challenges in quantifying the ER calcium store in differing live cells, and intensity-based measurements make it difficult to detect local calcium microdomains in the ER. Here, we developed a genetically encoded ratiometric ER calcium indicator [GCEPIA1-SNAPer] that can detect the real-time ER calcium store and local calcium microdomains in live cells. GCEPIA1-SNAPer was located in the lumen of the ER and showed a linear;reversible and rapid response to changes in the ER calcium store. The GCEPIA1-SNAPer probe effectively monitored the depletion of the ER calcium store by TG or starvation treatment, and through 让s use we identified heterogeneously distributed calcium microdomains in the ER which were correlated w让h the distribution of STIM1 clusters upon ER calcium store depletion. Lastly, GCEPIA1-SNAPer can be used to detect the ER calcium store by high-throughput flow cytometry and confers the ability to study the function of calcium microdomains of the ER. | Chen Luo Huiyu Wang Qi Liu Wenting He Lin Yuan Pingyong Xu | 2019 | Biophysics Reports2019，5，1： | 3 |
| 4 | Oxidative dehydrogenation of ethane with carbon dioxide over silica molecular sieves supported chromium oxides:Pore size effect显示文摘SBA-15 with varied pore size from 4 to 8 nm were synthesized by tuning the temperature of hydrothermal treatment,the supports were then used to load the active phase Cr Oxthrough a conventional impregnation method.The resulting catalysts were characterized by small/wide angle XRD,N_(2) adsorption/desorption,FT-IR,TEM-EDX,XPS,TPR and CO_(2)-TPD to study the feature of structure,surface chemical state,redox and basicity.It was found from these results that the metal species could be well dispersed on catalysts with larger pore size.Cr^(6+)species could enter into the framework by substituting the Si atoms of SBA-15,and Cr^(3+)mainly exist on extra framework.Pore size had profound effects on reducibility,surface composition and basicity.Cr^(6+)species were necessary to activate the C-H bonds of alkanes,while the basicity played an important role in activating C-O bonds of CO_(2).The best performances were achieved over the sample Cr supported on SBA-15 with a pore diameter of 7 nm in oxidative dehydrogenation of ethane in the presence of CO_(2). | Zhibin Deng Xing Ge Wenting Zhang Shizhong Luo Jun Shen Fangli Jing Wei Chu | 2021 | Chinese Journal of Chemical Engineering2021，34，6： | 2 |
| 5 | Multi-view video coding based on video correction 显示文摘 | Yan Tao Zhou Xiaoxiong Luo Wenting | 2014 | Materials Sci- ence Computer and Information Technology2014，11，1： | 1 |
| 6 | Soil contamination by phthalate esters in Chinese intensive vegetable production systems with different modes of use of plastic film显示文摘 | Jun Wang Yongming Luo Ying Teng Wenting Ma Peter Christie Zhengao Li | 2013 | Environmental Pollution2013，，： | 1 |
| 7 | Ionic conductivity of polymer electrolytes de- rived from various diisocyanate - based waterborne polyurethanes 显示文摘 | WenT C Luo S S Yang C H | 2000 | Polymer2000，41，18： | 1 |
| 8 | Effect of Avastin on the migration and invasion of pterygium fibroblasts显示文摘Purpose:.To evaluate the effect of Avastin on human pterygium fibroblast migration and invasiveness.Methods:.VEGF secretion was compared between human pterygium fibroblasts and conjunctival fibroblasts by measuring VEGF-A by ELISA. The influence of Avastin on HPF migration and invasiveness was observed by wound scratch and Transwell migration assays..The expression of p-ERK1 / 2 and p-FAK was analyzed by western blotting.Results:(1)VEGF was secreted in higher amounts by human pterygium fibroblasts than by conjunctival fibroblasts.(2)Avastin treatment decreased HPF migration and invasion.(3)Avastin significantly decreased the expression of p-ERK1 / 2and p-FAK in human pterygium fibroblasts.Conclusion:.Avastin can inhibit migration and invasion of HPFs by decreasing the expression of p-ERK1 / 2 and p-FAK. | Wei Liu Xiangyin Sha Ye Wen Wenting Zhao Wei Luo Zanmei Hua | 2014 | Eye Science2014，29，4： | 1 |
| 9 | Investigation into the tribological behaviors of press hardening steels on the tailored conditions显示文摘There has been a growing demand for safety parts with tailored properties in automobile industry.However,the understanding of tribological behavior of press hardening steels(PHS)on the tailored conditions is highly inadequate.The present work aims at creating new knowledge about the tribological characteristics of PHS on the tailored conditions and bridging this existing gap.The paper proposes an improved hot drawing tribo-simulator to simulate the realistic experimental conditions industry.Investigations were carried out on the condition of different initial heating temperatures,tool temperatures,austenitizing temperatures,cooling rates and microstructures.The presented results show that the whole frictional process is divided into three stages for both coated and uncoated steels.The frictional factor changes a lot and the peak value of frictional factor occurs for serious adhesive wear.The frictional factor rises as the tool temperature and austenitizing temperature rise.The surface morphology of tools indicates that the coating adhering to tool gets thicker as the tool temperature increases.With the increase of cooling rate,the frictional factor declines firstly and then rises to some extent.Flat dies with different temperatures are used to form specimens with different microstructures,which also affects the frictional factor and wear. | WANG ZiJian LUO XiaoYu HE WenTing ZHANG YiSheng | 2015 | Science China(Technological Sciences)2015，58，1： | 1 |
| 10 | Design and characterization of metallic glass/graphene multilayer with excellent nanowear properties显示文摘The excellent properties of metallic glass(MG)films make them perfect candidates for the use in miniature systems and tools.However,their high coefficients of friction(COFs)and poor wear resistance considerably limit their long-term performance in nanoscale contact.We report the fabrication of a MG/graphene multilayer by the repeated deposition of Cu_(50)Zr_(50) MG with alternating layers of graphene.The microstructure of the multilayer was characterized by the transmission electron microscopy(TEM).Its mechanical and nanotribological properties were studied by nanoindentation and nanoscratch tests,respectively.A molecular dynamics(MD)simulation revealed that the addition of graphene endowed the MG with superelastic recovery,which reduced friction during nanoscratching.In comparison with the monolithic MG film,the multilayer exhibited improved wear resistance and a low COF in repeated nanowear tests owing to the enhanced mechanical properties and lubricating effect caused by the graphene layer.This work is expected to motivate the design of other novel MG films with excellent nanowear properties for engineering applications. | Qing ZHOU Dawei LUO Dongpeng HUA Wenting YE Shuo LI Qiguang ZOU Ziqiang CHEN Haifeng WANG | 2022 | Friction2022，10，11： | 1 |
| 11 | Split graphs whose half-strong endomorphisms form a monoid显示文摘In this paper,the half-strong,the locally strong and the quasi-strong endomorphisms of a split graph are investigated.Let X be a split graph and let End(X),hEnd(X),lEnd(X) and qEnd(X) be the endomorphism monoid,the set of all half-strong endomorphisms,the set of all locally strong endomorphisms and the set of all quasi-strong endomorphisms of X,respectively.The conditions under which hEnd(X) forms a submonoid of End(X) are given.It is shown that lEnd(X) = qEnd(X) for any split graph X.The conditions under which lEnd(X)(resp.qEnd(X)) forms a submonoid of End(X) are also given.In particular,if hEnd(X) forms a monoid,then lEnd(X)(resp.qEnd(X)) forms a monoid too. | LUO YanFeng ZHANG WenTing QIN YingYing HOU HaiLonga | 2012 | Science China Mathematics2012，55，6： | 1 |
| 12 | Bootstrap Inference on the Variance Component Functions in the Two-Way Random Effects Model with Interaction显示文摘In this paper,using the Bootstrap approach and generalized approach,the authors consider the one-sided hypothesis testing problems for variance component functions in the two-way random effects model.Firstly,the test statistics and confidence intervals for the sum of variance components are constructed.Next,the one-sided hypothesis testing problems for the ratio of variance components are also discussed.The Monte Carlo simulation results indicate that the Bootstrap approach is better than the generalized approach in most cases.Finally,the above approaches are applied to the real data examples of mice blood p H and molded plastic part’s dimensions. | YE Rendao GE Wenting LUO Kun | 2021 | Journal of Systems Science & Complexity2021，34，2： | 0 |
| 13 | A neuropsin-based optogenetic tool for precise control of Gq signaling显示文摘G_(q)-coupled receptors regulate numerous physiological processes by activating enzymes and inducing intracellular Ca^(2+)signals.There is a strong need for an optogenetic tool that enables powerful experimental control over G_(q) signaling.Here,we present chicken opsin 5(cOpn5)as the long sought-after,single-component optogenetic tool that mediates ultra-sensitive optical control of intracellular G_(q) signaling with high temporal and spatial resolution.Expressing cOpn5 in HEK 293T cells and primary mouse astrocytes enables blue light-triggered,G_(q)-dependent Ca^(2+) release from intracellular stores and protein kinase C activation.Strong Ca^(2+) transients were evoked by brief light pulses of merely 10 ms duration and at 3 orders lower light intensity of that for common optogenetic tools.Photostimulation of cOpn5-expressing cells at the subcellular and single-cell levels generated fast intracellular Ca^(2+)transition,thus demonstrating the high spatial precision of cOpn5 optogenetics.The cOpn5-mediated optogenetics could also be applied to activate neurons and control animal behavior in a circuit-dependent manner.cOpn5 optogenetics may find broad applications in studying the mechanisms and functional relevance of G_(q) signaling in both non-excitable cells and excitable cells in all major organ systems. | Ruicheng Dai Tao Yu Danwei Weng Heng Li Yuting Cui Zhaofa Wu Qingchun Guo Haiyue Zou Wenting Wu Xinwei Gao Zhongyang Qi Yuqi Ren Shu Wang Yulong Li Minmin Luo | 2022 | Science China(Life Sciences)2022，65，7： | 0 |
| 14 | Spatial Distribution of Parvalbumin-Positive Fibers in the Mouse Brain and Their Alterations in Mouse Models of Temporal Lobe Epilepsy and Parkinson’s Disease显示文摘Parvalbumin interneurons belong to the major types of GABAergic interneurons.Although the distribution and pathological alterations of parvalbumin interneuron somata have been widely studied,the distribution and vulnerability of the neurites and fibers extending from parvalbumin interneurons have not been detailly interrogated.Through the Cre recombinase-reporter system,we visualized parvalbumin-positive fibers and thoroughly investigated their spatial distribution in the mouse brain.We found that parvalbumin fibers are widely distributed in the brain with specific morphological characteristics in different regions,among which the cortex and thalamus exhibited the most intense parvalbumin signals.In regions such as the striatum and optic tract,even long-range thick parvalbumin projections were detected.Furthermore,in mouse models of temporal lobe epilepsy and Parkinson’s disease,parvalbumin fibers suffered both massive and subtle morphological alterations.Our study provides an overview of parvalbumin fibers in the brain and emphasizes the potential pathological implications of parvalbumin fiber alterations. | Changgeng Song Yan Zhao Jiajia Zhang Ziyi Dong Xin Kang Yuqi Pan Jinle Du Yiting Gao Haifeng Zhang Ye Xi Hui Ding Fang Kuang Wenting Wang Ceng Luo Zhengping Zhang Qinpeng Zhao Jiazhou Yang Wen Jiang Shengxi Wu Fang Gao | 2023 | Neuroscience Bulletin2023，39，11： | 0 |
| 15 | Correction:Spatial Distribution of Parvalbumin‑Positive Fibers in the Mouse Brain and Their Alterations in Mouse Models of Temporal Lobe Epilepsy and Parkinson’s Disease显示文摘In this article the wrong figure appeared as Fig.3,the figure should have appeared as shown below. | Changgeng Song Yan Zhao Jiajia Zhang Ziyi Dong Xin Kang Yuqi Pan Jinle Du Yiting Gao Haifeng Zhang Ye Xi Hui Ding Fang Kuang Wenting Wang Ceng Luo Zhengping Zhang Qinpeng Zhao Jiazhou Yang Wen Jiang Shengxi Wu Fang Gao | 2023 | Neuroscience Bulletin2023，39，11： | 0 |
| 16 | Investigation on the short-term outcome and prognostic impact of predisposition,and precipitants in inpatients with chronic liver disease from Chinese AcuTe on CHronic LIver FailurE(CATCH-LIFE)cohorts显示文摘Aim:The study aimed to investigate the short-term outcomes of hospitalized patients with chronic liver disease(CLDs)and assess the prognostic impact of predisposition and precipitants,which currently remains unclear.Methods:The study included 3970 hospitalized patients with CLDs from two prospective longitudinal multicenter studies(NCT02457637 and NCT03641872)conducted in highly endemic hepatitis B virus(HBV)areas.Competing risk analysis was used to evaluate the effect of predispositions,including the etiology and severity of CLDs and precipitants;on sequential 28,90,and 365-day liver transplantation(LT)-free mortality.Results:Among all enrolled patients,76.8%of adverse outcomes(including death and LT)within one year occurred within 90 days.Compared with alcoholic etiology,the association of HBV etiology with poorer outcomes was remarkably on the 28th day(hazard ratio[HR],1.81;95%confidence interval[CI],1.07-3.06;p=0.026);however,and dimin-ished or became insignificant at 90 days and 365 days.Cirrhosis increased the adjusted risk for 365-day(HR,1.50;CI,1.13-1.99;p=0.004)LT-free mortality when compared with noncirrhosis.In patients with cirrhosis,prior decompensation(PD)independently increased the adjusted risk of 365-day LT-free mortality by 1.25-fold(p=0.021);however,it did not increase the risk for 90-day mortality.Neither the category nor the number of precipitants influenced the adjusted risk of 28 or 90-day LT-free mortality.Conclusions:The 90-day outcome should be considered a significant endpoint for evaluating the short-term prognosis of hospitalized patients with CLD.Predisposing factors,other than etiology,mainly affected the delayed(365-day)outcome.Timely effective therapy for CLD etiology,especially antiviral treatments for HBV,and post-discharge long-term surveillance monitoring in cirrhotic patients undergoing PD are suggested to enhance disease management and reduce mortality. | Yan Zhang Wenting Tan Xiaobo Wang Xin Zheng Yan Huang Beiling Li Zhongji Meng Yanhang Gao Zhiping Qian Feng Liu Xiaobo Lu Jia Shang Yubao Zheng Weituo Zhang Shan Yin Wenyi Gu Tongyu Wang Jianyi Wei Zixuan Shen Guohong Deng Yi Zhou Yixin Hou Qun Zhang Shue Xiong Jing Liu Liyuan Long Ruochan Chen Jinjun Chen Xiuhua Jiang Sen Luo Yuanyuan Chen Chang Jiang Jinming Zhao Liujuan Ji Xue Mei Jing Li Tao Li Rongjiong Zheng Xinyi Zhou Haotang Ren Yu Shi Hai Li for the CATCH‐LIFE Study Investigators of Chinese(Acute‐on)Chronic Liver Failure(CLIF)Consortium(Ch‐CLIFC) | 2023 | Portal Hypertension & Cirrhosis2023，2，3： | 0 |
| 17 | Dielectric and ferroelectric properties of CuO-doped lead magnesium niobate-based relaxor ferroelectric ceramics显示文摘In this work,we report the dielectric and ferroelectric properties of CuO-doped(1-x)[0.5573Pb(Mg_(1/3)Nb_(2/3))O_(3)-0.4427PbTiO_(3)]-xBa(Zn_(1/3)Nb_(2/3))_(3)(PMNT-xBZN)relaxor ferrielectric ceramic samples with x=0.1725,0.1925,02125 and 0.2325,which were fabricated by a conventional solid-state reaction method.By introducing the CuO into PMNT-xBZN,the sintering temperature of this system is drastically lowered from 1280℃to 1120℃.The second pyrochlore phase,which is often generated during sintering at high temperature,is also inhibited.Meanwhile,broad dielectric peaks with strong dielectric relaxation characteristics are observed from150℃to 100℃.Slim and slanted P-E hysteresis loops and purely electrostrictive strains with V-shape are obtained simultaneously in studied compositions from 30℃to 150℃.These results suggest that CuO could effectively lower the sintering temperature while maintaining the dielectric and ferroelectric properties of PMNT-xBZN relaxor ferroelectric ceramics. | Li Jin Jing Pang Yunyao Huang Wenting Luo Xu Lu Xiaoyong Wei | 2019 | Journal of Advanced Dielectrics2019，9，4： | 0 |
| 18 | The investigation of electrical properties and microstructure of ZnO-doped Ba_(0.9)Sr_(0.1)TiO_(3)ceramics显示文摘Ba_(0.9)Sr_(0.1)TiO_(3) ceramics with or without ZnO have been prepared by traditional solid state reaction method.The XRD analysis showed that the doped Zn^(2+) ions diffused into the BST crystal lattice,resulting in the variation of dielectric properties.Especially the dielectric constant at Curie point decreased with doping ZnO content when it is lower than 0.5 mol%.Due to the promotion of sintering,doping ZnO can enhance the density of ceramics but increase grain size.However,ZnO is a kind of semiconductor and can lead to the decrease in electrical breakdown strength value. | Gang Liu Wentao Jiang Jingyong Jiao Li Liu Ziyang Wang Jing Cai Wenting Luo Chunlin Song | 2017 | Journal of Advanced Dielectrics2017，7，1： | 0 |
| 19 | WaveLines:towards effective visualization and analysis of stability in power grid simulation显示文摘Closely related to the safety and stability of power grids,stability analysis has long been a core topic in the electric industry.Conventional approaches employ computational simulation to make the quantitative judgement of the grid stability under distinctive conditions.The lack of in-depth data analysis tools has led to the difficulty in analytical tasks such as situation-aware analysis,instability reasoning and pattern recognition.To facilitate visual exploration and reasoning on the simulation data,we introduce WaveLines,a visual analysis approach which supports the supervisory control of multivariate simulation time series of power grids.We design and implement an interactive system that supports a set of analytical tasks proposed by domain experts and experienced operators.Experiments have been conducted with domain experts to illustrate the usability and effectiveness of WaveLines. | Tianye ZHANG Qi WANG Liwen LIN Jiazhi XIA Xiwang XU Yanhao HUANG Xiaonan LUO Wenting ZHENG Wei CHEN | 2021 | Frontiers of Computer Science2021，15，6： | 0 |
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