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| 1 | Gold nanorods together with HSP inhibitor-VER-155008 micelles for colon cancer mild-temperature photothermal therapy显示文摘Enhancing the heat-sensitivity of tumor cells provides an alternative solution to maintaining the therapeutic outcome of photothermal therapy(PTT). In this study, we constructed a therapeutic system, which was composed of methoxy-polyethylene-glycol-coated-gold-nanorods(MPEG-AuN R) and VER-155008-micelles, to evaluate the effect of VER-155008 on the sensitivity of tumor cells to heat, and further investigate the therapeutic outcome of MPEG-AuN R mediated PTT combined with VER-155008-micelles. VER-155008-micelles downregulate the expression of heat shock proteins and attenuate the heat-resistance of tumor cell. The survival of HCT116 cells treated with VER-155008-micelles under 45 ℃ is equal to that treated with high temperature hyperthermia(55 ℃) in vitro. Furthermore, we proved either the MPEG-AuN R or VER-155008-micelles can be accumulate in the tumor site by photoacoustic imaging and fluorescent imaging. In vivo anti-cancer evaluation showed that tumor size remarkably decreased(smaller than 100 mm^3 or vanished) when treated with combing 45℃ mild PTT system, which contrasted to the tumor size when treated with individual 45℃ mild PTT(around 500nm^3) or normal saline as control(larger than 2000 nm^3). These results proved that the VER-155008-micelles can attenuate the heat-resistance of tumor cells and enhance the therapeutic outcome of mild-temperature photothermal therapy. | Xichuan Tang Liwei Tan Kun Shi Jinrong Peng Yao Xiao Wenting Li Lijuan Chen Qian Yang Zhiyong Qian | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 12 |
| 2 | Ship detection and classification from optical remote sensing images: A survey显示文摘Considering the important applications in the military and the civilian domain, ship detection and classification based on optical remote sensing images raise considerable attention in the sea surface remote sensing filed. This article collects the methods of ship detection and classification for practically testing in optical remote sensing images, and provides their corresponding feature extraction strategies and statistical data. Basic feature extraction strategies and algorithms are analyzed associated with their performance and application in ship detection and classification.Furthermore, publicly available datasets that can be applied as the benchmarks to verify the effectiveness and the objectiveness of ship detection and classification methods are summarized in this paper. Based on the analysis, the remaining problems and future development trends are provided for ship detection and classification methods based on optical remote sensing images. | Bo LI Xiaoyang XIE Xingxing WEI Wenting TANG | 2021 | Chinese Journal of Aeronautics2021，34，3： | 7 |
| 3 | Removal of antimonite and antimonate from water using Fe-based metal-organic frameworks: The relationship between framework structure and adsorption performance显示文摘We investigated the adsorption performance of five Fe-based MOFs(Fe-BTC,MIL-100(Fe),MIL-101(Fe),MIL-53(Fe)and MIL-88 C(Fe))for removal of antimonite(Sb(Ⅲ))and antimonate(Sb(Ⅴ))from water.Among these MOFs,MIL-101(Fe)exhibited the best adsorption capacities for both Sb(Ⅲ)and Sb(Ⅴ)(151.8 and 472.8 mg/g,respectively)which were higher than those of most adsorbents previously reported.The effect of steric hindrance was evident during Sb removal using the Fe-based MOFs,and the proper diameter of the smallest cage windows/channels should be considered an important parameter during the evaluation and selection of MOFs.Additionally,the adsorption capacities of MIL-101(Fe)for Sb(Ⅴ)decreased with increasing initial p H values(from 3.0 to 8.0),while the opposite trend was observed for Sb(Ⅲ).Chloride,nitrate and sulfate ions had a negligible influence on Sb(Ⅴ)adsorption,while NO3-and SO42-improved Sb(Ⅲ)adsorption.This result implies that inner sphere complexes might form during both Sb(Ⅲ)and Sb(Ⅴ)adsorption. | Wei Zhang Na Li Ting Xiao Wenting Tang Guangli Xiu | 2019 | Journal of Environmental Sciences2019，31，12： | 7 |
| 4 | H2S protects PC12 cells against toxicity of corticosterone by modulation of BDNF-TrkB pathway显示文摘 | Shenglan Gao Wenting Li Wei Zou Ping Zhang Ying Tian Fan Xiao Hongfeng Gu Xiaoqing Tang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 6 |
| 5 | CAS FGOALS-f3-L Model Datasets for CMIP6 GMMIP Tier-1 and Tier-3 Experiments显示文摘The Chinese Academy of Sciences(CAS)Flexible Global Ocean Atmosphere Land System(FGOALS-f3-L)model datasets prepared for the sixth phase of the Coupled Model Intercomparison Project(CMIP6)Global Monsoons Model Intercomparison Project(GMMIP)Tier-1 and Tier-3 experiments are introduced in this paper,and the model descriptions,experimental design and model outputs are demonstrated.There are three simulations in Tier-1,with different initial states,and five simulations in Tier-3,with different topographies or surface thermal status.Specifically,Tier-3 contains four orographic perturbation experiments that remove the Tibetan Iranian Plateau,East African and Arabian Peninsula highlands,Sierra Madre,and Andes,and one thermal perturbation experiment that removes the surface sensible heating over the Tibetan Iranian Plateau and surrounding regions at altitudes above 500 m.These datasets will contribute to CMIP6’s value as a benchmark to evaluate the importance of long-term and short-term trends of the sea surface temperature in monsoon circulations and precipitation,and to a better understanding of the orographic impact on the global monsoon system over highlands. | Bian HE Yimin LIU Guoxiong WU Qing BAO Tianjun ZHOU Xiaofei WU Lei WANG Jiandong LI Xiaocong WANG Jinxiao LI Wenting HU Xiaoqi ZHANG Chen SHENG and Yiqiong TANG | 2020 | Advances in Atmospheric Sciences2020，37，1： | 4 |
| 6 | C:N:P stoichiometry of Ericaceae species in shrubland biomes across Southern China:influences of climate,soil and species identity显示文摘Aims Carbon(C),nitrogen(N)and phosphorus(P)stoichiometry strongly affect functions and nutrient cycling within ecosystems.However,the related researches in shrubs were very limited.In this study,we aimed to inves-tigate leaf stoichiometry and its driving factors in shrubs,and whether stoichiometry significantly differs among closely related species.Methods We analyzed leaf C,N and P concentrations and their ratios in 32 species of Ericaceae from 161 sites across southern China.We examined the relationships of leaf stoichiometry with environmen-tal variables using linear regressions,and quantified the interactive and independent effects of climate,soil and species on foliar stoi-chiometry using general linear models(GLM).Important Findings The foliar C,N and P contents of Ericaceae were 484.66,14.44 and 1.06 mg g−1,respectively.Leaf C,N and P concentrations and their ratios in Ericaceae were significantly related with latitude and altitude,except the N:P insignificantly correlated with latitude.Climate(mean annual temperature and precipitation)and soil properties(soil C,N and P and bulk density)were significantly influenced element stoichiom-etry.The GLM analysis showed that soil exerted a greater direct effect on leaf stoichiometry than climate did,and climate affected leaf traits mainly via indirect ways.Further,soil properties had stronger influ-ences on leaf P than on leaf C and N.Among all independent factors examined,we found species accounted for the largest proportion of the variation in foliar stoichiometry.These results suggest that species can largely influence foliar stoichiometry,even at a lower taxonomic level. | Qiang Zhang Qing Liu Huajun Yin Chunzhang Zhao Lin Zhang Guoying Zhou Chunying Yin Zhijun Lu Gaoming Xiong Yuelin Li Jiaxiang Li Wenting Xu Zhiyao Tang Zongqiang Xie | 2019 | Journal of Plant Ecology2019，12，2： | 4 |
| 7 | Planning for distributed wind generation under active management mode显示文摘 | Jietan Zhang Hong Fan Wenting Tang Maochun Wang Haozhong Cheng Liangzhong Yao | 2013 | International Journal of Electrical Power and Energy Systems2013，，： | 2 |
| 8 | Lycium barbarum polysaccharides ameliorate canine acute liver injury by reducing oxidative stress,protecting mitochondrial function,and regulating metabolic pathways显示文摘The development of acute liver injury can result in liver cirrhosis,liver failure,and even liver cancer,yet there is currently no effective therapy for it.The purpose of this study was to investigate the protective effect and therapeutic mechanism of Lycium barbarum polysaccharides(LBPs)on acute liver injury induced by carbon tetrachloride(CCl_(4)).To create a model of acute liver injury,experimental canines received an intraperitoneal injection of 1 mL/kg of CCl_(4)solution.The experimental canines in the therapy group were then fed LBPs(20 mg/kg).CCl_(4)-induced liver structural damage,excessive fibrosis,and reduced mitochondrial density were all improved by LBPs,according to microstructure data.By suppressing Kelch-like epichlorohydrin(ECH)-associated protein 1(Keap1),promoting the production of sequestosome 1(SQSTM1)/p62,nuclear factor erythroid 2-related factor 2(Nrf2),and phaseⅡdetoxification genes and proteins downstream of Nrf2,and restoring the activity of anti-oxidant enzymes like catalase(CAT),LBPs can restore and increase the antioxidant capacity of liver.To lessen mitochondrial damage,LBPs can also enhance mitochondrial respiration,raise tissue adenosine triphosphate(ATP)levels,and reactivate the respiratory chain complexes I–V.According to serum metabolomics,the therapeutic impact of LBPs on acute liver damage is accomplished mostly by controlling the pathways to lipid metabolism.9-Hydroxyoctadecadienoic acid(9-HODE),lysophosphatidylcholine(Lyso PC/LPC),and phosphatidylethanolamine(PE)may be potential indicators of acute liver injury.This study confirmed that LBPs,an effective hepatoprotective drug,may cure acute liver injury by lowering oxidative stress,repairing mitochondrial damage,and regulating metabolic pathways. | JIANJIA HUANG YUMAN BAI WENTING XIE RONGMEI WANG WENYUE QIU SHUILIAN ZHOU ZHAOXIN TANG JIANZHAO LIAO RONGSHENG SU | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 2 |
| 9 | Pigment- based tricolor ink particles via mini-emulsion polymerization for chromatic electrophoretic displays 显示文摘 | WenT MengXW LiZY Ren J Tang F Q | 2010 | Journal of Materials Chemistry2010，20，： | 1 |
| 10 | Pay-it-forward gonorrhea and chlamydia testing among men who have sex with men in China:a study protocol for a three-arm cluster randomized controlled trial显示文摘Background:Gonorrhea and chlamydia testing rates are poor among Chinese men who have sex with men(MSM).A quasi-experimental study suggested that a pay-it-forward strategy increased dual gonorrhea/chlamydia testing among MSM.Pay-it-forward offers an individual a gift(e.g.,a free test)and then asks the same person if they would like to give a gift to another person.This article reports the protocol of a randomized controlled trial to evaluate dual gonorrhea/chlamydia test uptake and other outcomes among MSM in three arms-a pay-it-forward arm,a pay-what-you-want arm,and a standard of care arm.Methods:Three hundred MSM will be recruited at three HIV testing sites in Guangzhou and Beijing.Testing sites include two hospital-based MSM sexually transmitted diseases clinics and one MSM community-based organization.Eligible participants will be born biologically male,aged 16 years or older,reporting previous anal sex with another man,having never participated in the pay-it-forward program,without previous gonorrhea and chlamydia testing in the past 12 months,and residing in China.Following a cluster randomized design,every cluster of ten participants will be randomly allocated into one of three arms:(1)a pay-it-forward arm in which men are offered free gonorrhea and chlamydia testing and then asked whether they would like to donate('pay it forward')toward testing for future testers;(2)a pay-what-you-want arm in which men are offered free testing and told to decide how much to pay after receiving the test;(3)a standard of care arm in which men can pay the full price for dual gonorrhoea and chlamydia testing.The primary outcome is dual gonorrhoea/chlamydia testing as verified by administrative records.Secondary outcomes include incremental cost per test,incremental cost per diagnosis,community connectedness,and social cohesion.Primary outcome will be calculated for each arm using intention-to-treat and compared using one-sided 95%confidence intervals with a margin of 20%increase defined as superiority.Discussion:This study will examine the pay-it-forward strategy in comparison to the standard of care in improving test uptake for gonorrhea and chlamydia.We will leverage the cluster randomized controlled trial to provide scientific evidence on the potential effect of pay-it-forward.Findings from this study will shed light on novel intervention methods for increasing preventive health service utilization and innovate ways to finance it among communities.Trial registration:ClinicalTrials.gov,NCT03741725.Registered on 12 November 2018. | Tiange P.Zhang Fan Yang Weiming Tang Marcus Alexander Laura Forastiere Navin Kumar Katherine Li Fei Zou Ligang Yang Guodong Mi Yehua Wang Wenting Huang Amy Lee Weizan Zhu Peter Vickerman Dan Wu Bin Yang Nicholas A.Christakis Joseph D.Tucker | 2019 | Infectious Diseases of Poverty2019，8，4： | 1 |
| 11 | Sequential quadratic programming enhanced backtracking search algorithm显示文摘 | Wenting ZHAO Lijin WANG Yilong YIN Bingqing WANG Yuchun TANG | 2018 | Frontiers of Computer Science2018，12，2： | 1 |
| 12 | Application research on expert system of incremental in- plane bending 显示文摘 | TANG Wenting TANG Chaoli HUANG Lei | 2008 | Materials Science Forum2008，，1： | 1 |
| 13 | Measuring and characterizing end-to-end internet service performance显示文摘 | Ludmila Cherkasova Yun Fu Wenting TANG | 2003 | ACM Transactions on Internet Technology2003，3，4： | 1 |
| 14 | Attenuation of microwave transmission in a diameter-variable drill string bore显示文摘With the drill string hole being regarded as an ultra-long irregular lossy cylindrical waveguide, the optimal frequency point for microwave transmission was calculated according to the electromagnetic wave coupling theory, the attenuation law and efficient transmission distance of microwave channel were obtained and the microwave mode in the waveguide was analyzed. Furthermore, the channel model and signal attenuation model were established by the microwave transmission equivalent circuit method. The power attenuation coefficient per unit of length was proposed to simplify the analysis on effective transmission distance for the ultra-long drill string. The optimal frequency points of 139.7 mm(5.5 in) and 127 mm(5 in) API drill pipes are 2.04 GHz and 2.61 GHz, respectively, and there are several inner diameter varying sections and break points in the drill string hole along the axial direction. The microwave transmission suffers a lot of reflections. The channel impedance change is a key factor affecting the transmission quality. The lab and field tests reveal that the attenuation model established in this paper is accurate, and it is applicable to the design of microwave transmission measurement while drilling system. | XIA Wenhe MENG Yingfeng TANG Bo GUAN Wenting | 2018 | Petroleum Exploration and Development2018，45，3： | 0 |
| 15 | Fungal community structure analysis of peanut pod rot in soil in Hebei Province,China显示文摘In recent years,peanut yield and quality are more seriously affected by pod rot disease in China.However,managing this disease has proven challenging due to the wide host range of its pathogens.In this study,four soil samples were collected from fields with pod rot disease in Hebei Province,and 454 pyrosequencing was used to analyze the fungal communities structure within them.All 38490 ITS high-quality sequences were grouped into 1203 operational taxonomic units,the fungal community diversity of four soil samples was evaluated and compared using Shannon index and Simpson index.The results showed that members of Ascomycota were dominant,followed by Basidiomycota.According to the BLAST results at the species level,Guehomyces had the highest abundance,accounting for about 7.27%,followed by Alternaria,Fusarium,and Davidiella.The relative abundance of Fusarium oxysporum isolated from rotting peanuts in soil with peanut rot was higher than that in the control,indicating that Fusarium oxysporum might be one of the main pathogenic fungus of peanut rot in this area.This study delved into the broader fungal community associated with peanut pod rot,providing a theoretical foundation for preventing and treating this disease in agriculture. | Lifei Zhu Chushu Zhang Yueyi Tang Haixiang Zhou Wenting Wang Mian Wang Qiang Yu Furong Song Jiancheng Zhang | 2023 | Oil Crop Science2023，8，2： | 0 |
| 16 | Molten Salts Strategy for the Synthesis of CoP Nanoparticles Entrapped,N,P co-Doped Mesoporous Carbons as Electrocatalysts for Hydrogen Evolution显示文摘Amolten salt process was developed to prepare CoP nanoparticles(NPs) embedded, N,P co-doped carbons with the combination of hand milling and high temperature carbonization. The characterization results implied that the as-prepared samples possessed mesoporous structures. Moreover, the mass ratios of the precursors affected the crystalline structures and the porosities of the final electrocatalysts. The as-prepared catalysts exhibited excellent electrocatalytic performances towards hydrogen evolution reaction(HER) under acidic and alkaline conditions. The as-prepared samples were designed as GxMyCoz, where x, y and z meant the amounts of glucose, melamine and CoCl2, respectively. The optimum sample of G6.0M2.0Co5.0 showed the best HER property with a low onset overpotential and a small Tafel slope, as well as excellent electrocatalytic stability. | XU Jing MIAO Sijia TANG Duihai ZHANG Wenting ZHAO Zhen QIAO Zhen-An | 2022 | Chemical Research in Chinese Universities2022，38，1： | 0 |
| 17 | Analysis of Knowledge Level and Use of Antiretroviral Pre-Exposure and Post-Exposure Prophylaxis Among MSM—China,2019–2022显示文摘Summary What is already known on this topic?Men who have sex with men(MSM)in China have a high rate of human immunodeficiency virus(HIV)infection.Pre-exposure prophylaxis(PrEP)and postexposure prophylaxis(PEP)have been shown to be effective in preventing HIV,which may help to contain the HIV epidemic among MSM.What is added by this report?This study found that knowledge and usage of PrEP were low among MSM,indicating that this population is at high risk for HIV infection.Promotion of PrEP and PEP among MSM is necessary to reduce the risk of HIV infection in this population.What are the implications for public health practice?PrEP and PEP are novel HIV prevention strategies that have been demonstrated to be effective and safe.To further reduce HIV transmission among MSM in China,it is necessary to promote the use of PrEP and PEP. | Jiahuan Guo Wenting Kang Tongtong Liu Jie Xu Houlin Tang Fan Lyu Guang Zhang | 2023 | China CDC weekly2023，5，13： | 0 |
| 18 | Establishment and drug sensitivity evaluation of murine ascites hepatocarcinoma cell line with high lymphatic metastatic potential (Hca-P/L_(6))显示文摘In order to provide a sensitive cell line model for investigating the mechanisms underlying the lymphatic metastasis of tumors and the effect of medicine against cells,a new murine ascites hepatocarcinoma cell line with high lymphatic metastatic potential(Hca-P/L_(6))was established and the effect of curcumin on biological behavior of Hca-P/L_(6) was observed.Murine ascites hepatocarcinoma cell strain with low lymphatic metastatic potential(Hca-P)was subcutaneously inoculated into the medioventral line of a mouse 615 and thefirst generation of metastatic tumor cells of inguinal lymph node(Hca-P/L_(1))was obtained.Then,Hca-P/L_(1) was screened by the route of mouse foot pad subcutaneously!lymph node!scale-up culture in vitro!mouse foot pad subcuta-neously forfive times consecutively.The sensitivity of two murine ascites hepatocarcinoma cell lines(Hca-P and Hca-P/L_(6))and two anchorage-dependent human hepato-carcinoma cell lines(SMC7721 and HepG_(2))to curcumin were studied by use of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay after these cells had been pretreated by curcumin at the concentration of 15–240μmol/L for 48 h.After pretreatment by curcumin at the maximum non-cytotoxic dose of 15μmol/L in vitro,the effect of curcumin against cell proliferation of Hca-P and Hca-P/L6 was observed by inverted micro-scope,cell growth curve and cell population doubling time;the effects of curcumin on cell cycles of Hca-P/L6 and Hca-P were studied byflow cytometry(FCM).The results showed Hca-P/L_(6) spreading to the lymph nodes at multiple sites in mice was screened from Hca-P.The lymph node metastatic rate was 100%.Curcumin had significant growth inhibiting effect on both murine ascites and human hepatocarcinoma cell lines in a dose-dependent manner(P<0.05).At concentrations of 30–120μmol/L,curcu-min had more inhibition on murine ascites hepatocarci-noma cell lines than on human anchorage-dependent hepatocarcinoma cell lines.At concentrations of 60–240μmol/L,curcumin had more inhibition on Hca-P/L_(6) with the 50%inhibitory concentration(IC50)of 51.48μmol/L than on Hca-P with IC50 of 90.87μmol/L.After pretreatment by curcumin at the maximum non-cytotoxic dose of 15 mol/L for 7 days,the proliferations of Hca-P/L_(6) and Hca-P were inhibited(P<0.05)in a time-dependent manner(P<0.01)and the population doubling time of Hca-P/L6 and Hca-P was prolonged(P<0.01),and curcumin had more inhibition on Hca-P/L6 than on Hca-P(P<0.05).After pretreatment by 15μmol/L curcumin for 48 h,the morphous of Hca-P/L_(6) was influenced more seriously than that of Hca-P and the cell cycle was redistributed with Hca-P/L6 being blocked in the S phase and Hca-P in the S and G_(2)/M phases.Hca-P/L_(6) was validated to be more sensitive to curcumin than Hca-P.Hca-P/L_(6) is a novel sensitive cell line model for investigating the mechanisms underlying tumor lymphatic metastasis and the effect of the medicine against cells. | Hongying ZHANG Jianwu TANG Wenting ZHU Chunxiu HU Guowang XU | 2009 | Frontiers of Medicine2009，3，2： | 0 |
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