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| 1 | 世界胃肠病学组织(WGO-OMGE)临床指南——发展中国家幽门螺杆菌感染显示文摘我非常高兴向大家推荐这份发展中国家幽门螺杆菌(H.priori)临床指南。该指南的编译是由数位在该领域具有丰富临床经验的世界知名专家共同完成的。 | Hunt RH Xiao SD Megraud F Leon-Barua R Bazzoli F Van der Merwe S vaz Coelho LG Fock KM Fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BC Krabshuis JH 杜颖 丛衍群 戴宁 | 2007 | 胃肠病学2007，12，1： | 85 |
| 2 | 世界胃肠病学组织全球指南——发展中国家幽门螺杆菌感染显示文摘世界上有一半人口感染幽门螺杆菌(H.pylori),其感染率因地理位置、种族、年龄和社会经济状况不同而存在很大差异.在发展中国家较高.发达国家较低。但总体而言,近年世界许多地区的H.pylori感染率均呈下降趋势。 | Hunt RH Xiao SD Megraud F Leon-Barua R Bazzoli F van der Merwe S Vaz Coelho LG Fock M Fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BCY Krabshuis J Le Mair A 杜颖 戴宁 | 2011 | 胃肠病学2011，16，7： | 27 |
| 3 | Magnetic resonance imaging in breast cancer:A literature review and future perspectives显示文摘Early detection and diagnosis of breast cancer are essential for successful treatment. Currently mammography and ultrasound are the basic imaging techniques for the detection and localization of breast tumors. The low sensitivity and specificity of these imaging tools resulted in a demand for new imaging modalities and breast magnetic resonance imaging(MRI) has become increasingly important in the detection and delineation of breast cancer in daily practice. However, the clinical benefits of the use of pre-operative MRI in women with newly diagnosed breast cancer is still a matter of debate. The main additional diagnostic value of MRI relies on specific situations such as detecting multifocal, multicentric or contralateral disease unrecognized on conventional assessment(particularly in patients diagnosed with invasive lobular carcinoma), assessing the response to neoadjuvant chemotherapy, detection of cancer in dense breast tissue, recognition of an occult primary breast cancer in patients presenting with cancer metastasis in axillary lymph nodes, among others. Nevertheless, the development of new MRI technolo-gies such as diffusion-weighted imaging, proton spectroscopy and higher field strength 7.0 T imaging offer a new perspective in providing additional information in breast abnormalities. We conducted an expert literature review on the value of breast MRI in diagnosing and staging breast cancer, as well as the future potentials of new MRI technologies. | Gisela LG Menezes Floor M Knuttel Bertine L Stehouwer Ruud M Pijnappel Maurice AAJ van den Bosch | 2014 | World Journal of Clinical Oncology2014，5，2： | 25 |
| 4 | 血管紧张素转换酶抑制剂和血管紧张素受体拮抗剂的使用与2019冠状病毒疾病检测阳性之间的关系显示文摘血管紧张素转换酶抑制剂(angiotensin-converting enzyme inhibitor,ACEI)和血管紧张素受体拮抗剂(angiotensin receptor blocker,ARB)在2019新型冠状病毒疾病(coronavirus disease 2019,COVID-19)全球大流行背景下的作用备受争议。此类药物是治疗一些慢性病的必须药物,有建议停止使用这些药物. | Mehta N KalraA Nowacki AS Anjewierden S Han Z Bhat p Rubio AEC Jacob M Procop GW Harrington S Milinovich A Svensson LG Jehi L Young JB Chung MK 周卫(译) 叶鹏(校) | 2020 | 中华高血压杂志2020，28，5： | 9 |
| 5 | 宫颈炎是盆腔感染的先驱显示文摘宫颈是一种细菌隐藏的部位,与感染的开始和向整个生殖道传播有关。本文主要讨论宫颈炎及其在引起上生殖道感染的潜在作用。宫颈呈圆锥形,下端外直径在1.5~4.5cm之间,颈管管道狭小,宽2~5 mm,月经中期时精子和细菌较易上行,如宫颈变形或变宽,则精子或细菌亦可在其它时间通过。经期时,血和宫内膜碎片通过颈管下行。子宫颈管内膜基本结构是一种有腺窝或沟的错综复杂的系统。成年期的粘膜皱褶类似棕榈树的复叶,称为棕榈皱襞。 | Keith LG 钱丽娟 | 1990 | 国外医学(妇产科学分册)1990，17，4： | 7 |
| 6 | 组蛋白甲基转移酶SETD2在肝组织中的缺陷导致脂质代谢异常及肝癌显示文摘【据Hepatology 2021年5月报道】题:组蛋白甲基转移酶SETD2在肝组织中的缺陷导致脂质代谢异常及肝癌(作者Li XJ等)组蛋白甲基转移酶SETD2所催化的H3K36me3是从酵母到哺乳动物都保守的表观遗传修饰之一。SETD2可以抑制肿瘤发生且在多种癌症中频繁发生突变。来自武汉大学生命科学学院免疫与代谢前沿科学中心的Li等利用SETD2肝脏特异性敲除的小鼠模型发现,SETD2缺失可导致自发性肝癌。 | LI XJ LI QL JU LG 吴旻 | 2021 | 临床肝胆病杂志2021，37，6： | 6 |
| 7 | CT显示淋巴结中央液化坏死提示头颈鳞癌淋巴结包膜外转移:初步研究报告显示文摘该文旨在研究淋巴结中央液化坏死和肿瘤组织学包膜外转移的关系。方法:对17例头颈部鳞癌患者的术前CT、手术记录及术后组织病理学进行研究。结果:术前CT显示的26个中央液化的淋巴结,20个术后病理证实发生肿瘤包膜外转移(77%)。21例肿瘤淋巴结包膜外转移的淋巴结.20个在CT上显示为中央液化坏死。85%的无包膜外转移的淋巴结在CT上无中央液化表现。结论:术前CT显示淋巴结中央液化坏死,提示肿瘤可能发生淋巴结包膜外转移.淋巴结直径并非淋巴结包膜外转移的预测因素。 | Zoumalan RA Kleinberger AJ Morris LG 王延安 | 2010 | 中国口腔颌面外科杂志2010，8，4： | 4 |
| 8 | 左心质量与脑磁共振成像和认知功能的关系显示文摘左心室质量(1eft ventricularmass,LVM)被证实可以作为长期暴露于数个危险因素下时造成的靶器官损害的评估标准。有关中年LVM和晚期认知表现之间联系的资料很少。纳入StrongHeart研究(SHS,1993—1995)及其附属的CDCAI(脑血管病及其对美国印第安人的影响)研究(2010—2013)中721名成年研究对象(平均基础年龄56岁),这些人群心血管病风险较高。 | 黄洁 叶鹏 Haring B Omidpanah A Suchy Dicey AM Best LG Verney SP Shibata DK Cole SA Ali T Howard BV Buchwald D Devereux RB | 2017 | 中华高血压杂志2017，25，10： | 4 |
| 9 | Aberrant glycosylation of the anti-Thomsen-Friedenreich glycotope immunoglobulin G in gastric cancer patients显示文摘AIM: To study whether alterations in the glycosylation of immunoglobulin G (IgG) specific to the ThomsenFriedenreich glycotope (TF) have diagnostic and prognostic potential in gastric cancer. METHODS: Serum samples were obtained from patients with histologically verified gastric carcinoma (n = 89), healthy blood donors (n = 40), and patients with benign stomach diseases (n = 22). The lectin-enzymelinked immunosorbent assay-based glycoprofiling of TF-specific IgG (anti-TF IgG) was performed using synthetic TF-polyacrylamide conjugate as antigen, total IgG purified by affinity chromatography on protein G sepharose, and lectins of various sugar specificities: mannose-specific concanavalin A (ConA), fucose-specificAleuria aurantia lectin (AAL) and sialic acid-specific Sambucus nigra agglutinin (SNA). The sensitivity and specificity of the differences between cancer patients and controls were evaluated by receiver operator characteristic (ROC) curve analysis. Overall survival was analyzed by the Kaplan-Meier method. Time-dependent ROC curve statistics were applied to determine cut-off values for survival analysis. All calculations and comparisons were performed using the GraphPad Prism 5 and SPSS 15.0 software.RESULTS: The level of TF-specific IgG was significantly increased in cancer patients compared with non-cancer controls (P < 0.001). This increase was pronounced mostly in stage 1 of the disease. Cancer patients showed a higher level of ConA binding to antiTF-IgG (P < 0.05) and a very low level of SNA lectin binding (P = 0.0001). No appreciable stage-dependency of the binding of any lectin to anti-TF IgG was found. A strong positive correlation between the binding of AAL and SNA was found in all groups studied (r = 0.71-0.72; P < 0.0001). The changes in ConA reactivity were not related to those of the fucoseor sialic acid-specific lectin. Changes in the SNA binding index and the ConA/SNA binding ratio demonstrated good sensitivity and specificity for stomach cancer: sensitivity 78.79% (95%CI: 61.09-91.02) and 72.73% (95%CI: 57.21-85.04); specificity 79.17 (95%CI: 65.01-89.53) and 88.64% (95%CI: 71.8-96.6), for the SNA binding index and the ConA/SNA binding ratio, respectively. The other combinations of lectins did not improve the accuracy of the assay. The low level of ConA-positive anti-TF IgG was associated with a survival benefit in cancer patients (HR = 1.56; 95%CI: 0.78-3.09; P = 0.19), especially in stages 3-4 of the disease (HR = 2.17; 95%CI: 0.98-4.79; P = 0.048). A significantly better survival rate was found in all cancer patients with a low reactivity of anti-TF IgG to the fucose-specific AAL lectin (HR = 2.39; 95%CI: 1.0-5.7;P = 0.038).CONCLUSION: The changes in the TF-specific IgG glycosylation pattern can be used as a biomarker for stomach cancer detection, and to predict patient survival. | Kristel Kodar Jelena Izotova Kersti Klaamas Boris Sergeyev Lilian Jrvekülg Oleg Kurtenkov | 2013 | World Journal of Gastroenterology2013，19，23： | 3 |
| 10 | Coronary artery disease in congenital single coronary artery in adults:A Dutch case series显示文摘AIM:To assess the current diagnostic and therapeutic management and the clinical implications of congenital single coronary artery(SCA) in adults.METHODS:We identified 15 patients with a SCA detected from four Dutch angiography centers in the period between 2010 and 2013.Symptomatic patients who underwent routine diagnostic coronary angiography(CAG) for suspected coronary artery disease and who incidentally were found to have isolated SCA were analyzed.RESULTS:Fifteen(7 females) with a mean age of 58.5 ± 13.78 years(range 43-86) had a SCA.ConventionalCAG demonstrated congenital isolated SCA originating as a single ostium from the right sinus of Valsalva in 6 patients and originating from the left in 9 patients.Minimal to moderate coronary atherosclerotic changes were found in 4,and severe stenotic lesions in another 4 patients.Seven patients were free of coronary atherosclerosis.Runs of non-sustained ventricular tachycardia were documented in 2 patients,one of whom demonstrated transmural ischemic changes on presentation.Myocardial perfusion scintigraphic evidence of transmural myocardial ischemia was found in 1 patient due to kinking and squeezing of the SCA with an interarterial course between the aorta and pulmonary artery.Multi-slice computed tomography(MSCT) was helpful to delineate the course of the anomalous artery relative to the aorta and pulmonary artery.Percutaneous coronary intervention was successfully performed in 3 patients.Eight patients were managed medically.Arterial bypass graft was performed in 4 patients with the squeezed SCA.CONCLUSION:SCA may be associated with transient transmural myocardial ischemia and aborted sudden death in the absence of coronary atherosclerosis.The availability and sophistication of MSCT facilitates the delineation of the course of a SCA.We present a Dutch case series and review of the literature. | Salah AM Said Willem G de Voogt Suat Bulut Jacques Han Peter Polak Rogier LG Nijhuis Jeroen W op den Akker Andries Slootweg | 2014 | World Journal of Cardiology2014，6，4： | 3 |
| 11 | Faecalibacterium prausnitzii and human intestinal health显示文摘 | S Miquel R Martín O Rossi LG Bermúdez-Humarán JM Chatel H Sokol M Thomas JM Wells P Langella | 2013 | Current Opinion in Microbiology2013，，： | 3 |
| 12 | Exercise-induced left bundle branch block: an infrequent phenomenon: Report of two cases显示文摘Exercise-induced left bundle branch block(EI-LBBB)is infrequent phenomenon.We present two patients with angina pectoris who developed EI-LBBB during exercise tolerance test.The first patient with typical angina pectoris had significant obstructive coronary artery disease(CAD)requiring percutaneous coronary intervention of multiple lesions including placement of drug eluting stents.The second patient had atypical chest pain without signs of CAD at all.EI-LBBB occurred at a heart rate of 80 bpm and 141 bpm in the first and second patient,respectively.EI-LBBB remained visible through the test till the recovery period in the first patient at a heart rate of 83 bpm and disappeared at 96bpm in the second patient.Both patients with this infrequent phenomenon are discussed and the literature is reviewed. | Salah AM Said Marisa Bultje-Peters Rogier LG Nijhuis | 2013 | World Journal of Cardiology2013，5，9： | 3 |
| 13 | Experience with 1509 patients undergoing thoracoabdominal aortic operations显示文摘 | Svensson LG Crawford ES Hess KR Coselli JS Safi HJ | 1993 | J Vasc Surg1993，17，2： | 2 |
| 14 | Angioplasty for long-term treatment of patients with Budd-Chiari syndrome显示文摘 | Martin LG Henderson JM Millikan WJ | 1990 | AJR1990，154，8： | 2 |
| 15 | Immunotherapy for colorectal cancer显示文摘 | Maxwell-Armstrong CA Durrant LG Scholefield JH | 1999 | Am J Sur1999，177，4： | 2 |
| 16 | 植物生长调节剂在蔗,糖生产上的应用显示文摘 | Nick.,LG 董月容 | 1989 | 国外农学(甘蔗)1989，，2： | 2 |
| 17 | Studies of the structure of glutamate receptor ion channels and the mechanisms of their blockade by organic cations 显示文摘 | Magazanik LG Tikhonov DB Bol'shakov KV | 2003 | Neurosci Behav Physiol2003，33，3： | 2 |
| 18 | Discovery and significance of Xucun late Proterozoic composite dike swarm in southern Anhui Province显示文摘GEOLOGICALLY, southern Anhui Province, East China, is a part of late Proterozoic collision orogens of the southeast margin of the Yangtze Block. In this region the development of late Proterozoic Fuchuan ophiolite suite and collision granitoids of Xiuning, Xucun and Shexian mark the existence of the intensely tectonic-magmatic events. Recently discovered Xucun | Tang, HF Zhou, XM Zhi, LG | 1997 | Chinese Science Bulletin1997，42，4： | 2 |
| 19 | 中东呼吸综合征患者的胸部CT表现显示文摘背景:中东呼吸综合征(middle east respiratory syndrome,MERS)是由一种新的冠状病毒(MERS—CoV)引发的严重社区获得性肺炎。既往的研究大多数没有影像学资料,因此对MERS的影像学特别是胸部CT表现知之甚少。方法:回顾性分析沙特阿拉伯2家医院中住院的7例MERS患者的临床和影像学资料。所有患者的呼吸道分泌物均采用逆转录聚合酶链反应检测并确诊为MERS,由2位经过培训的放射科医生分别对其胸部CT影像进行分析。结果:7例患者中男5例,女2例,年龄19~83岁。 | Ajlan AM Ahyad RA Jamjoom LG 牟向东 | 2015 | 中华结核和呼吸杂志2015，38，1： | 2 |
| 20 | Viral clearance without destruction of infected cells during acute HBV infection显示文摘 | Guidotti LG Rochford R Chung J | 1999 | Science1999，284，5415： | 2 |
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