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475篇 您的检索式:作者名="LEACH M"
    题名 作者 年代 出处 被引量
1Pancreatic cancer显示文摘Theresa Pluth Yeo Ralph H Hruban Steven D Leach Robb E Wilentz Taylor A Sohn Scott E Kern Christine A Iacobuzio-Donahue Anirban Maitra Michael Goggins Marcia I Canto Ross A Abrams Daniel Laheru Elizabeth M Jaffee Manuel Hidalgo Charles J Yeo 2002Current Problems in Cancer2002,,4:2
2向在人的察觉到钙的受体的 allosteric 药的结构的理解显示文摘allosterically 指向人的察觉到钙的受体(CaSR ) 的药有实质的治疗学的潜力,但是当前被限制。给 CaSR 的高分辨率的结构的缺席,我们把 mutagenesis 与一条新奇分析途径并且开发 “ 的分子的建模相结合; enriched”为在 Ca 2+ 在 CaSRs 7 transmembrane (7TM ) 以内的 o 和 allosteric 调节的人领域。修改多重有约束力的地点以适应在结构上的一个扩大的洞多样的 ligands 被识别。Phenylalkylamines 绑在与通常认为的 Ca 2+ o -binding 地点并且向一个细胞外的门厅延长。相反,在结构上和 pharmacologically 不同的 AC-265347 在 7TM 领域以内更深绑。而且,不同氨基酸网络被发现调停由不同调节的人的 cooperativity。这些调查结果可以与不同、潜在地偏导小径的药理学效果便于 allosteric 调节的人的合理设计。Katie Leach Karen J Gregory Irina Kufareva Elham Khajehali Anna E Cook Ruben Abagyan Arthur D Conigrave Patrick M Sexton Arthur Christopoulos 2016Cell Research2016,26,5:2
3Foot pressure distribution during walking in young and old adults显示文摘Hessert MJ Vyas M Leach J 2005BMC Geriatr2005,19,5:1
4Developmental regulation of respiratory activity in pea leaves 显示文摘Lennon A M Pratt J Leach G e al 1995Plant Physiol1995,107,:1
5Effect of graded doses of ionizing radiation on the human testis显示文摘Rowley M J Leach DR Warner GA 1974Radiat Res1974,59,3:1
6Demand re- sponse experience in Europe: policies, programmes and im- plementation 显示文摘TORRITI J HASSAN M G LEACH M 2009Energy2009,35,4:1
7Modelling high level system design and unit commitment for a microgrid 显示文摘HAWKES A D LEACH M A 2009Applied Energy2009,86,17:1
8Demand response experience in Europe: Policies, programsand implementation 显示文摘Torriti J Hassan M G Leach M 2010Energy2010,35,4:1
9Nucleotide sequence,organization and nature of protein products of the carotenoid biosynthesis gene cluster of Rhodobacter capsulatus显示文摘ARMSTRONG G A ALBERTI M LEACH F 1989Mol Gen Genet1989,216,:1
10The impact of research education on student nurse attitude, skill and uptake of evidence-based practice: a descriptivelongitudinalsurvey显示文摘Leach M J Hofmeyer A Bobridge A 2016JClinNurs2016,25,12:1
11Measuring the orbital angular momentum of a single photon显示文摘LEACH J PADGEFTT M J BARNETT S M 2002Phys Rev Lett2002,88,25:1
12Building customer relations over the Internet显示文摘BAUER H H' GRETHER M LEACH M 2002Industrial Marketing Management2002,31,:1
13Group-level self-definition and self-investment:A hierarchical(multicomponent)model of in-group identification显示文摘Leach C Van Zomeren M Zebel S 2008Journal of Personality and Social Psychology2008,95,1:1
14The Kelian disseminated gold deposit,East Kalimantan,Indonesia显示文摘Van Leeuwen T M Leach T Hawke A A 1990Journal of Geochemical Exploration1990,50,:1
15The growth performance,carcass characteristics,and meat quality of halothane carrier and negative pigs显示文摘Leach L M Ellis M Sutton D S 1996Journal of Animal Science1996,74,:1
16Earth mother myths and other ecofeminist fables: How a strategic notion rose and fell显示文摘Leach M 2007Development and Change2007,38,1:1
17The art of clutch hitting显示文摘LEACH M 2007Baseball Digest2007,66,5:1
18Conditions for Photovoltaics Development in the UK: The Rrole of Policy and Technical Developments 显示文摘Candelise C Gross R & Leach M A 2010Power&En- ergy2010,224,2:1
19Modelling high level system design and unit commitment for a microgrid显示文摘HAWKES A D LEACH M A 0,,7:1
20Upward So- cial Comparison and Self-concept:Inspiration and Inferiori- ty among Art Student in An Advanced Programme 显示文摘Burleson K C W Leach C W Harrington D M 2005The British Journal of Social Psychology2005,44,1:1
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