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| 1 | Stem cell therapy in the management of shoulder rotator cuff disorders显示文摘Rotator cuff tears are frequent shoulder problems that are usually dealt with surgical repair. Despite improved surgical techniques, the tendon-to-bone healing rate is unsatisfactory due to difficulties in restoring the delicate transitional tissue between bone and tendon. It is essential to understand the molecular mechanisms that determine this failure. The study of the molecular environment during embryogenesis and during normal healing after injury is key in devising strategies to get a successful repair. Mesenchymal stem cells(MSC) can differentiate into different mesodermal tissues and have a strong paracrine, anti-inflammatory, immunoregulatory and angiogenic potential. Stem cell therapy is thus a potentially effective therapy to enhance rotator cuff healing. Promising results have been reported with the use of autologous MSC of different origins in animal studies: they have shown to have better healing properties, increasing the amount of fibrocartilage formation and improving the orientation of fibrocartilage fibers with less immunologic response and reduced lymphocyte infiltration. All these changes lead to an increase in biomechanical strength. However, animal research is still inconclusive and more experimental studies are needed before human application. Future directions include expanded stem cell therapy in combination with growth factors or different scaffolds as well as new stem cell types and gene therapy. | Maria Valencia Mora Miguel A Ruiz Ibán Jorge Díaz Heredia Raul Barco Laakso Ricardo Cuéllar Mariano García Arranz | 2015 | World Journal of Stem Cells2015，7，4： | 6 |
| 2 | Surveys on magnetospheric plasmas based on the Double Star Project (DSP) exploration显示文摘The equatorial and polar satellites of the Double Star Project (DSP) were launched successfully on December 29, 2003 and July 25, 2004, respectively, and both of them are operating smoothly. The DSP provides a good opportunity for investigat-ing the structure of the magnetosphere. Based on the DSP data collected during 2004, we have surveyed the distribution of the magnetic fields and plasmas in the magnetosphere. It is found that: (1) Near the Earth’s equatorial plane within geo-centric distances of less than 7 RE, the Earth’s magnetic field is dipolar. In the vi-cinity of the magnetopause, the magnetic field is enhanced by a factor of about 1.5, and on the nightside, the magnetic field can vary significantly from the Earth’s di-pole field, likely caused by the presence of the near-Earth tail current sheet. (2) In the day-side magnetosheath, the electron and ion densities are usually both in the range of 10―30 cm?3; the ion and electron temperatures are usually about 200 and 50 eV, respectively. The flow pattern is usually smooth, with a low velocity in the subsolar region and with significantly higher velocities in the dawn and dusk flanks. (3) In the region between the magnetopause and plasmasphere the density is low, approximately 0.5―5 cm?3, and the temperature is high, about 1―10 keV for ions and 0.1―5 keV for electrons. The ion temperature has an apparent anisotropy, with the ratio of the perpendicular and parallel temperatures being about 1.0―1.3 for the night- and dusk-side magnetosphere and about 1.3―2.0 for the day- and dawn-side magnetosphere. There is an evident sunward convection of about 50 km/s in the magnetosphere. On the dawn side, the flow becomes somewhat turbulent, and in the vicinity of the night-noon meridian plane, the convection is rather slow. (4) The high-energy electrons with energies higher than 2 MeV are mainly located in the regions with 3 < L < 4.5; the size of the high-energy electrons area varies with time, it may expand and shrink occasionally according to different solar wind conditions and magnetic activities. | C. P. ESCOUBET C. M. CARR H. RME A. FAZAKERLEY H. LAAKSO I. DANDOURAS M. DUNLOP | 2008 | Science China(Technological Sciences)2008，51，10： | 5 |
| 3 | 应用超短波治疗COVID-19患者需考虑的风险显示文摘2020年初,新型冠状病毒疾病(COVID-19)占据了全球政府公共卫生防控最重要的位置。我国正在做出巨大的努力以应对COVID-19构成的公共卫生威胁,并积极探索治疗该疾病的方法。康复同仁为此也付出了辛苦的工作,并提议使用超短波疗法(USWD)为患者提供康复治疗。回顾了国内外相关超短波疗法的研究报道,拟阐明将其用于干预急性期COVID-19患者可能潜在的风险。在管理COVID-19患者时,必须首先考虑避免医务人员和患者之间的交叉感染风险;此外,在应用任何电疗为患者提供治疗之前,必须评估电疗仪器输出量的可靠性和进行患者正常皮肤感觉的测试程序。由于COVID-19患者的心脏功能可能会受病毒影响,必须考虑电流靠近心脏区域的风险。并通过检索已有的国内外关于USWD的研究发现,在过去的20年中,物理因子的可用性和使用量呈急剧下降趋势;也没有证据表明物理因子疗法可以治疗肺部疾病。英语文献中完全没有关于USWD治疗肺炎的临床试验报告。尽管在中国有一些关于使用USWD治疗肺炎的报道,但仍缺乏描述适当的随机化方法、详细的治疗过程以及安全防范措施程序,或考虑对肺功能的长期影响的报道。所以,在使用USWD对COVID-19患者进行康复治疗建议前,需要系统化的数据收集及研究USWD对急性和慢性肺损伤的作用机制和安全性。 | 喻鹏铭 ALICE Y M Jones E-LIISA Laakso | 2020 | 康复学报2020，30，2： | 3 |
| 4 | Chemical composition and antioxidative activity of Moldavian balm ( Dracocephalum moldavica L.) extracts显示文摘 | Keyvan Dastmalchi H.J. Damien Dorman Into Laakso Raimo Hiltunen | 2006 | LWT - Food Science and Technology2006，，9： | 2 |
| 5 | Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α显示文摘 | Marie Lagouge Carmen Argmann Zachary Gerhart-Hines Hamid Meziane Carles Lerin Frederic Daussin Nadia Messadeq Jill Milne Philip Lambert Peter Elliott Bernard Geny Markku Laakso Pere Puigserver Johan Auwerx | 2006 | Cell2006，，6： | 2 |
| 6 | Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial显示文摘 | Jean-Louis Chiasson Robert G Josse Ramon Gomis Markolf Hanefeld Avraham Karasik Markku Laakso | 2002 | The Lancet . 2002 (9323)2002，，9323： | 2 |
| 7 | Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial显示文摘 | Jean-Louis Chiasson Robert G Josse Ramon Gomis Markolf Hanefeld Avraham Karasik Markku Laakso | 2002 | The Lancet2002，，9323： | 2 |
| 8 | Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α显示文摘 | Marie Lagouge Carmen Argmann Zachary Gerhart-Hines Hamid Meziane Carles Lerin Frederic Daussin Nadia Messadeq Jill Milne Philip Lambert Peter Elliott Bernard Geny Markku Laakso Pere Puigserver Johan Auwerx | 2006 | Cell2006，，6： | 2 |
| 9 | Initial steps of aerosol growth 显示文摘 | Kulmala M Laakso L Lehtinen K E J | 2004 | Atmospheric Chemistry and Physics2004，4，1112： | 1 |
| 10 | Increased kidney xanthine oxidoreductase activity in salt-induced experimental hypertension显示文摘 | Laakso J Mervaala E Himberg J | 1998 | Hypertension1998，32，： | 1 |
| 11 | Benefits of strick glucose and blood pressure control in type 2 diabetes-Lessons from the uk prospective diabetes study显示文摘 | LaaKso M | 1999 | Circulation1999，99，10： | 1 |
| 12 | The common polymor- phisms (single nucleotide polymorphism +45 and SNP+276) of the adiponectin gene predict the conversion from impaired glu- cose tolerance to type 2 diabetes: the STOP-NIDDM trial显示文摘 | Zacharova J Chiasson JL Laakso M | 2005 | Diabe- tes2005，54，3： | 1 |
| 13 | Apolipoprotein E polymorphism and acute ischemic stroke: a diffusion-and perfusion-weighted magnetic resonance imaging study 显示文摘 | Liu Y Laakso MP Karonen JO | 2002 | J Cereb Blood Flow Metab2002，22，11： | 1 |
| 14 | Comparative effect of losartan and enalapril on exercise capacity and clinical status in patients with heart failure 显示文摘 | Chicago P Laakso M Beissner JJ | 2001 | JACC2001，30，： | 1 |
| 15 | Characterization of seed oil of wild, edible Finnish berries 显示文摘 | JOHANSSN A LAAKSO P KALLIO H | 1997 | Zeitschrifi fur Lebensmittel- Untersuchung und- Forschung A1997，204，： | 1 |
| 16 | Benefits of strick glucose and blood pressure control in type 2 diabetes Lessons from the uk prospec tive diabetes study显示文摘 | Laakso M | 1999 | Circulation1999，99，10： | 1 |
| 17 | Elevated plasma homocyst eine level is an independent predictor of coronary heart disease events in patients with type2 diabetes mellitus显示文摘 | Soinio M Marniemi J Laakso M | | 0，，： | 1 |
| 18 | Apolipoprotein E epsilon4 allele,elevated midlife total cholesterol level,and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease显示文摘 | Kivipelto M Helkala EL Laakso MP | 2002 | Ann Intern Med2002，137，3： | 1 |
| 19 | Lipids and lipopro- teins predicting coronary heart disease mortality and morbidity in patients with non-insulin-dependent diabetes 显示文摘 | LAAKSO M LEHTO S PENTTILA I | 1993 | Circulation1993，88，4： | 1 |
| 20 | Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease 显示文摘 | Kivipelto M Helkala EL Laakso MP | 2002 | Ann Intern Med2002，137，3： | 1 |
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