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| 1 | Pharmacogenetics of the systemic treatment in advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers. To date, most patients with HCC are diagnosed at an advanced tumor stage, excluding them from potentially curative therapies (i.e., resection, liver transplantation, percutaneous ablation). Treatments with palliative intent include chemoembolization and systemic therapy. Among systemic treatments, the small-molecule multikinase inhibitor sorafenib has been the only systemic treatment available for advanced HCC over 10 years. More recently, other smallmolecule multikinase inhibitors (e.g., regorafenib, lenvatinib, cabozantinib) have been approved for HCC treatment. The promising immune checkpoint inhibitors (e.g., nivolumab, pembrolizumab) are still under investigation in Europe while in the US nivolumab has already been approved by FDA in sorafenib refractory or resistant patients. Other molecules, such as the selective CDK4/6inhibitors (e.g., palbociclib, ribociclib), are in earlier stages of clinical development, and the c- MET inhibitor tivantinib did not show positive results in a phase III study. However, even if the introduction of targeted agents has led to great advances in patient response and survival with an acceptable toxicity profile, a remarkable inter-individual heterogeneity in therapy outcome persists and constitutes a significant problem in disease management. Thus, the identification of biomarkers that predict which patients will benefit from a specific intervention could significantly affect decision-making and therapy planning. Germ-line variants have been suggested to play an important role in determining outcomes of HCC systemic therapy in terms of both toxicity and treatment efficacy. Particularly, a number of studies have focused on the role of genetic polymorphisms impacting the drug metabolic pathway and membrane translocation as well as the drug mechanism of action as predictive/prognostic markers of HCC treatment. The aim of this review is to summarize and critically discuss the pharmacogenetic literature evidences, with particular attention to sorafenib and regorafenib, which have been used longer than the others in HCC treatment. | Elena De Mattia Erika Cecchin Michela Guardascione Luisa Foltran Tania Di Raimo Francesco Angelini Mario D’Andrea Giuseppe Toffoli | 2019 | World Journal of Gastroenterology2019，25，29： | 8 |
| 2 | Nano albumin bound-paclitaxel in pancreatic cancer: Current evidences and future directions显示文摘Pancreatic cancer(PDAC) is an aggressive and chemoresistant disease, representing the fourth cause of cancer related deaths in western countries. Majority of patients have unresectable, locally advanced or metastatic disease at time of diagnosis and the 5-year survival rate in these conditions is extremely low. For more than a decade gemcitabine has been the cornerstone of metastatic PDAC treatment, although survival benefit was very poor. PDAC cells are surrounded by an intense desmoplastic reaction that may create a barrier to the drugs penetration within the tumor. Recently PDAC stroma has been addressed as a potential therapeutic target. Nano albumin bound(Nab)-paclitaxel is an innovative molecule depleting tumor stroma, through interaction between albumin and secreted protein acidic and rich in cysteine. Addition of nab-paclitaxel to gemcitabine has showed activity and efficacy in metastatic PDAC first-line treatment improving survival and overall response rate vs gemcitabine alone in the MPACT phase Ⅲ study. This combination represents one of the standards of care in advanced PDAC therapy and is suitable to a broader spectrum of patients compared to other schedules. Nab-paclitaxel is under investigation as a backbone of chemotherapy in novel combinations with target agents or immunotherapy in locally advanced or metastatic PDAC. In this article, we provide an updated and critical overview about the role of nab-paclitaxel in PDAC treatment based on the latest advances in preclinical and clinical research. Furthermore, we focus on the use of nab-paclitaxel within the context of metastatic PDAC treatment landscape and we discuss about future implications in the light of current clinical ongoing trials. | Guido Giordano Massimo Pancione Nunzio Olivieri Pietro Parcesepe Marianna Velocci Tania Di Raimo Luigi Coppola Giuseppe Toffoli Mario Rosario D’Andrea | 2017 | World Journal of Gastroenterology2017，23，32： | 7 |
| 3 | 泥炭开采的环境影响评价——泥炭生产周边关系与对环境影响评价指南显示文摘泥炭开采环境影响评价是泥炭开采许可证颁发和开采设计的基础,也是减少泥炭开采对环境影响的首要工作。本文介绍了芬兰泥炭开采环境评价的基本内容、方法和程序,对我国泥炭开发进行环境影响评价具有一定的借鉴作用。 | Raimo Sopo 孟宪民 | 2004 | 腐植酸2004，，1： | 4 |
| 4 | UV Spectrophotometic Determination of Lignin From Alkaline Pulping Liquors显示文摘 | Raimo Alen Timo Hartus | 1988 | Cellulose Chem Technol1988，22，： | 2 |
| 5 | IBM Voice Conversion Systems for 2007 TC-STAR Evaluation显示文摘This paper proposes a novel voice conversion method by frequency warping. The frequency warp-ing function is generated based on mapping formants of the source speaker and the target speaker. In addi-tion to frequency warping, fundamental frequency adjustment, spectral envelope equalization, breathiness addition, and duration modification are also used to improve the similarity to the target speaker. The pro-posed voice conversion method needs only a very small amount of training data for generating the warping function, thereby greatly facilitating its application. Systems based on the proposed method were used for the 2007 TC-STAR intra-lingual voice conversion evaluation for English and Spanish and a cross-lingual voice conversion evaluation for Spanish. The evaluation results show that the proposed method can achieve a much better quality of converted speech than other methods as well as a good balance between quality and similarity. The IBM1 system was ranked No. 1 for English evaluation and No. 2 for Spanish evaluation. Evaluation results also show that the proposed method is a convenient and competitive method for cross-lingual voice conversion tasks. | 双志伟 Raimo Bakis 秦勇 | 2008 | Tsinghua Science and Technology2008，13，4： | 2 |
| 6 | Chemical composition and antioxidative activity of Moldavian balm ( Dracocephalum moldavica L.) extracts显示文摘 | Keyvan Dastmalchi H.J. Damien Dorman Into Laakso Raimo Hiltunen | 2006 | LWT - Food Science and Technology2006，，9： | 2 |
| 7 | Regionalism: Old and New 显示文摘 | Raimo V yrynen | 2003 | International Studies Review2003，，1： | 1 |
| 8 | Dynamic Cooperative Electricity Exchange in a PowerPool显示文摘 | Jukka R Harri E Raimo P H etal | 1991 | IEEE Trans on System Man and Cybernetics1991，21，4： | 1 |
| 9 | Thermochemical conversion of hydroxy carboxylic acids in the liquid phase显示文摘 | RAIMO A ANJA O | 1989 | Holzforschung1989，43，3： | 1 |
| 10 | Cystatin C as a marker of kidney dysfunction in an elderly population显示文摘 | Elise W Pauli S Raimo I | 2002 | Clin chem2002，48，7： | 1 |
| 11 | Is the narrow-crowned Norway spruce an economically solid altemative to wood production for private forest owners 显示文摘 | Pertti P Raimo J | 2006 | Silva Fennica2006，42，3： | 1 |
| 12 | Bedside Femoral Block Performed on the First Postoperative Day After Unilateral Total Knee Arthroplasty – A Randomized Study of 49 Patients显示文摘 | Raimo Niskanen Niko Strandberg | 2005 | J Knee Surg2005，，： | 1 |
| 13 | Formation of the main degration compounds groups from wood and its components during pyrolysis显示文摘 | Raimo A Kuoppala E Oesch P | 1996 | A nal Appl Pyrolysis1996，36，： | 1 |
| 14 | Interactive computer support in decision conferencing:two cases on off-site nuclear emergency management显示文摘 | RAIMO P | 2007 | Decision Support Systems2007，42，4： | 1 |
| 15 | Protective effect of Ligusticum chuanxiong and Angelica sinensis on endothelial cell damage induced by hydrogen peroxide显示文摘 | Yong Zhong Hou Guang Rong Zhao Jie Yang Ying Jin Yuan Guo Guang Zhu Raimo Hiltunen | 2004 | Life Sciences2004，，14： | 1 |
| 16 | A new method for m easuring the time-of-flight in fast laser range finding显示文摘 | Risto Myllyla¨ | 1986 | SPIE, Auto matic Optical Inspection,1986,6541986，654，： | 1 |
| 17 | Pyrolysis of vegetable oil soaps Palm, olive, rapeseed and castor oils显示文摘 | Hanna Lappi Raimo A16n | 2011 | Journal of AnalyticalandAppliedPyrolysis2011，91，： | 1 |
| 18 | We-Intentions Revisited 显示文摘 | Raimo Tuomela | 2005 | Philo- sophical Studies2005，125，： | 1 |
| 19 | Detection of volatile organic compounds by desorption combined with mass spectrometry and Fourier transform infrared spectroscopy 显示文摘 | Ketola Raimo A Kiuru Jari T Tarkiainen Virpi | 2006 | Analytical ChimicaActa2006，562，2： | 1 |
| 20 | Thermogravimetfic behavior of black liquor and their organic constituents 显示文摘 | Raimo A Sari R P MeKeough | 1995 | Journal of Analytical and Applied Pyolysis1995，31，1： | 1 |
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