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| 1 | Low-radiation and high image quality coronary computed tomography angiography in “real-world” unselected patients显示文摘AIM To determine the radiation dose and image quality in coronary computed tomography angiography(CCTA)using state-of-the-art dose reduction methods in unselected'real world'patients.METHODS In this single-centre study,consecutive patients in sinus rhythm underwent CCTA for suspected coronary artery disease(CAD)using a 320-row detector CT scanner.All patients underwent the standard CT acquisition protocol at our institute(Morriston Hospital)a combination of dose saving advances including prospective electrocardiogram-gating,automated tube current modulation,tube voltage reduction,heart rate reduction,and the most recent novel adaptive iterative dose reconstruction 3D(AIDR3D)algorithm.The cohort comprised real-world patients for routine CCTA who were not selected on age,body mass index,or heart rate.Subjective image quality was graded on a 4-point scale(4=excellent,1=non-diagnostic).RESULTS A total of 543 patients were included in the study with a mean body weight of 81±18 kg and a pre-scan mean heart rate of 70±11 beats per minute(bpm).When indicated,patients received rate-limiting medication with an oral beta-blocker followed by additional intravenous beta-blocker to achieve a heart rate below 65 bpm.The median effective radiation dose was 0.88 mSv(IQR,0.6-1.4 mSv)derived from a Dose Length Product of61.45 mGy.cm(IQR,42.86-100.00 mGy.cm).This also includes what we believe to be the lowest ever-reported radiation dose for a routine clinical CCTA(0.18 mSv).The mean image quality(SD)was 3.65±0.61,with a subjective image quality score of 3('good')or above for 93%of patient CCTAs.CONCLUSION Combining a low-dose scan protocol and AIDR3D with a 320-detector row CT scanner can provide high quality images at exceptionally low radiation dose in unselected patients being investigated for CAD. | Caryl Elizabeth Richards Stephen Dorman Patricia John Anthony Davies Sharon Evans Tishi Ninan David Martin Sriranj Kannoly Gail Roberts-Davies Mark Ramsey Daniel Rhys Obaid | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 2 | Atlantoaxial rotatory displacement in children显示文摘AIM To correlate the Pang and Lee class with the clinical course in a consecutive series of patients presenting with painful torticollis.METHODS Forty-seven dynamic rotational computed tomography(CT) scans in 35 patients were classified into one of the five types defined by Pang and Li, including types Ⅰ(atlantoaxial rotatopry fixation), Ⅱ('pathologic stickiness' without crossover of C1 on C2), Ⅲ('pathologic stickiness' with crossover of C1 on C2), Ⅳ(normal or muscular torticollis), and Ⅴ(diagnostic grey zone). The Pang and Li class was then compared with the radiologist's report, which was graded abnormal, diagnosis of rotatory subluxation or fixation, or non-diagnostic. Medical records were reviewed and the clinical course was compared among the five subtypes.RESULTS We reviewed 47 CT scans in 35 patients, and the majority were performed without sedation. The average age was 7.7 years(4-14 years old) and associated conditions included minor trauma(20%), surgical procedures around the head and neck(29%), and Grisels syndrome(20%). Twenty-six percent of our studies fell within the pathologic spectrum(5% type 1 or rotatory fixation, 21% types 2 and 3 or rotatory subluxation), while 45% were classified as muscular torticollis(45%) and 28% fell within the diagnostic grey zone. Seven radiologists interpreted these studies, and their interpretation was discordant in 45% of cases. Clinical resolution occurred in 27 of 29 cases for which follow-up was available. One of two patients with fixed rotatory subluxation required a C1-C2 arthrodesis.CONCLUSION The Pang and Li classification characterizes a spectrum of abnormalities in rotation to facilitate communication, although the indications for dynamic CT scan should be further defined. | David Spiegel Shikshya Shrestha Prakash Sitoula Norma Rendon John Dormans | 2017 | World Journal of Orthopedics2017，8，11： | 3 |
| 3 | Chemical composition and antioxidative activity of Moldavian balm ( Dracocephalum moldavica L.) extracts显示文摘 | Keyvan Dastmalchi H.J. Damien Dorman Into Laakso Raimo Hiltunen | 2006 | LWT - Food Science and Technology2006，，9： | 2 |
| 4 | Interferon-gamma and interleuk-12 path way defects and human disease 显示文摘 | DORMAN S HOLLAND S M | 2000 | Cytokine Growth Factor Reviews2000，11，： | 1 |
| 5 | Pulmonary clearance of manganese phosphate,manganese sulfate,and manganese tetraoxide by CD rats following intratracheal instillation显示文摘 | VITARELLA D MOSS O R DORMAN D C | 2000 | Inhal Toxicol2000，12，： | 1 |
| 6 | Antioxidant properties and composition of aqueous extracts from Mentha species, hybrids , varieties, and cultivars 显示文摘 | Dorman H J D Kosar M Kahlos K | 2003 | J Agric Food Chem2003，51，： | 1 |
| 7 | In vitro techniques for the assessment of neurotoxicity 显示文摘 | Harry GJ Billingsley M Bruinink A Campbell IL Classen W Dorman DC | 1998 | Environ Health Perspect1998，106，1： | 1 |
| 8 | Respiratory syncytial virus, pneumonia virus of mice, and influenza A virus differently affect respiratory allergy in mice 显示文摘 | Barends M de Rond LG Dormans J | 2004 | Clin Exp Allergy2004，34，3： | 1 |
| 9 | Antimicrobial agents from plants:antibacterial activity of plant volatile oils显示文摘 | Dorman H Deans S | | 0，，2： | 1 |
| 10 | Prospective comparison of openvs. laparoscopic colon surgery for carcinoma显示文摘 | Dr. Morris E. Franklin M.D. Daniel Rosenthal M.D. Daniel Abrego-Medina M.D. James P. Dorman M.D. Jeffrey L. Glass M.D. Richard Norem M.D. Antonio Diaz M.D | 1996 | Diseases of the Colon & Rectum1996，，10： | 1 |
| 11 | Physician staffing patterns and clinical outcomes in critically illpatients:a systematic review显示文摘 | Pronovost PJ Angus DC Dorman T | 2002 | JAMA2002，288，17： | 1 |
| 12 | Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection显示文摘 | Dorman S E Holland S M | 1998 | J Clin Invest1998，101，： | 1 |
| 13 | Immunoassay with coated piezoelectric crystal显示文摘 | Shons A Dorman F Najarian J J | 1972 | J Biomed Mater Res1972，6，： | 1 |
| 14 | Old age and gender influence the pharmacokinetics of inhaled manganese sulfate and manganese phosphate in rats显示文摘 | DORMAN D C McMANUS B E MARSHALL M W | 2004 | Toxicol Appl Pharmacol2004，197，： | 1 |
| 15 | Mannitol- induced acute renal failure 显示文摘 | Dorman HR Sondheimer JH Cadnapaphomchai P | 1990 | Medicine ( Baltimore)1990，69，3： | 1 |
| 16 | Antenatal maternaladministration of phenobarbital for the prevention of exchange transfusion in neonates with hemolytic disease of the fetus and newhorn显示文摘 | Trevett TN Dorman K Lamvu G | 2005 | ArnJ Obstet Gynecol2005，192，： | 1 |
| 17 | Susceptibility to tuberculo- sis: clues from studies with inbred and outbred New Zealand White rabbits显示文摘 | Dorman S E Hatem C L Tyagi S | 2004 | Infect Immun2004，72，3： | 1 |
| 18 | Hemolytic-uremic syndrome in association with both cyclosporine and tacrolimus显示文摘 | Abraham KA Little MA Dorman AM | 2000 | Transpl Int2000，13，6： | 1 |
| 19 | Do gene variants explain the heterogeneous outcomes in sepsis?显示文摘 | Dorman T Faraday B | 2001 | Crit Care Med2001，29，3： | 1 |
| 20 | Mannitol induced acute renal failure显示文摘 | Dorman HR | 1990 | Medicine, 1990,69(3):153~1591990，69，3： | 1 |
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