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| 1 | Prognostic significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with stage Ⅲ and Ⅳcolorectal cancer显示文摘AIM To evaluate the prognostic value of the neutrophil-tolymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) in patients with colorectal cancer(CRC).METHODS Between April 1996 and December 2010, medical records from a total of 1868 patients with CRC were retrospectively reviewed. The values of simple inflammatory markers including NLR and PLR in predicting the long-term outcomes of these patients were evaluated using Kaplan-Meier curves and Cox regression models.RESULTS The median follow-up duration was 46 mo(interquartile range, 22-73). The estimation of NLR and PLR was based on the time of diagnosis. In multivariate Cox regression analysis, high NLR (≥ 3.0) and high PLR(≥ 160) were independent risk factors predicting poor long-term outcomes in patients with stage Ⅲ and Ⅳ CRC. However, high NLR and high PLR were not prognostic factors in patients with stage Ⅰ and Ⅱ CRC.CONCLUSION In this study, we identified that high NLR (≥ 3.0) and high PLR (≥ 160) are useful prognostic factors to predict long-term outcomes in patients with stage Ⅲ and Ⅳ CRC. | Jae Hyun Kim Jun Yeop Lee Hae Koo Kim Jin Wook Lee Sung Gyu Jung Kyoungwon Jung Sung Eun Kim Won Moon Moo In Park Seun Ja Park | 2017 | World Journal of Gastroenterology2017，23，3： | 16 |
| 2 | Role of endoscopy in acute gastrointestinal bleeding in real clinical practice:An evidence-based review显示文摘Although upper gastrointestinal bleeding is usually segregated from lower gastrointestinal bleeding, and guidelines for gastrointestinal bleeding are divided into two separate sections, they may not be distinguished from each other in clinical practice. Most patients are first observed with signs of bleeding such as hematemesis, melena, and hematochezia. When a patient with these symptoms presents to the emergency room, endoscopic diagnosis and treatment are considered together with appropriate initial resuscitation. Especially, in cases of variceal bleeding, it is important for the prognosis that the endoscopy is performed immediately after the patient stabilizes. In cases of suspected lower gastrointestinal bleeding, full colonoscopy after bowel preparation is effective in distinguishing the cause of the bleeding and treating with hemostasis. The therapeutic aspect of endoscopy, using the mechanical method alone or injection with a certain modality rather than injection alone, can increase the success rate of bleeding control. Therefore, it is important to consider the origin of bleeding and how to approach it. In this article, we aim to review the role of endoscopy in diagnosis, treatment, and prognosis in patients with acute gastrointestinal bleeding in a real clinical setting. | Kyoungwon Jung Won Moon | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，2： | 13 |
| 3 | Detrital Zircon U-Pb Geochronologyof Sinian–Cambrian Strata in the Eastern Guangxi Area, China显示文摘The Eastern Guangxi area locates in the southwestern part of the transition zone between Yangtze and Cathaysia blocks, which is an important region because the boundary between two blocks probablycrosses there. We determined LA-ICPMS U-Pb ages for detrital zircons extracted from three sandstone samples in the Sinian-Cambrian strata in this region. The resulting ages are in the range of the Archeozoic and Neoproterozoic, with three notable concentrates at 991 Ma, 974 Ma, and 964 Ma, all of which are coeval to the Grenvillian magmatic activity. The new age distribution is similar to the data reported in the Precambrian strata of the adjacent southwestern Cathaysia Block, suggesting that most of our detrital zircons are likely derived from the Cathaysia Block. Combined with others' research, we are more inclined to accept the opinion that there was not an ocean basin between the two blocks during the Sinian-Cambrian period in Eastern Guangxi area if the timing of collision is the Early Neoproterzoic. But if the timing of collision is the Early Paleozoic, we conclude that Luzhai uplift(i.e., the uplift between Guilin-Yongfu faultand Lipu fault) beyond the west of Dayaoshan regoin might be one part of southwestern sedimentation boundary of Cathaysia Block and Yangtze Block. We also get a few of detrital zircons with ages of ~590 Ma which probably sourced from northeastern Gondwana and 13 detrital zircons with over 3 000 Ma U-Pb ages which record the early formation of the earth. | Ruxin Ding Heping Zou Kyoungwon Min Feng Yin Xiaodong Du Xuxuan Ma Zhangxin Su Wenjie Shen | 2017 | Journal of Earth Science2017，28，2： | 5 |
| 4 | Post-Orogenic Tectonic Evolution of the Jiangnan-Xuefeng Orogenic Belt:Insights from Multiple Geochronometric Dating of the Mufushan Massif,South China显示文摘The Mufushan massif, as continental intra-plate magmatites located in the Jiangnan-Xuefeng orogenic belt of the South China. The Mufushan massif constitutes the largest Mesozoic intrusive complex, intruded the Mesoproterozoic Lengjiaxi Formation. Multiple geochronometric dating was used to reconstruct their evolution from emplacement to exhumation. The Mufushan granitoids were emplaced at ~150 Ma(U-Pb zircon) as post-orogenic magmatites contributing to Triassic crustal thickening. Onset of regional extension at ~128 Ma(40Ar/39Ar white mica and biotite) manifests a tectonic regime switch. Intense exhumation prior to ~55 Ma was followed by slow denudation and peneplanation for the next 37 Ma(~55–18 Ma). Accelerated cooling since ~18 Ma may have been caused by a far-field effect of the collision between IndiaAsia Plate or the Pacific-Plate subduction. Through a multi-geochronometric approach, this study provides a new comprehensive model for the cause of the intra-plate magmatism formation in the South China, and also established a reliable geochronological framework of the post-orogenic tectonic evolutions of the Jiangnan-Xuefeng orogenic belt. | Chuanbo Shen Di Hu Kyoungwon Min Chaoqun Yang Xiaowei Zeng Hongyang Fu Xiang Ge | 2020 | Journal of Earth Science2020，31，5： | 4 |
| 5 | Extensive frontal focused ultrasound Check for updates mediated blood-brain barrier opening for the treatment of Alzheimer's disease:a proof-of-concept study显示文摘Background:Focused ultrasound(FUS)-mediated blood-brain barrier(BBB)opening has shown efficacy in removal of amyloid plaque and improvement of cognitive functions in preclinical studies,but this is rarely reported in clinical studies.This study was conducted to evaluate the safety,feasibility and potential benefits of repeated extensive BBB opening.Methods:In this open-label,prospective study,six patients with Alzheimer's disease(AD)were enrolled at Severance Hospital in Korea between August 2020 and September 2020.Five of them completed the study.FUS-mediated BBB opening,targeting the bilateral frontal lobe regions over 20 cm^(3),was performed twice at three-month intervals.Magnetic resonance imaging,^(18)F-Florbetaben(FBB)positron emission tomography,Caregiver-Administered Neuropsychiatric Inventory(CGA-NPI)and comprehensive neuropsychological tests were performed before and after the procedures.Results:FUS targeted a mean volume of 21.1±2.7 cm^(3)and BBB opening was confirmed at 95.7%±9.4%of the targeted volume.The frontal-to-other cortical region FBB standardized uptake value ratio at 3 months after the procedure showed a slight decrease,which was statistically significant,compared to the pre-procedure value(-1.6%,0.986 vs 1.002,P=0.043).The CGA-NPI score at 2 weeks after the second procedure significantly decreased compared to baseline(2.2±3.0 vs 8.6±6.0,P=0.042),but recovered after 3 months(5.2±5.8 vs 8.6±6.0,P=0.89).No adverse effects were observed.Conclusions:The repeated and extensive BBB opening in the frontal lobe is safe and feasible for patients with AD.In addition,the BBB opening is potentially beneficial for amyloid removal in AD patients. | So Hee Park Kyoungwon Baik Seun Jeon Won Seok Chang Byoung Seok Ye Jin Woo Chang | 2021 | Translational Neurodegeneration2021，10，4： | 3 |
| 6 | Second-line bismuth-containing quadruple therapy for Helicobacter pylori eradication and impact of diabetes显示文摘AIM To investigate Helicobacter pylori (H. pylori) eradication rates using second-line bismuth-containing quadruple therapy and to identify predictors of eradication failure.METHODS This study included 636 patients who failed firstline triple therapy and received 7d of bismuthcontaining quadruple therapy between January 2005 and December 2015. We retrospectively demonstrated H. pylori eradication rates with respect to the year of therapy as well as demographic and clinical factors. H. pylori eradication was confirmed by a 13C-urea breath test or a rapid urease test at least 4 wk after the completion of bismuth-based quadruple therapy: proton pump inhibitor, metronidazole, bismuth, and tetracycline.RESULTS The overall eradication rates by intention-to-treat analysis and per-protocol analysis were 73.9%( 95% CI : 70.1 %- 77.4%) and 94.5% (95% CI : 92.4%-96.5%), respectively. Annual eradication rates from 2005 to 2015 were 100.0%, 92.9%, 100.0%, 100.0%, 100.0%, 97.4%, 100.0%, 93.8%, 84.4%, 98.9%, and 92.5%, respectively, by per-protocol analysis. A multivariate analysis showed that diabetes mellitus (OR=3.99, 95%CI: 1.56-10.20, P=0.004)was associated with H. pylori eradication therapy failure.CONCLUSION The second-line bismuth-containing quadruple therapy for H. pylori infection is still effective in Korea, and diabetes mellitus is suggested to be a risk factor for eradication failure. | Sung Eun Kim Moo In Park Seun Ja Park Won Moon Jae Hyun Kim Kyoungwon Jung Hae Koo Kim Young Dal Lee | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 7 | Assessment of colon polyp morphology: Is education effective?显示文摘AIM To determine the inter-observer variability for colon polyp morphology and to identify whether education can improve agreement among observers.METHODS For purposes of the tests, we recorded colonoscopy video clips that included scenes visualizing the polyps. A total of 15 endoscopists and 15 nurses participated in the study. Participants watched 60 video clips of the polyp morphology scenes and then estimated polyp morphology(pre-test). After education for 20 min, participants performed a second test in which the order of 60 video clips was changed(post-test). To determine if the effectiveness of education was sustained, four months later, a third, follow-up test was performed with the same participants.RESULTS The overall Fleiss' kappa value of the inter-observer agreement was 0.510 in the pre-test, 0.618 in the post-test, and 0.580 in the follow-up test. The overall diagnostic accuracy of the estimation for polyp morphology in the pre-, post-, and follow-up tests was 0.662, 0.797, and 0.761, respectively. After education, the inter-observer agreement and diagnostic accuracy of all participants improved. However, after four months, the inter-observer agreement and diagnostic accuracy of expert groups were markedly decreased, and those of beginner and nurse groups remained similar to pre-test levels. CONCLUSION The education program used in this study can improve inter-observer agreement and diagnostic accuracy in assessing the morphology of colon polyps; it is especially effective when first learning endoscopy. | Jae Hyun Kim Kyoung Sik Nam Hye Jung Kwon Youn Jung Choi Kyoungwon Jung Sung Eun Kim Won Moon Moo In Park Seun Ja Park | 2017 | World Journal of Gastroenterology2017，23，34： | 2 |
| 8 | Characteristics of YouTube network traffic at a campus network – Measurements, models, and implications显示文摘 | Michael Zink Kyoungwon Suh Yu Gu Jim Kurose | 2008 | Computer Networks2008，，4： | 1 |
| 9 | Push- to-peer video-on-demand system: design and evaluation 显示文摘 | Suh Kyoungwon Diot Christophe Kurose James F | 2007 | IEEE Journal on Selected Areas in Communications2007，25，9： | 1 |
| 10 | Rice OsACDR1 ( Oryza sativa accelerated cell death and resistance 1) is a potential positive regulator of fungal disease resistance显示文摘 | Jung-A Kim Kyoungwon Cho Raksha Singh Young-Ho Jung Seung-Hee Jeong So-Hee Kim Jae-eun Lee Yoon-Seong Cho Ganesh K. Agrawal Randeep Rakwal Shigeru Tamogami Birgit Kersten Jong-Seong Jeon Gynheung An Nam-Soo Jwa | 2009 | Molecules and Cells2009，，5： | 1 |
| 11 | Behaviour of a tunnel Face Reinforced by Bolts 显示文摘 | Kyoungwon seo Tsuyoshi Domon Kazuo Nishimu- ra | 2006 | Tunnelling and Underground Space Technology2006，21，3： | 1 |
| 12 | Dual positional specificity and expression of non-traditional lipoxygenase induced by wounding and methyl jasmonate in maize seedlings显示文摘 | Eun-Seon Kim Eunyoung Choi Youngsun Kim Kyoungwon Cho Ayoung Lee Jaehan Shim Randeep Rakwal Ganesh Kumar Agrawal Oksoo Han | 2003 | Plant Molecular Biology2003，，6： | 1 |
| 13 | Novel rice OsSIPK is a multiple stress responsive MAPK family member showing rhythmic expression at mRNA level显示文摘 | Mi-Ok Lee Kyoungwon Cho So-Hee Kim Seung-Hee Jeong Jung-A Kim Young-Ho Jung Jaekyung Shim Junko Shibato Randeep Rakwal Shigeru Tamogami Akihiro Kubo Ganesh Kumar Agrawal Nam-Soo Jwa | 2008 | Planta2008，，5： | 1 |
| 14 | Screen-printed anodic stripping voltammetric sensor containing HgO for heavy metal analysis显示文摘 | Jung-Yuen Choi Kyoungwon Seo | 2001 | Analytica Chimica Acta2001，443，： | 1 |
| 15 | Superior mesenteric vein thrombosis induced by influenza infection:A case report显示文摘BACKGROUND Among the various types and causes of mesenteric ischemia,superior mesenteric vein(SMV)thrombosis is a rare and ambiguous disease.If a patient presents with SMV thrombosis,past medical history should be reviewed,and the patient should be screened for underlying disease.SMV thrombosis may also occur due to systemic infection.In this report,we describe a case of SMV thrombosis complicated by influenza B infection.CASE SUMMARY A 64-year-old male visited the hospital with general weakness,muscle aches,fever,and abdominal pain.The patient underwent computed tomography(CT)and was diagnosed with SMV thrombosis.Since the patient’s muscle pain and fever could not be explained by the SMV thrombosis,the clinician performed a test for influenza,which produced a positive result for influenza B.The patient had a thrombus in the SMV only,with no invasion of the portal or splenic veins,and was clinically stable.Anticoagulation treatment was prescribed without surgery or other procedures.The follow-up CT scan showed improvement,and the patient was subsequently discharged with continued oral anticoagulant treatment.CONCLUSION This case provides evidence that influenza may be a possible risk factor for SMV thrombosis.If unexplained abdominal pain is accompanied by an influenza infection,examination of an abdominal CT scan may be necessary to screen for possible SMV thrombosis. | Gyu Man Oh Kyoungwon Jung Jae Hyun Kim Sung Eun Kim Won Moon Moo In Park Seun Ja Park | 2020 | World Journal of Clinical Cases2020，8，18： | 0 |
| 16 | Bulk-Si photonics technology for DRAM interface[Invited]显示文摘We present photonics technology based on a bulk-Si substrate for cost-sensitive dynamic random-access memory(DRAM)optical interface application.We summarize the progress on passive and active photonic devices using a local-crystallized Si waveguide fabricated by solid phase epitaxy or laser-induced epitaxial growth on bulk-Si substrate.The process of integration of a photonic integrated circuit(IC)with an electronic IC is demonstrated using a 65 nm DRAM periphery process on 300 mm wafers to prove the possibility of seamless integration with various complementary metal-oxide-semiconductor devices.Using the bulk-Si photonic devices,we show the feasibility of high-speed multidrop interface:the Mach–Zehnder interferometer modulators and commercial photodetectors are used to demonstrate four-drop link operation at 10 Gb∕s,and the transceiver chips with photonic die and electronic die work for the DDR3 DRAM interface at 1.6 Gb∕s under a 1∶4 multidrop configuration. | Hyunil Byun Jinkwon Bok Kwansik Cho Keunyeong Cho Hanmei Choi Jinyong Choi Sanghun Choi Sangdeuk Han Seokyong Hong Seokhun Hyun TJJeong Ho-Chul Ji In-Sung Joe Beomseok Kim Donghyun Kim Junghye Kim Jeong-Kyoum Kim Kiho Kim Seong-Gu Kim Duanhua Kong Bongjin Kuh Hyuckjoon Kwon Beomsuk Lee Hocheol Lee Kwanghyun Lee Shinyoung Lee Kyoungwon Na Jeongsik Nam Amir Nejadmalayeri Yongsang Park Sunil Parmar Junghyung Pyo Dongjae Shin Joonghan Shin Yong-hwack Shin Sung-Dong Suh Honggoo Yoon Yoondong Park Junghwan Choi Kyoung-Ho Ha Gitae Jeong | 2014 | Photonics Research2014，2，3： | 0 |
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