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| 1 | Metabolite profile comparisons between ascending and descending colon tissue in healthy adults显示文摘BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished from normal weight participants and associated with gut inflammation,nutrient absorption,and products of microbiota metabolism. | Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan | 2020 | World Journal of Gastroenterology2020，26，3： | 2 |
| 2 | Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease显示文摘 | Jiang Changtao Xie Cen Li Fei Zhang Limin Nichols Robert G Krausz Kristopher W Cai Jingwei Qi Yunpeng Fang Zhong-Ze Takahashi Shogo Tanaka Naoki Desai Dhimant Amin Shantu G Albert Istvan Patterson Andrew D Gonzalez Frank J | 2015 | Journal of Clinical Investigation2015，，1： | 1 |
| 3 | Optimization strategies for electrospun silk fibroin tissue engineering scafolds显示文摘 | Anne J M Kristopher E K Enrico K | 2009 | Biomaterials2009，30，： | 1 |
| 4 | Mediation analysis in social psychology:current practices and new recommendations显示文摘 | Derek D R Kristopher J P Zakary L T | 2011 | Social and Personality Psychology Compass2011，5，6： | 1 |
| 5 | Expression of ERG, an Ets family transcription factor, distinguishes cutaneous angiosarcoma from histological mimics显示文摘 | Kristopher M McKay Leona A Doyle Alexander J Lazar Jason L Hornick | 2012 | Histopathology2012，，5： | 1 |
| 6 | Characterizing heat release rates using an inverse fire modeling technique 显示文摘 | Kristopher J 0 Ofodike A E | 2012 | Fire Technology2012，48，4： | 1 |
| 7 | 显示文摘 | Kristopher E Wise Cheol Park Emilie J Siochi | 2004 | Chem Phys Lett2004，391，： | 1 |
| 8 | Evaluating shortfalls in mixed-integer programming approaches for the optimal design and dispatch of distributed generation systems 显示文摘 | KRISTOPHER A P ROBERT J B ALEXANDRA M | 2013 | Applied Energy2013，102，： | 1 |
| 9 | Expression of ERG, an Ets family transcription factor, distinguishes cutaneous angiosarcoma from histological mimics显示文摘 | Kristopher M McKay Leona A Doyle Alexander J Lazar Jason L Hornick | 2012 | Histopathology2012，，5： | 1 |
| 10 | Ra- diation Metabolomics: Identification of Minimally Invasive Urine Biomarkers for Gamma-radiation Exposure in Mice 显示文摘 | Tyburski J B Patterson A D Kristopher W K | 2008 | Radiation Research2008，170，1： | 1 |
| 11 | Ra- diation Metabolomics 2: Dose and Time Dependent Urinary Ecretion of Deaminated Purines and Pyrimidines after Sub- lethal Gamma-radiation Exposure in Mice显示文摘 | Tyburski J B Patterson A D Kristopher W K | 2009 | Radiation Research2009，172，1： | 1 |
| 12 | Expression of ERG, an Ets family transcription factor, distinguishes cutaneous angiosareoma from histological mimics 显示文摘 | Kristopher M M Leona A D Alexander J L | 2012 | Histopathology2012，61，5： | 1 |
| 13 | Chronic stress and age-related increases in the proinflammatory cytokine IL-6显示文摘 | Janice K Kristopher J Robert C | 2003 | Proc Natl Acad Sci U S A2003，100，15： | 1 |
| 14 | As- ymptotic and resampling strategies for assessing and compa- ring indirect effects in multiple mediator models显示文摘 | KRISTOPHER J PREACHER ANDREW F HAYES | 2008 | Behav- ior Research Methods2008，40，3： | 1 |
| 15 | Eight inhibitory monoclonal antibodies define the role of individual P450 in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism 显示文摘 | TIAN J KRISTOPHER W YANG S | 1999 | Drug Metab Dispos1999，27，1： | 1 |
| 16 | Addressing Moderated Mediation Hypotheses: Theory, Methods, and Prescriptions 显示文摘 | Preacher Kristopher J Rucker Derek D Hayes Andrew F | 2007 | Multivariate Behavioral Research2007，42，1： | 1 |
| 17 | Effect of food deprivation and hormones of glucose homeostasis on the acetyl CoA carboxylase activity in mouse brain: a potential role of acc in the regulation of energy balance 显示文摘 | Kristophe J Karami John Coppola Karthik Krlshnamurthy et at | 2006 | Nutrition & Metabolism2006，，3： | 1 |
| 18 | Nowcasting Convective Storm Initiation Using Satellite-Based Box-Averaged Cloud-Top Cooling and Cloud-Type Trends显示文摘 | Sieglaff Justin M Cronce Lee M Feltz Wayne F Bedka Kristopher M Pavolonis Michael J Heidinger Andrew K | 2011 | Journal of Applied Meteorology and Climatology2011，，1： | 1 |
| 19 | Quantifying and testing in-direct effects in simple mediation models when the constitu-ent paths are nonlinear显示文摘 | ANDREW F KRISTOPHER J | 2010 | Multivariate behavioral research2010，45，4： | 1 |
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