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| 1 | Colon perforation due to antigenemia-negative cytomegalovirus gastroenteritis after liver transplantation: A case report and review of literature显示文摘BACKGROUND Cytomegalovirus(CMV) remains a critical complication after solid-organ transplantation. The CMV antigenemia(AG) test is useful for monitoring CMV infection. Although the AG-positivity rate in CMV gastroenteritis is known to be low at onset, almost all cases become positive during the disease course. We treated a patient with transverse colon perforation due to AG-negative CMV gastroenteritis, following a living donor liver transplantation(LDLT).CASE SUMMARY The patient was a 52-year-old woman with decompensated liver cirrhosis as a result of autoimmune hepatitis who underwent a blood-type compatible LDLT with her second son as the donor. On day 20 after surgery, upper and lower gastrointestinal endoscopy(GE) revealed multiple gastric ulcers and transverse colon ulcers. The biopsy tissue immunostaining confirmed a diagnosis of CMV gastroenteritis. On day 28 after surgery, an abdominal computed tomography revealed transverse colon perforation, and simple lavage and drainage were performed along with an urgent ileostomy. Although the repeated remission and aggravation of CMV gastroenteritis and acute cellular rejection made the control of immunosuppression difficult, the upper GE eventually revealed an improvement in the gastric ulcers, and the biopsy samples were negative for CMV. The CMV-AG test remained negative, therefore, we had to evaluate the status of the CMV infection on the basis of the clinical symptoms and GE.CONCLUSION This case report suggests a monitoring method that could be useful for AGnegative CMV gastroenteritis after a solid-organ transplantation. | Takahiro Yokose Hideaki Obara Masahiro Shinoda Yutaka Nakano Minoru Kitago Hiroshi Yagi Yuta Abe Yohei Yamada Kentaro Matsubara Go Oshima Shutaro Hori Sho Ibuki Hisanobu Higashi Yuki Masuda Masanori Hayashi Miho Kawaida Takehiko Mori Takumi Fujimura Ken Hoshino Kaori Kameyama Tatsuo Kuroda Yuko Kitagawa | 2019 | World Journal of Gastroenterology2019，25，15： | 5 |
| 2 | Pre-hepatectomy type Ⅳ collagen 7S predicts post-hepatectomy liver failure and recovery显示文摘BACKGROUND Liver resection is an effective treatment for benign and malignant liver tumors.However,a method for preoperative evaluation of hepatic reserve has not yet been established.Previously reported assessments of preoperative hepatic reserve focused only on liver failure in the early postoperative period and did not consider the long-term recovery of hepatic reserve.When determining eligibility for hepatectomy,the underlying pathophysiology needs to be considered to determine if the functional hepatic reserve can withstand both surgery and any postoperative therapy.AIM To identify pre-hepatectomy factors associated with both early postoperative liver failure and long-term postoperative liver function recovery.METHODS This study was a retrospective cohort study.We retrospectively investigated 215 patients who underwent hepatectomy at our hospital between May 2013 and December 2016.Early post-hepatectomy liver failure(PHLF)was defined using the International Study Group of Liver Surgery’s definition of PHLF.Long-term postoperative recovery of liver function was defined as the time taken for serum total bilirubin and albumin levels to return to levels of<2 mg/dL and>2.8 g/dL,respectively,and the time taken for Child-Pugh score to return to Child-Pugh class A.RESULTS Preoperative type IV collagen 7S was identified as a significant independent factor associated with both PHLF and postoperative long-term recovery of liver function.Further analysis revealed that the time taken for the recovery of Child-Pugh scores and serum total bilirubin and albumin levels was significantly shorter in patients with type IV collagen 7S≤6 ng/mL than in those with type IV collagen 7S>6 ng/mL.In additional analyses,similar results were observed in patients without chronic viral hepatitis associated with fibrosis.CONCLUSION Preoperative type IV collagen 7S is a preoperative predictor of PHLF and longterm postoperative liver function recovery.It can also be used in patients without chronic hepatitis virus. | Masatsugu Ishii Osamu Itano Masahiro Shinoda Minoru Kitago Yuta Abe Taizo Hibi Hiroshi Yagi Ayano Takeuchi Hanako Tsujikawa Tokiya Abe Yuko Kitagawa | 2020 | World Journal of Gastroenterology2020，26，7： | 3 |
| 3 | Regulation of RUNX3 tumor suppressor gene expression in cutaneous melanoma显示文摘 | Kitago M Martinez SR Nakamura T | 2009 | Clin Cancer Res2009，15，9： | 1 |
| 4 | Activation of Toll-like receptors 2, 3, and 4 on human melanoma cells induces inflammatory factors 显示文摘 | Goto Y Arigami T Kitago M | 2008 | Mol Cancer Ther2008，7，： | 1 |
| 5 | Molecular mechanisms of metastasis显示文摘 | Hoon DS Kitago M Kim J | 2006 | Cancer Metastasis Rev2006，25，2： | 1 |
| 6 | Lymphatic Mapping Establishes the Role of BRAF Gene Mutation in Papillary Thyroid Carcinoma显示文摘 | Joseph Kim Armando E. Giuliano Roderick R. Turner Robyn E. Gaffney Naoyuki Umetani Minoru Kitago David Elashoff Dave S. B. Hoon | 2006 | Annals of Surgery2006，，5： | 1 |
| 7 | Utility of circulating B- RAF DNA mutation in serum for monitoring melanoma patients re- ceiving biochemotherapy 显示文摘 | Shinozaki M O' Day S J Kitago M | 2007 | Clin Cancer Res2007，13，7： | 1 |
| 8 | Change in undrained shear strength characteristics of saturated remoulded clay due to swelling显示文摘 | Mitachi T Kitago S | 1976 | Soils and Foundation1976，16，1： | 1 |
| 9 | Regulation of RUNX3 tumor Suppressor gene expression incutaneous melanoma显示文摘 | Kitago M Martinez SR Nakamura T | 2009 | Clin Cancer Res2009，15，： | 1 |
| 10 | Activation of Toll like receptors 2, 3, and 4 on human melanoma cells induces inflammatory factors 显示文摘 | Goto Y Arigami T Kitago M | 2008 | Molecular Cancer Therapeutics2008，7，11： | 1 |
| 11 | Suppressive Effects of Interleukin-18 on Liver Function in Rat Liver Allografts显示文摘 | Shigeshi Ono Hideaki Obara Atsushi Takayanagi Minoru Tanabe Shigeyuki Kawachi Osamu Itano Masahiro Shinoda Minoru Kitago Taizo Hibi Tomohiro Chiba Wenlin Du Kenji Matsumoto Arno W. Tilles Martin L. Yarmush Sadakazu Aiso Nobuyoshi Shimizu Michiie Sakamoto | 2012 | Journal of Surgical Research2012，，1： | 1 |
| 12 | Two cases of pancreatic ductal adenocarcinoma with intrapancreatic metastasis显示文摘There are no standardized diagnostic criteria for intrapancreatic metastasis of pancreatic ductal adenocarcinoma(PDAC). Here, we report two cases of patients with PDAC who were pathologically diagnosed as harboring intrapancreatic metastasis. In both cases, the main lesions were located in the pancreatic body, and no other lesion was detected preoperatively. The patients were diagnosed with pancreatic body cancers and distal pancreatectomy was performed. Pathological findings revealed microscopic cancer nests, which had connections to neither the main lesion nor the premalignant lesion in the pancreatic tail parenchyma. In both cases, the histological type of the daughter lesion was quite similar to that of the main lesion. Hence, we diagnosed the daughter lesions as metastatic foci in the pancreas. Although intrapancreatic metastasis of PDAC has been regarded as a poor prognostic factor, few reports of intrapancreatic metastasis are available. This article reports two such cases and provides a review of the literature. | Yusuke Fujita Minoru Kitago Yohei Masugi Osamu Itano Masahiro Shinoda Yuta Abe Taizo Hibi Hiroshi Yagi Yoko Fujii-Nishimura Michiie Sakamoto Yuko Kitagawa | 2016 | World Journal of Gastroenterology2016，22，41： | 1 |
| 13 | Effects of chemokines ontumor metastasis显示文摘 | Takeuchi H Kitago M Hoon D S | 2007 | Cancer Treat Res2007，135，： | 1 |
| 14 | Activation of toll-like receptors 2, 3 , and 4 on human melanoma cells induces inflammatory factors 显示文摘 | Goto Y Afigami T Kitago M | 2008 | Mol Cancer Therapeutics2008，7，11： | 1 |
| 15 | Activation of toll-like receptors 2, 3, and 4 on human melanoma cells induces inflammatory factors 显示文摘 | Goto Y Arigami T Kitago M | 2008 | Mol Cancer Ther2008，7，： | 1 |
| 16 | Activation of Toll-like receptors 2, 3, and 4 on human melanoma cells induces inflammatory factors显示文摘 | Goto Y Arigami T Kitago M | 2008 | Mol Cancer Ther2008，7，11： | 1 |
| 17 | Change in undrained shear strength characteristics of saturated remoulded clay due to swelling显示文摘 | MITACHI T KITAGO S | 1976 | Soils and Foundation1976，16，1： | 1 |
| 18 | Change in undrained shear strength characteristics of saturated remouded clay due to swelling显示文摘 | MITACHI T KITAGO S | 1976 | Soils and Foundations1976，16，1： | 1 |
| 19 | Utility of circulating B-RAF DNA mutation in serum for monitoring melanoma patients receiving biochemotherapy 显示文摘 | Shinozaki M ODay S J Kitago M | 2007 | Clin Cancer Res2007，13，7： | 1 |
| 20 | Activation of Toll-like receptors 2,3,and 4 on human melanoma cells induces inflammatory factors显示文摘 | Goto Y Arigami T Kitago M | 2008 | Mol Cancer Ther2008，7，： | 1 |
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