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| 1 | Health risks associated with heavy metals in the drinking water of Swat,northern Pakistan显示文摘The concentrations of heavy metals such as Cd, Cr, Cu, Mn, Ni, Pb and Zn were investigated in drinking water sources(surface and groundwater) collected from Swat valley, Khyber Pakhtunkhwa, Pakistan. The potential health risks of heavy metals to the local population and their possible source apportionment were also studied. Heavy metal concentrations were analysed using atomic absorption spectrometer and compared with permissible limits set by Pakistan Environmental Protection Agency and World Health Organization. The concentrations of Cd, Cr, Ni and Pb were higher than their respective permissible limits, while Cu, Mn and Zn concentrations were observed within their respective limits. Health risk indicators such as chronic daily intake(CDI) and health risk index(HRI) were calculated for adults and children separately. CDIs and HRIs of heavy metals were found in the order of Cr > Mn >Ni > Zn > Cd > Cu > Pb and Cd > Ni > Mn > Cr > Cu > Pb > Zn, respectively. HRIs of selected heavy metals in the drinking water were less than 1, indicating no health risk to the local people. Multivariate and univariate statistical analyses showed that geologic and anthropogenic activities were the possible sources of water contamination with heavy metals in the study area. | Kifayatullah Khan Yonglong Lu Hizbullah Khan Shahida Zakir Ihsanullah Sardar Khan Akbar Ali Khan Luo Wei Tieyu Wang | 2013 | Journal of Environmental Sciences2013，25，10： | 12 |
| 2 | Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders显示文摘Human genetic adaptation to high altitudes(>2500 m)has been extensively studied over the last few years,but few functional adaptive genetic variants have been identified,largely owing to the lack of deep-genome sequencing data available to previous studies.Here,w e build a list of putative adaptive variants,including 63 missense,7 loss-of-function;1,298 evolutionarily conserved variants and 509 expression quantitative traits loci.Notably,the top signal of selection is located in TMEM 247,a transmembrane protein-coding gene.The Tibetan version of TMEM 247 harbors one high-frequency(76.3%)missense variant,rsl 16983452(c.248C>T;p.Ala83Val);with the T allele derived from archaic ancestry and carried by>94%of Tibetans but absent or in low frequencies(<3%)in non-Tibetan populations.The rsl 16983452-T is strongly and positively correlated with altitude and significantly associated with reduced hemoglobin concentration(p=5.78×10^-5),red blood cell count(p=5.72×10^-7)and hematocrit(p=2.57×10^-6).In particular,TMEM247-rs 116983452 shows greater effect size and better predicts the phenotypic outcome than any E P A S1 variants in association with adaptive traits in Tibetans.Modeling the interaction between TM£M247-rsl 16983452 and EPAS1 variants indicates weak but statistically significant epistatic effects.Our results support that multiple variants may jointly deliver the fitness of the Tibetans on the plateau,where a complex model is needed to elucidate the adaptive evolution mechanism. | Lian Deng Chao Zhang Kai Yuan Yang Gao Yuwen Pan Xueling Ge Yaoxi He Yuan Yuan Yan Lu Xiaoxi Zhang Hao Chen Haiyi Lou Xiaoji Wang Dongsheng Lu Jiaojiao Liu Lei Tian Qidi Feng Asifullah Khan Yajun Yang Zi-Bing Jin Jian Yang Fan Lu Jia Qu Longli Kang Bing Su Shuhua Xu | 2019 | National Science Review2019，6，6： | 9 |
| 3 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 4 | Spatial systems approach to sustainable development: A conceptual framework显示文摘 | Wen-Yuan Niu Jonathan J. Lu Abdullah A. Khan | 1993 | Environmental Management1993，，2： | 5 |
| 5 | Behavioral interventions to eliminate fear responses显示文摘Fear memory underlies anxiety-related disorders, including posttraumatic stress disorder(PTSD). PTSD is a fear-based disorder,characterized by difficulties in extinguishing the learned fear response and maintaining extinction. Currently, the first-line treatment for PTSD is exposure therapy, which forms an extinction memory to compete with the original fear memory. However,the extinguished fear often returns under numerous circumstances, suggesting that novel methods are needed to eliminate fear memory or facilitate extinction memory. This review discusses research that targeted extinction and reconsolidation to manipulate fear memory. Recent studies indicate that sleep is an active state that can regulate memory processes. We also discuss the influence of sleep on fear memory. For each manipulation, we briefly summarize the neural mechanisms that have been identified in human studies. Finally, we highlight potential limitations and future directions in the field to better translate existing interventions to clinical settings. | Jingli Yue Le Shi Xiao Lin Muhammad Zahid Khan Jie Shi Lin Lu | 2018 | Science China(Life Sciences)2018，61，6： | 4 |
| 6 | Climate change induced eutrophication of cold-water lake in an ecologically fragile nature reserve显示文摘Aquatic ecosystem sustainability around the globe is facing crucial challenges because of increasing anthropogenic and natural disturbances. In this study, the Tianchi Lake, a typical cold-water lake and a UNESCO/MAB(Man and Biosphere) nature reserve located in high latitude and elevation with the relatively low intensity of human activity was chosen as a system to examine the linkages between climate change and eutrophication. As a part of the UNESCO Bogda Man and Biosphere Reserve, Tianchi Lake has been well preserved for prevention from human intervention, but why has it been infected with eutrophication recent years? Our results show that climate change played a significant role in the eutrophication in the Tianchi Lake. Increased temperature, changed precipitation pattern and wind-induced hydrodynamic fluctuations in the summer season were suggested to make a major contribution to the accelerated eutrophication. The results also showed that the local temperature and precipitation changes were closely linked to the large-scale atmospheric circulation, which opens the door for the method to be applied in other regions without local climatic information. This study suggests that there is an urgent need to take into consideration of climate change adaptation into the conservation and management of cold-water lakes globally. | Xiaotian Lu Yonglong Lu Deliang Chen Chao Su Shuai Song Tieyu Wang Hanqin Tian Ruoyu Liang Meng Zhang Kifayatullah Khan | 2019 | Journal of Environmental Sciences2019，31，1： | 4 |
| 7 | Role of digestive protease enzymes and related genes in host plant adaptation of a polyphagous pest,Spodoptera frugiperda显示文摘The evolutionary success of phytophagous insects depends on their ability toefficiently exploit plants as a source of energy for survival.Herbivorous insects largelydepend on the efficiency,flexibility,and diversity of their digestive physiology and sophistication of their detoxification system to use chemically diverse host plants as foodsources.The fall armyworm,Spodoptera frugiperda(J.E.Smith),is a polyphagous pest ofmany commercially important crops.To elucidate the ability of this insect pest to adaptto host plant mechanisms,we evaluated the impact of primary(corn)and alternate(rice)host plants after 1l generations on gut digestive enzymatic activity and expression profiles of related genes.Results indicated that the total protease and classspecific trypsinand chymotrypsinlike protease activity of S.frugiperda significantly differed among hostplant treatments.The classspecifiq protease profiles greatly differed in S.frugiperdamidguts upon larval exposure to different treatments with inhibitors compared with treatments without inhibitors.Similarly,the single and cumulative effects of the enzymespecific inhibitors TLCK,TPCK,and E64 significantly increased larval mortality and reduced larval growth/mass across different plant treatments.Furthermore,the quantitativereverse transcription polymerase chain reaction results revealed increased transcription oftwo trypsin(SfTry3,SfTry7)and one chymotrypsin gene(Sfchym9),which indicatedthat they have roles in host plant adaptation.Knockdown of these genes resulted in significantly reduced mRNA expression levels of the trypsin genes.This was related to theincreased mortality observed in treatments compared with the dsRED control.This resultindicates possible roles of S.frugiperda gut digestive enzymes and related genes in hostplant adaptation. | Muhammad Hafeez Xiao-Wei Li Jin-Ming Zhang Zhi-Jun Zhang Jun Huang Li-Kun Wang Muhammad Musa Khan Sakhawat Shah G.Mandela Fernandez-Grandon Yao-Bin Lu | 2021 | Insect Science2021，28，3： | 2 |
| 8 | Heavy metals in agricultural soils and crops and their health risks in swat district, northern Pakistan 显示文摘 | KHAN K LU Y L KHAN H | 2013 | Food and Chemical Toxicology2013，58，： | 1 |
| 9 | Relationship between structural properties and CO2 capture performance of CaO-based sorbents obtained from different organometallic precursors 显示文摘 | LU Hong KHAN A SMIRNIOTIS P G | 2008 | Industrial & Engineering Chemistry Research2008，47，16： | 1 |
| 10 | Behavior of air plasma sprayed thermal barrier coatings,subject to intense thermal cycling显示文摘 | J Lu | 2003 | Surface and Coatings Technology2003，166，： | 1 |
| 11 | Thermal cyclic behavior of air plasma sprayed thermal barrier coatings sprayed on stainless steel substrates显示文摘 | Khan A N Lu J | 2007 | Surface & Coatings Technology2007，201，8： | 1 |
| 12 | AlGaN/GaN HEMTs on SiC with over 100 GHz fT and low microwave noise显示文摘 | Yang W Khan M Asif | 2001 | IEEE Trans Electron Device2001，48，3： | 1 |
| 13 | AlGaN/GaN HEMTs on SiC with over 100GHz fT and low microwave noise显示文摘 | Lu Wu Yang J-W Khan M A | 2001 | IEEE Trans Elec Dev2001，48，3： | 1 |
| 14 | Relationship between structural properties and CO2 capture performance of CaO-based sorbents obtained from different organometallic precursors 显示文摘 | Lu Hong Khan Ataullah | 2008 | Industrial & Engineering Chemistry2008，47，62： | 1 |
| 15 | Flame-made durable doped-CaO nanosorbentsfor C02 capture 显示文摘 | Lu Hong Khan AtauUah | 2009 | Energy & Fuels2009，23，： | 1 |
| 16 | Dynam- ic weighted discrimination power analysis: a novel approach for face and palmprint recognition in DCT domain显示文摘 | Leng Lu Zhang Jia-shu Khan M K | 2010 | International Journal of the Physical Sci- ences2010，5，17： | 1 |
| 17 | Behavior of air plasma sprayed thermal barrier coatings,subject to intense thermal cycling显示文摘 | Nusair Khan A Lu J | 2003 | Surface and Coatings Technology2003，166，1： | 1 |
| 18 | Heat treatment of thermal barrier coatings显示文摘 | Khan A N Lu J Liao H | 2003 | Materials and Engineering2003，，359： | 1 |
| 19 | Absorptive capacity and disbursements by the Global Fund to fight AIDS,tubercu- losis and malaria:analysis of grant implementation显示文摘 | Lu C Michaud CM Khan K | 2006 | Lancet2006，368，9534： | 1 |
| 20 | Thermal cyclic behavior of air plasma sprayed thermal barrier coatings sprayed on stainless steel sbustrates 显示文摘 | KHAN A N LU J | 2007 | Surface and Coatings Technology2007，201，5： | 1 |
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