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| 1 | 北京地区中国荷斯坦牛体细胞评分差值变化规律及遗传力估计显示文摘旨在对北京地区中国荷斯坦牛体细胞评分(SCS)差值变化规律进行探索以及遗传力估计。本研究通过对相邻两个泌乳月SCS差值的计算,利用最小二乘法对北京地区1998-2016年间121个牛场中78 386头中国荷斯坦奶牛DHI数据进行分析,并利用DMU软件和线性混合模型估计SCS差值各方差组分,计算其遗传力。结果表明,场规模、当前测定年、当前测定季节、胎次、产犊季节、当前泌乳月对SCS差值具有极显著性影响(P<0.01);SCS差值遗传力为(0.054±0.003)。其中,一胎、二胎、三胎SCS差值遗传力分别为(0.070±0.005)、(0.045±0.004)、(0.052±0.007)。结果表明,SCS差值作为一种实时简易检测隐性乳房炎发生的指标,其遗传力的估计在中国荷斯坦牛抗隐性乳房炎选择中具有重要作用。 | 史良玉 张瑞强 李想 Serafino Musa Abdelkarim Augustino Muhammad Zahoor Khan 刘林 肖炜 唐韶青 张毅 王雅春 俞英 | 2018 | 畜牧兽医学报2018，49，5： | 9 |
| 2 | Role of digestive protease enzymes and related genes in host plant adaptation of a polyphagous pest,Spodoptera frugiperda显示文摘The evolutionary success of phytophagous insects depends on their ability toefficiently exploit plants as a source of energy for survival.Herbivorous insects largelydepend on the efficiency,flexibility,and diversity of their digestive physiology and sophistication of their detoxification system to use chemically diverse host plants as foodsources.The fall armyworm,Spodoptera frugiperda(J.E.Smith),is a polyphagous pest ofmany commercially important crops.To elucidate the ability of this insect pest to adaptto host plant mechanisms,we evaluated the impact of primary(corn)and alternate(rice)host plants after 1l generations on gut digestive enzymatic activity and expression profiles of related genes.Results indicated that the total protease and classspecific trypsinand chymotrypsinlike protease activity of S.frugiperda significantly differed among hostplant treatments.The classspecifiq protease profiles greatly differed in S.frugiperdamidguts upon larval exposure to different treatments with inhibitors compared with treatments without inhibitors.Similarly,the single and cumulative effects of the enzymespecific inhibitors TLCK,TPCK,and E64 significantly increased larval mortality and reduced larval growth/mass across different plant treatments.Furthermore,the quantitativereverse transcription polymerase chain reaction results revealed increased transcription oftwo trypsin(SfTry3,SfTry7)and one chymotrypsin gene(Sfchym9),which indicatedthat they have roles in host plant adaptation.Knockdown of these genes resulted in significantly reduced mRNA expression levels of the trypsin genes.This was related to theincreased mortality observed in treatments compared with the dsRED control.This resultindicates possible roles of S.frugiperda gut digestive enzymes and related genes in hostplant adaptation. | Muhammad Hafeez Xiao-Wei Li Jin-Ming Zhang Zhi-Jun Zhang Jun Huang Li-Kun Wang Muhammad Musa Khan Sakhawat Shah G.Mandela Fernandez-Grandon Yao-Bin Lu | 2021 | Insect Science2021，28，3： | 2 |
| 3 | Comparative assessment of clinical profile and outcomes after primary percutaneous coronary intervention in young patients with single vs multivessel disease显示文摘BACKGROUND Even though percutaneous coronary intervention(PCI)improved the survival of patients with acute myocardial infarction,still multivessel coronary artery disease remains an important factor burdening prognosis and it is being associated with a worse prognosis compared to single-vessel disease(SVD).AIM To compare the clinical profile and outcomes after the primary PCI in young patients with SVD vs multivessel disease(MVD).METHODS The retrospective cohort of patients were divided into two groups:SVD and MVD group.The study population consisted of both male and female young(≤45 years)patients presented with ST-elevation myocardial infarction(STEMI)at the National Institute of Cardiovascular Disease,Karachi,Pakistan and undergone primary PCI from 1 st July 2017 to 31 st March 2018.Pre and postprocedure management of the patients was as per the guidelines and institutional protocols.RESULTS A total of 571 patients with STEMI,≤45 years were stratified into two groups by the number of vessels involved,342(59.9%)with SVD and 229(40.1%)with MVD.The average age of these patients was 39.04±4.86 years.A lower prevalence of hypertension and diabetes was observed in SVD as compare to MVD group(25.1%vs 38%,P<0.01;11.7%vs 27.5%,P<0.001)respectively.While,smoking was more prevalent among the SVD group as compare to MVD group(36.3%vs 28.4%,P=0.05).The high-C Lesion was observed in a significantly higher number of younger patients with MVD as compared to SVD group(48.8%vs 39.2%,P=0.021).Post-procedure thrombolysis in myocardial infarction flow grade was found to be not associated with the number of diseased vessels with a P value of 0.426 and thrombolysis in myocardial infarction flow grade III was observed in 98%vs 96.5%of the patients is SVD vs MVD group.CONCLUSION The MVD comprised of around 40%of the young patients presented with STEMI.Also,this study shows that diabetes and hypertension have a certain role in the pathogenesis of multivessel diseases,therefore,preventive measures for diabetes and hypertension can be effective strategies in reducing the burden of premature STEMI. | Atif Sher Muhammad Tariq Ashraf Ayaz Mir Syed Alishan Faiza Farooq Ali Ammar Musa Karim Syed Nadeem Hassan Rizvi Tahir Saghir Jawaid Akbar Sial Naveed Ullah Khan | 2020 | World Journal of Cardiology2020，12，4： | 1 |
| 4 | In vitro biological screening of the stem of Desmodium elegans显示文摘Objective:To explore the medicinal importance of the stem of Desmodium elegans,methanolic extract,and its different solvent fractions were evaluated for brine shrimp lethality,insecticidal and phytotoxicity,antifungal,and antibacterial activities.Methods:The methanolic extract and its solvent fractions were tested for cytotoxic,phytotoxic,insecticidal,antifungal,and antibacterial effects using our previous published protocols.Results:The methanolic,DCM,ethyl acetate and n-butanol fractions exhibited insecticidal effect against Callosobruchus analis and Rhyzopertha dominie.The methanolic extract,n-hexane,DCM ethyl acetate and n-butanol showed 75,85,85,65 and 5%phytotoxicity at the tested concentration of 500μg/ml.respectively.The solvent fractions(DCM and ethyl acetate)were effective against F.solani(10%and 20%,inhibition respectively).All the tested samples were devoid of cytotoxic and antibacterial effects.Conclusions:It was concluded diat diis plant can be practiced for control of weeds and insects. | Arshad Khan Rabia Usman Ming-Liang Wang Abdur Rauf Naveed Muhammad Akhatar Aman Taha Hussein Musa Tahir | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，9： | 0 |
| 5 | Gastric Tract Disease Recognition Using Optimized Deep Learning Features显示文摘Artificial intelligence aids for healthcare have received a great deal of attention.Approximately one million patients with gastrointestinal diseases have been diagnosed via wireless capsule endoscopy(WCE).Early diagnosis facilitates appropriate treatment and saves lives.Deep learning-based techniques have been used to identify gastrointestinal ulcers,bleeding sites,and polyps.However,small lesions may be misclassified.We developed a deep learning-based best-feature method to classify various stomach diseases evident in WCE images.Initially,we use hybrid contrast enhancement to distinguish diseased from normal regions.Then,a pretrained model is fine-tuned,and further training is done via transfer learning.Deep features are extracted from the last two layers and fused using a vector length-based approach.We improve the genetic algorithm using a fitness function and kurtosis to select optimal features that are graded by a classifier.We evaluate a database containing 24,000 WCE images of ulcers,bleeding sites,polyps,and healthy tissue.The cubic support vector machine classifier was optimal;the average accuracy was 99%. | Zainab Nayyar Muhammad Attique Khan Musaed Alhussein Muhammad Nazir Khursheed Aurangzeb Yunyoung Nam Seifedine Kadry Syed Irtaza Haider | 2021 | Computers, Materials & Continua2021，，8： | 0 |
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