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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid显示文摘 | Rosenbaum DM Rosenbaum PS Gupta A Michaelson MD Hall DH Kessler JA | 1997 | Vision Res1997，37，24： | 1 |
| 3 | 白细胞端粒长度缩短较动脉粥样硬化的临床表现提前出现:血液和肌肉模型显示文摘白细胞端粒长度与动脉粥样硬化性心血管病(atherosclerotic cardiovascular disease,ASCVD)相关。目前还不清楚这种关系是否源于出生时天生较短的白细胞端粒长度(leukocy tetelomere length,LTL)和(或)之后较快的LTL消耗。LTL代表高增殖性造血系统中的端粒长度,而骨骼肌中的端粒长度(muscle tetelomere length,MTL)代表最低限度复制的组织。 | Benetos A Toupance S Gautier S Labat C Kimura M Rossi PM Settembre N Hubert J Frimat L Bertrand B Boufi M Flecher X Sadoul N Eschwege P Kessler ML Tzanetakou IP Doulamis IP Konstantopoulos PS Tzani AI Korou LM Gkogkos A Perreas KG Menenakos E Samanidis G Vasiloglou-Gkanis M Kark JD Malikov S Verhulst S Aviv A 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，1： | 1 |
| 4 | The macrophage cholesterol ex-porter ABCA1 functions as an anti-inflammatory receptor显示文摘 | Tang C Liu Y Kessler PS | 2009 | J Bi-ol Chem2009，284，32： | 1 |
| 5 | The effects of chronic medical conditions on work loss and work cutback 显示文摘 | Kessler RC Greenberg PE Mickelson KD Meneades LM Wang PS | 2001 | J Occup Environ Med2001，43，3： | 1 |
| 6 | The epidemiology of major depressive disorder:results from the National Comorbidity Survey Replication (NCS-R)显示文摘 | Kessler RC Berglund R Demler O Jin R Koretz D Merikangas KR Rush AJ Waiters EE Wang PS National Comorbidity Survey Replication | | 0，，23： | 1 |
| 7 | Prevalence,comorbidity,and service utilization for mood disorders in the United States at the beginning of the twenty-first century显示文摘 | Kessler RC Merikangas KR Wang PS | 2007 | Annu Rev Clin Psychol2007，3，： | 1 |
| 8 | The Descriptive Epidemiology of Commonly Occurring Mental Disorders in the United States显示文摘 | Kessler RC Wang PS | 2008 | Annual Review of Public Health2008，29，： | 1 |
| 9 | The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor 显示文摘 | Tang C Liu Y Kessler PS | 2009 | J Bil Chem2009，284，32： | 1 |
| 10 | Joint space narrowing and Kellgren- Lawrence progression in knee osteoarthritis: an analytic literature synthesis显示文摘 | Emrani PS Katz JN Kessler CL | 2008 | Osteoarthritis Cartilage2008，16，8： | 1 |
| 11 | Prevalence, comorbidity, and service utilization for mood disorders in the United States at the beginning of the twenty-first century 显示文摘 | Kessler RC Merikangas KR Wang PS | 2007 | Annu Rev Clin Psychol2007，3，： | 1 |
| 12 | The descriptive epidemiology of commonly occurring mental disorders in the United States显示文摘 | Kessler RC Wang PS | 2008 | Annu Rev Public Health2008，29，： | 1 |
| 13 | Prevalence, comorbidity, and service utilization for mood disorders in the United States at the beginning of the twenty - first century显示文摘 | Kessler RC Merikangas KR Wang PS | 2007 | Annu Rev Clin Psychol2007，3，： | 1 |
| 14 | Probing the role of compartmentation of glycolysis in procyclic form Trypanosoma brucei:RNA interference studies of PEX14,hexokinase,and phosphofructokinase显示文摘 | Kessler PS Parsons M | 2005 | J Biol Chem2005，280，10： | 1 |
| 15 | Adequacy of treatment for serious mental illness in the United States显示文摘 | Wang PS Demler O Kessler RC | 2002 | Am J Public Health2002，92，1： | 1 |
| 16 | The descriptive epidemiology of commonly occurring mental disorders in the United States 显示文摘 | KESSLER RC WANG PS | 2008 | Annu Rev Public Health2008，29，： | 1 |
| 17 | The macrophage cholesterolexporter ABCA1 functions as an anti-inflammatory receptor显示文摘 | Tang C Liu Y Kessler PS | 2009 | JBiol Chem2009，284，32： | 1 |
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