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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study显示文摘 | Shamir R Mehta Salim Yusuf Ron JG Peters Michel E Bertrand Basil S Lewis Madhu K Natarajan Klas Malmberg Hans-Jürgen Rupprecht Feng Zhao Susan Chrolavicius Ingrid Copland Keith AA Fox | 2001 | The Lancet . 2001 (9281)2001，，9281： | 4 |
| 3 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 4 | Induction of a high incidence of lung tumors in C57BL/6 mice with multiple ethyl carbamate injections显示文摘 | York E Miller Lori D Dwyer-Nield Robert L Keith Mysan Le Wilbur A Franklin Alvin M Malkinson | 2003 | Cancer Letters2003，，2： | 2 |
| 5 | Three-Dimensional Seed Size and Shape QTL in Hexaploid Wheat (Triticum aestivum L.) Populations显示文摘 | Williams Keith Sorrells Mark E | 2014 | Crop Science2014，，1： | 2 |
| 6 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 7 | Heat shock response by the hyperthermophilic archaeon Pyrococcus furiosus显示文摘 | Donald E Swapnil R | 2003 | Applied and Environmental Microbiology2003，69，4： | 1 |
| 8 | An increased understanding of soil organic carbon stocks and changes in non-temperate areas:national and global implications显示文摘 | ELEANOR M KEITH P MARK E | 2007 | Agriculture Ecosystems and Environment2007，122，： | 1 |
| 9 | Cloning of a delta opioid receptor by functional expression显示文摘 | Evans C J Keith D E Morrison H | 1992 | Science1992，258，5090： | 1 |
| 10 | ABC of wound healing: pressureulcers显示文摘 | Joseph EG Keith GH Stuart E | 2006 | BMJ2006，332，47： | 1 |
| 11 | Temperature-Dependent Poling Behavior of Lead-free BZT-BCT Piezoelectrics 显示文摘 | Li B Z John E B Keith J B | 2011 | Journal of the American Ceramic Society2011，94，10： | 1 |
| 12 | Effects of simulated acidic rain on yields of field-grown crops显示文摘 | LNACE S E KEITH F L ELIZABETH A C | 1982 | New Phytol1982，91，： | 1 |
| 13 | Induction of a high incidence of lung tumors in C57BL/6 mice with multiple ethyl carbamate injection 显示文摘 | Miller Y E Dwyer-Nield Keith R L | 2003 | Cancer Letters2003，198，2： | 1 |
| 14 | Revisions to the ORNL series of adult and pediatric computational phantoms for use with the MIRD schema显示文摘 | EUN Y H WESLEY E B KEITH F E | 2006 | Health Phys2006，90，： | 1 |
| 15 | Flash-lamp-pumped Ho∶ Tm∶ Cr∶ YAG and Ho∶ Tm∶ Er∶ YLF lasers:experimental results of a single,long pulse length comparison显示文摘 | Mahendra G Jani Norman P Barnes Keith E Murray | 1997 | Applied Optics1997，36，15： | 1 |
| 16 | 显示文摘 | Christian Lastoskie Keith E Gubbins Nicholas Quirke | 1993 | The Journal of Physical Chemistry1993，97，18： | 1 |
| 17 | Plant responses to atmospberic CO2 enrichment in the face of enviromental constraints:a review of the past 10 years reseach 显示文摘 | Keith E I Sherwood BI | 1994 | Agricultural and Forest Meteorology1994，69，： | 1 |
| 18 | Control of p70 S6 kinase by kinase activity of FRAP in vivo显示文摘 | Brown E J Beal P A Keith C T | 1995 | Nature1995，377，6548： | 1 |
| 19 | Intellectual property in a globalizing world:Issues for economic research显示文摘 | KEITH E | 2015 | Asia-Pacific Journal of Accounting&Economics2015，22，3： | 1 |
| 20 | Determination of flavor threshold levels and sub-threshold additive and concentration effects 显示文摘 | Keith E S Powers J J | 1968 | Journal of Food Science1968，33，： | 1 |
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