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| 1 | Global kinematics of tectonic plates and subduction zones since the late Paleozoic Era显示文摘Detailed global plate motion models that provide a continuous description of plate boundaries through time are an effective tool for exploring processes both at and below the Earth's surface. A new generation of numerical models of mantle dynamics pre-and post-Pangea timeframes requires global kinematic descriptions with full plate reconstructions extending into the Paleozoic(410 Ma). Current plate models that cover Paleozoic times are characterised by large plate speeds and trench migration rates because they assume that lowermost mantle structures are rigid and fixed through time. When used as a surface boundary constraint in geodynamic models, these plate reconstructions do not accurately reproduce the present-day structure of the lowermost mantle. Building upon previous work, we present a global plate motion model with continuously closing plate boundaries ranging from the early Devonian at 410 Ma to present day.We analyse the model in terms of surface kinematics and predicted lower mantle structure. The magnitude of global plate speeds has been greatly reduced in our reconstruction by modifying the evolution of the synthetic Panthalassa oceanic plates, implementing a Paleozoic reference frame independent of any geodynamic assumptions, and implementing revised models for the Paleozoic evolution of North and South China and the closure of the Rheic Ocean. Paleozoic(410-250 Ma) RMS plate speeds are on average ~8 cm/yr, which is comparable to Mesozoic-Cenozoic rates of ~6 cm/yr on average.Paleozoic global median values of trench migration trend from higher speeds(~2.5 cm/yr) in the late Devonian to rates closer to 0 cm/yr at the end of the Permian(~250 Ma), and during the Mesozoic-Cenozoic(250-0 Ma) generally cluster tightly around ~1.1 cm/yr. Plate motions are best constrained over the past 130 Myr and calculations of global trench convergence rates over this period indicate median rates range between 3.2 cm/yr and 12.4 cm/yr with a present day median rate estimated at~5 cm/yr. For Paleozoic times(410-251 Ma) our model results in median convergence rates largely~5 cm/yr. Globally,~90% of subduction zones modelled in our reconstruction are determined to be in a convergent regime for the period of 120-0 Ma. Over the full span of the model, from 410 Ma to 0 Ma,~93% of subduction zones are calculated to be convergent, and at least 85% of subduction zones are converging for 97% of modelled times. Our changes improve global plate and trench kinematics since the late Paleozoic and our reconstructions of the lowermost mantle structure challenge the proposed fixity of lower mantle structures, suggesting that the eastern margin of the African LLSVP margin has moved by as much as ~1450 km since late Permian times(260 Ma). The model of the plate-mantle system we present suggests that during the Permian Period, South China was proximal to the eastern margin of the African LLSVP and not the western margin of the Pacific LLSVP as previous thought. | Alexander Young Nicolas Flament Kayla Maloney Simon Williams Kara Matthews Sabin Zahirovic R.Dietmar Müller | 2019 | Geoscience Frontiers2019，10，3： | 10 |
| 2 | Role of functional imaging in the development and refinement of invasive neuromodulation for psychiatric disorders显示文摘Deep brain stimulation(DBS) is emerging as a pow-erful tool for the alleviation of targeted symptoms in treatment-resistant neuropsychiatric disorders. Despite the expanding use of neuropsychiatric DBS, the mecha-nisms responsible for its effects are only starting to be elucidated. Several modalities such as quantitative elec-troencephalography as well a intraoperative recordings have been utilized to attempt to understand the under-pinnings of this new treatment modality, but functional imaging appears to offer several unique advantages. Functional imaging techniques like positron emission tomography, single photon emission computed tomog-raphy and functional magnetic resonance imaging have been used to examine the effects of focal DBS on activ-ity in a distributed neural network. These investigations are critical for advancing the field of invasive neuro-modulation in a safe and effective manner, particularly in terms of defining the neuroanatomical targets and refining the stimulation protocols. The purpose of this review is to summarize the current functional neuroim-aging findings from neuropsychiatric DBS implantation for three disorders: treatment-resistant depression, obsessive-compulsive disorder, and Tourette syndrome. All of the major targets will be discussed(Nucleus ac-cumbens, anterior limb of internal capsule, subcallosal cingulate, Subthalamic nucleus, Centromedial nucleus of the thalamus-Parafasicular complex, frontal pole, and dorsolateral prefrontal cortex). We will also address some apparent inconsistencies within this literature, and suggest potential future directions for this promis-ing area. | Nolan R Williams Joseph J Taylor Kayla Lamb Colleen A Hanlon E Baron Short Mark S George | 2014 | World Journal of Radiology2014，6，10： | 6 |
| 3 | Transcriptomic analysis in Anemone flaccida rhizomes reveals ancillary pathway for triterpene saponins biosynthesis and differential responsiveness to phytohormones显示文摘Anemone flaccida Fr. Schmidt is a perennial medicinal herb that contains pentacyclic triterpenoid saponins as the major bioactive constituents. In China, the rhizomes are used as treatments for a variety of ailments including arthritis. However, yields of the saponins are low, and little is known about the plant's genetic background or phytohormonal responsiveness. Using one-quarter of the 454 pyrosequencing information from the Roche GS FLX Titanium platform, we performed a transcriptomic analysis to identify 157 genes putatively encoding 26 enzymes involved in the synthesis of the bioactive compounds. It was revealed that there are two biosynthetic pathways of triterpene saponins in A. flaccida. One pathway depends on β-amyrin synthase and is similar to that found in other plants. The second, subsidiary('backburner') pathway is catalyzed by camelliol C synthase and yields β-amyrin as minor byproduct. Both pathways used cytochrome P450-dependent monooxygenases(CYPs) and family 1 uridine diphosphate glycosyltransferases(UGTs) to modify the triterpenoid backbone. The expression of CYPs and UGTs were quite different in roots treated with the phytohormones methyl jasmonate, salicylic acid and indole-3-acetic acid. This study provides the first large-scale transcriptional dataset for the biosynthetic pathways of triterpene saponins and their phytohormonal responsiveness in the genus Anemone. | MO Guo-Yan HUANG Fang FANG Yin HAN Lin-Tao Kayla K.Pennerman BU Li-Jing DU Xiao-Wei Joan W.Bennett YIN Guo-Hua | 2019 | Chinese Journal of Natural Medicines2019，17，2： | 6 |
| 4 | Efficacy of Lycium barbarum polysaccharide in adolescents with subthreshold depression: interim analysis of a randomized controlled study显示文摘Subthreshold depression is a highly prevalent condition in adolescents who are at high risk for developing major depressive disorder.In preclinical models of neurological and psychiatric diseases,Lycium barbarum polysaccharide(LBP)extracted from Goji berries had antidepressant effects including but not limited to anti-oxidative and anti-inflammatory properties.However,the effect of LBP on subthreshold depression is unclear.To investigate the clinical efficacy and safety of LBP for treating subthreshold depression in adolescents,we conducted a randomized,double-blind,placebo-controlled trial(RCT)with 29 adolescents with subthreshold depression recruited at The Fifth Affiliated Hospital of Guangzhou Medical University.The participants were randomly assigned to groups where they received either 300 mg LBP(LBP group,n=15,3 boys and 12 girls aged 15.13±2.17 years)or a placebo(placebo group,n=14,2 boys and 12 girls aged 15±1.71 years)for 6 successive weeks.Interim analyses revealed that the LBP group exhibited a greater change in Hamilton Depression Scale(HAMD-24)scores relative to the baseline and a higher remission rate(HAMD-24 total score≤7)at 6 weeks compared with the placebo group.Scores on the Beck Depression Inventory-II(BDI-II),Pittsburgh Sleep Quality Index(PSQI),Kessler Psychological Distress Scale(Kessler),and Screen for Child Anxiety-Related Emotional Disorders(SCARED)were similar between the LBP and placebo groups.No side effects related to the intervention were reported in either group.These results indicate that LBP administration reduced depressive symptoms in adolescents with subthreshold depression.Furthermore,LBP was well tolerated with no treatment-limiting adverse events.Clinical trials involving a larger sample size are needed to further confirm the anti-depressive effects of LBP in adolescents with subthreshold depression.This study was approved by the Medical Ethics Committee of the Fifth Affiliated Hospital of Guangzhou Medical University(Guangzhou,China;approval No.L2019-08)on April 4,2019 and was registered on ClinicalTrials.gov(identifier:NCT04032795)on July 25,2019. | Xiaoyue Li Xuan Mo Tao Liu Robin Shao Kayla Teopiz Roger S.McIntyre Kwok-Fai So Kangguang Lin | 2022 | Neural Regeneration Research2022，17，7： | 6 |
| 5 | Targeted therapy for leptomeningeal metastases in non-small cell lung cancer-Changing treatment paradigms显示文摘Leptomeningeal metastasis is an uncommon but serious complication in patients with advanced cancers.Leptomeningeal metastasis is diagnosed in approximately 5% of the patients,most commonly among patients with cancers of breast and lung,melanoma,and gastrointestinal malignancies.Treatment goal is to improve survival and quality of the patients.Use of targeted therapies and immunotherapy has led to improved survival of patients with non-small cell lung cancer(NSCLC).In this article,we review emerging data on use of mutation-specific agents and immunotherapy in the treatment of leptomeningeal metastasis among patients with NSCLC. | Binay Kumar Shah Isaac Pak Nibash Budhathoki Kayla Buker | 2017 | Chinese Journal of Cancer Research2017，29，6： | 3 |
| 6 | Suppression of monosodium urate crystal-induced inflammation by inhibiting TGF-β-activated kinase 1-dependent signaling:role of the ubiquitin proteasome system显示文摘Monosodium urate(MSU)crystals activate inflammatory pathways that overlap with interleukin-1β(IL-1β)signaling.However,the post-translational mechanisms involved and the role of signaling proteins in this activation are unknown.In the present study,we investigated the intracellular signaling mechanisms involved in MSU-induced activation of THP-1 macrophages and human nondiseased synovial fibroblasts(NLSFs)and the in vivo efficacy of an inhibitor of tumor grovArth factor-β(TGF-β)-activated kinase 1(TAK1),5Z-7-oxozeaenoI,in MSU-induced paw inflammation in C57BL76 mice.THP-1 macrophage activation with MSU crystals(25-200 ng/ml)resulted in the rapid and sustained phosphorylation of interleukin-1 receptor-activated kinase 1(IRAK1 Thr^(209))and TAK1(Thr^(184/187))and their association with the E3 ubiquitin ligase TRAF6.At the cellular level,MSU inhibited the deubiquitinases A20 and UCHL2 and increased 20s proteasomal activity,leading to a global decrease in K^(63)-linked ubiquitination and increase in K^(48)-linked ubiquitination in THP-1 macrophages.While MSU did not stimulate cytokine produaion in NLSFs,it significantly amplified IL-1β-induced IL-6,IL-8,and ENA-78/CXCL5 production.Docking studies and MD simulations followed by TAK1 in vitro kinase assays revealed that uric acid molecules are capable of arresting TAK1 in an active-state conformation,resulting in sustained TAK1 kinase activation.Importantly,MSU-induced proinflammatory cytokine production was completely inhibited by 5Z-7-oxozeaenol but not IRAK1/4 or TRAF6 inhibitors.Administration of 5Z-7-oxozeaenol(5 or 15 mg/kg;orally)significantly inhibited MSU-induced paw inflammation in C57BL/6 mice.Our study identifies a novel post-translational mechanism of TAK1 activation by MSU and suggests the therapeutic potential of TAK1 in regulating MSU-induced Inflammation. | Anil K.Singh Mahamudul Haque Kayla O'Sullivan Mukesh Chourasia Madhu M.Ouseph Salahuddin Ahmed | 2021 | Cellular & Molecular Immunology2021，18，1： | 2 |
| 7 | Building the Internet of Things Using RFID: The RFID Ecosystem Experience显示文摘 | Welbourne Evan Battle Leilani Cole Garret Gould Kayla Rector Kyle Raymer Samuel Balazinska Magdalena Borriello Gaetano | 2009 | IEEE Internet Computing2009，，3： | 2 |
| 8 | Climate drives differences in the germination niche of a globally distributed invasive grass显示文摘外来入侵物种在入侵地经常面临很强的选择压力,这常常导致种内变异。在生活史事件发生的时间上,种群分化对气候梯度的响应被认为是促进许多入侵物种扩张的重要机制。对于产生种子的植物来说,种子萌发的时间决定了萌芽所经历的第一个环境条件,这对入侵植物的成功定植、种群建立和传播具有重要意义——尽管对于萌发在植物入侵成功中所起的作用仍然知之甚少。在本研究中,我们评估了入侵植物石茅(Sorghum halepense)在北美分布的10个种群的种子萌发在温度和降水梯度上的动态变化,以及这种变化是否与本地气候有关。种子被放置于一个较宽的温度范围(11-48℃)以及两个水分梯度处理中。我们发现,石茅的种子可以在很宽的温度范围下萌发,但在不同的种群中,种子萌发的比例随温度和水分的不同而有较大的变化。有证据表明,当石茅的生长范围从温暖的气候扩展到寒冷的气候时,种子萌发温度的生态位也同时发生了向低温的转变。我们的研究结果表明,石茅种子的萌发已经适应了当地的气候,使其在整个生长范围内的萌发最大化,这可能是其入侵新环境的一个重要贡献因素。 | Rebecca A.Fletcher Kayla M.Varnon Jacob N.Barney | 2020 | Journal of Plant Ecology2020，13，2： | 2 |
| 9 | Hepatitis B control in the World Health Organization’s Western Pacific Region: Targets, strategies, status显示文摘 | Karen Hennessey Jorge Mendoza-Aldana Benjamin Bayutas Kayla Mae Lorenzo-Mariano Sergey Diorditsa | 2013 | Vaccine2013，，： | 1 |
| 10 | Mesenchymal Stem Cells Transmigrate Between and Directly Through Tumor Necrosis Factor‐α‐Activated Endothelial Cells Via Both Leukocyte‐Like and Novel Mechanisms显示文摘 | Grace S. L. Teo James A. Ankrum Roberta Martinelli Sarah E. Boetto Kayla Simms Tracey E. Sciuto Ann M. Dvorak Jeffrey M. Karp Christopher V. Carman | 2012 | STEM CELLS2012，，11： | 1 |
| 11 | Challenges in the microbiological food safety of fresh produce:Limitations of post-harvest washing and the need for alternative interventions显示文摘Fresh produce(processed fruit and vegetables)continues to be the main source of foodborne illness outbreaks implicating pathogens such as Escherichia coli O157:H7,Salmonella,Listeria monocytogenes and human parasites(e.g.hepatitis A,Cyclospora).Previously,outbreaks were primarily limited to leafy greens,tomatoes,and cantaloupes,but more recently there has been a trend of more diverse produce types(e.g.cucumbers and papayas)being implicated.Although on-farm good agriculture practices(GAP)contribute to preventing pathogens entering the fresh produce chain,it cannot be relied upon completely due to the open nature of farming.As a consequence,there is an identified need for interventions that can remove field-acquired contamination,especially given fresh produce is eaten raw.In the following review,an overview of foodborne illness outbreaks linked to contaminated fresh produce will be described along with potential sources of contamination.Post-harvest washing that was once considered decontamination is now viewed as a high-risk cross-contamination point.The challenges in monitoring the post-harvest wash process will be discussed along with processing factors that need to be considered.A range of alternative,or supplemental,non-aqueous interventions will be described including irradiation,ultraviolet light,high hydrostatic pressure,gas phase(ozone and chlorine dioxide),and hydroxyl radicals generated through advanced oxidative process or gas plasma.All have been proved to be effective at pathogen control on the laboratory scale and are poised to enter commercial application.The current status of these alternative interventions along with challenges of integrating into commercial practice will be described. | Kayla Murray Fan Wu John Shi Sophia Jun Xue Keith Warriner | 2017 | Food Quality and Safety2017，1，4： | 1 |
| 12 | Development and deployment of an intemet based data management system for use by the Asthma Clinical Research Network显示文摘 | Curley RM Evam RL Kayla J | 2003 | Control Clint Trials2003，22，： | 1 |
| 13 | Type II diabetes promotes a myofibroblast phenotype in cardiac fibroblasts显示文摘 | Vennece Fowlkes Jessica Clark Charity Fix Brittany A. Law Mary O. Morales Xian Qiao Kayla Ako-Asare Jack G. Goldsmith Wayne Carver David B. Murray Edie C. Goldsmith | 2013 | Life Sciences2013，，11： | 1 |
| 14 | MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices 显示文摘 | Saunders WB Kayla JB George ED | 2005 | J Cell Sci2005，118，10： | 1 |
| 15 | A multicenter blinded study to evaluate KRAS mutation testing methodologies in the clinical setting 显示文摘 | Vicki Whitehall Kayla Tran Aarti mmapathy | 2009 | J Mol Diagnos2009，11，6： | 1 |
| 16 | Linking tree growth rate, damage repair, and susceptibility to a genus-specific pest infestation显示文摘Pest preference and subsequent susceptibility of a host individual is likely related to previous growth patterns in that host.Emerald ash borer(Agrilus planipennis Fairmaire)is a pestiferous beetle introduced to North America from Asia.While all species of ash are susceptible to attack,some individual trees appear to survive infestation.We selected ash trees in southeastern Michigan,collected cores and categorized trees as high tolerance to emerald ash borer attack(high overall health,low crown dieback),low tolerance(low overall health,high crown dieback)and intermediate tolerance(in-between the other categories).We artificially wounded trees and measured wound closure after 3 years.Ring width indices were not correlated between high and low tolerance trees.Regression slopes comparing growth and years were significantly different between the three tolerance categories,with high tolerance trees having the steepest slope.Wound closure was greatest in high tolerance trees.High tolerance trees demonstrating more rapid(steeper regression slope),consistent(lower variance),and effective(greater wound closure)growth.Those vigorously growing trees likely had more capacity to repair damage caused by emerald ash borer,leading to healthier trees in our categorization.Linking previous host growth patterns to health may have implications related to identifying individual trees potentially tolerant to attack. | Kayla N.Boyes Kathryn G.Hietala-Henschell Alexander P.Barton Andrew J.Storer Jordan M.Marshall | 2019 | Journal of Forestry Research2019，30，5： | 1 |
| 17 | Resistance of Neisseria gonorrhoeae to antimocrobial hydrophobic agents is modulated by the mtrRCDE efflux system 显示文摘 | Wubin P Brian G | 1995 | Microbiology1995，141，3： | 1 |
| 18 | MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices显示文摘 | Saundeers WB Kayla JB George ED | 2005 | J Cell Sci2005，118，10： | 1 |
| 19 | Short-term, daily intake of yogurt containing Bifidobacterium animalis ssp . lactis Bf-6 (LMG 24384) does not affect colonic transit time in women显示文摘 | Daniel J. Merenstein Frank D’Amico Caren Palese Alexander Hahn Jessy Sparenborg Tina Tan Hillary Scott Kayla Polzin Lore Kolberg Robert Roberts | 2013 | British Journal of Nutrition2013，，2： | 1 |
| 20 | Time to spur um culture conversion in mul2tidrug2resistant tuberculosis : predictors and relation2ship to t reatment outcome显示文摘 | Timot hy H Holtz MD Maya Steinberg PhD Steve Kammerer MBA Kayla F Laserson ScD Vija Riekstina MD Evija Zarovskska MD Vija Skripconaka MD Charles D Wells MD Vaira Leimane MD | 2006 | Annals of Internal Medicine2006，144，9： | 1 |
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