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| 1 | Optical coherence tomography angiography for the anterior segment显示文摘Optical coherence tomography angiography(OCTA)is a rapid and non-invasive technique for imaging vasculature in the eye.As OCTA can produce high-resolution cross-sectional images and allow depth-resolved analysis for accurate localization of pathology of interest,it has become a promising method for anterior segment imaging.Furthermore,OCTA offers a more patient-friendly alternative to the conventional invasive dye-based fluorescent angiography.However,conventional OCTA systems are typically designed and optimized for the posterior segment of the eye,and thus using OCTA for anterior segment imaging can present several difficulties and limitations.In this review,we summarized the recent developments and clinical applications in anterior segment OCTA(AS-OCTA)imaging,such as for the cornea,iris,sclera and conjunctiva.We also compared commercially available OCTA systems,discussed the limitations of adapting current OCTA technology for the anterior segment imaging,and proposed possible future directions for AS-OCTA systems.AS-OCTA provides potential for future clinical applications such as diagnosis of corneal and iris pathologies,pre-operative surgical planning,assessment of new antiangiogenic therapeutics or evaluation of limbal stem cell deficiency.With further development,OCTA for anterior segment imaging in the clinics may become common in the near future. | Wen Di Lee Kavya Devarajan Jacqueline Chua Leopold Schmetterer Jodhbir S.Mehta Marcus Ang | 2019 | Eye and Vision2019，6，1： | 9 |
| 2 | Optical coherence tomography angiography in diabetic retinopathy: a review of current applications显示文摘Background:Diabetic retinopathy(DR)is a leading cause of vision loss in adults.Currently,the standard imaging technique to monitor and prognosticate DR and diabetic maculopathy is dye-based angiography.With the introduction of optical coherence tomography angiography(OCTA),it may serve as a potential rapid,non-invasive imaging modality as an adjunct.Main text:Recent studies on the role of OCTA in DR include the use of vascular parameters e.g.,vessel density,intercapillary spacing,vessel diameter index,length of vessels based on skeletonised OCTA,the total length of vessels,vascular architecture and area of the foveal avascular zone.These quantitative measures may be able to detect changes with the severity and progress of DR for clinical research.OCTA may also serve as a non-invasive imaging method to detect diabetic macula ischemia,which may help predict visual prognosis.However,there are many limitations of OCTA in DR,such as difficulty in segmentation between superficial and deep capillary plexus;and its use in diabetic macula edema where the presence of cystic spaces may affect image results.Future applications of OCTA in the anterior segment include detection of anterior segment ischemia and iris neovascularisation associated with proliferative DR and risk of neovascular glaucoma.Conclusion:OCTA may potentially serve as a useful non-invasive imaging tool in the diagnosis and monitoring of diabetic retinopathy and maculopathy in the future.Future studies may demonstrate how quantitative OCTA measures may have a role in detecting early retinal changes in patients with diabetes. | Kai Yuan Tey Kelvin Teo Anna C.S.Tan Kavya Devarajan Bingyao Tan Jacqueline Tan Leopold Schmetterer Marcus Ang | 2019 | Eye and Vision2019，6，1： | 6 |
| 3 | Higher infliximab and adalimumab trough levels are associated with fistula healing in patients with fistulising perianal Crohn’s disease显示文摘BACKGROUND Tumor necrosis factor-alpha inhibitors,including infliximab and adalimumab,are effective medical treatments for perianal fistulising Crohn’s disease(CD),but not all patients achieve fistula healing.AIM To determine the correlation between perianal fistula healing and closure with infliximab and adalimumab trough levels.METHODS In this multicentre retrospective study conducted across four tertiary inflammatory bowel disease centres in Australia,we identified CD patients with perianal fistulae on maintenance infliximab or adalimumab who had a trough level within twelve weeks of clinical assessment.Data collected included demographics,serum infliximab and adalimumab trough levels(mg/L)within 12 wk before or after their most recent clinical assessment and concomitant medical or surgical therapy.The primary outcome was fistula healing,defined as cessation in fistula drainage.The secondary outcome was fistula closure,defined as healing and closure of all external fistula openings.Differences between patients who did or did not achieve fistula healing were compared using the chi-square test,t test or Mann-Whitney U test.RESULTS One hundred and fourteen patients(66 infliximab,48 adalimumab)were included.Forty-eight(72.7%)patients on maintenance infliximab achieved fistula healing and 18(27.3%)achieved fistula closure.Thirty-seven(77%)patients on maintenance adalimumab achieved fistula healing and 17(35.4%)achieved fistula closure.Patients who achieved fistula healing had significantly higher infliximab and adalimumab trough levels than patients who did not[infliximab:6.4(3.8-9.5)vs 3.0(0.3-6.2)mg/L,P=0.003;adalimumab:9.2(6.5-12.0)vs 5.4(2.5-8.3)mg/L,P=0.004].For patients on infliximab,fistula healing was associated with lower rates of detectable anti-infliximab antibodies and younger age.For patients on adalimumab,fistula healing was associated with higher rates of combination therapy with an immunomodulator.Serum trough levels for patients with and without fistula closure were not significantly different for infliximab[6.9(4.3-10.2)vs 5.5(2.5-8.3)mg/L,P=0.105]or adalimumab[10.0(6.6-12.0)vs 7.8(4.2-10.0)mg/L,P=0.083].CONCLUSION Higher maintenance infliximab and adalimumab trough levels are associated with perianal fistula healing in CD. | Bonita Gu Kavya Venkatesh Astrid-Jane Williams Watson Ng Crispin Corte Ali Gholamrezaei Simon Ghaly Wei Xuan Sudarshan Paramsothy Susan Connor | 2022 | World Journal of Gastroenterology2022，28，23： | 2 |
| 4 | Ameliorative effect of Koflet formulations against pyridine-induced pharyngitis in rats 显示文摘 | Viswanatha C L Rafiq M Thippeswamy A H M Yuvaraj H C Kavya K J Mirza R B Suryakant A Mohammed A Patki P S Pushpalatha H B Prafulla S C Shyam R | 2014 | Toxicology Reports2014，1，： | 1 |
| 5 | Nitric oxide synthase regulation and diversity: implications in Parkinson' s dis- ease显示文摘 | Kavya R Saluja R Singh S | 2006 | Nitric Oxide2006，15，4： | 1 |
| 6 | Synthesis and characterization of chitosan/chondroitin sulfate/nano- SiOz composite scaffold for bone tissue engineering 显示文摘 | KAVYA K C DIXIT R JAYAKUMAR R | 2012 | J Bi- omed Nanotechnol2012，8，1： | 1 |
| 7 | Advances in Functionalized Ionic Liquids as Reagents and Scavengers in Organic Synthesis显示文摘 | Manoj K Muthyala Kavya Velisetti | 2014 | Curr Ore Chem2014，15，19： | 1 |
| 8 | Modifications of Cell Signalling and Redox Balance by Targeting Protein Acetylation Using Natural and Engineered Molecules: Implications in Cancer Therapy显示文摘 | Kavya Venkateswaran Amit Verma Anant N. Bhatt Paban K. Agrawala Hanumantharao G. Raj Shashwat Malhotra Ashok K. Prasad Olivier De Wever Marc E. Bracke Luciano Saso Virinder S. Parmar Anju Shrivastava B.S. Dwarakanath | 2014 | Current Topics in Medicinal Chemistry2014，，22： | 1 |
| 9 | Nitric oxide synthase regulation and diversity: implications in Parkinson's disease显示文摘 | Kavya R Saluja R Singh S Dikshit M | 2006 | Nitric Oxide2006，15，4： | 1 |
| 10 | A Survey on Methods, Attacks and Metric for Privacy Preserving Data Publishing 显示文摘 | Kiran P Kavya N P | 2012 | International Journal of Computer Applications2012，53，18： | 1 |
| 11 | Comparative study of two doses of intrathecal dexmedetomidine as adjuvant with low dose hyperbaric bupivacaine in ambulatory perianal surgeries:A prospective random- ised controlled study 显示文摘 | Sudheesh K Rao RR Kavya M | 2015 | Indian J Anaesth2015，59，10： | 1 |
| 12 | Fine tuning the role of cultures in today's cheese making显示文摘 | Kavya M Anjani | 2002 | Innovations in dairy2002，，5： | 1 |
| 13 | Synthesisand in-vitro Cytotoxicity Evaluation of Gatifloxacin MannichBases显示文摘 | YOGEESWARI P SRIRAM D KAVYA R | 2005 | Biochemical Pharmacology2005，59，9： | 1 |
| 14 | Bacterial Diversity and Bioprospecting for Cold-Active Lipases, Amylases and Proteases, from Culturable Bacteria of Kongsfjorden and Ny-?lesund, Svalbard, Arctic显示文摘 | T. N. R. Srinivas S. S. S. Nageswara Rao P. Vishnu Vardhan Reddy M. S. Pratibha B. Sailaja B. Kavya K. Hara Kishore Z. Begum S. M. Singh S. Shivaji | 2009 | Current Microbiology2009，，5： | 1 |
| 15 | Raltegra- vir, elvitegravir, and metoogravir: the birth of 'me-too' HIV-1 integrase inhibitors显示文摘 | Erik Serrao Srinivas Odde Kavya Ramkumar | 2009 | Retrovirology2009，6，： | 1 |
| 16 | Fine tuning the role of cultures in today's cheese making显示文摘 | Ms Kavya Anjan | 2002 | Innovations in dairy2002，，5： | 1 |
| 17 | Synthesis and characterization of ehitosan/chondroitin sulfate/nano- SiO2 composite scaffold for bone tissue engineering 显示文摘 | Kavya K C Jayakumar B Nair S V | 2013 | Int J Biol Macromol2013，59，3： | 1 |
| 18 | Physicochemical and nanostrnctural properties of gelatin from uneconomical marine cornet fish (Fistularia petimba)显示文摘 | NAZEER R A KAVYA M DEEPTHI | 2013 | Food Science2013，22，1： | 1 |
| 19 | Salivary total protein, sialic acid, lipid peroxidation and glutathione in oral squamous cell carcinoma显示文摘 | Shivashankara AR Kavya Prabhu M | 2011 | Biomed Res2011，22，3： | 1 |
| 20 | Synthesis and invitro cytotoxicity evaluation of gatifloxacin Mannieh bases显示文摘 | Yogeeswari P Sriram D Kavya R | 2005 | BiomedPharmacother2005，59，9： | 1 |
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