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| 1 | Bitter melon: a panacea for inflammation and cancer显示文摘Nature is a rich source of medicinal plants and their products that are useful for treatment of various diseases and disorders. Momordica charantia, commonly known as bitter melon or bitter gourd, is one of such plants known for its biological activities used in traditional system of medicines. This plant is cultivated in all over the world, including tropical areas of Asia, Amazon, east Africa, and the Caribbean and used as a vegetable as well as folk medicine. All parts of the plant, including the fruit, are commonly consumed and cooked with different vegetables, stir-fried, stuffed or used in small quantities in soups or beans to give a slightly bitter flavor and taste. The plant is reported to possess anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, anti-bacterial, anti-obesity, and immunomodulatory activities. The plant extract inhibits cancer cell growth by inducing apoptosis, cell cycle arrest, autophagy and inhibiting cancer stem cells. The plant is rich in bioactive chemical constituents like cucurbitane type triterpenoids, triterpene glycosides, phenolic acids, flavonoids, essential oils, saponins, fatty acids, and proteins. Some of the isolated compounds(Kuguacin J, Karaviloside XI, Kuguaglycoside C, Momordicoside Q-U, Charantin, α-eleostearic acid) and proteins(α-Momorcharin, RNase MC2, MAP30) possess potent biological activity. In the present review, we are summarizing the anti-oxidant, anti-inflammatory, and anti-cancer activities of Momordica charantia along with a short account of important chemical constituents, providing a basis for establishing detail biological activities of the plant and developing novel drug molecules based on the active chemical constituents. | Prasad R. Dandawate Dharmalingam Subramaniam Subhash B. Padhye Shrikant Anant | 2016 | Chinese Journal of Natural Medicines2016，14，2： | 14 |
| 2 | MicroRNA-99a mimics inhibit M1 macrophage phenotype and adipose tissue inflammation by targeting TNFα显示文摘In human adipose tissue and obesity,miR-99a expression is negatively correlated with inflammation.Therefore,the present study investigated the role of miR-99a in macrophage phenotype activation and adipose tissue inflammation.M2 BMDMs showed a significant increase in miR-99a expression when compared to the M0 and M1 phenotypes.Phenotype-switching experiments established an association between upregulated miR-99a expression and the M2 phenotype.Overexpression of miR-99a prevented M1 phenotype activation and attenuated bactericidal activity.Likewise,knockdown of miR-99a abolished M2 phenotype activation.By means of in silico target prediction tools and a luciferase reporter assay,TNFαwas identified as a direct target of miR-99a.Knockdown of TNFαrecapitulated the effect of miR-99a overexpression in M1 BMDMs.In a db/db mice model,miR-99a expression was reduced in eWAT and F4/80+ATMs.Systemic overexpression of miR-99a in db/db mice attenuated adipocyte hypertrophy with increased CD301 and reduced CD86 immunostaining.Flow cytometry analysis also showed an increased M2 and a reduced M1 macrophage population.Mimics of miR-99a also improved the diabetic dyslipidemia and insulin signaling in eWAT and liver,with an attenuated expression of gluconeogenesis and cholesterol metabolism genes in the liver.Furthermore,adoptive transfer of miR-99a-overexpressing macrophages in the db/db mice recapitulated in vivo miR-99a mimic effects with increased M2 and reduced M1 macrophage populations and improved systemic glucose,insulin sensitivity,and insulin signaling in the eWAT and liver.The present study demonstrates that miR-99a mimics can regulate macrophage M1 phenotype activation by targeting TNFα.miR-99a therapeutics in diabetic mice reduces the adipose tissue inflammation and improves insulin sensitivity. | Anant Jaiswal Sukka Santosh Reddy Mohita Maurya Preeti Maurya Manoj Kumar Barthwal | 2019 | Cellular & Molecular Immunology2019，16，5： | 7 |
| 3 | Analyzing hydro abrasive erosion in Kaplan turbine:A case study from India显示文摘Sediment flow through hydro turbine causes erosion of hydraulic components resulting in drop of turbine efficiency, particularly in hydropower plants of the Himalayan region. The measurement of erosion and monitoring of sediment flow in turbine are major concerns in erosion study. Attempts have been made to study erosion mainly in Pelton and Francis turbines. In this study, a simple and effective method has been presented to measure erosion in a Kaplan turbine of a run-of-river scheme Chilla hydropower plant in foothills of Himalaya. Recent techniques were used to measure sediment parameters like concentration, size, shape and mineral content. A standard erosion model is applied to estimate the erosion in Kaplan turbine blade, runner chamber and draft tube cone. A calibration factor has been proposed to apply the erosion model for site specific conditions. It has been found that the outer trailing edges of the turbine blade and upper runner chamber are most erosion prone zones. Sediment analysis revealed that effective operation can reduce erosion in turbine components. The estimated erosion values from model are found to be consistent with measured values. Finally, suggestions for design improvements and effective operation of erosion affected hydropower plants are given. | Anant Kr.RAI Arun KUMAR | 2016 | Journal of Hydrodynamics2016，28，5： | 6 |
| 4 | 山嵛酸甘油酯在药剂学中的应用显示文摘山嵛酸甘油酯是一类多用途的长链脂肪酸甘油酯,具有优良的生物相容性,广泛应用于食品、药品和化妆品领域。本文以Gattefosse的产品Compritol 888 ATO为例,从口服给药、注射给药和局部给药三个方面综述山嵛酸甘油酯在药剂学中的应用和研究进展。 | 张伟 贺小玲 杨怡静 Anand Kulkarni Deepak Anant Hegde 涂家生 | 2012 | 药学与临床研究2012，20，6： | 5 |
| 5 | Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward?显示文摘 | Bhushan Patwardhan Raghunath Anant Mashelkar | 2009 | Drug Discovery Today2009，，15： | 2 |
| 6 | Aggressive Approach to Staghorn Calculi—Safety and Efficacy of Multiple Tracts Percutaneous Nephrolithotomy显示文摘 | Manish Singla Aneesh Srivastava Rakesh Kapoor Nitin Gupta Mohd S. Ansari Deepak Dubey Anant Kumar | 2008 | Urology2008，，6： | 2 |
| 7 | 认知无线电的主要限制显示文摘认知无线电指的是通信系统不是工作在一个固定的频段中,而是能自动搜寻一个合适的频段并在该频段上进行通信的体系结构。本文将从基本原理的角度探讨认知无线电系统为避免干扰其工作频段上可能存在的授权用户而要满足的基本要求。首先指出,为了能达到实际应用,认知无线电系统必须能够检测到无法解码的信号。接着说明如何权衡非授权用户的权限、可用空间和主营接收机干扰保护之间的关系。我们证明了在通常情况下,从一个已知零均值星座中检测微弱未知信号的最佳检测器是能量检测器(辐射计)。但是我们发现,已知的导频信号可以起到很大的帮助。因为仅仅在中等噪声不确定性的影响下,辐射计就会失去作用,因此我们又进一步强调对导频信号的需要。最后我们指出了包含不确定性噪声的量化分析,在低于一定的信噪比闽值时,任何检测器都绝对不可能检测到信号。 | Anant Sahai Niels Hoven Rahul Tandra 黄雅铮(译) 唐秀玲(审校) 楼财义(审校) | 2006 | 通信对抗2006，，4： | 2 |
| 8 | Assessment of quadriceps muscle thickness using bedside ultrasonography by nurses and physicians in the intensive care unit:Intra- and inter-operator agreement显示文摘BACKGROUND Data regarding the agreement among multiple operators for measurement of quadriceps muscle thickness by bedside ultrasonography(USG)are sparse.AIM To statistically assess the agreement among 5 operators for measurement of quadriceps muscle thickness on bedside USG.METHODS This was a cross-sectional observational study.The 5 operators of varied experience(comprised of 1 critical care consultant,2 fellows,and 2 nurses)independently measured quadriceps muscle thickness in triplicate for 45 critically ill patients each,using USG.Intra-and interrater agreement rates among the 5 operators were assessed using intraclass correlation coefficient(ICC)and expressed with 95%confidence interval(CI).RESULTS The 5 operators produced a total of 135 readings and 675 observations for ICC calculations to determine the intraoperator and interoperator variations respectively.For intraoperator agreement,the overall ICC(95%CI)was 0.998(0.997,0.999)for operator 1,0.998(0.997,0.999)for operator 2,0.997(0.995,0.999)for operator 3,0.999(0.998,0.999)for operator 4,and 0.998(0.997,0.999)for operator 5.For interoperator agreement,the overall ICC(95%CI)was 0.977(0.965,0.986;P<0.001)for reading 1,0.974(0.960,0.984;P<0.001)for reading 2,and 0.975(0.961,0.985;P<0.001)for reading 3.CONCLUSION USG measurement of quadriceps muscle thickness was not dependent on clinical experience,supporting training for nurses in it. | Rohit Kumar Tajamul Hussain Shah Vijay Hadda Pawan Tiwari Saurabh Mittal Karan Madan Maroof Ahmad Khan Anant Mohan | 2019 | World Journal of Critical Care Medicine2019，8，7： | 2 |
| 9 | In union lies strength: Collaborative competence in new product development and its performance effects显示文摘 | Anant A. Mishra Rachna Shah | 2008 | Journal of Operations Management2008，，4： | 2 |
| 10 | ASchum perian Model of the Product Life Cycle显示文摘 | Segerst rom P Anant T and Dinopoulos E | 1990 | American Economic Review1990，，12： | 1 |
| 11 | Knockdown of RNA Binding Protein Musashi-1 Leads to Tumor Regression In Vivo显示文摘 | Sripathi M. Sureban Randal May Robert J. George Brian K. Dieckgraefe Howard L. McLeod Satish Ramalingam Kumar S. Bishnupuri Gopalan Natarajan Shrikant Anant Courtney W. Houchen | 2008 | Gastroenterology2008，，5： | 1 |
| 12 | Seismic Analysis of Steel Braced Reinforced Concrete Frames显示文摘 | Viswanath K G Prakash K B Anant Desai | 2010 | In- ternational Journal of Civil and Structure Engineering2010，1，1： | 1 |
| 13 | Melt sonocrystallization of ibuprofen: Effect on crystal properties显示文摘 | Maheshwari Manish Jabagirdar Harshal Paradkar Anant | 2005 | Eur J Pharm Sci2005，，25： | 1 |
| 14 | Specific Expression of Activation-induced Cytidine Deaminase (AID),a novel member of the RNA-editing deaminase family in germinal center B cells显示文摘 | Muramatsu M Sankaranand V S Anant S | 1999 | Cell1999，274，18： | 1 |
| 15 | C--> U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type Ⅱ transcript and apobec-1,the catalytic subunit of the apolipoprotein B mRNA -editing enzyme显示文摘 | Mukhopadhyay D Anant S Lee RM | 2002 | Am J Hum Genet2002，70，1： | 1 |
| 16 | 提高悬浮浸渍开孔泡沫Inconel 625高温合金的烧结动力学和成分均匀性显示文摘采用悬浮液浸渍法制备开孔泡沫Inconel 625高温合金,先用混合粉末悬浮液复制纯镍泡沫带,然后进行热处理。本研究的目的是寻找一种合适的方法,在不使用低熔点添加剂的情况下,确保泡沫高温合金带的完全致密化,并在适中的烧结温度下获得均匀的化学成分。通过扫描电子显微镜和能谱仪对上述方法制备的泡沫带的显微组织和成分变化进行表征,并对其准静态压缩性能进行评估。结果表明,用Cr、Mo和Ni元素粉末作为高温合金粉末悬浮液的添加剂,在适中的烧结温度下,可获得化学成分均匀、密度高、符合Inconel 625标准的高温合金粉末悬浮液。这是因为低熔点共晶的形成,以及存在元素粉末时大的成分梯度所产生的非平衡热力学条件加速了扩散动力学。 | Oleg SMORYGO Vitali MIKUTSKI Anastasia VAZHNOVA Viachaslau HANCHAROU Serguei TIKHOV Vinod Kumar JANAGAM Amol Anant GOKHALE | 2021 | Transactions of Nonferrous Metals Society of China2021，31，8： | 1 |
| 17 | Comparative evaluation of successive extracts of leaf and stem bark of Albizzia lebbeck for mast cell stabilization activity显示文摘 | S. Shashidhara Anant V. Bhandarkar M. Deepak | 2008 | Fitoterapia2008，，4： | 1 |
| 18 | A schumpeterian model of the product life cycle显示文摘 | Segerstrom P T Anant E Dinopoulos | 1990 | American Economic Review1990，80，： | 1 |
| 19 | The Purpose and Accountability of The Corporation in Contemporary Society: Corporate Governance at A Crossroads显示文摘 | Michael Bradley Cindy A Schipane Anant K Sundaram | 1999 | Law and Contemporary Problems1999，62，3： | 1 |
| 20 | Three-dimensional characterization of optical coherence tomography point spread functions with a nanoparticle-embedded phantom 显示文摘 | Agrawal Anant Prefer T Joshua Gilani Naureen | 2010 | Optics Letters(S0146-9592)2010，35，13： | 1 |
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