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| 1 | Optical coherence tomography angiography for the anterior segment显示文摘Optical coherence tomography angiography(OCTA)is a rapid and non-invasive technique for imaging vasculature in the eye.As OCTA can produce high-resolution cross-sectional images and allow depth-resolved analysis for accurate localization of pathology of interest,it has become a promising method for anterior segment imaging.Furthermore,OCTA offers a more patient-friendly alternative to the conventional invasive dye-based fluorescent angiography.However,conventional OCTA systems are typically designed and optimized for the posterior segment of the eye,and thus using OCTA for anterior segment imaging can present several difficulties and limitations.In this review,we summarized the recent developments and clinical applications in anterior segment OCTA(AS-OCTA)imaging,such as for the cornea,iris,sclera and conjunctiva.We also compared commercially available OCTA systems,discussed the limitations of adapting current OCTA technology for the anterior segment imaging,and proposed possible future directions for AS-OCTA systems.AS-OCTA provides potential for future clinical applications such as diagnosis of corneal and iris pathologies,pre-operative surgical planning,assessment of new antiangiogenic therapeutics or evaluation of limbal stem cell deficiency.With further development,OCTA for anterior segment imaging in the clinics may become common in the near future. | Wen Di Lee Kavya Devarajan Jacqueline Chua Leopold Schmetterer Jodhbir S.Mehta Marcus Ang | 2019 | Eye and Vision2019，6，1： | 9 |
| 2 | Optical coherence tomography angiography in diabetic retinopathy: a review of current applications显示文摘Background:Diabetic retinopathy(DR)is a leading cause of vision loss in adults.Currently,the standard imaging technique to monitor and prognosticate DR and diabetic maculopathy is dye-based angiography.With the introduction of optical coherence tomography angiography(OCTA),it may serve as a potential rapid,non-invasive imaging modality as an adjunct.Main text:Recent studies on the role of OCTA in DR include the use of vascular parameters e.g.,vessel density,intercapillary spacing,vessel diameter index,length of vessels based on skeletonised OCTA,the total length of vessels,vascular architecture and area of the foveal avascular zone.These quantitative measures may be able to detect changes with the severity and progress of DR for clinical research.OCTA may also serve as a non-invasive imaging method to detect diabetic macula ischemia,which may help predict visual prognosis.However,there are many limitations of OCTA in DR,such as difficulty in segmentation between superficial and deep capillary plexus;and its use in diabetic macula edema where the presence of cystic spaces may affect image results.Future applications of OCTA in the anterior segment include detection of anterior segment ischemia and iris neovascularisation associated with proliferative DR and risk of neovascular glaucoma.Conclusion:OCTA may potentially serve as a useful non-invasive imaging tool in the diagnosis and monitoring of diabetic retinopathy and maculopathy in the future.Future studies may demonstrate how quantitative OCTA measures may have a role in detecting early retinal changes in patients with diabetes. | Kai Yuan Tey Kelvin Teo Anna C.S.Tan Kavya Devarajan Bingyao Tan Jacqueline Tan Leopold Schmetterer Marcus Ang | 2019 | Eye and Vision2019，6，1： | 6 |
| 3 | Vessel density and En-face segmentation of optical coherence tomography angiography to analyse corneal vascularisation in an animal model显示文摘Background:Optical coherence tomography angiography(OCTA)is a novel non-invasive angiography technology that has recently been extensively studied for its utility in anterior segment imaging.In this study,we compared a split-spectrum amplitude decorrelation angiography(SSADA)OCTA and an optical micro-angiography(OMAG SD)OCTA system to current angiographic technique,indocyanine green angiography(ICGA),to assess corneal vascularisation in an animal model.Methods:We imaged 16 rabbits,(one eye per animal)with corneal vascularisation using SSADA OCTA(AngioVue;Optovue Inc.,USA),OMAG OCTA(Angioscan;RS-3000 Nidek Co.Ltd.,Japan)and ICGA in the same region of interest of the cornea at successive time-points.We then analysed all scanned images for vessel density measurements and used paired t-tests and Bland-Altman plots to examine for significant differences.The en-face segmentation images from each of the OCTA scans were also extracted and were matched at every 50μm segmentation to be compared for vessel density at the respective depths.Results:Bland-Altman plots revealed a good agreement between all three imaging techniques(P>0.05)for all vessel density measurements computed,and the ranges of 95%limit of agreement were acceptable from a clinical perspective.No significant difference was reported,with ICGA(μ=16.52±8.94%)being more comparable to the OMAG OCTA(μ=16.23±9.51%;p=0.50)than the SSADA OCTA(μ=17.09±7.34%;p=0.33)system.Also,a good correlation value(r>0.9)was obtained when comparing the vessel density measurements of the en-face segmentations between the OCTA systems.Conclusions:Comparable vessel density quantification between the two OCTA systems,and with ICGA was obtained.Segmentation analysis of the vasculature at different depths showed varied performance in the two OCTA systems relative to each other.The implications of the study may help to aid in the development of better OCTA algorithms for the anterior segment and its use in clinical translational research. | Kavya Devarajan Wen Di Lee Hon Shing Ong Nyein C.Lwin Jacqueline Chua Leopold Schmetterer Jodhbir S.Mehta Marcus Ang | 2019 | Eye and Vision2019，6，1： | 0 |
| 4 | Correction to: Vessel density and En-face segmentation of optical coherence tomography angiography to analyse corneal vascularisation in an animal model显示文摘In the original publication of this article[1]the algorithm of the OCTA(Nidek RS-3000)was described incorrectly as OMAG(Optical micro angiography).However,the system uses CODAA(Complex OCT signal difference angiography).Thus,‘OMAG’in the article should be replaced with‘CODAA’,and‘Optical micro angiography’should be replaced with‘Complex OCT signal difference angiography’! | Kavya Devarajan Wen Di Lee Hon Shing Ong Nyein CLwin Jacqueline Chua Leopold Schmetterer Jodhbir S.Mehta Marcus Ang | 2019 | Eye and Vision2019，6，1： | 0 |
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