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| 1 | Single small molecule-assembled nanoparticles mediate efficient oral drug delivery显示文摘Oral drug delivery,which requires surviving the harsh environment in the gastrointestinal(Gl)tract and penetrating the intestinal epithelium,has not bee n achieved using simple formulatio n nan oparticles(NPs).Medici nal natural products(MNPs)have bee n widely used in traditi onal medicine for disease management through oral consumption.However,most pharmacologically active compounds within MNPs do not have the properties suitable for oral applicatio ns.We hypothesize that some MNPs contain n atural nano materials that can convert those compounds into oral formulations by forming NPs.After screening 66 MNPs,we identified five classes of small molecules that form NPs,many of which are capable of efficient drug encapsulation and Gl penetration.We show that one of them,dehydrotrametenolic acid(DTA),is capable of mediating oral delivery for effective disease treatment.We determined that DTA NPs assemble through hydrogen bonding and penetra怕the Gl tract via apical sodium-depe ndent bile acid tran sporter.Our study reveals a no vel class of single comp orient,small molecule-assembled NPs for oral drug delivery,and suggests a n ovel approach to modernizi ng MNPs through nano material discovery. | Xin Yang Chao Ma Zeming Chen Jun Liu Fuyao Liu Rongbin Xie Haitian Zhao Gang Deng Ann TChen Ningbo Gong Lei Yao Pengjian Zuo Kangkang Zhi Jiacheng Wang Xiaobin Gao Jing Wang Louzhen Fan Jiangbing Zhou | 2019 | Nano Research2019，12，10： | 4 |
| 2 | Electrochemically-driven interphase conditioning of magnesium electrode for magnesium sulfur batteries显示文摘The earth-abundant magnesium metal is a kind of promising anode material due to its low reduction potential (-2.356V vs. SHE), high volumetric and gravimetric specific capacities of 3882 mAh cm-3 and 2234 mAh g_1 respectively [1]. Moreover, the magnesium anode shows high safety due to the non-dentritic electrodeposition mechanism during cycling, which is related to the strong Mg-Mg bonding and the consequent high energy barrier between the crystal boundaries of different crystal orientation [2]. | Yaqi Li Pengjian Zuo Ruinan Li Mengxue He Yulin Ma Yingxin Shi Xinqun Cheng Chunyu Du Geping Yin | 2019 | Journal of Energy Chemistry2019，28，10： | 1 |
| 3 | Tuning the phase evolution pathway of LiNi_(0.5)Mn_(1.5)O_(4) synthesis from binary intermediates to ternary intermediates with thermal regulating agent显示文摘Transition metal cation ordering is essential for controlling the electrochemical performance of cubic spinel LiNi_(0.5)Mn_(1.5)O_(4)(LNMO),which is conventionally adjusted by optimizing the high temperature sintering and annealing procedures.In this present work,multiple characterization techniques,including 6,7Li NMR,XRD and HRTEM,have been combined to trace the phase transformation and morphology evolution during synthesis.It has been illustrated that simultaneous formation of LiMn_(2)O_(4)(LMO)and LiNiO_(2)(LNO)binary oxides and their conversion into highly reactive LixNi^(3+)_(y)Mn_(3.5+)_(z)O ternary intermediate is a thermal dynamically difficult but crucial step in the synthesis of LNMO ternary oxide.A new strategy of modifying the intermediates formation pathway from binary mode to ternary mode using thermal regulating agent has been adopted.LNMO synthesized with thermal regulating agent exhibits supreme rate capability,long-cycling performance(even at elevated temperature)and excellent capacity efficiency.At a high rate of 100 C,the assembled battery delivers a discharge capacity of 99 mAh g^(-1).This study provides a way to control the formation pathway of complex oxides using thermal regulating agent. | Libin Wu Hua Huo Qun Wang Xucai Yin Shu Guo Jiajun Wang Chunyu Du Pengjian Zuo Geping Yin Yunzhi Gao | 2022 | Journal of Energy Chemistry2022，31，2： | 1 |
| 4 | Effects of fluoroethylene carbonate on low temperature performance of mesocarbon microbeads anode显示文摘 | Liao Lixia Zuo Pengjian Ma Yongxin | | 0，，： | 1 |
| 5 | A phosphorous additive for lithium-ion batteries 显示文摘 | Ma Yulin Yin Geping Zuo Pengjian | 2008 | Eleetrochem Solid State Lett2008，11，8： | 1 |
| 6 | Effects of temperature on charge/discharge behaviors of LiFePO4 cathode for Li-ion batteries 显示文摘 | LIAO Lixia ZUO Pengjian MA Yulin | 2012 | Eleetrochim Acta2012，60，1： | 1 |
| 7 | Electrochemical stability of silicon/carbon composite anode for lithium ion batteries显示文摘 | Pengjian Zuo Geping Yin Yulin Ma | 2007 | Electrochimica Acta2007，，15： | 1 |
| 8 | Highly efficient and stable nonplatinum anode catalyst with Au@Pd core–shell nanostructures for methanol electrooxidation显示文摘 | Qiang Tan Chunyu Du Geping Yin Pengjian Zuo Xinqun Cheng Meng Chen | 2012 | Journal of Catalysis2012，，： | 1 |
| 9 | Electrochemical stability of silicon/carbon composite anode for lithium ion batteries显示文摘 | ZUO Pengjian YIN Geping MA Yulin | 2007 | Eectroehimica Acta2007，52，： | 1 |
| 10 | A bifunctional perovskite oxide catalyst:The triggered oxygen reduction/evolution electrocatalysis by moderated Mn-Ni co-doping显示文摘ABO_(3)-type perovskite oxides(e.g.,LaCoO_(3))with flexible and adjustable A-and B-sites are ideal model catalysts to unravel the relationship between the electronic structure and electrocatalytic activity(e.g.,oxygen reduction/evolution reactions,ORR/OER).It has been well understood in our recent work that the secondary metal dopant at B-site(e.g.,Mn in LaMn_(x)Co_(1-x)O_(3))can regulate the electronic structure and improve the ORR/OER activity.In this work,the Mn-Ni pairs are employed as the dual dopant in LaMn_(x)Ni_(y)Co_(z)O_(3)(x+y+z=1)catalysts toward bifunctional ORR and OER.The structure-property relationships between the triple metal B-site(Mn,Ni and Co)and the electrochemical performance are particularly investigated.Compared to the individual Mn doping(e.g.,LaMnCoO3(Mn:Co=1:3)catalyst),the dual Mn-Ni doping significantly improves the ORR mass activity@0.8 V by 1.54 times;meanwhile,the OER overpotential@10 mA cm^(-2) is reduced from 420 to 370 mV,and the OER current density at 1.55 V is increased by 2.43 times.Reasonably,the potential gap between EDRR@-1 mA cm^(-2) and EDER@10 mA cm^(-2) is achieved as only 0.76 V by using the optimal LaMn_(x)Ni_(y)Co_(z)O_(3)(x:y:z=1:2:3)catalyst.It is revealed that the dual Mn-Ni dopant efficiently optimizes electron structures of the LaMnNiCoO_(3)(1:2:3)catalyst,which not only decreases the e_(g) orbital electron number,but also modulates the O 2 p-band closer to the Femi level,accounting for the enhanced bifunctional activity. | Jia Sun Lei Du Baoyu Sun Guokang Han Yulin Ma Jiajun Wang Hua Huo Pengjian Zuo Chunyu Du Geping Yin | 2021 | Journal of Energy Chemistry2021，30，3： | 1 |
| 11 | Fluoroethylene carbonate as electrolyte additive to improve low temperature performance of LiFePO 4 electrode显示文摘 | Lixia Liao Xinqun Cheng Yulin Ma Pengjian Zuo Wei Fang Geping Yin Yunzhi Gao | 2013 | Electrochimica Acta2013，，： | 1 |
| 12 | Effects of fluoroethylene carbonate on low temperature performance of mesocarbon microbeads anode显示文摘 | Lixia Liao Pengjian Zuo Yulin Ma Yongxin An Geping Yin Yunzhi Gao | 2012 | Electrochimica Acta2012，，： | 1 |
| 13 | Stabilizing electrode-electrolyte interface for high-performance SiO_(x) anode by dual electrolyte additive显示文摘Macro-and micro-interface instability of SiO_(x)anode caused by its dramatic volume variation during cycling will result in low Coulombic efficiency and rapid capacity degradation.In this work,an organic-inorganic composite interfacial layer rich in benzene ring groups,polyisocyanates,and LiF was obtained on SiO_(x)anode by the introduction of 4-fluorophenyl isocyanate(FPI)and fluoroethylene carbonate(FEC)co-additives in electrolyte.The SiO_(x)anode material shows a capacity retention of 69.2%after 100 cycles at a current density of 1 A g^(-1)and rate capacity of 523 m A h g^(-1)at the current density of 3A g^(-1),while the SiO_(x)anode cycling in reference electrolyte has almost no capacity. | Renlong Li Binghan Cui Qingjie Zhou Xue Mu Yunzhi Gao Geping Yin Chuankai Fu Pengjian Zuo | 2023 | Journal of Energy Chemistry2023，，11： | 0 |
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