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41篇 您的检索式:作者名="Kai Mo"
    题名 作者 年代 出处 被引量
1Ibrolipim increases ABCA1/G1 expression by the LXRα signaling pathway in THP-1 macrophage- derived foam cells显示文摘Si-guo CHEN Ji XIAO Xie-hong LIU Mei-mei LIU Zhong-cheng MO Kai YIN Guo-jun ZHAO Jin JIANG Li-bao CUI Chun-zhi TAN Wei-dong YIN Chao-ke TANG 2010Acta Pharmacologica Sinica2010,31,10:18
2Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 2020Biomedical and Environmental Sciences2020,33,12:8
3OxLDL up-regulates Niemann-Pick type C1 expression through ERK1/2/COX-2/ PPARα-signaling pathway in macrophages显示文摘NiemannPick 类型 C1 (NPC1 ) 主要位于迟了的 endosome/lysosome 的膜并且从迟了的 endosome/lysosome 控制细胞内部的胆固醇 trafficking 到血浆膜。它被报导了那氧化低密度的脂蛋白(oxLDL ) 罐头起来调整 NPC1 表情。然而,详细机制充分没被理解。在这研究,我们在 THP-1 巨噬细胞在 NPC1 表示上调查了 oxLDL 刺激的效果。我们的结果显示出在 mRNA 和蛋白质的起来调整的 NPC1 表示在一个剂量依赖者和时间依赖者举止铺平的那 oxLDL。另外, oxLDL 也导致了细胞外的调整信号的 kinase 1/2 (ERK1/2 ) 的 phosphorylation。有 oxLDL 的处理显著地在巨噬细胞增加了 cyclooxygenase-2 (COX-2 ) mRNA 和蛋白质表示,并且这些增加被 ERK1/2 禁止者 PD98059 或 ERK1/2 压制小介入 RNA (siRNA ) 处理。OxLDL 起来调整在 mRNA 和蛋白质的激活 proliferator 的受体(PPAR ) 铺平的 peroxisome 的表示,它能被 COX-2 siRNA 或 COX-2 禁止者 NS398 处理在这些巨噬细胞废除。OxLDL 戏剧性地提高了细胞的胆固醇流出,它被禁止 ERK1/2 或 COX-2 废除。另外,导致 oxLDL 的 NPC1 表示和细胞的胆固醇流出被 PPAR siRNA 或 GW6471 颠倒, PPAR 的一个对手。一起拿,这些结果提供证据那 oxLDL 罐头起来调整通过在巨噬细胞的 ERK1/2/COX-2/PPAR-signaling 小径的 NPC1 的表示。Xiaohua Yu Xiaoxu Li Guojun Zhao Ji Xiao Zhongcheng Mo Kai Yin Zhisheng Jiang Yuchang Fu Xiaohui Zha Chaoke Tang 2012Acta Biochimica et Biophysica Sinica2012,44,2:6
4Monte Carlo simulation based on Geant4 of single event upset induced by heavy ions显示文摘The present work is a computational simulation of single event upset(SEU) induced by heavy ions passing through the device with Geant4-tool based on Monte Carlo transport code.Key parameters affecting SEU occurrence are examined,and related geometrical construction and critical charge are quantified.The MUlti-Functional Package for SEU Analysis(MUFPSA) has been successfully programmed and applied for SEU occurrence after the completion of device geometrical construction,critical charge,and SEU cross section calculation.The proposed MUFPSA has yielded a good agreement with MRED.Specifically,the results show that higher LET incident ions lead to increased SEU vulnerability due to more diffusion and higher energy deposition.In addition,the analytical method of radial ionization profile provides a good complementary interpretation.GENG Chao LIU Jie ZHANG ZhanGang HOU MingDong SUN YouMei XI Kai GU Song DUAN JingLai YAO HuiJun MO Dan LUO Jie 2013Science China(Physics,Mechanics & Astronomy)2013,56,6:6
5Effect of preemptive local injection of ropivocaine with dexmedetomidine on mirror pain in rats and its mechanism显示文摘Objective:To observe the effect of preemptive local injection of ropivocaine with dexmedetomidine on activation of glial cells and on the mirror pain in rats and its mechanism.Methods:A total of 48 adult male Sprague-Dawley rats(weighing 180 g-220 g)were included in the study and randomized into 3 groups,Group S,Group R,and Group RD,.A rat model of persistent postoperative pain evoked by skin/muscle incision and retraction was established in the three groups.Before procedures and nerve extraction,Group S(n=16)was injected 0.9%saline locally;Group R(n=16)was injected 0.5%ropivocaine locally,and Group RD,(n=16)was injected 0.5%ropivocaine in combined with 1μg dexmedetomidine locally.After the model being established in the three groups,8 rats were used for behavior test until 28 d,and dorsal root ganglions(DRGs)of the other 8 rats were harvested on the3 rd day after surgery.Immunofluorescent and transmission electron microscopy were used to observe the activation of glial cells in DRG,and the behavior test results in the three groups were compared.Results:The results showed that mechanical pain threshold in ipsilateral hindpaws of the Group S,Group R,Group RD,animals dropped to(3.640±1.963)g,(5.827±1.204)g,(7.482)±1.412 g at 3 d respectively;while in contralateral paws dropped to(7.100±1.789)g,(17.687±1.112)g,(16.213±1.345)g on the 3 d respectively.Immunofluorescent showed that the glial cells were activated in bilateral side DRG after surgery in 3 groups,but ipsilateral paws expressed more active glial cells than contralateral paws.Transmission electron microscopy showed that mitochondria swelling/vacuolization and lysosomes were more obvious in ipsilateral paws than contralateral paws,but Group RD,formula could reduce glial cells activity,mitochondria swelling/vacuolization and the amount of lysosomes.Conclusions:Local injection of ropivocaine and/or dexmedetomidine can effectively inhibit the activation of glial cells in DRG,mitigate the pathological changes of neuron in DRG and reduce mirror image pain.Xi-Zhao Huang Wei-Feng Tu Jie Peng Rong-Fang Deng Kai Mo Zu-Rong Hu Yi Lu 2015Asian Pacific Journal of Tropical Medicine2015,8,10:6
6Excavating bioactivities of nanozyme to remodel microenvironment for protecting chondrocytes and delaying osteoarthritis显示文摘Osteoarthritis(OA)is the main cause of disability in the elderly.Effective intervention in the early and middle stage of osteoarthritis can greatly prevent or slow down the development of the disease,and reduce the probability of joint replacement.However,there is to date no effective intervention for early and middle-stage OA.OA microenvironment mainly destroys the balance of oxidative stress,extracellular matrix synthesis and degradation of chondrocytes under the joint action of biological and mechanical factors.Herein,hollow Prussian blue nanozymes(HPBzymes)were designed via a modified hydrothermal template-free method.The aim of this study was to investigate the effects of HPBzymes on chondrocytes and the progression of OA.The intrinsic bioactivities of HPBzymes were excavated in vitro and in vivo,remodeling microenvironment for significantly protecting chondrocytes and delaying the progression of traumatic OA by inhibiting reactive oxygen species(ROS)and Rac1/nuclear factor kappa-B(NF-κB)signaling in a rat model.HPBzyme significantly diminished interleukin(IL)-1β-stimulated inflammation,extracellular matrix degradation,and apoptosis of human chondrocytes.HPBzyme attenuated the expression of Rac1 and the ROS levels and prevented the release and nuclear translocation of NF-κB.Deeply digging the intrinsic bioactivities of nanozyme with single component to remodel microenvironment is an effective strategy for ROS-associated chronic diseases.This study reveals that excavating the bioactivities of nanomedicine deserves attention for diagnosis and treatment of severe diseases.Weiduo Hou Chenyi Ye Mo Chen Wei Gao Xue Xie Jianrong Wu Kai Zhang Wei Zhang Yuanyi Zheng Xiaojun Cai 2021Bioactive Materials2021,6,8:5
7High-entropy alloy and amorphous alloy composites fabricated by ultrasonic vibrations显示文摘We successfully fabricate high-entropy alloys and amorphous alloy composites by adopting the proposed ultrasonic vibration method.The low-stress,low-temperature method enables us to create composites that combine both amorphous and crystalline properties.Microscopic observations and computed tomography measurements indicate good bonding quality without pores or cracks in the composites.Due to the unique structure which mixes soft and rigid phases,the composite exhibits improved mechanical performance compared to that obtained from a pure single phase.Our results are promising for the manual design and fabrication of smart materials containing multiple phases and compositions.Xiong Liang XiaoLong Zhu Xin Li RuoDong Mo YongJing Liu Kai Wu Jiang Ma 2020Science China(Physics,Mechanics & Astronomy)2020,63,11:4
8Multifunctional bioactive core-shell electrospun membrane capable to terminate inflammatory cycle and promote angiogenesis in diabetic wound显示文摘Diabetic wound(DW)healing is a major clinical challenge due to multifactorial complications leading to prolonged inflammation.Electrospun nanofibrous(NF)membranes,due to special structural features,are promising biomaterials capable to promote DW healing through the delivery of active agents in a controlled manner.Herein,we report a multifunctional composite NF membrane loaded with ZnO nanoparticles(NP)and oregano essential oil(OEO),employing a new loading strategy,capable to sustainedly co-deliver bioactive agents.Physicochemical characterization revealed the successful fabrication of loaded nanofibers with strong in vitro anti-bacterial and anti-oxidant activities.Furthermore,in vivo wound healing confirmed the potential of bioactive NF membranes in epithelialization and granulation tissue formation.The angiogenesis was greatly prompted by the bioactive NF membranes through expression of vascular endothelial growth factor(VEGF).Moreover,the proposed NF membrane successfully terminated the inflammatory cycle by downregulating the pro-inflammatory cytokines interleukin��6(IL-6)and matrix metalloproteinases-9(MMP-9).In vitro and in vivo studies revealed the proposed NF membrane is a promising dressing material for the healing of DW.Atta ur Rehman Khan Kai Huang Mina Shahriari Khalaji Fan Yu Xianrui Xie Tonghe Zhu Yosry Morsi Zhao Jinzhong Xiumei Mo 2021Bioactive Materials2021,6,9:3
9Biosynthesis of Unsaturated Fatty Acids via Mortierella Isabellina Cultivated in a Medium Containing Butanol显示文摘Mortierella isabellina was found to accumulate large amounts of unsaturated fatty acids when it was grown in a medium containing butanol(5 g/L) and yeast extract(10 g/L) and cultivated at 25 ℃ for 5 d during which additional feeding butanol of 2 g/L was fed after being cultivated for 48 h . The resultant mycelial lipids accounted for 40 1% of the dry mycelia, while about 34% of butanol in the medium was converted. The mycelial lipids contained four kinds of unsaturated fatty acids, i.e ., palmitoleic(4 9%), oleic(54 1%), linoleic(10 4%) and linolenic(5 4%) acids. Those accounted for 74 8% of the total fatty acids. The effects of the culture conditions, such as cultivation temperature, initial pH of the medium and additional feeding butanol in the course of cultivation, on the production of mycelial lipids by M. isabellina were studied.XIAN Mo 1, YAN Ji chang 2, CHENG Tie xin 1, KANG Yi jian 3, LI Wen xing 1, BI Ying li 1 and ZHEN Kai ji 1** 1. College of Chemistry, Jilin University, Changchun 130023, P. R. China 2. College of Chemistry, Northeast Normal University, C 2002Chemical Research in Chinese Universities2002,18,3:3
10Discovery of novel double pyrazole Schiff base derivatives as anti-tobacco mosaic virus(TMV) agents显示文摘Many pyrazole derivatives were reported to exhibit highly activity towards tobacco mosaic virus(TMV).In this work,an optimized pyrazole Schiff base scaffold was designed and introduced to derive novel potential TMV inhibitors.Thirty-six compounds were synthesized,characterized by elemental analysis,mass spectra and nuclear magnetic resonance(NMR) spectroscopy and evaluated by biological experiments.The bioassay results showed that some of the synthesized compounds exhibited excellent anti-TMV activities.Especially,5-chloro-3-methyl-1H-pyrazole contained compound 4j showed ningnanmycin comparable inhibitory activity and can be considered as potential anti-TMV candidate agent.With molecular docking,compound 4j insert into nucleotide sequence(GAAGUU) of OriRNA stably which revealed nucleotide could be a target of these compounds.Xian-Hai Lv Zi-Li Ren Dong-Dong Li Ban-Feng Ruan Qing-Shan Li Ming-Jie Chu Cheng-Ying Ai Dao-Hong Liu Kai Mo Hai-Qun Cao 2017Chinese Chemical Letters2017,28,2:2
11Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants.Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang 2022Virologica Sinica2022,37,5:2
12Enhanced primary treatment of low-concentration municipal wastewater by means of bio-flocculant Pullulan显示文摘Jar tests were conducted to investigate the performance of enhanced primary treatment processes for low-concentra-tion municipal wastewater from South China by using composite flocculant combined with bio-flocculants Pullulan and poly-aluminum-chloride (PAC). The optimum dosage for composite flocculant and conditions for flocculation were determined. The experimental results indicated that composite flocculant had high efficiency for removing over 95% of turbidity, over 58% of CODCr (chemical oxygen demand determined with potassium dichromate), over 91% of TP (total phosphate), and over 15% of NH3-N. Moreover, it could improve sludge settling and dehydration properties, and decrease the treatment cost.YANG Kai YANG Xiao-Jun YANG Mo 2007Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007,8,5:2
13SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2显示文摘Dear Editor,SARS-coronavirus-2(SARS-CoV-2)Omicron variant(B.1.1.529)is of great concern to the world due to its multiple mutations that may have an impact on transmissibility and immune evasion.1 Compared to the wild type(WT),Omicron carries as many as 30 single point mutations,3 deletion mutation and one insertion mutation on its spike protein.Strikingly,there are 15 mutations observed in the Omicron receptor-binding domain(RBD),10 of which are in the receptor-binding motif(RBM)that human angiotensin-converting enzyme 2(ACE2)and most monoclonal antibodies(mAbs)interact directly with.As a comparison,the currently dominant variant Delta(B.1.617.2)has only 2 mutations(L452R and T478K)in its RBM and additional K417N and E484K mutations sometimes.Therefore,Omicron variant may significantly impact the binding affinity to ACE2 and effectiveness of currently available mAbs.Consequently,Omicron mutant has aroused wide concern,many countries have taken measures on entry restrictions to prevent its rapid spread.However,the transmissibility and immune evasion risk of Omicron have not been properly evaluated.Leyun Wu Liping Zhou Mengxia Mo Tingting Liu Chengkun Wu Chunye Gong Kai Lu Likun Gong Weiliang Zhu Zhijian Xu 2022Signal Transduction and Targeted Therapy2022,7,2:2
14Atomic scale characterization of shear bands in an amorphous metal 显示文摘Qi Kai Li Mo Li 2006Applied physics letters2006,88,24:1
15Medical Additive Manufacturing: From a Frontier Technology to the Research and Development of Products显示文摘1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3D)printing.Problems and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common features.For example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of biomedicine.The most widely used materials in biomedicine are biocompatible.Various homogeneous and non-homogeneous composites are also available for 3D printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3D printing is particularly challenging.Guixing Qiu Wenjiang Ding Wei Tian Ling Qin Yu Zhao Lianmeng Zhang Jian Lu Daijie Chen Guangyi Yuan Chengtie Wu Bingheng Lu Ruxu Du Jimin Chen Mo Elbestawi Zhongwei Gu Dichen Li Wei Sun Yuanjin Zhao Jie He Dadi Jin Bin Liu Kai Zhang Jianmo Li Kam WLeong Dewei Zhao Dingjun Hao Yingfang Ao Xuliang Deng Huilin Yang ShaoKeh Hsu Yingqi Chen Long Li Jianping Fan Guohui Nie Yun Chen Hui Zeng Wei Chen Yuxiao Lai 2020Engineering2020,6,11:1
16Model reference adaptive control design for a shunt active- power-filter system显示文摘Kuo Kai Shyu Ming Ji Yang Yen Mo 2008IEEE Transactions on Industrial Electronics2008,55,1:1
17Combining push-pull airflow and top draft hood for local exhaust of tyre vulcanization process显示文摘This paper proposes a push-pull airflow combined with a top draft hood to conduct local exhaust in a rubber workshop.Field measurements are carried out to investigate the characteristics of the emission source,while numerical simulation is performed based on the measurement to test the capture efficiency and to further optimize various parameters including push velocity,hood height and exhaust air rate.Compared with the high-hanging hood,the low-hanging hood can effectively capture the pollutant generated by tyre with lower exhaust air rate.The capture efficiency of the low-hanging hood reaches 98.18%with exhaust air rate of 6000 m^(3)/h and push air velocity of 5m/s.The results indicates that the new ventilation appliance can effectively collect the pollutant at a relatively low exhaust rate.Kai Liu Shengwei Yang Lingjie Zeng Jun Gao Yumei Hou Changsheng Cao Bo Shi Xiangjin Mo Qingyu Zhang Chun Hou 2020Energy and Built Environment2020,1,3:1
18RhoE is Associated with Relapse and Prognosis of Patients with Colorectal Cancer显示文摘Jinfeng Zhou Jianjun Yang Kai Li Ping Mo Bin Feng Xin Wang Yongzhan Nie Daiming Fan 2013Annals of Surgical Oncology2013,,:1
19NEQR: A novel enhanced quantum representation of digital images显示文摘ZHANG Yi LU Kai GAO Ying-hui WANG Mo Quantum Information Processing0,12,8:1
20Epigallocatechin-3-gallate prevents TNF-α-induced NF-κB activation therebyupregulating ABCA1 via the Nrf2/Keap1 pathway in macrophage foam cells显示文摘Jin Jiang Zhong-Cheng Mo Kai Yin Guo-Jun Zhao Yun-Cheng Lv Xin-Ping Ouyang Zhi-Sheng Jiang Yuchang Fu Chao-Ke Tang 2012International Journal of Molecular Medicine2012,,5:1
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