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| 1 | 我国正常人皮肤表面皮脂和水分含量的研究显示文摘目的:了解我国不同年龄、不同性别正常人皮肤角质层含水量、皮肤表面皮脂含量及皮肤皮脂的分泌速度。方法:利用皮肤表面皮脂测量仪和皮肤水分含量测量仪对我国北方325名正常人的前额及前臂屈侧皮肤皮脂量和皮肤含水量进行测量。结果:12岁以前,男女前额皮脂量无差异;13岁以后,男性前额的皮脂量明显高于女性。除36~50岁年龄组外,女性前额的皮脂分泌快于男性。男女前臂的皮脂量无差异。除男性13~35岁组的前额皮肤含水量高于女性外,其他各年龄组各部位男、女皮肤含水量无显著差别。13~35岁组男、女性前额的含水量均高于前臂。其他各年龄组前额和前臂皮肤含水量无明显部位差异。13~35岁组男性前额皮肤含水量最高。结论:正常人皮肤表面含水量和皮脂含量因性别、年龄和部位的不同而有差异。 | 辛淑君 刘之力 史月君 Kenneth R Feingold Peter M Elias 蔄茂强 | 2007 | 临床皮肤科杂志2007，36，3： | 26 |
| 2 | 正常人皮肤表面酸碱度的研究显示文摘皮肤是人类机体的重要组成部分.皮肤表面的酸碱度不仅是皮肤的生理指标.同时也反映了整个机体的状态。迄今为止,关于正常人皮肤表面pH值的报道不尽相同。据报道,婴儿出生时,皮肤表而的pH较高。数天后则逐渐降低。Wilhelm等曾对29例成人皮肤表面的pH进行了研究,结果发现,皮肤表而的pH囚皮肤解剖部位的不同而不同:老年人的前额和踝部皮肤表而的pH值高于年轻者。Zlotogorski的研究也证实了Wilhelm等的结果.但是也有报道,皮肤表面的pH因性别的差异而不同。这种差异性有多种因素,可能与研究组别的大小和分组的条件等有关。关于我国正常人皮肤表面pH的研究报道较少,笔者根据人体生长发育期的生理特点进行年龄分组;根据皮肤的生理特点进行部位分组。对我国正常人不同年龄、不同性别和不同部位的皮肤pH进行检测,为临床工作提供参考。 | 辛淑君 刘之力 史月君 Kenneth R Feingold Peter M Elias 蔄茂强 | 2007 | 临床皮肤科杂志2007，36，5： | 11 |
| 3 | Diabetes mellitus as a risk factor for gastrointestinal cancer among American veterans显示文摘AIM:To assess the risk of biliary and pancreatic cancers in a large cohort of patients with type 2 diabetes mellitus(DM) .METHODS:Eligibility for this study included patients with type 2 DM(ICD-9 code 250.0) who were discharged from Department of Veteran Affairs hospitals between 1990 and 2000.Non-matched control patients without DM were selected from the same patient treatment files during the same period.Demographic information included age,sex and race.Secondary diagnoses included known risk factors based on their ICD-9 codes.By multivariate logistic regression,the occurrence of biliary and pancreatic cancer was compared between case subjects with DM and controls without DM.RESULTS:A total of 1172496 case and control subjects were analyzed.The mean age for study and control subjects was 65.8 ± 11.3 and 64.8 ± 12.6 years,respectively.The frequency of pancreatic cancer in subjects with DM was increased(0.9%) in comparison to control subjects(0.3%) with an OR of 3.22(95% CI:3.03-3.42) .The incidence of gallbladder andextrahepatic biliary cancers was increased by twofold in diabetic patients when compared to controls.The OR and 95% CI were 2.20(1.56-3.00) and 2.10(1.61-2.53) ,respectively.CONCLUSION:Our study demonstrated that patients with DM have a threefold increased risk for developing pancreatic cancer and a twofold risk for developing biliary cancer. | M Mazen Jamal Eugene J Yoon Kenneth J Vega Mehrtash Hashemzadeh Kenneth J Chang | 2009 | World Journal of Gastroenterology2009，15，42： | 10 |
| 4 | Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells显示文摘人的 pluripotent 干细胞(hPSC ) 导出 endothelial 系细胞组成有希望的来源因为在这个竞技场的治疗学的 revascularization,而是进步被临床上可伸缩的区别协议和在移植之上与宿主发行量集成的一个功能的容器网络的低效的形成的缺乏妨碍了。在绿的地方,使用一根人的胚胎的干细胞记者房间线荧光灯蛋白质表示被 endothelial 驾驶房间特定的 VE-cadherin (VEC ) 倡导者,我们为 > 屏蔽了;60 bioactive 将支持 endothelial 区别,并且发现 BMP4 和 GSK-3β 的那个政府的小分子;在有 VEGF 的一个早阶段和处理的禁止者 -- 在一个以后的阶段表明小径的槽口的 A 和抑制在六天以内导致了 hPSCs 的有效区别到 endothelial 系。这条顺序的途径产生了 >到 endothelial 房间(EC ) 的 hPSCs 的50%变换,明确地 VEC + CD31 + CD34 + CD14 − KDR 在 endothelial 系房间之中展出了更高的 angiogenic 和 clonogenic 增长潜力的高 endothelial 祖先( EP )。药品的抑制或基因槽口发信号击倒,在有 VEGF 的联合 -- 一个处理,经由 KDR + mesodermal 先锋和对成熟 EC 的 EP 的变换的封锁导致了 EP 的有效形成。当移植了进 immunocompromised 老鼠时,产生 EP 成功地与吻合在 vivo 形成了功能的毛状的容器到主人容器。在我们的协议表明电路的这 VEGF-A-Notch 的操作由 12- 导致导出 hPSC 的 EP 的快速的大规模生产到 20 褶层对当前的方法,它可以与与成熟 EC 相比形成能力的优异容器为再生 vascularization 用作一张吸引人的房间人口。 | Makoto Sahara Emil M Hansson Oliver Wemet Kathy O Lui Daniela Spater Kenneth R Chien | 2014 | Cell Research2014，24，7： | 10 |
| 5 | Stem cell therapy for the treatment of Leydig cell dysfunction in primary hypogonadism显示文摘The production of testosterone occurs within the Leydig cells of the testes. When production fails at this level from either congenital, acquired, or systemic disorders,the result is primary hypogonadism. While numerous testosterone formulations have been developed, none are yet fully capable of replicating the physiological patterns of testosterone secretion. Multiple stem cell therapies to restore androgenic function of the testes are under investigation. Leydig cells derived from bone marrow, adipose tissue, umbilical cord, and the testes have shown promise for future therapy for primary hypogonadism. In particular, the discovery and utilization of a group of progenitor stem cells within the testes, known as stem Leydig cells(SLCs), has led not only to a better understanding of testicular development, but of treatment as well. When combining this with an understanding of the mechanisms that lead to Leydig cell dysfunction, researchers and physicians will be able to develop stem cell therapies that target the specific step in the steroidogenic process that is deficient. The current preclinical studies highlight the complex nature of regenerating this steroidogenic process and the problems remain unresolved. In summary, there appears to be two current directions for stem cell therapy in male primary hypogonadism. The first method involves differentiating adult Leydig cells from stem cells of various origins from bone marrow, adipose, or embryonic sources. The second method involves isolating, identifying, and transplanting stem Leydig cells into testicular tissue. Theoretically, in-vivo re-activation of SLCs in men with primary hypogonadism due to age would be another alternative method to treat hypogonadism while eliminating the need for transplantation. | Taylor C Peak Nora M Haney William Wang Kenneth J DeLay Wayne J Hellstrom | 2016 | World Journal of Stem Cells2016，8，10： | 5 |
| 6 | 表皮通透屏障功能与表皮CD44表达关系的研究显示文摘目的:研究表皮通透屏障功能破坏后表皮CD44的表达。方法:外用胶带破坏裸鼠躯干部表皮通透屏障功能,分别于30min、1h、3h、6h、24h和48h后取皮肤标本,用免疫组化的方法观察CD44在表皮的表达。结果:在表皮通透屏障功能破坏后30min,表皮CD44的表达明显上调;1h和3h后,恢复至正常水平;6h后,表皮CD44的表达又明显增强,并持续到48h;人为地纠正屏障功能(封包)对表皮CD44的表达没有明显影响。结论:表皮通透屏障功能破坏后,表皮CD44的表达增强,其表达的改变与屏障功能本身无显著相关性。 | Mona Man 吕成志 辛淑君 Kenneth R Feingold Peter M Elias 蔄茂强 | 2008 | 临床皮肤科杂志2008，37，7： | 5 |
| 7 | 糖皮质激素对表皮功能的调节显示文摘糖皮质激素是临床上最常用的药物之一。它对表皮的发育、表皮屏障功能的形成、表皮脂代谢、角质层致密性、角质形成细胞的增生和分化均具有重要的调节作用。恰当地应用糖皮质激素能有利于治疗包括皮肤病在内某些疾病;使用不当可引起严重的不良反应。因此,很好地了解糖皮质激素对表皮功能的影响,对于指导临床合理应用糖皮质激素以及防治由其引起的不良反应具有重要意义。 | 蔄茂强 宋顺鹏 Kenneth R.Feingold Peter M Elias | 2009 | 临床皮肤科杂志2009，38，12： | 4 |
| 8 | Comparison of reflux esophagitis and its complications between African Americans and non-Hispanic whites显示文摘AIM: To determine the effect of ethnicity on the severity of reflux esophagitis (RE) and its complications. METHODS: A retrospective search of the endoscopy database at the University of Florida Health Science Center/Jacksonville for all cases of reflux esophagitis and its complications from January 1 to March 31, 2001 was performed. Inclusion criteria were endoscopic evidence of esophagitis using the LA classif ication, reflux related complications and self-reported ethnicity. The data obtained included esophagitis grade, presence of a hiatal hernia, esophageal ulcer, stricture and Barrett's esophagus, and endoscopy indication. RESULTS: The search identified 259 patients with RE or its complications, of which 171 were non-Hispanic whites and 88 were African Americans. The mean ages and male/female ratios were similar in the two groups. RE grade, esophageal ulcer, stricture and hiatal hernia frequency were likewise similar in the groups. Barrett's esophagus was present more often in non-Hispanic whites than in African Americans (15.8% vs 4.5%; P < 0.01). Heartburn was a more frequent indication for endoscopy in non-Hispanic whites with erosive esophagitis than in African Americans (28.1% vs 7.9%; P < 0.001). CONCLUSION: Distribution of RE grade and frequency of reflux-related esophageal ulcer, stricture andhiatal hernia are similar in non-Hispanic whites and African Americans. Heartburn was more frequently and nausea/vomiting less frequently reported as the primary endoscopic indication in non-Hispanic whites compared with African Americans with erosive esophagitis or its complications. African Americans have a decreased prevalence of Barrett's esophagus compared with non-Hispanic whites. | Kenneth J Vega Sian Chisholm M Mazen Jamal | 2009 | World Journal of Gastroenterology2009，15，23： | 4 |
| 9 | 中国正常老年人与年轻人皮肤共振传导特性比较显示文摘目的研究中国正常老年人和年轻人不同部位皮肤共振传导特性。方法152例年龄20~40岁的正常年轻人和64例年龄60~88岁的正常老年人参加本研究。利用Reviscometer RVM600分别于左手背、左前臂屈侧、前额及左眼外眦处测量不同方向皮肤共振传导时间(CRRT)。结果CRRT因测量部位和方向的不同而不同。在前臂,除在2—8点方向外,其他各方向老年人的CRRT大于年轻人:0—6点方向,f=7.46;1—7点方向,f=3.38;3—9点方向,t=3.88;4—10点方向,f=6.82;5—11点方向,卜7.42,P值〈0.01或〈0.05。在手背部位,除在3—9点方向外,其他各方向年轻人的CRRT则大于老年人:0—6点方向,t=4.53;1—7点方向,t=5.71;2—8点方向,t=2.74;4—10点方向,t=2.67;5—11点方向,t=4.20,P值均〈0.01或〈0.05。在前额部位,年轻人的CRRT与老年人差异无统计学意义。在眼外眦部位的1—7点和2—8点方向,年轻人CRRT大于老年人:1—7点方向,t=3.18,P〈0.01;2—8点方向,k5.11,P〈0.01。男女之间各部位CRRT没有明显差异。结论CRRT因年龄、方向及部位的不同而不同,性别对CRRT没有明显影响。 | 辛淑君 朱英华 吕成志 Kenneth R. Feingold Peter M Elias 蔄茂强 | 2010 | 中华皮肤科杂志2010，43，4： | 4 |
| 10 | TLR2和TLR4在不同皮炎模型皮肤的表达显示文摘目的研究Toll样受体2(TLR2)和TLR4在不同皮肤炎症的表达是否有区别。方法分别外涂弗博酯、oxazolone或胶带法于裸鼠躯干部制作皮炎模型。用免疫组化的方法观察TLR2和TLR4在真皮和表皮的表达。结果皮炎上调TLR2在表皮的表达及TLR4在真皮的表达;分别外涂弗博酯及oxazolone所诱发的皮炎中炎症细胞浸润较为明显,其TLR2和TLR4的表达增强也较明显;胶带法所诱导的皮炎中其炎症细胞浸润较轻,TLR2和TLR4的表达也较轻。结论皮炎分别上调皮肤TLR2和TLR4在真皮和表皮的表达;TLR2表达增强的程度与炎症程度有关。 | 吕成志 Mona Man 张信江 Kenneth R Feingold Peter M Elias 蔺茂强 | 2009 | 中国皮肤性病学杂志2009，23，7： | 4 |
| 11 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 12 | International Consensus Statement on surveillance and management of dysplasia in inflammatory bowel disease显示文摘 | Loren Laine Tonya Kaltenbach Alan Barkun Kenneth R. McQuaid Venkataraman Subramanian Roy Soetikno James E. East Francis A. Farraye Brian Feagan John Ioannidis Ralf Kiesslich Michael Krier Takayuki Matsumoto Robert P. McCabe Klaus M?nkemüller Robert Odze M | 2014 | Gastrointestinal Endoscopy2014，，： | 3 |
| 13 | 老年人与交通事故的调查分析(英文)显示文摘目的中国目前正在经历老年人口与交通车辆的同时快速增长。随着人口的老龄化加剧以及社会的发展,老年驾驶者人数将预期明显增加。国际上对老年人交通安全的经验可能对中国即将增加的老年驾驶者有借鉴作用。方法检索并分析了中国以及一些发达国家,如美国等有关老年驾驶者以及交通事故安全的论文及论著。结果尽管老年人较少开车且普遍地使用安全带,但他们交通事故发生数以及死亡率较其他年龄组高。老年人视觉以及感知功能的损害也增加了发生交通事故的危险性,同时也产生了其独特的事故形式。与年轻人相比,在相同的受伤程度下,老年人体格上的衰退和疾病因素可能对会产生更坏的结果。虽然老年驾驶者在中国还是少数,与其他年龄组相比,老年人有较高的交通事故伤害率、步行者死亡率和较高的农村老年人受害率。结论国际上对老年人交通安全的经验,比如更好的道路安全设计,高可视安全标识和安全带法律的实施,安全带使用的公共教育,以及老年驾驶证的更新等对中国的交通安全设计者以及法律的制定者可能会有帮助。这些经验对损伤预防研究者在老年人交通事故危险因素的识别方面,以及对工程师在驾驶环境和车辆设计等方面也有着重要的意义。 | HENG Kenneth PAN Shuming LAYDE M Peter ZHU Shankuan | 2006 | 中华急诊医学杂志2006，15，1： | 3 |
| 14 | Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth显示文摘 | Alexander Pietras Amanda M. Katz Elin J. Ekstr?m Boyoung Wee John J. Halliday Kenneth L. Pitter Jillian L. Werbeck Nduka M. Amankulor Jason T. Huse Eric C. Holland | 2014 | Cell Stem Cell2014，，3： | 3 |
| 15 | 仙人掌果提取液对卵巢癌的抑制作用显示文摘目的:研究仙人掌果提取液在动物体内和体外对卵巢癌的抑制作用。方法:用Crystalviolet方法测定、细胞周期分析及细胞凋亡TUNEL分析观察仙人掌果提取液在体外对卵巢癌细胞生长的抑制作用;仙人掌果提取液对人卵巢癌的动物模型的治疗效果。结果:2种卵巢癌细胞(OVCA420和SKOV3)对于不同浓度仙人掌果提取液反应敏感程度不同,IC50分别是0·8%和8%,正常卵巢上皮细胞(IOSE)的IC50为2%;仙人掌果提取液可以有效的抑制卵巢癌在动物体内的生长(P<0·05),与N-(4-hydroxyphernyl)retinamide(4HPR)作用相似(P>0·05)。结论:仙人掌果提取液对体外卵巢癌细胞生长和动物体内的卵巢癌生长均有明显抑制作用。 | 邹大明 刘华钢 Molly Brewer Jean M Feugang 梁秋云 Kenneth D. Hatch Changping Zou | 2008 | 广西医学院学报2008，18，2： | 3 |
| 16 | MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca^sup 2+^ overload and cell death显示文摘 | Aurora Arin B Mahmoud Ahmed I Luo Xiang Johnson Brett A van Rooij Eva Matsuzaki Satoshi Humphries Kenneth M Hill Joseph A Bassel-Duby Rhonda Sadek Hesham A Olson Eric N | 2012 | EN2012，，4： | 2 |
| 17 | Ankle Fractures in the Elderly: What You Get Depends on Where You Live and Who You See显示文摘 | Kenneth J Koval Jon Lurie Weiping Zhou Michael B Sparks Robert V Cantu Scott M Sporer James Weinstein | 2005 | Journal of Orthopaedic Trauma2005，，9： | 2 |
| 18 | Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass显示文摘 | George Asimakopoulos Peter L.C Smith Chandana P Ratnatunga Kenneth M Taylor | 1999 | The Annals of Thoracic Surgery1999，，3： | 2 |
| 19 | Assessment of the diagnostic performance and interobserver variability of endocytoscopy in Barrett's esophagus:A pilot ex-vivo study显示文摘AIM:To investigate a classification of endocytoscopy(ECS)images in Barrett’s esophagus(BE)and evaluate its diagnostic performance and interobserver variability.METHODS:ECS was applied to surveillance endoscopic mucosal resection(EMR)specimens of BE ex-vivo.The mucosal surface of specimen was stained with 1%methylene blue and surveyed with a catheter-type endocytoscope.We selected still images that were most representative of the endoscopically suspect lesion and matched with the final histopathological diagnosis to accomplish accurate correlation.The diagnostic performance and inter-observer variability of the new classification scheme were assessed in a blinded fashion by physicians with expertise in both BE and ECS and inexperienced physicians with no prior exposure to ECS.RESULTS:Three staff physicians and 22 gastroenterology fellows classified eight randomly assigned unknown still ECS pictures(two images per each classification)into one of four histopathologic categories as follows:(1)BEC1-squamous epithelium;(2)BEC2-BE without dysplasia;(3)BEC3-BE with dysplasia;and(4)BEC4-esophageal adenocarcinoma(EAC)in BE.Accuracy of diagnosis in staff physicians and clinical fellows were,respectively,100%and 99.4%for BEC1,95.8%and83.0%for BEC2,91.7%and 83.0%for BEC3,and95.8%and 98.3%for BEC4.Interobserver agreement of the faculty physicians and fellows in classifying each category were 0.932 and 0.897,respectively.CONCLUSION:This is the first study to investigate classification system of ECS in BE.This ex-vivo pilot study demonstrated acceptable diagnostic accuracy and excellent interobserver agreement. | Yutaka Tomizawa Prasad G Iyer Louis M Wongkeesong Navtej S Buttar Lori S Lutzke Tsung-Teh Wu Kenneth K Wang | 2013 | World Journal of Gastroenterology2013，19，46： | 2 |
| 20 | Evolution of endovascular mechanical thrombectomy for acute ischemic stroke显示文摘Acute ischemic stroke(AIS) is a common medical problem associated with significant morbidity and mortality worldwide. A small proportion of AIS patients meet eligibility criteria for intravenous thrombolysis(IVT) with recombinant tissue plasminogen activator, and its efficacy for large vessel occlusion is poor. Therefore, an increasing number of patients with AIS are being treated with endovascular mechanical thrombectomy when IVT is ineffective or contraindicated. Rapid advancement in catheter-based and endovascular device technology has led to significant improvements in rates of cerebral reperfusion with these devices. Stentrievers and modern aspiration catheters have now surpassed earlier generation devices in the degree and rapidity of revascularization. This progress has been achieved with no concurrent increase in risk of major complications or mortality, both when used alone or in combination with IVT. The initial randomized controlled trials comparing endovascular therapy to IVT for AIS failed to show superior outcomes with endovascular treatment, butkey limitations of each trial may limit the significance of these results to current practice. While endovascular devices and operator experience continue to evolve, we are optimistic that this will be accompanied by improvements in patient outcomes. This review highlights the major endovascular devices used in current practice and the trials which have investigated their efficacy. | Colin J Przybylowski Dale Ding Robert M Starke Christopher R Durst R Webster Crowley Kenneth C Liu | 2014 | World Journal of Clinical Cases2014，2，11： | 2 |
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