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| 1 | Oral microbiota and host innate immune response in bisphosphonate-related osteonecrosis of the jaw显示文摘Bacterial biofilms have emerged as potential critical triggers in the pathogenesis of bisphosphonate(BP)-related osteonecrosis of the jaw(ONJ) or BRONJ. BRONJ lesions have shown to be heavily colonized by oral bacteria, most of these difficult to cultivate and presents many clinical challenges. The purpose of this study was to characterize the bacterial diversity in BRONJ lesions and to determine host immune response. We examined tissue specimens from three cohorts(n530); patients with periodontal disease without a history of BP therapy(Control, n510), patients with periodontal disease having history of BP therapy but without ONJ(BP, n55) and patients with BRONJ(BRONJ, n515). Denaturing gradient gel electrophoresis of polymerase chain reaction(PCR)-amplified 16 S r RNA gene fragments revealed less bacterial diversity in BRONJ than BP and Control cohorts. Sequence analysis detected six phyla with predominant affiliation to Firmicutes in BRONJ(71.6%), BP(70.3%) and Control(59.1%). Significant differences(P,0.05) in genera were observed, between Control/BP, Control/BRONJ and BP/BRONJ cohorts. Enzyme-linked immunosorbent assay(ELISA)results indicated that the levels of myeloperoxidase were significantly lower, whereas interleukin-6 and tumor necrosis factor-alpha levels were moderately elevated in BRONJ patients as compared to Controls. PCR array showed significant changes in BRONJ patients with downregulation of host genes, such as nucleotide-binding oligomerization domain containing protein 2, and cathepsin G, the key modulators for antibacterial response and upregulation of secretory leukocyte protease inhibitor, proteinase 3 and conserved helix–loop–helix ubiquitous kinase. The results suggest that colonization of unique bacterial communities coupled with deficient innate immune response is likely to impact the pathogenesis of ONJ. | Smruti Pushalkar Xin Li Zoya Kurago Lalitha V Ramanathapuram Satoko Matsumura Kenneth E Fleisher Robert Glickman Wenbo Yan Yihong Li Deepak Saxena | 2014 | International Journal of Oral Science2014，6，4： | 4 |
| 2 | Characterization of the Yeast Transcriptome显示文摘 | Victor E Velculescu Lin Zhang Wei Zhou Jacob Vogelstein Munira A Basrai Douglas E Bassett Phil Hieter Bert Vogelstein Kenneth W Kinzler | 1997 | Cell1997，，2： | 4 |
| 3 | Evaluation of Burkholdderia cepacia strains:Root colonization of Catharanthus roseus and in vitro inhibition of selected of soil borne fungal pathogens 显示文摘 | Mansour B Martin A D Kenneth E C | 1999 | Proceedings of the Oklahoma Academy of Science1999，79，： | 3 |
| 4 | Tissue engineering for neuromuscular disorders of the gastrointestinal tract显示文摘The digestive tract is designed for the optimal processing of food that nourishes all organ systems.The esophagus,stomach,small bowel,and colon are sophisticated neuromuscular tubes with specialized sphincters that transport ingested food-stuffs from one region to another.Peristaltic contractions move ingested solids and liquids from the esophagus into the stomach;the stomach mixes the ingested nutrients into chyme and empties chyme from the stomach into the duodenum.The to-and-fro movement of the small bowel maximizes absorption of fat,protein,and carbohydrates.Peristaltic contractions are necessary for colon function and defecation. | Kenneth L Koch Khalil N Bitar John E Fortunato Khalil N Bitar | 2012 | World Journal of Gastroenterology2012，18，47： | 2 |
| 5 | Predictive dynamic model of a small pressure swing adsorption air separation unit 显示文摘 | Kenneth G Teague J Thomas E | 1999 | Ind Eng Chem Res1999，38，10： | 1 |
| 6 | Resource assessment methodologies: Current status and future direction显示文摘 | Meneley Robert A Calverley Alfred E Logan Kenneth G | 2003 | AAPG Bulletin2003，87，4： | 1 |
| 7 | Tempera-ture effects:methane generation from Land fill samples显示文摘 | KENNETH E H ROBERT E K ROBERT K H | 1982 | Jourmal of Envirnmental Engineering Divisiong1982，108，： | 1 |
| 8 | Nitrogen transfer from phaseolus bean to intercropped maize measured using 15N-enrichment and 15N-isotope dilution methods显示文摘 | Kenneth E G Ormesher J Awah F M | 1991 | Biochemistry1991，23，4： | 1 |
| 9 | Numerical Modeling of Concrete Confined by Fiber-Reinforced Composites显示文摘 | Malvar L J Kenneth B M John E C | 2004 | Journal of Composites for Construction2004，8，4： | 1 |
| 10 | Direct dating of sulfides by Rb-Sr:Acritical test using the Polaris Mississippi Valley-type Zn-Pb deposit显示文摘 | Christensen J N Halliday A N Kenneth E L Roderick N R and Stephen E K | | 0，，： | 1 |
| 11 | The Nature and Impacts of the July 1999 Heat Wave in the Mid- western United States: Learning from the Lessons of 1995 显示文摘 | Michael A Palecki Stanley A Changnon Kenneth E Kunkel | 2001 | Bulletin of the American Meteorological Society2001，82，7： | 1 |
| 12 | Detection of microcystins using electrospray ionization high-field asymmetric waveform ion mobility mass spectrometry/mass spectrometry显示文摘 | Kenneth Froese Steve E Hrudey | 2000 | Rapid Commun Mass Spectrom2000，14，： | 1 |
| 13 | Unique application of car-bon-carboncomposite materials(part two)显示文摘 | Donald L S Kenneth E D | 1999 | Sample Journal1999，35，4： | 1 |
| 14 | The physics of proton NMR显示文摘 | Robert L Dixon Kenneth E | 1982 | Med Phys1982，9，6： | 1 |
| 15 | The prevalence of comorbid depression in adults with diabetes: a meta-analysis 显示文摘 | Anderson BA Kenneth E Freedland PH | 2001 | Diabetes Care2001，24，： | 1 |
| 16 | Unique application of carbon/carbon composite materials (PART THREE)显示文摘 | Schm idt L Kenneth E | 1999 | SAMPE J1999，35，5： | 1 |
| 17 | The cross-section of expected stock returns 显示文摘 | Fama E F Kenneth R F | 1992 | Journal of Finance1992，47，： | 1 |
| 18 | The measurement of responsibility in Children显示文摘 | Dale B Harris Kenneth E Clark Arnold M Rose Frances Valasek | 1954 | Child Development1954，25，1： | 1 |
| 19 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 20 | Usefulness of an abnomal ankle-brachial index to predict presence of coronary artery disease in African-Americans显示文摘 | Kenneth E Atul M Eseroghene O | 2004 | Am J Cardiol2004，93，2： | 1 |
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