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| 1 | Clinical impacts of mesothelin expression in gastrointestinal carcinomas显示文摘Mesothelin,C-ERC/mesothelin is a 40-kD a cell surface glycoprotein that is normally present on normal mesothelial cells lining the pleura,peritoneum,and pericardium.Moreover,mesothelin has been shown to be overexpressed in several human cancers,including virtually all mesothelioma and pancreatic cancer approximately 70% of ovarian cancer and extra bile duc cancer,and 50% of lung adenocarcinomas and gastric cancer.The full-length human mesothelin gene encodes the primary product,a 71-k Da precursor protein.The71-kD a mesothelin precursor is cleaved into two products40-k Da C-terminal fragment that remains membranebound via glycosylphosphatidylinositol anchor,and a31-kD a N-terminal fragment,megakaryocyte potentiating factor,which is secreted into the blood.The biologica functions of mesothelin remain largely unknown However,results of recent studies have suggested tha the mesothelin may play a role of cell proliferation and migration.In pancreatic cancer,mesothelin expression was immunohistochemically observed in all cases,bu absent in normal pancreas and in chronic pancreatitis Furthermore,the expression of mesothelin was correlated with an poorer patient outcome in severa human cancers.The limited mesothelin expression in normal tissues and high expression in many cancers makes it an attractive candidate for cancer therapy.The present review discusses the expression and function o mesothelin in cancer cells and the utility of mesothelin as a target of cancer therapy. | Takahiro Einama Futoshi Kawamata Hirofumi Kamachi Hiroshi Nishihara Shigenori Homma Fumihiko Matsuzawa Tatsuzo Mizukami Yuji Konishi Munenori Tahara Toshiya Kamiyama Okio Hino Akinobu Taketomi Satoru Todo | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 4 |
| 2 | Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss显示文摘Osteoclasts are bone-specific multinucleated cells generated by the differentiation of monocyte/macrophage lineage precursors.Regulation of osteoclast differentiation is considered an effective therapeutic approach to the treatment of bone-lytic diseases.Periodontitis is an inflammatory disease characterized by extensive bone resorption. In this study, we investigated the effects of sodium fluoride(Na F) on osteoclastogenesis induced by Porphyromonas gingivalis, an important colonizer of the oral cavity that has been implicated in periodontitis. Na F strongly inhibited the P. gingivalis-induced alveolar bone loss. That effect was accompanied by decreased levels of cathepsin K, interleukin(IL)-1β, matrix metalloproteinase 9(MMP9), and tartrate-resistant acid phosphatase,which were up-regulated during P. gingivalis-induced osteoclastogenesis. Consistent with the in vivo anti-osteoclastogenic effect,Na F inhibited osteoclast formation caused by the differentiation factor RANKL(receptor activator of nuclear factor kB ligand)and macrophage colony-stimulating factor(M-CSF). The RANKL-stimulated induction of the transcription factor nuclear factor of activated T cells(NFAT) c1 was also abrogated by Na F. Taken together, our data demonstrate that Na F inhibits RANKL-induced osteoclastogenesis by reducing the induction of NFATc1, ultimately leading to the suppressed expression of cathepsin K and MMP9.The in vivo effect of Na F on the inhibition of P. gingivalis-induced osteoclastogenesis strengthens the potential usefulness of Na F for treating periodontal diseases. | Ujjal K Bhawal Hye-Jin Lee Kazumune Arikawa Michiharu Shimosaka Masatoshi Suzuki Toshizo Toyama Takenori Sato Ryota Kawamata Chieko Taguchi Nobushiro Hamada Ikuo Nasu Hirohisa Arakawa Koh Shibutani | 2015 | International Journal of Oral Science2015，7，4： | 3 |
| 3 | Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study显示文摘 | Kazuaki Kitajima Takahiro Fujimori Shigehiko Fujii Jun Takeda Yasuo Ohkura Hitoshi Kawamata Toshihide Kumamoto Shingo Ishiguro Yo Kato Tadakazu Shimoda Akinori Iwashita Yoichi Ajioka Hidenobu Watanabe Toshiaki Watanabe Tetsuichiro Muto Ko Nagasako | 2004 | Journal of Gastroenterology2004，，6： | 2 |
| 4 | Change in Expression of GBP28/Adiponectin in Carbon Tetrachloride-Administrated Mouse Liver显示文摘 | Madoka Yoda-Murakami Michiko Taniguchi Katsuhiko Takahashi Sakura Kawamata Kiyomi Saito Nam-Ho Choi-Miura Motowo Tomita | 2001 | Biochemical and Biophysical Research Communications2001，，： | 2 |
| 5 | Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study显示文摘 | Kazuaki Kitajima Takahiro Fujimori Shigehiko Fujii Jun Takeda Yasuo Ohkura Hitoshi Kawamata Toshihide Kumamoto Shingo Ishiguro Yo Kato Tadakazu Shimoda Akinori Iwashita Yoichi Ajioka Hidenobu Watanabe Toshiaki Watanabe Tetsuichiro Muto Ko Nagasako | 2004 | Journal of Gastroenterology2004，，6： | 2 |
| 6 | Molecular analysis of the cyclin-dependent kinase inhibitor gene p27Kip1 in human malignancies显示文摘 | Kawamata N Morosetti R Miller | 1995 | Cnacer Res1995，55，11： | 2 |
| 7 | Design study of the JT-60SA supervisory control system 显示文摘 | Kawamata Y Naito O Kiyono K | 2008 | Fusion Engineering and Design2008，11，9： | 1 |
| 8 | Risks and pregnancy outcome in women with prosthetic mechanical heart valve replacement显示文摘 | KAWAMATA K NEKI R YAMANAKA K | 2007 | Circ J2007，71，2： | 1 |
| 9 | Postcarotid endarterectomy cerebral hyperperfusion can be prevented by minimizing intraoperative cerebral ischemia and strict postoperative blood pressure control under continuous sedation 显示文摘 | Kawamata T Okada Y Kawashima A | 2009 | Neurosurgery2009，64，3： | 1 |
| 10 | Minimally invasive endoscopeassisted endonasal trans-sphenoidal microsurgery for pituitary tumors: experience with 215 cases comparing with sublabial trans-sphenoidal approach 显示文摘 | Kawamata T Iseki H Ishizaki R | 2002 | Neurol Res2002，24，3： | 1 |
| 11 | A G protein-coupled receptor responsive to bile acids显示文摘 | Kawamata Y Fujii R Hosoya M | 2003 | J Bid Chem2003，278，11： | 1 |
| 12 | Small contractions of four di- mensional algebraic manifolds 显示文摘 | KAWAMATA Y | 1989 | Math Ann1989，284，： | 1 |
| 13 | Free fatty acids regulate insulin secretion from pancreatic β cell through GPR40显示文摘 | Itoh Y Kawamata Y Harada M | | 0，，6928： | 1 |
| 14 | The addition of epidural morphine to ropivacaine epidural analgesia after lower abdominal surgery显示文摘 | Niiyama Y Kawamata T Shimizu H | 2005 | Can J A anesth2005，52，2： | 1 |
| 15 | Radial displacement of the medial meniscus in varus osteoarthritis of the knee显示文摘 | Sugita T Kawamata T Ohnuma M | 2001 | Clin Orthop Relat Res2001，，387： | 1 |
| 16 | Three-dimensional computed tomography imaging in dentistry显示文摘 | Kawamata A Ariji Y Langlais RP | 2000 | Dent Clin North Am2000，44，2： | 1 |
| 17 | Three--dimensional com- puted tomograpraphic evaluation of morphologic airway chan- ges after mandibular setback osteotomy for prognathism 显示文摘 | Kawamata A Fujishita M | 2000 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2000，89，3： | 1 |
| 18 | Radial displacement of the medial meniscus in varus osteoarthritis of the knee 显示文摘 | Sugita T Kawamata T Ohnuma M | 2001 | Clin Orthop Relat Res2001，，387： | 1 |
| 19 | All-trans retinoic acid upregulates thrombomodulin and downregulates tissue-factor expression in acute promyelocytic leukemia cells:Distinct expression of thrombomodulin and tissue factor in human leukemic cells显示文摘 | KOYAMA T HIROSAWA S KAWAMATA N | | 0，，： | 1 |
| 20 | Incidence and predictive factors of cerebral hyperperfusion after extracranial-intracranial bypass for occlusive cerebrovascular diseases显示文摘 | Yamaguchi K Kawamata T Kawashima A | 2010 | Neurosurgery2010，67，6： | 1 |
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