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| 1 | Effect of Clostridium butyricum on fecal flora in Helicobacter pylori eradication therapy显示文摘AIM: To investigate the effect of probiotic bacterium,Clostridium butyricum MIYAIRI 588 strain (CBM) on the changes of the fecal flora in Helicobacter pylori(H pylori)treatment.METHODS: Thirty-five patients with gastric or duodenal ulcers positive for Hpylori were randomized either to 1 wk amoxicillin, clarithromycin, lansoprazole (Group 1) or to the same regimen supplemented with CBM 7 dahead of the triple therapy (Group 2). Stool samples were collected before and 2, 4, 7, 15, and 22 d after the starting eradication therapy, and were examined intestinal flora. Patients were required to keep a diary record of their condition. RESULTS: Obligate anaerobes decreased significantly on d 2, 4, 8 and 15 in Group 1. On the other hand, they did not decrease significantly in Group 2. The Escherichiacoli was dominant bacterium in Enterobacteriaceae, butthat was replaced by other species such as Klebsiella and Enterobacter after eradication in Group 1. The change was suppressed in Group 2. Abdominal symptoms were less frequent in Group 2 than in Group 1.CONCLUSION: The combined use of CBM reduced the changes in the intestinal flora and decreased the incidence of gastrointestinal side effects. | Izumi Shimbo Taketo Yamaguchi Takeo Odaka Kenichi Nakajima Akinori Koide Hidehiko Koyama Hiromitsu Saisho | 2005 | World Journal of Gastroenterology2005，11，47： | 18 |
| 2 | 微通道内超临界二氧化碳的压降与传热特性显示文摘进行了微通道内超临界CO2的局部和平均传热与压降特性实验研究。结果表明,临界点附近物性参数的剧烈变 化使压降增大,但传热被大大强化。同时也发现,系统压力、质量流速及CO2温度对流动与传热特性有重要影响。在大 量实验数据的基础上,得出了冷却条件下水平微通道内超临界CO2强制对流换热关联式。 | 淮秀兰 Shigeru Koyama | 2004 | 工程热物理学报2004，25，5： | 13 |
| 3 | Study on adsorption behavior of cesium using ammonium tungstophosphate(AWP)-calcium alginate microcapsules显示文摘A functional microcapsule was prepared by encapsulating the fine crystalline ammonium tungstophosphate(AWP) in calcium alginate polymer(CaALG).The characterization of AWP-CaALG microcapsule was examined by SEM and EPMA.The adsorption behavior of Cs(I),Rb(I),Sr(II),Pd(II),Ru(III),Rh(III),La(III),Ce(III),Dy(III) and Zr(IV) was investigated by the batch method.The batch experiments were carried out by varying the shaking times,HNO 3 concentration,and initial concentration of metal ions.Relatively large K d values above 10 5 cm 3 /g for Cs(I) were obtained in the range of 0.1-5 M HNO 3,resulting in a separation factor of Cs/Rb exceeding 10 2.In contrast,the K d values of Sr(II),Pd(II),Ru(III),La(III),Dy(III),Ce(III) and Zr(IV) were considerably lower than 50 cm 3 /g.The K d value of Cs(I) decreased in the order of the coexisting ions,H + > Na + >> NH 4 +,and a linear relationship with a slop of about 1 was obtained between log K d and log [NH 4 + ]([NH 4 + ] > 0.01 M).The adsorption of Cs(I) was found to be controlled by chemisorption mechanism,and followed a Langmuir-type adsorption equation.A high uptake percentage of 99.4% for Cs(I) was obtained by using the dissolved solutions of spent fuel from FBR-JOYO(JAEA). | WU Yan MIMURA Hitoshi NIIBORI Yuichi OHNISHI Takashi KOYAMA Shinichi WEI YueZhou | 2012 | Science China Chemistry2012，55，9： | 11 |
| 4 | Genomic characterization of esophageal squamous cellcarcinoma:insights from next-generation sequencing显示文摘Two major types of cancer occur in the esophagus: squamous cell carcinoma, which is associated with chronic smoking and alcohol consumption, and adenocarcinoma, which typically arises in gastric reflux-associated Barrett's esophagus. Although there is increasing incidence of esophageal adenocarcinoma in Western counties, esophageal squamous cell carcinoma(ESCC) accounts for most esophageal malignancies in East Asia, including China and Japan. Technological advances allowing for massively parallel, high-throughput next-generation sequencing(NGS) of DNA have enabled comprehensive characterization of somatic mutations in large numbers of tumor samples. Recently, several studies were published in which whole exome or whole genome sequencing was performed in ESCC tumors and compared with matched normal DNA. Mutations were validated in several genes, including in TP53, CDKN2 A, FAT1, NOTCH1, PIK3 CA, KMT2 D and NFE2L2, which had been previously implicated in ESCC. Several new recurrent alterations have also been identified in ESCC. Combining the clinicopathological characteristics of patients with information obtained from NGS studies may lead to the development of effective diagnostic and therapeutic approaches for ESCC. As this research becomes more prominent, it is important that gastroenterologist become familiar with the various NGS technologies and the results generated using these methods. In the present study, we describe recent research approaches using NGS in ESCC. | Yasushi Sasaki Miyuki Tamura Ryota Koyama Takafumi Nakagaki Yasushi Adachi Takashi Tokino | 2016 | World Journal of Gastroenterology2016，22，7： | 10 |
| 5 | The utility of diffusion-weighted MR imaging for differentiating uterine sarcomas from benign leiomyomas显示文摘 | Ken Tamai Takashi Koyama Tsuneo Saga Nobuko Morisawa Koji Fujimoto Yoshiki Mikami Kaori Togashi | 2008 | European Radiology2008，，4： | 6 |
| 6 | Effect of adiponectin on carotid arterial stiffness in type 2 diabetic patients treated with pioglitazone and metformin显示文摘 | Takahiro Araki Masanori Emoto Megumi Teramura Hisayo Yokoyama Katsuhito Mori Sawako Hatsuda Takaaki Maeno Kayo Shinohara Hidenori Koyama Tetsuo Shoji Masaaki Inaba Yoshiki Nishizawa | 2006 | Metabolism2006，，8： | 5 |
| 7 | FTY720,Sphingosine 1-Phosphate Receptor Modulator,Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibition of T Cell Infiltration显示文摘FTY720, a sphingosine 1-phosphate receptor modulator, induces a marked decrease in the number of peripheral blood lymphocytes and exerts immunomodulating activity in various experimental allograft and autoimmune disease models. In this study, we evaluated the effect of FTY720 and its active metabolite, (S)-enantiomer of FTY720-phosphate [(S)-FTY720-P] on experimental autoimmune encephalomyelitis (EAE) in rats and mice.Prophylactic administration of FTY720 at 0.1 to 1 mg/kg almost completely prevented the development of EAE,and therapeutic treatment with FTY720 significantly inhibited the progression of EAE and EAE-associated histological change in the spinal cords of LEW rats induced by immunization with myelin basic protein. Consistent with rat EAE, the development of proteolipid protein-induced EAE in SJL/J mice was almost completely prevented and infiltration of CD4+ T cells into spinal cord was decreased by prophylactic treatment with FTY720 and (S)-FTY720-P. When FTY720 or (S)-FTY720-P was given after establishment of EAE in SJL/J mice, the relapse of EAE was markedly inhibited as compared with interferon-β, and the area of demyelination and the infiltration of CD4+ T cells were decreased in spinal cords of EAE mice. Similar therapeutic effect by FTY720 was obtained in myelin oligodendrocyte glycoprotein-induced EAE in C57BL/6 mice. These results indicate that FTY720 exhibits not only a prophylactic but also a therapeutic effect on EAE in rats and mice, and that the effect of FTY720 on EAE appears to be due to a reduction of the infiltration of myelin antigen-specific CD4+ T cells into the inflammation site. | Hirotoshi Kataoka Kunio Sugaharal Kyoko Shimano Koji Teshima Mamoru Koyama Atsyshi Fukunari Kenji Chiba | 2005 | Cellular & Molecular Immunology2005，2，6： | 5 |
| 8 | Pro-and anti-epileptic roles of microglia显示文摘Microglia are brain-resident immune cells that contribute to the maintenance of brain homeostasis.In the epileptic brain, microglia show various activation phenotypes depending on the stage of epileptogenesis.Therefore, it remains unclear whether microglial activation acts in a pro-epileptic or anti-epileptic manner.In mesial temporal lobe epilepsy, one of the most common form of epilepsies, microglia exhibit at least two distinct morphologies, amoeboid shape and ramified shape.Amoeboid microglia are often found in sclerotic area, whereas ramified microglia are mainly found in non-sclerotic area;however, it remains unclear whether these structurally distinct microglia share separate roles in the epileptic brain.Here, we review the roles of the two distinct microglial phenotypes, focusing on their pro-and anti-epileptic roles in terms of inflammatory response, regulation of neurogenesis and microglia-neuron interaction. | Shinichi Kinoshita Ryuta Koyama | 2021 | Neural Regeneration Research2021，16，7： | 5 |
| 9 | Basket pattern blood flow signals discovered in a case of splenic hamartoma by power Doppler ultrasonography显示文摘We present the gray-scale ultrasonography (GSUS), power Doppler ultrasonography (PDUS), abdominal computed tomography (CT), and magnetic resonance imaging (MRI) findings for a case of splenic hamartoma in a 27-year-old man, showing a ψ 50 mm homogeneous, iso- and hypo-echoic splenic mass with evidence of a small plural cystic lesion.This splenic hamartoma showed increased vascularity on power Doppler sonograms. PDUS showed multiple circular blood flow signals inside the mass (i.e. a basket pattern),which was consistent with the small plural cystic lesion shown by GSUS. Spectral analysis also confirmed arterial and venous flow. CT scans showed that the mass had lowdensity relative to the normal spleen and MRI showed that the mass was isodense, relative to the normal spleen.Therefore, CT and MRI are not useful for the diagnosis of splenic hamartoma. Ultrasonography can be used to diagnose splenic hamartoma without administration of a contrast material and therefore is an indispensable method for the diagnosis of splenic hamartoma. | Shigeo Nakanishi Katsuya Shiraki Kouji Yamamoto Takeshi Nakano Mutsumi Koyama Takatsugu Yano Takayuki Sanda Hisao Tamaki Tadanori Hirano Kazuo Fukudome Akinori Ishihara | 2005 | World Journal of Gastroenterology2005，11，33： | 4 |
| 10 | Hepcidin/ferroportin expression levels involve efficacy of pegylated-interferon plus ribavirin in hepatitis C virusinfected liver显示文摘AIM:To investigate the relationship between the ironmetabolism-related gene expression profiles and efficacy of antiviral therapy in chronic hepatitis C patients.METHODS:The hepatic expression profile of ironmetabolism-related genes was analyzed and its association with virological response to pegylated-interferon plus ribavirin combination therapy was evaluated.A hundred patients with chronic hepatitis C(genotype1b,n = 50; genotype 2,n = 50) were enrolled and retrospectively analyzed.Liver biopsy samples were subjected to quantitative polymerase chain reaction for iron-metabolismrelated genes and protein expression(Western blotting analysis) for ferroportin.As a control,normal liver tissue was obtained from 18 living donors of liver transplantation.Serum hepcidin level was measured by sensitive liquid chromatography/electrospray ionization tandem mass spectrometry.RESULTS:Iron overload is associated with liver damage by increasing oxidative stress and hepatitis C virus(HCV)is reported to induce iron accumulation in hepatocytes in vivo.Conversely,iron administration suppresses HCV replication in vitro.Therefore,the association between HCV infection and iron metabolism remains unclear.Compared with controls,patients had significantly higher gene expression for transferrin,iron-regulatoryproteins 1 and 2,divalent metal transporter 1,and ferroportin,but similar for transferrin receptors 1 and2,and hepcidin.When the expression profiles were compared between sustained virological response(SVR)and non-SVR patients,the former showed significantly lower transcription and protein expression of hepcidin and ferroportin.Expression of hepcidin-regulating genes,BMPR1,BMPR2,and hemojuvelin,was significantly increased,whereas BMP2 was decreased in HCV-infected liver.BMPR2 and hemojuvelin expression was significantly lower in the SVR than non-SVR group.HCV infection affects the expression of iron-metabolism-related genes,leading to iron accumulation in hepatocytes.CONCLUSION:Decreased expression of hepcidin and ferroportin in SVR patients indicates the importance of hepatocytic iron retention for viral response during pegylated-interferon plus ribavirin treatment. | Motoyuki Kohjima Tsuyoshi Yoshimoto Munechika Enjoji Nobuyoshi Fukushima Kunitaka Fukuizumi Tsukasa Nakamura Miho Kurokawa Nao Fujimori Yusuke Sasaki Yasushi Shimonaka Yusuke Murata Susumu Koyama Ken Kawabe Kazuhiro Haraguchi Yorinobu Sumida Naohiko Harada Masaki Kato Kazuhiro Kotoh Makoto Nakamuta | 2015 | World Journal of Gastroenterology2015，21，11： | 4 |
| 11 | NUMERICAL EVALUATION OF TWO-FLUID MIXING IN A SWIRL MICRO-MIXER显示文摘A collaborative investigation of two-fluid mixing in a swirl micro-mixer was carried out by the Shanghai Jiao Tong University and the Tokyo Denki University. Pure water and a mixture of glycerol and water were separately injected into branch channels and they were subsequently mixed in the central chamber. The two-fluid flow pattern was numerically modeled, in which the dependence of the mixture viscosity and density on the mass fraction of glycerol in the mixing fluid was carefully taken into consideration. The mixing performance of the two fluids was evaluated by varying the Reynolds numbers and the mass fractions of glycerol in water. The mixing process was extensively analyzed using streamline maps and contour plotting distributions of pressure and glycerol concentration. The numerical results show that the acceptable uniformity of mixing at Re = 0.1 is primarily attributed to the time-consuming molecular diffusion, whereas the cost-effective mixing at Re > 500 was obtained because of the generation of the swirling flow. The increasing mass fraction of glycerol in water was found to attenuate the mixing performance. The preliminary microscopic visualization of the two-fluid mixing at Re=1300 demonstrated the consistence with the numerical results. | JIN Si-yu LIU Ying-zheng WANG Wei-zhe CAO Zhao-min KOYAMA Hide S. | 2006 | Journal of Hydrodynamics2006，18，5： | 3 |
| 12 | Non-destructive testing of weld zone with a uniform eddy current probe显示文摘 | Hoshikawa H Koyama K | 1998 | Insight1998，40，4： | 3 |
| 13 | Influence of cognitive impairment on cardiac mortality after percutaneous coronary intervention in very elderly patients: a retrospective observational study显示文摘Background Cognitive impairment (CI) increases cardiac mortality among very elderly patients. Percutaneous coronary intervention (PCI) for ischemic heart disease (IHD) patients is considered a favorable strategy for decreasing cardiac mortality. Here, we investigated the influence of CI on cardiac mortality after PCI in very elderly patients. Methods We performed a retrospective observational analysis of patients who received PCI between 2012 and 2014 at the South Miyagi Medical Center, Japan. IHD patients over 80 years old who underwent the Mini-Mental State Examination for CI screening during hospitalization and/or who had been diagnosed with CI were included. Participants were divided into CI and non-CI groups, and cardiac mortality and incidence of adverse cardiac events in a 3-year follow-up period were compared between groups. Statistical analyses were performed using the t-test,χ^2 test, and multivariable Cox regression analysis, with major comorbid illness and conventional cardiac risk factors as confounders. Results Of 565 patients, 95 were included (41 CI, 54 non-CI). Cardiac mortality during the follow-up period was significantly higher in the CI group (36%) compared with the non-CI group (13%)(OR = 4.3, 95% CI: 1.56–11.82, P < 0.05). CI was an independent cardiac prognostic factor after PCI and, for CI patients, living only with a CI partner was an independent predictor of cardiac death within three years. Conclusions CI significantly affected cardiac prognosis after PCI in very elderly patients, particularly those living with a CI partner. To improve patients’ prognoses, social background should be considered alongside conventional medical measures. | Tomoko Tomioka Ryokichi Takahashi Yosuke Ikumi Shuhei Tanaka Yoshitaka Ito Hiroki Shioiri Jiro Koyama Kanichi Inoue | 2019 | Journal of Geriatric Cardiology2019，16，10： | 3 |
| 14 | Single-port laparoscopic hepatectomy: technique, safety, and feasibility in a clinical case series显示文摘 | Masayasu Aikawa Mitsuo Miyazawa Kojun Okamoto Yasuko Toshimitsu Katsuya Okada Yosuke Ueno Shigeki Yamaguchi Isamu Koyama | 2012 | Surgical Endoscopy2012，，6： | 3 |
| 15 | Upregulation of macrophage migration inhibitory factor and calgizzarin by androgen in TM4 mouse Sertoli cells显示文摘瞄准:为了识别蛋白质,在精子发生期间在 Sertoli 房间由雄激素导致了。方法:我们在用表面与二氢睾酮(DHT ) 对待的 TM4 Sertoli 房间分析了蛋白质侧面提高的激光解吸附作用电离 time-of-flight 团分光术(SELDI-TOF-MS ) 。结果:我们在 15 点在 5.0-kDa 蛋白质的表示发现了增加在在处理以后的 48 h 的 min,在 24 h 的 11.3-kDa 蛋白质和 4.3 kDa, 5.7 kDa, 5.8 kDa, 9.95 kDa 和 9.98 kDa 蛋白质。相反, 6.3 kDa 的表示和 8.6 kDa 蛋白质在 30 点减少了在在处理以后的 48 h 的 min,和 4.9 kDa, 5.0 kDa, 12.4 kDa 和 19.8 kDa 蛋白质。11.3-kDa 蛋白质作为为有各种各样的功能所知的巨噬细胞迁居抑制因子(MIF ) 被识别。9.98-kDa 蛋白质作为与钙隧道有关的 calgizzarin 被识别。预定他们的表示建议 MIF 和 calgizzarin 被雄激素在 Sertoli 房间涉及精子发生的迟了的规定。结论:MIF 和 calgizzarin 是 Sertoli 房间生产的二重要雄激素应答的蛋白质,他们可能在调整精子发生起一个作用。 | Hiroyuki Kasumi Shinji Komori KazukoSakata NaokoYamamoto TomohikoYamasaki YonehiroKanemura Koji Koyama | 2006 | Asian Journal of Andrology2006，8，5： | 3 |
| 16 | Exercise,microglia,and beyond–workout to communicate with microglia显示文摘Microglia are brain-resident immune cells that use their ramified processes to survey the brain parenchyma.They maintain brain homeostasis by mediating immune responses through cytokine release,phagocytosing pathogens and protein aggregation(Salter et al.,2017).Furthermore,in both healthy and disease states,microglia interacting with neurons regulate synaptic formation,elimination and plasticity(Salter et al.,2017).It is thought that these functions may be altered by environmental stimuli such as lifestyle,stress,infection and air pollution,the effects of which may result in brain dysfunction and the development of neurodegenerative diseases(Branchi et al.,2014;Hanamsagar et al.,2017). | Megumi Andoh Ryuta Koyama | 2020 | Neural Regeneration Research2020，15，11： | 3 |
| 17 | 针刺脊髓骶段对皮层兴奋性和膀胱功能的影响(英文)显示文摘目的:探讨针刺对大脑皮层兴奋性和膀胱功能的影响及其之间的相互关系,探讨脑干背外侧被盖区(LDT)胆碱能神经元在其中的作用。方法:将SD大鼠109只,乌拉坦麻醉,采用立体定位法,在额骨和顶骨上植入皮层电极进行脑电图(EEG)记录,通过玻璃微电极记录单个神经细胞的放电活动。用导管插入膀胱并用微量注射泵向内注入生理盐水,使膀胱收缩并记录其活动。以直径为0.35mm毫针手针刺激大鼠脊髓骶部第2、3节段旁开0.5cm处1min,深度3~4mm。结果:在膀胱充盈的情况下,当EEG表现为低幅度高频率的快波时,给予脊髓骶段手针刺激,膀胱活动受到抑制,与此同时EEG转变为高幅度低频率慢波的比例为6/27(22.2%),抑制效应开始于针刺后45s至12min。在膀胱空虚的情况下,针刺引起EEG转变为高幅度低频率慢波的比例为71/82(86.6%)。针刺引起LDT内的胆碱能神经元放电频率由(2.9±1.5)Hz下降到(1.2±0.6)Hz(n=12,P<0.05,t-test),神经元放电活动的下降提前于EEG高幅度低频率的慢波的出现。结论:针刺脊髓骶段能降低大鼠大脑皮层的兴奋状态,并抑制膀胱活动,这种变化与针刺抑制了LDT胆碱能神经元的活动密切相关。 | 王慧 Yoshi masa Koyama Yukihiko Kayama | 2009 | World Journal of Acupuncture-Moxibustion2009，19，1： | 3 |
| 18 | Successful endovascular treatment of endoscopically unmanageable hemorrhage from a duodenal ulcer fed by a renal artery: A case report显示文摘A 52-year-old woman was admitted with hypovolemic shock. Emergency endoscopy revealed three hemorrhagic duodenal ulcers(all stage A1) with exposed vessels. Two ulcers were successfully treated by endoscopic clipping; however, the remaining ulcer on the posterior wall of the horizontal portion of the duodenum could not be clipped. Because her vital signs were rapidly worsening, we performed transcatheter arterial embolization(TAE) as it is less invasive than surgery. Computed tomography aortography showed that the duodenal hemorrhage was sourced from the lower branch of the right renal artery. In general, the duodenum is fed by branches from the gastroduodenal artery or superior mesenteric artery. However, this patient had three right renal arteries. The lower branch of the right renal artery at the L3 vertebral level was at the same level as the horizontal portion of the duodenum. Complete hemostasis was achieved by TAE using metallic coils and n-butyl-2-cyanoacrylate. After TAE, she recovered from the hypovolemic shock and was discharged from hospital. She has had no recurrence of the hemorrhagic duodenal ulcer for over 1 yr, and followup endoscopy showed no necrosis or stricture of the duodenum. Although she developed a small infarct of her right kidney, her renal function was satisfactory. In summary, the present case is the first reported case of hemorrhagic duodenal ulcer in which the culprit vessel was a renal artery that was successfully treated by TAE. Computed tomography aortography before TAE provides valuable information regarding the source of a duodenal hemorrhage. | Shimpei Anami Hiroki Minamiguchi Naoaki Shibata Takao Koyama Hirotatsu Sato Akira Ikoma Motoki Nakai Takuji Yamagami Tetsuo Sonomura | 2018 | World Journal of Clinical Cases2018，6，15： | 3 |
| 19 | Immunolocalization of aquaporin-9 in rat hepatocytes and Leydig cells 显示文摘 | Nihei K Koyama Y Tani T | 2001 | Arch HistolCytol2001，64，1： | 2 |
| 20 | Uniform eddy current probe with little disrupting noise显示文摘 | Hoshikawa H Koyama K | 1998 | Review of Progress in QNDE1998，17，： | 2 |
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