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	题名	作者	年代	出处	被引量
1	Bisphenol A in combination with TNF-a selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity显示文摘Bisphenol A(BPA)is a monomer used in manufacturing a wide range of chemical products,including epoxy resins and polycarbonate.BPA,an important endocrine disrupting chemical that exerts estrogen-like activities,is detectable at nanomolar levels in human serum worldwide.The pregnancy associated doses of 17b-estradiol(E2)plus tumor-necrosis factor-a(TNF-a)induce distorted maturation of human dendritic cells(DCs)that result in an increased capacity to induce T helper(Th)2 responses.The current study demonstrated that the presence of BPA during DC maturation influences the function of human DCs,thereby polarizing the subsequent Th response.In the presence of TNF-a,BPA treatment enhanced the expression of CC chemokine ligand 1(CCL1)in DCs.In addition,DCs exposed to BPA/TNF-a produced higher levels of IL-10 relative to those of IL-12p70 on CD40 ligation,and preferentially induced Th2 deviation.BPA exerts the same effect with E2 at the same dose(0.01–0.1 mM)with regard to DC-mediated Th2 polarization.These findings imply that DCs exposed to BPA will provide one of the initial signals driving the development and perpetuation of Th2-dominated immune response in allergic reactions.	Hongchuan Guo Tianyi Liu Yasushi Uemura Shunchang Jiao Deqing Wang Zilin Lin Yayoi Narita Motoharu Suzuki Narumi Hirosawa Yasuko Ichihara Osamu Ishihara Hirosato Kikuchi Yasushi Sakamoto Satoru Senju Qiuhang Zhang Feng Ling	2010	Cellular & Molecular Immunology2010，7，3：	6
2	Three-Dimensional Atom Probe Characterization of Nanoclusters Responsible for Multistep Aging Behavior of an Al-Mg-Si Alloy显示文摘	A. Serizawa S. Hirosawa T. Sato	2008	Metallurgical and Materials Transactions A2008，，2：	4
3	Solidification and crystallization behaviors of Fe3B/Nd2Fe14B based nanocomposite permanent magnet alloys and influence of micro-alloyed Cu,Nb and Zr显示文摘	Hirosawa S	2002	J Magn Magn Mater2002，239，：	2
4	Application of standardized principal component analysis to land - cover characterization using Multitemporal AVHRR data显示文摘	Hirosawa Y Marsh S E kliman D H	1996	Remote Sensing of Environment1996，58，3：	1
5	All-trans retinoic acid upregulates thrombomodulin and downregulates tissue-factor expression in acute promyelocytic leukemia cells:Distinct expression of thrombomodulin and tissue factor in human leukemic cells显示文摘	KOYAMA T HIROSAWA S KAWAMATA N		0，，：	1
6	An incremental formulation for computer analysis of space framed structures 显示文摘	Yoshida Y Masuda N Morimoto T Hirosawa N	1980	Journal of Structural Mechanics and Earthquake Engineering JSCE1980，300，：	1
7	Phthalates levels in baby milk powders sold in several countries显示文摘	YANO K HIROSAWA N SAKAMOTO Y	2005	Bull Environ Contam Toxicol2005，74，2：	1
8	All - trans - retinoic acid (ATRA) upregulates thrombomodulin downregulates tissue factor expression of thrombomodulin and tissue factor in human leukemia cell 显示文摘	Koyama T Hirosawa s KawamataN	1994	Blood1994，84，：	1
9	Nano-scale clusters formed in the early state of phase decomposition显示文摘	HIROSAWA S SATO T	2005	Mater Sci Forum2005，，：	1
10	Characterization of molecular orientation of rubbed polyimide film by grazing incidence X-ray scattering显示文摘	Hirosawa I Sasaki N	1999	Jpn J Appl Phys1999，88，：	1
11	New aspects of Nd-Fe-B based hydrogenation disproportionation desporption recombination powders and anisotropic bonded magnets made from them microstructure and magnetic properties显示文摘	Hirosawa S Uehara M	1997	Journal of Applied Physics1997，81，8：	1
12	Roles of microalloying elements on the cluster formation in the initial stage of phase decomposition of Al-based alloys显示文摘	Sato T Hirosawa S Hirose K	2003	Metallurgical and Materials Transactions A2003，34，12：	1
13	Renal tubulointerstitial injury in weanling rats with hyperhomocysteinemia显示文摘	KUMAGAI H KATOH S HIROSAWA K	2002	Kidney Int2002，62，4：	1
14	Quantitative characterization of precipitate free zones in A1 - Zn - Mg ( - Ag) alloys by micro- chemical analysis and nanoindentation measurement 显示文摘	Ogura T Hirosawa S Sato T	2004	Science and Technology of Advanced Materials2004，5，4：	1
15	Pharmacokinetics and pharmacodynamics of human chorionic gonadotropin(hCG) after rectal administration of hollow-type s uppositories containing hCG显示文摘	Hirosawa I Kurai H	2002	Biol Pharm Bull2002，25，5：	1
16	Persistent organochlorine pesticides (OCPs) in fiver waters of Southern part of Okinawa Island, Japan显示文摘	Imo T S Hirosawa E Ali S M	2006	Geochimica et Cosmochimica Acta2006，70，18：	1
17	Organization of the human alpha 2-plasmin inhibitor gene显示文摘	Hirosawa S Nakamura Y Miura O		0，，：	1
18	MASCOT:multiple alignment system for protein sequences based on three-way dynamic programming显示文摘	Makoto Hirosawa Masaki Hoshida Masato Ishikawa	1993	Bioinformatics1993，9，4：	1
19	Three-dimensional atom probe characterization of nano clusters re- sponsible for muhistep aging behavior of an A1-Mg-Si alloy 显示文摘	SERIZAWA A HIROSAWA S SATO T	2008	Metallurgical and Materials Transactions a- Physical Metallurgy and Materials Science2008，39，2：	1
20	Corrosion resistance ofNd-Fe--B sintered magnets 显示文摘	TOKUHARA K HIROSAWA S	1991	Journal of Applied Physics1991，69，8：	1

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