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	题名	作者	年代	出处	被引量
1	Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss显示文摘Osteoclasts are bone-specific multinucleated cells generated by the differentiation of monocyte/macrophage lineage precursors.Regulation of osteoclast differentiation is considered an effective therapeutic approach to the treatment of bone-lytic diseases.Periodontitis is an inflammatory disease characterized by extensive bone resorption. In this study, we investigated the effects of sodium fluoride(Na F) on osteoclastogenesis induced by Porphyromonas gingivalis, an important colonizer of the oral cavity that has been implicated in periodontitis. Na F strongly inhibited the P. gingivalis-induced alveolar bone loss. That effect was accompanied by decreased levels of cathepsin K, interleukin(IL)-1β, matrix metalloproteinase 9(MMP9), and tartrate-resistant acid phosphatase,which were up-regulated during P. gingivalis-induced osteoclastogenesis. Consistent with the in vivo anti-osteoclastogenic effect,Na F inhibited osteoclast formation caused by the differentiation factor RANKL(receptor activator of nuclear factor kB ligand)and macrophage colony-stimulating factor(M-CSF). The RANKL-stimulated induction of the transcription factor nuclear factor of activated T cells(NFAT) c1 was also abrogated by Na F. Taken together, our data demonstrate that Na F inhibits RANKL-induced osteoclastogenesis by reducing the induction of NFATc1, ultimately leading to the suppressed expression of cathepsin K and MMP9.The in vivo effect of Na F on the inhibition of P. gingivalis-induced osteoclastogenesis strengthens the potential usefulness of Na F for treating periodontal diseases.	Ujjal K Bhawal Hye-Jin Lee Kazumune Arikawa Michiharu Shimosaka Masatoshi Suzuki Toshizo Toyama Takenori Sato Ryota Kawamata Chieko Taguchi Nobushiro Hamada Ikuo Nasu Hirohisa Arakawa Koh Shibutani	2015	International Journal of Oral Science2015，7，4：	3
2	Design study of the JT-60SA supervisory control system 显示文摘	Kawamata Y Naito O Kiyono K	2008	Fusion Engineering and Design2008，11，9：	1
3	Risks and pregnancy outcome in women with prosthetic mechanical heart valve replacement显示文摘	KAWAMATA K NEKI R YAMANAKA K	2007	Circ J2007，71，2：	1
4	Incidence and predictive factors of cerebral hyperperfusion after extracranial-intracranial bypass for occlusive cerebrovascular diseases显示文摘	Yamaguchi K Kawamata T Kawashima A	2010	Neurosurgery2010，67，6：	1
5	Introduction to the minimal model problem显示文摘	Kawamata Y Matsuda K Matsuki K	2002	Advan Stud Pure Math2002，10，：	1
6	Influence of dietary conjugated linoleic acid isomers on early inflaramatory responses in male broiler chickens显示文摘	Takahashi K Kawamata K Akiba Y	2002	Br Poult Sci2002，43，：	1
7	Angiogenesis inhibitor TNP470 suppresses tumorigenesis in rat urinary bladder 显示文摘	Tanaka Y Kawamata H Fujimoto K	1997	J Urol1997，157，5：	1
8	Vesnarinone: a differentiation-inducing anti-cancer drug 显示文摘	KAWAMATA H OMEOTEHARA F NAKASHIRO K	2003	Anti- Cancer Drugs2003，14，6：	1
9	Involvement of increased excitatory amino acids and intracellular Ca^2+ concentration in the spinal dorsal horn in an animal model of neuropathic pain显示文摘	KAWAMATA M OMOTE K	1996	Pain1996，68，1：	1
10	Marked acceleration of the metastatic phenorype of a rat bladder carcinoma cell line by the expression of human gelatinaseA 显示文摘	KAMEYAMA S KAWAI K	1995	Intj cancer1995，63，4：	1
11	lntracytoplasmic localization of cathepsin D reflects the invasive potential of gastric carcinoma显示文摘	Kashida H Kawamata H Ichikawa K	2001	J Gastroenteorl2001，36，12：	1
12	Development ofmicrosatellite markers for Japanese scallop (Mizuhopectenyessoensis) and their application to a population geneticstudy 显示文摘	Sato M Kawamata K Zaslavskaya N	2005	Marine Biotechnology2005，7，6：	1
13	Development of Microsatellite Markers for Japanese Scallop (Mizuhopecten yessoensis) and Their Application to a Population Genetic study显示文摘	Sato M Kawamata K Zaslavskaya N	2005	Marine Biotechnology2005，7，：	1
14	No-Contact Magnetic Torque Sensor显示文摘	Miyashita K Takahashi T Kawamata S	1990	IEEE Trans Magn1990，26，5：	1
15	Time courses of increased expression of signaling transduction molecules induced by basic fibroblast growth factor in PC12 cells 显示文摘	Yamaguchi T Shin-ya K	2001	Neurol Res2001，23，4：	1
16	Pure yolk sac tumor of the ovary with mosaic 45X/46X -r- mar Turner's syndrome with a Y-chromosomal fragment显示文摘	ho K Kawamata Y Osada H	1998	Arch Gynecol Obstet1998，262，：	1
17	Effects of argon ion irradia-tion on the microstructures and physical properties of carbon fibers 显示文摘	OKU T KURUMADA A KAWAMATA K	2002	Journal of Nuclear Materials2002，303，：	1
18	Marked acceleration of the metastatic phenotype of a rat bladder carcinoma cell line by the expression of human gelatinase A显示文摘	Kawamata H Kameyama S Kawai K	1995	Int J Cancer1995，63，：	1
19	Balance between activated-STAT and MAP kinase regulates the growth of human bladder cell lines after treatment with epidermal growth factor显示文摘	Kawamata H Hattori K Omotehara F	1999	Int J Oncol1999，15，4：	1
20	Development of microsatellite markers for Japanese scallop(Mizuhopecten yessoensis)and their application to a population genetic study显示文摘	Sato M Kawamata K Zaslavskaya N	2005	Mar Biotechn2005，7，6：	1

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