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| 1 | Osteonecrosis of the femoral head: An update in year 2012显示文摘Osteonecrosis is a phenomenon involving disruption to the vascular supply to the femoral head, resulting in articular surface collapse and eventual osteoarthritis. Although alcoholism, steroid use, and hip trauma remain the most common causes, several other etiologies for osteonecrosis have been identified. Basic science research utilizing animal models and stem cell applications continue to further elucidate the pathophysiology of osteonecrosis and promise novel treatment options in the future. Clinical studies evaluating modern joint-sparing procedures have demonstrated significant improvements in outcomes, but hip arthroplasty is still the most common procedure performed in these affected younger adults. Further advances in joint-preserving procedures are required and will be widely studied in the coming decade. | Anjan P Kaushik Anusuya Das Quanjun Cui | 2012 | World Journal of Orthopedics2012，3，5： | 68 |
| 2 | Microbial Degradation of Organophosphate Pesticides: A Review显示文摘Pesticides have become an inevitable part of the modern environment as they are widely used in agriculture,household,and public health sectors and,hence,are extensively distributed throughout most ecosystems.Currently,organophosphate pesticides are the most commercially favored group of pesticides,with large application areas all over the world.Depending on their fate,these organophosphorus compounds may become bioavailable for microbial degradation.Environmental microbes,such as Aspergillus,Pseudomonas,Chlorella,and Arthrobacter,are capable of coupling a variety of physical and biochemical mechanisms for the degradation of organophosphate pesticides,including adsorption,hydrolysis of P–O alkyl and aryl bonds,photodegradation,and enzymatic mineralization.Enzymes,such as esterase,diisopropyl fluorophosphatase,phosphotriesterase,somanase,parathion hydrolase,and paraoxonase,have been isolated from microbes to study and understand the catabolic pathways involved in the biotransformation of these xenobiotic compounds.This review highlights various aspects of biodegradation of organophosphate pesticides along with biological and molecular characterization of some organophosphate pesticide-degrading bacteria. | Shardendu KUMAR Garima KAUSHIK Mohd Ashraf DAR Surendra NIMESH Ulrico Javier LOPEZ-CHUKEN Juan Francisco VILLARREAL-CHIU | 2018 | Pedosphere2018，28，2： | 12 |
| 3 | 大高良姜的药理学及植物化学研究综述(英文)显示文摘传统医学使用大量具有医用及药用价值的植物治疗疾病,因此是生物活性物质的一个宝库。姜科植物大高良姜通常被用作调经剂、催欲剂、堕胎药、驱风剂、退热剂和抗炎药等,可用于治疗支气管炎、心脏疾病、慢性肠炎、肾结石、糖尿病、风湿病及肾脏疾病。大高良姜含有精油、鞣酸、苯酚、苷类、单萜及糖类等。过去几年,有报道大高良姜各部位提取物中还含有没食子酸、生姜异黄酮、β-谷甾醇、高良姜素、良姜素、花姜酮、山萘素等。本文总结了近年来有关大高良姜的研究中新的植物化学成分及药理学的研究内容。 | Dhirender Kaushik Jyoti Yadav Pawan Kaushik Disha Sacher Ruby Rani | 2011 | 中西医结合学报2011，9，10： | 10 |
| 4 | Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts显示文摘Immune dysfunction is well documented during tumor progression and likely contributes to tumor immune evasion.CD81 cytotoxic T lymphocytes(CTLs)are involved in antigen-specific tumor destruction and CD41 T cells are essential for helping this CD81 T cell-dependent tumor eradication.Tumors often target and inhibit T-cell function to escape from immune surveillance.This dysfunction includes loss of effector and memory T cells,bias towards type 2 cytokines and expansion of T regulatory(Treg)cells.Curcumin has previously been shown to have antitumor activity and some research has addressed the immunoprotective potential of this plant-derived polyphenol in tumor-bearing hosts.Here we examined the role of curcumin in the prevention of tumor-induced dysfunction of T cell-based immune responses.We observed severe loss of both effector and memory T-cell populations,downregulation of type 1 and upregulation of type 2 immune responses and decreased proliferation of effector T cells in the presence of tumors.Curcumin,in turn,prevented this loss of T cells,expanded central memory T cell(TCM)/effector memory T cell(TEM)populations,reversed the type 2 immune bias and attenuated the tumor-induced inhibition of T-cell proliferation in tumor-bearing hosts.Further investigation revealed that tumor burden upregulated Treg cell populations and stimulated the production of the immunosuppressive cytokines transforming growth factor(TGF)-b and IL-10 in these cells.Curcumin,however,inhibited the suppressive activity of Treg cells by downregulating the production of TGF-b and IL-10 in these cells.More importantly,curcumin treatment enhanced the ability of effector T cells to kill cancer cells.Overall,our observations suggest that the unique properties of curcumin may be exploited for successful attenuation of tumor-induced suppression of cell-mediated immune responses. | Sankar Bhattacharyya Dewan Md Sakib Hossain Suchismita Mohanty Gouri Sankar Sen Sreya Chattopadhyay Shuvomoy Banerjee Juni Chakraborty Kaushik Das Diptendra Sarkar Tanya Das Gaurisankar Sa | 2010 | Cellular & Molecular Immunology2010，7，4： | 7 |
| 5 | Self-powered pressure sensor for ultra-wide range pressure detection显示文摘传感器的下一代应该是自我动力的,没有维护,精确,并且广阔察觉到能力。尽管有压力传感器的领域里的广泛的研究和开发,大多数压力传感器的敏感在更高的压力显著地衰退,以便他们不能与一致地高的敏感检测大量压力。在这个工作,我们表明一个单个电极的摩擦电压力传感器,它能由利用自我极化的 polyvinyldifluoride-trifluoroethylene ( P ( VDF-TrFE ))的费用擦掉的压电的极化和摩擦电表面的 synergistic 效果越过全部范围与敏感的高度从 0.05~600 kPa 检测大量压力。考虑这个宽压力范围和敏感,这台设备相对以前报导的自我动力的压力传感器的展出最好的表演。这成就为许多应用便于宽范围的压力察觉,从简单人的触觉,传感器网络,聪明的机器人学,和运动应用,因此为下一代的察觉到的实现向前铺平道路设备。而且,这个工作在摩擦电 nanogenerators 处理浸透压力的关键问题并且当在摩擦电 nanogenerator 使用了时,在压电的聚合物上提供卓见进表面费用的角色。 | Kaushik Parida Venkateswarlu Bhavanasi Vipin Kumar Ramaraju Bendi Pooi See Lee | 2017 | Nano Research2017，10，10： | 4 |
| 6 | Role of Joshi's external stabilization system with percutaneous screw fixation in high-energy tibial condylar fractures associated with severe soft tissue injuries显示文摘Purpose: The treatment of high-energy tibial condylar fractures which are associated with severe soft tissue injuries remains contentious and challenging. In this study, we assessed the results of Joshi's external stabilization system (JESS) by using the principle of ligamentotaxis and percutaneous screw fixation for managing high-energy tibial condylar fractures associated with severe soft tissue injuries. Methods: Between June 2008 and June 2010, 25 consecutive patients who were 17-71 years (mean, 39.7), underwent the JESS fixation for high-energy tibial condylar fractures associated with severe soft tissue injuries. Out of 25 patients, 2 were lost during follow-up and in 1 case early removal of frame was done, leaving 22 cases for final follow-up. Among them, 11 had poor skin condition with abrasions and blisters and 2 were open injuries (Gustilo-Anderson grade I & 11). The injury mechanisms were motor vehicle accidents (n - 19), fall from a height (n = 2) and assault (n - 1). The fractures were classified according to Schatzker classification system. Results: There were 7 type-V, 14 type-Vl and 1 type-IV Schatzker's tibial plateau fractures. The average interval between the injury and surgery was 6.8 days (range 2-13). The average hospital stay was 13 days (range, 7-22). The average interval between the surgery and full weight bearing was 13.6 weeks (range 11-20). The average range of knee flexion was 121° (range 105°-135°). The normal extension of the knee was observed in 20 patients, and an extensor lag of 5°-8° was noted in 2 patients. The complications included superficial pin tract infections (n 4) with no knee stiffness. Conclusion: JESS with lag screw fixation combines the benefit of traction, external fixation, and limited internal fixation, at the same time as allowing the ease of access to the soft tissue for wound checks, pin care, dressing changes, measurement of compartment pressure, and the monitoring of the neurovascular status. In a nutshell, JESS along with screw fixation offers a promising alternative treatment for high- energy tibial condylar fractures associated with severe soft tissue injuries. | Ashish Kumar Gupta Rahul Sapra Rakesh Kumar Som Prakash Gupta Devwart Kaushik Sahil Gaba Mahesh Chand Bansal Ratan Lal Dayma | 2015 | Chinese Journal of Traumatology2015，18，6： | 4 |
| 7 | Pharmacognostic studies of insect gall of Quercus infectoria Olivier(Fagaceae)显示文摘Objective:To study the detailed pharmacognostic profile of galls of Quercus infectoria Olivier(Q.infectoria olivier)(Fagaceae),an important medicinal plant used in the Indian system of medicine.Methods:Samples of galls of Q.infectoria were studied by macroscopical,microscopical,physiochemical,phytochemical.fluorescence analysis and othjer methods for standardization as recommended by WHO.Results:Macroscopically,the crude drug is globose with horny appearances on external surface(1.4-2.3 cm in length and 1-1.5 cm in diameter),with greyish-brown to brownish-black in colour externally and dark brown buff colored.Surface is smooth with numerous horny protuberances giving rough touch,and witfi unpleasant odour.Microscopically,a wide zone of radially elongated parenchyma cells between upper and lower epidermis were found.The vascular strands were present at all places and radially elongated sclerides touched the lower epidermis.In physico-chemical studies,the moisture,total ash,acid insoluble ash,alcohol soluble,water soluble,petroleum ether,chloroform extractive value and tannin content were found to be 2.790,5.020,0.110,38.780,41.210,0.402,1.590 and 49.200 percentage respectively.Prcliminary phytochemical screening showed the presence of phenols,flavonoids,steroids,triterpenes,tannins,saponins and alkaloids.Cooclusions:The results of the present study serve as a valuable source of information and provide suitable standards for identification of this medicinally important plant drug material for future investigations and applications. | Savitri Shrestha Vasuki Srinivas Kaushik Ravi Shankara Birur Eshwarappa Sundara Rajan Subaramaihha Latha Muuaiah Ramanna Dhananjaya Bhadrapura Lakkappa | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，1： | 4 |
| 8 | Identification of miR-802-5p and its involvement in type 2 diabetes mellitus显示文摘MicroRNAs(miRNA)are recently discovered endogenous,small noncoding RNAs(of 22 nucleotides)that play pivotal roles in gene regulation.They are involved in post-transcriptional control of gene expression.miRNAs are emerging as important regulators of cell proliferation,development,cancer formation,stress responses,cell death and physiological conditions.Increasing evidence has demonstrated the human miRNAs bind to their target mRNA sequences with perfect or near-perfect sequence complementarily.This provides a powerful strategy for discovering potential type 2 diabetes mellitus(T2DM)targets and gives the probability to exploit them for diagnostic and therapeutic causes.About 6%of the world population is affected by T2DM,and it is recognized as a global epidemic by the World Health Organization.At present there is no valid biomarker to control or manage T2DM.Therefore,the present study applied a mature sequence of miRNAs from publicly accessible databases to identify the miRNA from T2DM expressed sequence tags,and the results are detailed and discussed below. | Kaushik Vishnu Rajkumar Ganesh Lakshmanan Durairaj Sekar | 2020 | World Journal of Diabetes2020，11，12： | 4 |
| 9 | Removal of arsenite by reductive precipitation in dithionite solution activated by UV light显示文摘This study investigates the removal of arsenite(As(III)) from water using dithionite activated by UV light. This work evaluated the removal kinetics of As(III) under UV light irradiation as affected by dithionite dose and light intensity, and characterized the nature of the precipitated solids using XPS and SEM-EDS. Photolysis of dithionite was observed by measuring dithionite concentration using UV absorbance at 315 nm. This study also investigated the effect of UV light path length on soluble As concentrations to understand resolubilization mechanisms. Total soluble As concentrations were observed to decrease with reaction time due to reduction of arsenite to form solids having a yellow-orange color.The removal mechanism was found to be reductive precipitation that formed solids of elemental arsenic or arsenic sulfide. However, these solids were observed to resolubilize at later times after dithionite had been consumed. Resolubilization of As was prevented and additional As removal was obtained by frequent dosing of dithionite throughout the experiment. As(III) removal is attributed to photolysis of dithionite by UV light and production of reactive radicals that reduce As(III) and convert it to solid forms. | Bahngmi Jung Aya Safan Yuhang Duan Vishakha Kaushik Bill Batchelor Ahmed Abdel-Wahab | 2018 | Journal of Environmental Sciences2018，30，12： | 3 |
| 10 | Biodegradation aspects of Polycyclic Aromatic Hydrocarbons (PAHs): A review显示文摘 | A.K. Haritash C.P. Kaushik | 2009 | Journal of Hazardous Materials2009，，1： | 3 |
| 11 | Surface Plasmon Resonance Based Sensing of Different Chemical and Biological Samples Using Admittance Loci Method显示文摘 | Kaushik BRAHMACHARI Sharmila GHOSH Mina RAY | 2013 | Photonic Sensors2013，3，2： | 3 |
| 12 | Sunflower response to potassium fertilization and nutrient requirement estimation显示文摘Field experiments were conducted in oil and edible sunflower to study the effects of potassium(K) fertilization on achene yield and quality, and to estimate the nutrient internal efficiency(IE) and nutrient requirement in sunflower production. All trials in edible sunflower and 75% trials in oil sunflower showed positive yield responses to K fertilization. Compared with control without K fertilization, the application of K increased achene yield by an average of 406 kg ha^(–1) for oil sunflower and 294 kg ha^(–1) for edible sunflower. K application also increased 1 000-achene weight and kernel rate of both oil and edible sunflower. K fertilization improved the contents of oil, oleic acid, linoleic acid and linolenic acid in achenes of oil sunflower, and increased contents of oil, total unsaturated fatty acid and protein in achenes of edible sunflower. The average agronomic efficiency of K fertilizer was 4.0 for oil sunflower and 3.0 kg achene kg^(–1) K_2O for edible sunflower. The average IE of N, P and K under balanced NPK fertilization was 22.9, 82.8, and 9.9 kg kg^(–1) for oil sunflower, and 27.3, 138.9, and 14.3 kg kg^(–1) for edible sunflower. These values were equivalent to 45.5, 14.1, and 108.1 kg, and 39.0, 8.0, and 71.7 kg of N, P and K, respectively, in above-ground dry matter required for production per ton of achenes. The average harvest index of N, P and K was 0.47, 0.56 and 0.05 kg kg^(–1) in oil sunflower, and 0.58, 0.58 and 0.14 kg kg^(–1) in edible sunflower. | LI Shu-tian DUAN Yu GUO Tian-wen ZHANG Ping-liang HE Ping Kaushik Majumdar | 2018 | Journal of Integrative Agriculture2018，17，12： | 3 |
| 13 | Effects of lysine administration on plasma arginine and on some nitrogenous catabolites in rainbow trout 显示文摘 | Kaushik S J Fauconneau B | 1984 | Comp Biochem Physiol1984，79，： | 2 |
| 14 | Phacoemulsification in a rare case of keratoconus with Fuch's endothelial corneal dystrophy显示文摘Dear Sir,Iam Dr.Jaya Kaushik from the Department of Ophthalmology of the Post Graduate Institute of Medical Education and Research,Chandigarh,India.I write to present a case report of phacoemulsification in a rare case of cataract associated with keratoconus and Fuch’s endothelial | Jaya Kaushik Arun Kumar Jain Vaibhav Kumar Jain Partha Chakma | 2015 | International Journal of Ophthalmology(English edition)2015，8，6： | 2 |
| 15 | Partial or total replacement of fish meal by soybean protein on growth, protein utilization, potential estrogenic or antigenic effects, cholesterolemia and flesh quality in rainbow trout, Oncorhynchus mykiss显示文摘 | S.J. Kaushik J.P. Cravedi J.P. Lalles J. Sumpter B. Fauconneau M. Laroche | 1995 | Aquaculture1995，，3： | 2 |
| 16 | New objective scoring system to clinically assess fecal incontinence显示文摘BACKGROUND Several scoring systems are used to assess fecal incontinence(FI),among which,the most commonly used are Wexner and Vaizey’s scoring systems.However,there are significant lacunae in these scoring systems,due to which they are neither accurate nor comprehensive.AIM To develop a new scoring system for FI that is accurate,comprehensive,and easy to use.METHODS A pro forma was made in which six types of FI were included:solid,liquid,flatus,mucous,stress,and urge.The weight for each FI was determined by asking a group of patients and laypersons to give a disability score to each type of FI from 0 to 100(0-least,100-maximum disability).The disability was assessed on a modified EQ-5D+(EuroQol)description system,4D3L(4 dimensions and 3 levels)for each FI.The average score of each FI was calculated,divided by 10,and rounded off to determine the weight of each FI type.The scores for the three levels of frequency of each FI were assigned as never=0(No episode of FI ever),occasional=1(≤1 episode of FI/wk),and common=2(>1 episode of FI/wk),and was termed as frequency score.The score for each FI would be derived by multiplying the frequency score and the weight for that FI type.In the second phase of the study,a group of colorectal surgeons was asked to rank the six FI types in order of severity,and their ranking was compared with the patient and laypersons’rankings.RESULTS Fifty patients and 50 laypersons participated in the study.The weight was assigned to each FI(solid-8,liquid-8,urge-7,flatus-6,mucus-6,and stress-5),and an new scoring system was formulated.The maximum possible score was 80(total incontinence),and the least 0(no incontinence).The surgeons’ranking of FI severity did not correlate well with patients’and laypersons’rankings of FI,highlighting that surgeons and patients may perceive the severity of FI differently.CONCLUSION A new scoring system for FI was formulated,which was simple,logical,comprehensive,and easy to use,and eliminated previous shortcomings.Patients’and surgeons’perceptions of FI severity of FI did not correlate well. | Pankaj Garg Iwona Sudol-Szopinska Małgorzata Kolodziejczak Kaushik Bhattacharya Gurleen Kaur | 2023 | World Journal of Gastroenterology2023，29，29： | 2 |
| 17 | Barium borosilicate glass – a potential matrix for immobilization of sulfate bearing high-level radioactive liquid waste显示文摘 | C.P. Kaushik R.K. Mishra P. Sengupta Amar Kumar D. Das G.B. Kale Kanwar Raj | 2006 | Journal of Nuclear Materials2006，，2： | 2 |
| 18 | FDTD based transition time dependent crosstalk analysis for coupled RLC interconnects显示文摘The performance of high density chips operating in the GHz range is mostly affected by on-chip interconnects. The interconnect delay depends on many factors, a few of them are inputs toggling patterns, line &coupling parasitics, input rise/fall time and source/load characteristics. The transition time of the input is of prime importance in high speed circuits. This paper addresses the FDTD based analysis of transition time effects on functional and dynamic crosstalk. The analysis is carried out for equal and unequal transition times of coupled inputs.The analysis of the effects of unequal rise time is equally important because practically, it is quite common to have mismatching in the rise time of the signals transmitting through different length wires. To demonstrate the effects,two distributed RLC lines coupled inductively and capacitively are taken into consideration. The FDTD technique is used because it gives accurate results and carries time domain analysis of coupled lines. The number of lumps in SPICE simulations is considered the same as those of spatial segments. To validate the FDTD computed results,SPICE simulations are run and results are compared. A good agreement of the computed results has been observed with respect to SPICE simulated results. An average error of less than 3.2% is observed in the computation of the performance parameters using the proposed method. | Devendra Kumar Sharma Brajesh Kumar Kaushik R.K.Sharma | 2014 | Journal of Semiconductors2014，35，5： | 2 |
| 19 | Abdominal cocoon in a young man显示文摘BACKGROUND:Intestinal obstruction remains a common problem encountered in the surgical emergency,and usually occurs secondary to adhesions,obstructed herniae or tubercular strictures. However,at times,rare causes of obstruction can also be encountered.METHODS:A 24-year-old male patient presented with recurrent episodes of intestinal obstruction that was found to be secondary to an abdominal cocoon on laparotomy.RESULTS:The patient underwent adhesiolysis of the cocoon,and remains well on a follow-up. Histopathological report of the cocoon wall revealed f ibrocollagenic tissues with a mixed inf lammatory inf iltrate,without any evidence of tuberculosis.CONCLUSIONS:Abdominal cocoon can be a rare cause of intestinal obstruction in male patients. Adhesiolysis of the cocoon membrane releases the obstruction and gives good results. | Mayank Jayant Robin Kaushik | 2014 | World Journal of Emergency Medicine2014，5，3： | 2 |
| 20 | Concurrent dengue and malaria due to Plasmodium falciparum and P. vivax显示文摘 | Rajeev M. Kaushik Amit Varma Reshma Kaushik Kunwar J.B.S. Gaur | 2007 | Transactions of the Royal Society of Tropical Medicine and Hygiene2007，，10： | 2 |
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