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| 1 | Natural polyphenols effects on protein aggregates in Alzheimer's and Parkinson's prion-like diseases显示文摘Alzheimer's and Parkinson's diseases are the most common neurodegenerative diseases. They are characterized by protein aggregates and so can be considered as prion-like disease. The major components of these deposits are amyloid peptide and tau for Alzheimer's disease, α-synuclein and synphilin-1 for Parkinson's disease. Drugs currently proposed to treat these pathologies do not prevent neurodegenerative processes and are mainly symptomatic therapies. Molecules inducing inhibition of aggregation or disaggregation of these proteins could have beneficial effects, especially if they have other beneficial effects for these diseases. Thus, several natural polyphenols, which have antioxidative, anti-inflammatory and neuroprotective properties, have been largely studied, for their effects on protein aggregates found in these diseases, notably in vitro. In this article, we propose to review the significant papers concerning the role of polyphenols on aggregation and disaggregation of amyloid peptide, tau, α-synuclein, synphilin-1, suggesting that these compounds could be useful in the treatments in Alzheimer's and Parkinson's diseases. | aline freyssin guylène page bernard fauconneau agnès rioux bilan | 2018 | Neural Regeneration Research2018，13，6： | 3 |
| 2 | Effects of lysine administration on plasma arginine and on some nitrogenous catabolites in rainbow trout 显示文摘 | Kaushik S J Fauconneau B | 1984 | Comp Biochem Physiol1984，79，： | 2 |
| 3 | Partial or total replacement of fish meal by soybean protein on growth, protein utilization, potential estrogenic or antigenic effects, cholesterolemia and flesh quality in rainbow trout, Oncorhynchus mykiss显示文摘 | S.J. Kaushik J.P. Cravedi J.P. Lalles J. Sumpter B. Fauconneau M. Laroche | 1995 | Aquaculture1995，，3： | 2 |
| 4 | Natural stilbenes effects in animal models of Alzheimer’s disease显示文摘Alzheimer’s disease is one of the most frequent neurodegenerative diseases.This pathology is characterized by protein aggregates,mainly constituted by amyloid peptide and tau,leading to neuronal death and cognitive impairments.Drugs currently proposed to treat this pathology do not prevent neurodegenerative processes and are mainly symptomatic therapies.However,stilbenes presenting multiple pharmacological effects could be good potential therapeutic candidates.The aim of this review is to gather the more significant papers among the broad literature on this topic,concerning the beneficial effects of stilbenes (resveratrol derivatives) in animal models of Alzheimer’s disease.Indeed,numerous studies focus on cellular models,but an in vivo approach remains of primary importance since in animals (mice or rats,generally),bioavailability and metabolism are taken into account,which is not the case in in vitro studies.Furthermore,examination of memory ability is feasible in animal models,which strengthens the relevance of a compound with a view to future therapy in humans.This paper is addressed to any researcher who needs to study untested natural stilbenes or who wants to experiment the most effective natural stilbenes in largest animals or in humans.This review shows that resveratrol,the reference polyphenol,is largely studied and seems to have interesting properties on amyloid plaques,and cognitive impairment.However,some resveratrol derivatives such as gnetin C,trans-piceid,or astringin have never been tested on animals.Furthermore,pterostilbene is of particular interest,by its improvement of cognitive disorders and its neuroprotective role.It could be relevant to evaluate this molecule in clinical trials. | Aline Freyssin Guylène Page Bernard Fauconneau Agnès Rioux Bilan | 2020 | Neural Regeneration Research2020，15，5： | 2 |
| 5 | Isolation, identification, and antioxidant activity of three stilbene glucosides newly extracted from Vitis vinifera cell cultures显示文摘 | TEGUO P W FAUCONNEAU B PEFFIEUX G | 1998 | Nat Prod1998，61，： | 1 |
| 6 | Growth and meat quality relations in carp显示文摘 | Fauconneau B Alami-Duranteb H Larochec M | 1995 | Aquaculture1995，129，2： | 1 |
| 7 | Orientation of carp,Cyprinus capio L,to free amino acids from Tu- bifex extract in an olfactometer 显示文摘 | Saglio P H Fauconneau B Blanc J M | 1990 | Journal of Fish Biology1990，37，6： | 1 |
| 8 | Health value and safety quality of aquaculture products显示文摘 | FAUCONNEAU B | 2002 | Bordeaux Aquaculture2002，153，5： | 1 |
| 9 | Health value and safety quality of aquaculture products显示文摘 | FAUCONNEAU B | 2011 | Bordeaux Aquac2011，153，5： | 1 |
| 10 | Comparative study of radical scavenger and antioxidant properties of phenolic compounds from Vitis vivifera cell cultures using in vitro tests显示文摘 | Waffo-Teguo P Huguet F | 1997 | Life Sci1997，61，： | 1 |
| 11 | Comparative study of radical scavenger and antioxidant properties of phenolic compounds from vitis vinifera cell cultures using in vitro tests显示文摘 | Fauconneau B Huguet F Barrier L | 1997 | Life Sciences1997，61，21： | 1 |
| 12 | Thermal denaturation and aggregation properties of Atlantic salmon myofibrils and myosin from white and red muscles显示文摘 | Lefevre F Fauconneau B Thompson J W | 2007 | Journal of Agricultural and Food Chemistry2007，55，12： | 1 |
| 13 | Effects of lysine administration on plasma arginine and on some nitrogenous catabolites in rainbow trout 显示文摘 | Kaushik S J Fauconneau B | 1984 | Comparative Biochemistry and Physiology-Part A: Physiology1984，79，3： | 1 |
| 14 | Thermal gelation of brown trout myofibrils: effect of muscle type, heating rate and protein concentration显示文摘 | Lefevre E Fauconneau B Ouali A | 2008 | Journal of Food Science2008，63，2： | 1 |
| 15 | Comparative study of radical scavenging and antioxidant properties of phenolic compound from Vitis V inif era cell cultures using in vitro tests显示文摘 | Bernard Fauconneau Pierre Waffo-Teguo Francois Hugue | 1997 | Life Sciences1997，61，21： | 1 |
| 16 | Arginine requirement and status assessed by different biochemical indices in rainbow trout ( Salmo gairdneri L)显示文摘 | Kaushik S J Fauconneau B Terrier L | 1988 | Aquaculture1988，70，12： | 1 |
| 17 | Comparative study of radical scavenging and antioxidant properities of phenolic compound from Vitis Vinifera cell cultures using in Vitro tests显示文摘 | Bernard Fauconneau Pierre Waffo-Teguo Francois Hugue | 1997 | Life sciences1997，61，21： | 1 |
| 18 | Comparative study of radical scavenger and antioxidant properties of phenolic compounds from Vitis vinifera cell cultures using in vitro tests显示文摘 | Fauconneau B Waffo-Teguo P Huguet F | 1997 | Life sciences1997，61，21： | 1 |
| 19 | Health value and safety quality of aquaculture products 显示文摘 | FAUCONNEAU B | 2002 | Revue Med Vet2002，153，5： | 1 |
| 20 | Thermal gelation of brown trout myofibrils from white and red muscles: effects of pH and ionic strength显示文摘 | LEFEVRE F FAUCONNEAU B OUALI A | 2002 | Journal of the Science of Food and Agriculture2002，82，4： | 1 |
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