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| 1 | A comparative review of HLA associations with hepatitis Band C viral infections across global populations显示文摘Hepatitis B (HBV) and hepatitis C (HCV) viral infection or co-infection leads to risk of development of chronic infection, cirrhosis and hepatocellular carcinoma (HCC). Immigration and globalization have added to the challenges of public health concerns regarding chronic HBV and HCV infections worldwide. The aim of this study is to review existing global literature across ethnic populations on HBV and HCV related human leukocyte antigen (HLA) associations in relation to susceptibility, viral persistence and treatment. Extensive literature search was conducted to explore the HLA associations in HBV and HCV infections reported across global populations over the past decade to understand the knowledge status, weaknesses and strengths of this information in different ethnic populations. HLA DR13 is consistently associated with HBV clearance globally. HLADRB1*11/*12 alleles and DQB1*0301 are associated with HBV persistence but with HCV clearance worldwide. Consistent association of DRB1*03 and *07 is observed with HCV susceptibility and non-responsiveness to HBV vaccination across the population. HLA DR13 is protective for vertical HBV and HCV transmission in Chinese and Italian neonates, but different alleles are associated with their susceptibility in these populations. HLA class Ⅰmolecule interactions with Killer cell immunoglobulin like receptors (KIR) of natural killer (NK) cells modulate HCV infection outcome via regulating immune regulatory cells and molecules. HLA associations with HBV vaccination, interferon therapy in HBV and HCV, and with extra hepatic manifestations of viral hepatitis are also discussed. Systematic studies in compliance with global regulatory standards are required to identify the HLA specific viral epitope, stage specific T cell populations interacting with different HLA alleles during disease progression and viral clearance of chronic HBV or HCV infections among different ethnic populations. These studies would facilitate stage specific therapeutic strategies for clearance of HBV and HCV infections or co-infections across global populations and aid in identification of HBV-HCV combined vaccine. HLA associations of chronic HBV or HCV development with confounding host factors including alcohol, drug abuse, insulin resistance, age and gender are lacking and warrant detailed investigation across global populations. | Rashmi Singh Rashmi Kaul Anil Kaul Khalid Khan | 2007 | World Journal of Gastroenterology2007，13，12： | 31 |
| 2 | Role of sex steroid receptors in pathobiology of hepatocellular carcinoma显示文摘The striking gender disparity observed in the incidence of hepatocellular carcinoma (HCC) suggests an important role of sex hormones in HCC pathogenesis. Though the studies began as early as in 1980s,the precise role of sex hormones and the significance of their receptors in HCC still remain poorly understood and perhaps contribute to current controversies about the potential use of hormonal therapy in HCC. A comprehensive review of the existing literature revealed several shortcomings associated with the studies on estrogen receptor (ER) and androgen receptor (AR) in normal liver and HCC. These shortcomings include the use of less sensitive receptor ligand binding assays and immunohistochemistry studies for ERα alone until 1996 when ERβ isoform was identified. The animal models of HCC utilized for studies were primarily based on chemical-induced hepatocarcinogenesis with less similarity to virus-induced HCC pathogenesis. However,recent in vitro studies in hepatoma cells provide newer insights for hormonal regulation of key cellular processes including interaction of ER and AR with viral proteins. In light of the above facts,there is an urgent need for a detailed investigation of sex hormones and their receptors in normal liver and HCC. In this review,we systematically present the information currently available on androgens,estrogens and their receptors in normal liver and HCC obtained from in vitro,in vivo experimental models and clinical studies. This information will direct future basic and clinical research to bridge the gap in knowledge to explore the therapeutic potential of hormonal therapy in HCC. | Mamta Kalra Jary Mayes Senait Assefa Anil K Kaul Rashmi Kaul | 2008 | World Journal of Gastroenterology2008，14，39： | 18 |
| 3 | Mortalin imaging in normal and cancer cells with quantum dot immuno conjugates显示文摘Quantum dots are the nanoparticles that are recently emerging as an alternative to organic fluorescence probes in cell biology and biomedicine,and have several predictive advantages.These include their i)broad absorption spectra allowing visualization with single light source,ii)exceptional photo-stability allowing long term studies and iii)narrow and symmetrical emission spectrum that is controlled by their size and material composition.These unique properties allow simultaneous excitation of different size of quantum dots with a single excitation light source,their simultaneous resolution and visualization as different colors.At present there are only a few studies that have tested quantum dots in cellular imaging.We describe here the use of quantum dots in mortalin imaging of normal and cancer cells.Mortalin staining pattern with quantum dots in both normal and cancer cells mimicked those obtained with organic florescence probes and were considerably stable. | ZEENIA KAUL TOMOKO YAGUCHI SUNIL C KAUL TAKASHI HIRANO RENU WADHWA KAZUNARI TAIRA | 2003 | Cell Research2003，13，6： | 14 |
| 4 | 喂养困难儿童126例临床分析显示文摘目的分析美国一组喂养困难儿童的临床特点,拟对我国喂养困难儿童的诊治提供借鉴。方法回顾性分析2008-01-01—2008-06-30美国辛辛拉提儿童医院医学中心多学科喂养协作门诊(IFT)首次就诊的126例喂养困难儿童病历资料,分析就诊年龄、就诊原因、喂养方式、营养状况、口腔功能及基础疾病等临床特点。结果 126例喂养困难儿童中,足月儿95例,早产儿31例,其中<1岁28例(22.2%),1~3岁63例(50.0%),>3~7岁25例(19.8%),>7~14.5岁10例(7.9%),以婴幼儿居多。91例(72.2%)完全经口进食,31例(24.6%)采用部分肠道管道喂养,4例(3.2%)采用完全肠道管道喂养。83例(65.9%)营养状况正常,33例(26.2%)轻度营养不良,10例(7.9%)中度营养不良。90例(71.4%)伴有口腔功能发育落后,其中71例(56.3%)咬、咀嚼等口腔运动功能延迟,42例(33.3%)口腔敏感性异常,30例(23.8%)有吞咽问题。68例(54.0%)存在慢性胃肠道疾病,59例(46.8%)伴神经发育落后,39例(30.9%)有慢性呼吸系统疾病。结论喂养困难是婴幼儿最常见的问题,常罹患1个或多个系统基础疾病,其中慢性胃肠道疾病、神经发育落后及慢性呼吸系统疾病的婴幼儿是喂养困难的高危人群。 | 尹华英 Ajay Kaul | 2010 | 中国实用儿科杂志2010，25，10： | 6 |
| 5 | Clinical efficacy of the over-the-scope clip device: A systematic review显示文摘BACKGROUND The over-the-scope clip(OTSC)system has been increasingly utilized as a nonsurgical option to endoscopically manage refractory gastrointestinal(GI)hemorrhage,perforations/luminal defects and fistulas.Limited data exist evaluating the efficacy and safety of OTSC.AIM To determine the clinical success and adverse event(AE)rates of OTSC across all GI indications.METHODS A PubMed search was conducted for eligible articles describing the application of the OTSC system for any indication in the GI tract.Any article or case series reporting data for less than 5 total patients was excluded.The primary outcome was the rate of clinical success.Secondary outcomes included:Technical success rate,OTSC-related AE rate and requirement for surgical intervention despite-OTSC placement.Pooled rates(per-indication and overall)were calculated as the number of patients with the event of interest divided by the total number of patients.RESULTS A total of 85 articles met our inclusion criteria(n=3025 patients).OTSC was successfully deployed in 94.4%of patients(n=2856/3025).The overall rate of clinical success(all indications)was 78.4%(n=2371/3025).Per-indication clinical success rates were as follows:(1)86.0%(1120/1303)for GI hemorrhage;(2)85.3%(399/468)for perforation;(3)55.8%(347/622)for fistulae;(4)72.6%(284/391)for anastomotic leaks;(5)92.8%(205/221)for defect closure following endoscopic resection(e.g.,following endoscopic mucosal resection or endoscopic submucosal dissection);and(6)80.0%(16/20)for stent fixation.AE’s related to the deployment of OTSC were only reported in 64 of 85 studies(n=1942 patients),with an overall AE rate of 2.1%(n=40/1942).Salvage surgical intervention was required in 4.7%of patients(n=143/3025).CONCLUSION This systematic review demonstrates that the OTSC system is a safe and effective endoscopic therapy to manage GI hemorrhage,perforations,anastomotic leaks,defects created by endoscopic resections and for stent fixation.Clinical success in fistula management appears limited.Further studies,including randomized controlled trials comparing OTSC with conventional and/or surgical therapies,are needed to determine which indication(s)are the most effective for its use. | Nicholas Bartell Krystle Bittner Vivek Kaul Truptesh H Kothari Shivangi Kothari | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 6 | Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis显示文摘AIM To investigate gender-specific liver estrogen receptor(ER) expression in normal subjects and patients with hepatitis C virus(HCV)-related cirrhosis and hepatocellular carcinoma(HCC).METHODS Liver tissues from normal donors and patients diagnosed with HCV-related cirrhosis and HCV-related HCC were obtained from the NIH Liver Tissue and Cell Distribution System. The expression of ER subtypes, ERα and ERβ, were evaluated by Western blotting and real-time RT-PCR. The subcellular distribution of ERα and ERβ was further determined in nuclear and cytoplasmic tissue lysates along with the expression ofinflammatory [activated NF-κB and IκB-kinase(IKK)] and oncogenic(cyclin D1) markers by Western blotting and immunohistochemistry. The expression of ERα and ERβ was correlated with the expression of activated NF-κB, activated IKK and cyclin D1 by Spearman's correlation. RESULTS Both ER subtypes were expressed in normal livers but male livers showed significantly higher expression of ERα than females(P < 0.05). We observed significantly higher m RNA expression of ERα in HCV-related HCC liver tissues as compared to normals(P < 0.05) and ERβ in livers of HCV-related cirrhosis and HCV-related HCC subjects(P < 0.05). At the protein level, there was a significantly higher expression of nuclear ERα in livers of HCV-related HCC patients and nuclear ERβ in HCV-related cirrhosis patients as compared to normals(P < 0.05). Furthermore, we observed a significantly higher expression of phosphorylated NF-κB and cyclin D1 in diseased livers(P < 0.05). There was a positive correlation between the expression of nuclear ER subtypes and nuclear cyclin D1 and a negative correlation between cytoplasmic ER subtypes and cytoplasmic phosphorylated IKK in HCV-related HCC livers. These findings suggest that dysregulated expression of ER subtypes following chronic HCVinfection may contribute to the progression of HCVrelated cirrhosis to HCV-related HCC.CONCLUSION Gender differences were observed in ERα expression in normal livers. Alterations in ER subtype expression observed in diseased livers may influence genderrelated disparity in HCV-related pathogenesis. | Janaki K Iyer Mamta Kalra Anil Kaul Mark E Payton Rashmi Kaul | 2017 | World Journal of Gastroenterology2017，23，37： | 5 |
| 7 | 硝酸甘油对局部心肌氧代谢和心肌收缩功能的影响显示文摘目的评价硝酸甘油对局部心肌氧代谢和心肌收缩功能的影响。方法实验应用8只具有静息状态血流限制的左前降支或左回旋支近端狭窄的开胸犬。以二维超声心动图评价室壁增厚率(%WT),放射性微球定量心肌血流量(MBF),用磷猝熄法在体直接测定心肌组织氧压(tPO_2)。分别在静息和左冠脉主干内输注硝酸甘油(0.3~0.6mg·kg-1)状态下,进行二维超声检查、核素微球注射,以及tPO_2和心肌氧耗量(MVO_2,ml·min-1·100g-1)测定,MVO_2等于冠状动脉与冠状静脉氧浓度差乘以MBF,心肌氧输送能力等于冠状动脉氧浓度差乘以MBF。结果与静息状态相比,经左冠脉主干内输注硝酸甘油时,无论是正常灌注区抑或是缺血灌注区的MBF明显增加(P<0.05),同时伴有%WT明显增加(P<0.05)。正常和缺血灌注区的心肌氧输送能力明显增加(P<0.05),尽管缺血灌注区的MVO2有明显增加(P<0.05),但是缺血灌注区的tPO_2仍明显增高(P<0.05)。缺血区心肌tPO_2增加的程度明显大于MBF增加的程度。结论硝酸甘油可明显提高正常和缺血灌注区心肌氧浓度,提高缺血灌注区血氧的解离和释放,可能具有正性肌力效应。除了其直接血管效应之外,硝酸甘油还通过对心肌氧代谢和收缩功能的影响在心血管中发挥重要的调节作用。 | 宾建平 D.Elizabeth Le 陈少敏 查道刚 刘伊丽 Sanjiv Kaul | 2007 | 南方医科大学学报2007，27，4： | 4 |
| 8 | 双嘧达莫负荷超声心动图探测冠状动脉狭窄的病理生理基础显示文摘目的 探讨双嘧达莫负荷超声评价冠状动脉狭窄的病理生理基础。方法 双嘧达莫负荷超声评价慢性冠脉狭窄犬的室壁增厚率 (%WT) ,放射性微球定量心肌血流量 (MBF)。结果 负荷状态 ,MBF储备 <2的心肌节段 %WT减小 ;2≤MBF储备 <3的节段 %WT无明显变化 ;而MBF储备≥ 3的节段 %WT反而增加。 | 宾建平 Elizabeth Le Robert A Pelberg 刘伊丽 查道刚 Sanjiv Kaul | 2001 | 中国医学影像技术2001，17，2： | 3 |
| 9 | 估算放射性核素所致内照射剂量的ICRP剂量学和生物动力学模型显示文摘1引言源器官中某一放射性核素对靶器官产生的当量剂量与该源器官中放射性核素的核变化总数和在靶器官中被吸收的发射能量的份额成比例。在所考虑的时间间隔内体内任一源器官或组织的核变化数是在这段时间内那个器官或组织中放射性核素活度的时间积分。靶器官或组织从源器... | Kaul,A 周永增 | 1999 | 辐射防护1999，19，1： | 3 |
| 10 | A striking local esophageal cytokine expression profile in eosinophilic esophagitis显示文摘 | Carine Blanchard Emily M. Stucke Beatriz Rodriguez-Jimenez Karen Burwinkel Margaret H. Collins Annette Ahrens Eileen S. Alexander Bridget K. Buckmeier Butz Sean C. Jameson Ajay Kaul James P. Franciosi Jonathan P. Kushner Philip E. Putnam J. Pablo Abonia M | 2010 | The Journal of Allergy and Clinical Immunology2010，，1： | 3 |
| 11 | 硝酸甘油对心肌血流灌注直接影响的对比超声评价显示文摘目的应用心肌对比成像(MCE)评价硝酸甘油对心肌血流灌注的直接影响。方法实验应用12只具有静息状态血流限制的左前降支近端狭窄的开胸犬(其中6只结扎远处的冠脉以消除侧支循环的影响),根据远处的冠脉是否结扎分组(非结扎犬为组1、结扎犬为组2)。分别在静息和左冠脉主干内直接输注硝酸甘油(0.3-0.6μg·kg^-1)状态下,测定全血黏滞性(WBη)和心肌血管阻力(MVR),同步应用放射性标记微球测定心肌血流量(MBF),MCE评估心肌血流容积(A)和心肌血流速度(β)。结果与静息状态相比,经冠脉内输注硝酸甘油时,组1和组2实验犬正常区、整个缺血区和缺血中心区的MBF均明显增加(P〈0.05),同时伴有MVR和WBη明显减低(P〈0.05)。MCE显示正常灌注区和整个缺血区β增加的程度明显大于标准化A增加的程度(P〈0.05);标准化A和β增加(%)与A与β的乘积(A×β)增加(%)之间均有良好的相关性。然而,无论正常灌注区和整个缺血区标准化A增加(%)与A×β增加(%)之间相关方程的斜率明显小于β增加(%)与A×β增加(%)之间的斜率(P〈0.05)。结论硝酸甘油可降低血液黏滞性和心肌血流阻力,进而增加心肌的血液供应,后者主要是源于红细胞在心肌微循环中流动的速度增快所致。MCE是全面定量评价心肌血流灌注的良好方法。 | 宾建平 李崇信 陈少敏 刘俭 刘伊丽 Sanjiv Kaul | 2007 | 临床超声医学杂志2007，9，6： | 3 |
| 12 | Importance of blood cellular genomic profile in coronary heart disease显示文摘 | M. Iqbal Baba Deepak Kaul Anil Grover | 2006 | Journal of Biomedical Science2006，，1： | 3 |
| 13 | NIH 3T3 cells malignantly transformed by mot-2 showinactivation and cytoplasmic sequestration of the p53protein显示文摘INTRODUCTIONInvolvementandinactivationofp53,atumorsuppressorandcellulartranscriptionfactorincellularimmortalizationhasbeenwelldocumented[1-4].Variousactivitiesofp53proteininvolveitsfunctionaldomains,viz.,anamino--terminustransactivationdomain(aminoac... | WADHIVA RENU SYIJICHI TAKANO YOUJIMITSUI SUNIL C KAUL( Chugai Research Institute for Molecular Medicine,153-2 Nagai, Niihari-Mura, Ibaraki 300-41, Japan)( National Institute of Bioscience and Hunan-Technology, AIST, 1-1 Higashi, Tsukusa, Ibaraki 305-85 | 1999 | Cell Research1999，9，4： | 3 |
| 14 | Development of Low Carbon Microalloyed High Strength Ultra-Thin Cast Strip Products Produced by the Castrip~ Process With Excellent Strength-Ductility Properties显示文摘The CASTRIP* process produces a range of high strength Ultra-thin Cast Strip (UCS) products (380-550 MPa) in thicknesses between 0.9 mm and 1.5 mm, which is very challenging to produce via conventional hot and cold rolled processing routes. The twin roll CASTRIP process fully exploits the hardenability and strengthening potential of Nb in a low C-Mn-Nb-V microalloyed steel type. Significant microstructural strengthening from solute Nb was obtained, even at low microalloying levels, as well as modest Mn additions, through enhancing the hardenability and further strengthening was obtained in coated products by exploiting age hardening during processing on a continuous hot dip galvanising line. Atom probe tomography and TEM determined that Nb was retained in solid solution and subsequent age hardening resulted from the formation of Nb and V rich nanosized particles. Age hardening was achieved without loss of ductility producing galvanised strip with an excellent strength-ductility combination (Y.S. >600 MPa, T.E. >10%). | C.R. Killmore K.R. Carpenter H.R. Kaul D.G. Edelman J.M. Cairney S.P. Ringer J.G. Williams P.C. Campbell W.N. Blejde | 2011 | Journal of Iron and Steel Research(International)2011，18，S1： | 3 |
| 15 | 慢性冠脉狭窄时局部心肌收缩功能与心肌血流的关系显示文摘目的 评价慢性冠脉狭窄时心肌收缩功能与心肌血流 (MBF)的关系 ,以探讨慢性可逆性左室收缩功能低下的发生机制。方法 于左前降支 (LAD)和左回旋支 (LCX )近端以安放“水膨胀”式缩窄器的方法 ,建立 13只慢性多支冠脉狭窄犬模型。二维超声评价室壁增厚率 (%WT) ,放射性微球定量心肌血流量 (MBF)。结果 术后第 7dLAD和LCX供血区的平均 %WT较术前均已降低 (P <0 .0 5 ) ,但MBF在术后第 2 1d才出现降低 (P <0 .0 5 )。术后第 7d 2 6个 (2 6 /5 0 )心肌节段表现为局部室壁运动异常(RWMA) ;在 15对配对的RWMA和非RWMA中 ,两者的MBF差异无显著性意义 (P >0 .0 5 ) ;MBF与 %WT间无明显相关 (P >0 .0 5 )。然而术后第 42d ,在 13对配对的RWMA和非RWMA中 ,RWMA的MBF均明显低于非RWMA(P <0 .0 5 ) ,且 36个RWMA的MBF均与 %WT有良好的相关性 (P <0 .0 0 0 1)。结论慢性冠脉狭窄时 ,存活而收缩功能低下的心肌可伴或不伴MBF的降低 。 | 宾建平 Robert A Pelberg 刘伊丽 查道刚 Soroosh Firoozan Sanjiv Kaul | 2001 | 中华超声影像学杂志2001，10，7： | 3 |
| 16 | Coronary heart disease:Significance of liver X receptor α genomics显示文摘Crosstalk between lipid peroxidation and inflammation is known to be a pathognomonic feature for the development of coronary heart disease(CHD).In this regard ligand activated liver X receptor(LXR)-α has emerged as a key molecular switch by its inherent ability to modulate an array of genes involved in these two fundamental cellular processes.In addition,LXR-α has also been found to play a role in hepatic lipogenesis and innate immunity.Although several lines of evidence in experimental model systems have established the atheroprotective nature of LXR-α,human subjects have been reported to possess a paradoxical situation in which increased blood cellular LXR-α gene expression is always accompanied by increased coronary occlusion.This apparent paradox was resolved recently by the finding that CHD patients possess a deregulated LXR-α transcriptome due to impaired ligand-receptor interaction.This blood cellular mutated LXR-α gene ex- pression correlated specifically with the extent of coro- nary occlusion and hence need is felt to devise new synthetic ligands that could restore the function of this mutated LXR-αprotein in order to modulate genes involved in reverse cholesterol transport and suppression of the inflammatory response leading to the effective treatment of CHD. | Vivek Priy Dave Deepak Kaul | 2010 | World Journal of Cardiology2010，2，6： | 3 |
| 17 | Tumor-Targeted Gene Delivery Using Poly(Ethylene Glycol)-Modified Gelatin Nanoparticles: In Vitro and in Vivo Studies显示文摘 | Goldie Kaul Mansoor Amiji | 2005 | Pharmaceutical Research2005，，6： | 2 |
| 18 | Standardized Myocardial Segmentation and Nomenclature for Tomographic Imaging of the Heart: A Statement for Healthcare Professionals From the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association显示文摘 | Manuel D. Cerqueira Neil J. Weissman Vasken Dilsizian Alice K. Jacobs Sanjiv Kaul Warren K. Laskey Dudley J. Pennell John A. Rumberger Thomas Ryan Mario S. Verani | 2002 | Circulation: Journal of the American Heart Association2002，，： | 2 |
| 19 | 2010美国心脏病学会基金会/美国心脏学会关于氯吡格雷的应用警告概述显示文摘2010年8月,美国心脏病学会基金会(ACCF)、美国心脏学会(AHA)共同发布了美国食品药品管理局(FDA)关于氯吡格雷的"盒装警告",主要针对医师和患者提出建议,其内容包括:通过检测药物基因型以明确患者氯吡格雷的代谢变化,患者不良反应的风险,基因多态性对氯吡格雷的代谢及临床影响。 | Holmes DR Jr Dehmer GJ Kaul S 黄红娟(译) 卢新政(校) | 2011 | 心血管病学进展2011，32，3： | 2 |
| 20 | Quantification of renal blood flow with contrast-enhanced ultrasound显示文摘 | Kevin Wei Elizabeth Le Jian-Ping Bin Matthew Coggins Jerrel Thorpe Sanjiv Kaul | 2001 | Journal of the American College of Cardiology2001，，： | 2 |
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