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| 1 | 他汀、高密度脂蛋白胆固醇与冠状动脉粥样硬化消退显示文摘背景:他汀类药物可以降低低密度脂蛋白胆固醇(low—density lipoprotein cholesterol,LDL—C)水平并减缓冠状动脉粥样硬化的进展。然而,对于他汀类药物所致高密度脂蛋白胆固醇(high—density lipoprotein cholesterol,HDL—C)变化与疾病进展的关系,目前仍无相关数据描述。目的:了解LDL—C和HDL—C水平变化与动脉粥样硬化的相互关系。设计、地点及患者:对4项前瞻性随机试验(1999~2005年在美国、北美、欧洲和澳大利亚进行)的原始数据进行事后分析。其中1455例经血管造影证实的冠心病患者在接受他汀治疗(18个月或24个月)时进行了系列血管内超声扫描。所有超声分析均在相同的核心实验室中进行。主要观测指标:脂蛋白水平变化与冠状动脉粥样斑块体积的相互关系。结果:他汀治疗期间,LDL—C平均(SD)水平从124.0(38.3)mg,/dL(3.2[0.99]mmol/L)降至87.5(28.8)mg,/dL(2.3[0.75]mmol/L)(下降23.5%;P〈0.001),HDL—C水平从42.5(11.0)mg/dL(1.1[0.28]mmol/L)升至45.1(11.4)mg/dL(1.2[0.29]mmol/L)(上升7.5%;P〈0.001)。LDL—C与HDL—C比值从平均(SD)3.0(1.1)降至2.1(0.9)(下降26.7%;P〈0.001)。这些变化同时伴随平均(SD)百分粥样斑块体积的增加(从39.7%[9.8%]增至40.1%[9.7%])(增加0.5%[3.9%];P=0.001)以及平均(SD)总粥样斑块体积的减小(2.4[23.6]mm^3;P〈0.001)。在单变量分析中,LDL—C、总胆固醇、非HDL胆固醇、载脂蛋白B以及载脂蛋白B与载脂蛋白A-1比值平均水平和治疗引起的变化与动脉粥样硬化进展速率显著相关,而治疗所致HDL—C变化则与动脉粥样斑块体积负相关。在多变量分析中,平均LDL—C水平(β系数,0.11[95%可信区间,0.07~0.15])以及HDL—C升高(β系数,-0.26[95%可信区间,-0.41--0.10])依然为动脉粥样硬化消退的独立预测因子。动脉硬化显著消退(动脉粥样斑块体积减少≥5%)见于治疗期间LDL—C水平低于均值(87.5mg/dL)和HDL—C升高百分比大于均值(7.5%;P〈0.001)的患者。临床事件的发生未见显著差异。结论:在LDL—C显著降低以及HDL上升〉7.5%时,他汀治疗与冠状动脉粥样硬化消退相关。这些结果提示他汀治疗的获益源自致动脉粥样硬化脂蛋白的降低以及HDL.C的升高。尽管血脂水平的这些变化与动脉粥样硬化消退相关,但是后者是否可以转化为临床事件的显著减少,并改善临床预后仍有待进一步研究确定。 | Stephen J. Nicholls, MBBS, PhD E. Murat Tuzcu, MD IIke Sipahi, MD Adam W. Grasso, MD Paul Schoenhagen, MD Tingfei Hu, MS Kathy Wolski, MPH Tim Crowe, BS Milind Y. Desai, MD Stanley L. Hazen, MD, PhD Samir R. Kapadia, MD Steven E. Nissen, MD 李呈亿(译) | 2007 | 美国医学会杂志(中文版)2007，26，3： | 48 |
| 2 | Cytotoxicity evaluation and hepatoprotective potential of bioassay guided fractions from Feronia limmonia Linn leaf显示文摘Objective:To evaluate the cytotoxicity and hepatoprotective potentials of extracts,fractions or isolated compound from the leaves of Feronia limonia(F.limonia).Methods:Qualitative phytochemical analysis of extracts,fractions or compound was performed by means of thin layer chromatography and spectroscopic assays.The%purity of compound was measured by analytical HPLC.Extracts,fractions or compound have been individually evaluated for their cytotoxicity effects(10,20,100,250,500,750 and 1 000 μg/mL).Based on the inhibitory concentration(IC_(50)) obtained from the cell viability assay,graded concentrations of extracts,fractions or isolated compound were assessed(10,20,50,100,200 μg/mL) for its hepatoprotective potential against CCl_4-induced hepatotoxicity by monitoring activity levels of serum glutamatic pyruvatic transaminase(SGPT) and serum glutamic oxaloacetic transaminase(SGOT).Results:Results indicated that the methanol extract of F.limonia was non-toxic and hepatoprotective in nature as compared with the petroleum ether extract.The acetone fraction of methanolic extract also showed similar properties but the subsequent two fractions were cytotoxic.However,the pure compound isolated from the penultimate fraction of methanolic extract was non-toxic and hepatoprotective in nature.Biochemical investigations(SCOT,SCPT) further corroborated these cytological observations.Conclusions:It can be concluded from this study that F.limonia methanol extract,some fractions and pure isolated compound herein exhibit hepatoprotective activity.However,cytotoxicity recorded in the penultimate fraction and investigation of structural details of pure compound warrants further study. | Mahendra Jain Rakhee Kapadia Ravirajsinh N Jadeja Menaka C Thounaojam Ranjitsinh V Devkar SH Mishra | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 11 |
| 3 | Challenges and Prospects of Nanopillar-Based Solar Cells显示文摘Materials and device architecture innovations are essential for further enhancing the performance of solar cells while potentially enabling their large-scale integration as a viable source of alternative energy.In this regard,tremendous research has been devoted in recent years with continuous progress in the field.In this article,we review the recent advancements in nanopillar-based photovoltaics while discussing the future challenges and prospects.Nanopillar arrays provide unique advantages over thin films in the areas of optical properties and carrier collection,arising from their three-dimensional geometry.The choice of the material system,however,is essential in order to gain the advantage of the large surface/interface area associated with nanopillars with the constraints different from those of the thin film devices. | Zhiyong Fan Daniel J.Ruebusch Asghar A.Rathore Rehan Kapadia Onur Ergen Paul W.Leu Ali Javey | 2009 | Nano Research2009，2，11： | 5 |
| 4 | Diagnostic accuracy of EUS in differentiating mucosal versus submucosal invasion of superficial esophageal cancers: a systematic review and meta-analysis显示文摘 | Nirav Thosani Harvinder Singh Asha Kapadia Nobuo Ochi Jeffrey H. Lee Jaffer Ajani Stephen G. Swisher Wayne L. Hofstetter Sushovan Guha Manoop S. Bhutani | 2012 | Gastrointestinal Endoscopy2012，，2： | 3 |
| 5 | A Practical Guide to Multimodality Imaging of Transcatheter Aortic Valve Replacement显示文摘 | Gerald S. Bloomfield Linda D. Gillam Rebecca T. Hahn Samir Kapadia Jonathon Leipsic Stamatios Lerakis Murat Tuzcu Pamela S. Douglas | 2012 | JACC: Cardiovascular Imaging2012，，4： | 2 |
| 6 | Elevated circulating levels of serum tumor necrosis factor- alpha in patients with hemodynamically significant pressure and volume overload显示文摘 | Kapadia SR Yakoob K Nader S | 2000 | J Am Coll Cardiol2000，36，1： | 2 |
| 7 | Cytokines and heart failure 显示文摘 | Kapadia SR | 1999 | Cardiol Rev1999，7，4： | 2 |
| 8 | Hepatitis C Virus Induces Epidermal Growth Factor Receptor Activation via CD81 Binding for Viral Internalization and Entry显示文摘 | Jingyu Diao Homer Pantua Hai Ngu Laszlo Komuves Lauri Diehl Gabriele Schaefer Sharookh B. Kapadia | 2012 | Journal of Virology2012，，20： | 2 |
| 9 | EUS vs MRCP for detection of choledocholithiasis显示文摘 | Dharmendra Verma Asha Kapadia Glenn M. Eisen Douglas G. Adler | 2006 | Gastrointestinal Endoscopy2006，，2： | 2 |
| 10 | Heat conduction in high speed laser welding显示文摘 | Grateke U Kapadia P Dowden J | 1991 | Journal of Physics D: Applied Physics1991，24，12： | 1 |
| 11 | Tumor necrosis factor - and tumor necrosis factor receptors in the failing human heart显示文摘 | Torre-Amione G Kapadia S Lee J | 1996 | Circulation1996，93，： | 1 |
| 12 | Evaluation and management of congenital nasolacrimal duct obstruction显示文摘 | Kapadia MK Freitag SK Woog JJ | 2006 | Otolaryngol Clin North Am2006，39，5： | 1 |
| 13 | Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVE) 显示文摘 | Torre-Amione G Kapadia S Benedict C | 1996 | J Am Coll Cardiol1996，27，： | 1 |
| 14 | Extent and direction of arterial remolding in stable and unstable cironary syndromes显示文摘 | Schoenhagen P Ziada KM Kapadia SR | 2000 | Circulation2000，101，6： | 1 |
| 15 | Randomised controlled trial of the onset of analgesic efficacy of dexketoprofen and diclofenac in lower limb injury显示文摘 | Leman P Kapadia Y Herington J | 2003 | Emerg Med2003，20，6： | 1 |
| 16 | Minimal sufficient statistics for the group divisible partially balanced incomplete block design (GD-PBIBD) with interaction under an Eisenhart Model Ⅱ显示文摘 | Kapadia C H Weeks D L | 1984 | Metrika1984，31，： | 1 |
| 17 | Situation agents: agent-based externalized steering logic 显示文摘 | Schuerman M Singh S Kapadia M | 2010 | Computer Animation and Virtual Worlds2010，21，34： | 1 |
| 18 | Enhancement ofadipogenic and osteogenic differentiation of human bone-mar- row-derived mesenchymal stem cells by supplementation with umbilical cord blood serum 显示文摘 | Tekkatte C Vidyasekar P Kapadia NK eta! | 2012 | Cell Tissue Res2012，347，2： | 1 |
| 19 | Gastric atrophy, metaplasia, and dysplasia: a clinical perspective显示文摘 | Kapadia CR | 2003 | J Clin Gastroenterol2003，36，5： | 1 |
| 20 | Amatoxin Poisoning: Case Reports and Review of Current Therapies显示文摘 | Jeanine Ward Kishan Kapadia Eric Brush Steven D. Salhanick | 2012 | Journal of Emergency Medicine2012，，： | 1 |
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