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| 1 | Direct anterior total hip arthroplasty: Literature review of variations in surgical technique显示文摘The direct anterior approach to the hip has been suggested to have several advantages compared to previously popular approaches through its use of an intra-muscular and intra-nervous interval betweenthe tensor fasciae latae and sartorius muscles. Recent increased interest in tissue-sparing and minimallyinvasive arthroplasty has given rise to a sharp increase in the utilization of direct anterior total hip arthroplasty. A number of variations of the procedure have been described and several authors have published their experiences and feedback to successfully accomplishing this procedure. Additionally, improved understanding of relevant soft tissue constraints and anatomic variants has provided improved margin of safety for patients. The procedure may be performed using speciallydesigned instruments and a fracture table, however many authors have also described equally efficacious performance using a regular table and standard arthroplasty tools. The capacity to utilize fluoroscopy intraoperatively for component positioning is a valuable asset to the approach and can be of particular benefit for surgeons gaining familiarity. Proper management of patient and limb positioning are vital to reducing risk of intra-operative complications. An understanding of its limitations and challenges are also critical to safe employment. This review summarizes the key features of the direct anterior approach for total hip arthroplasty as an aid to improving the understanding of this important and effective method for modern hip replacement surgeons. | Keith P Connolly Atul F Kamath | 2016 | World Journal of Orthopedics2016，7，1： | 33 |
| 2 | Role of dental plaque,saliva and periodontal disease in Helicobacter pylori infection显示文摘Helicobacter pylori(H.pylori)infection is one of the most common bacterial infections in humans.Although H.pylori may be detected in the stomach of approximately half of the world’s population,the mechanisms of transmission of the microorganism from individual to individual are not yet clear.Transmission of H.pylori could occur through iatrogenic,fecal-oral,and oral-oral routes,and through food and water.The microorganism may be transmitted orally and has been detected in dental plaque and saliva.However,the role of the oral cavity in the transmission and recurrence of H.pylori infection has been the subject of debate.A large number of studies investigating the role of oral hygiene and periodontal disease in H.pylori infection have varied significantly in terms of their methodology and sample population,resulting in a wide variation in the reported results.Nevertheless,recent studies have not only shown that the microorganism can be detected fairly consistently from the oral cavity but also demonstrated that the chances of recurrence of H.pylori infection is more likely among patients who harbor the organism in the oral cavity.Furthermore,initial results from clinical trials have shown that H.pylori-positive dyspeptic patients may benefit from periodontal therapy.This paper attempts to review the current body of evidence regarding the role of dental plaque,saliva,and periodontal disease in H.pylori infection. | Pradeep S Anand Kavitha P Kamath Sukumaran Anil | 2014 | World Journal of Gastroenterology2014，20，19： | 15 |
| 3 | Direct anterior total hip arthroplasty:Comparative outcomes and contemporary results显示文摘Direct anterior total hip arthroplasty has become increasingly more popular among arthroplasty surgeons,in large part due to the use of an intramuscular interval and desire to reduce soft tissue damage.Several studies have now been published comparing the anterior intramuscular to other commonly used approaches,and many studies have published complication rates on large series of patients.Review of comparative studies indicates direct anterior hips tend towards shorter hospital stays and high rates of patients discharged to home.Although some studies show evidence of early benefit in functional outcomes,there is no strong evidence that the anterior approach provides any long term functional improvements compared to other approaches.Additionally,evidence to support reduced damage to soft tissue may not translate to certain clinical significance.Rates of intra-operative femur fracture,operative time and blood loss rates are notably higher for those developing familiarity with this approach.However,when surgeons have performed a modest number of procedures,the complication rates tend to markedly decrease in most studies to levels comparable to other approaches.Accuracy of component positioning also favors the anterior approach in some studies.This review summarizes the available literature comparing the direct anterior to other approaches for total hip arthroplasty and provides a comprehensive summary of common complications. | Keith P Connolly Atul F Kamath | 2016 | World Journal of Orthopedics2016，7，2： | 14 |
| 4 | A model to predict survival in patients with end-stage liver disease显示文摘 | Patrick S. Kamath Russell H. Wiesner Michael Malinchoc Walter Kremers Terry M. Therneau Catherine L. Kosberg Gennaro D’Amico E.Rolland Dickson W.Ray Kim | 2001 | Hepatology2001，，2： | 10 |
| 5 | 卵磷脂对甲烷水合物形成的影响显示文摘建立了用于测定卵磷脂(lecithin)对钻井液中水合物形成影响的实验装置及方法,以理解化学添加剂卵磷脂对北极Cascade地区钻井过程中水合物层的稳定作用。本研究旨在理解卵磷脂对纯水中甲烷水合物形成热力学和动力学的影响。结果表明,卵磷脂基本上不影响甲烷水合物生成的热力学条件,但当卵磷脂在水中的浓度超过0.003g.g-1时,它会影响甲烷水合物的生成速度和数量,是很好的水合物生成动力学促进剂。 | 陈卫东 Patil S.L. Kamath V.A. Chukwu G.A. | 2007 | 化工学报2007，58，11： | 7 |
| 6 | Monocyte chemoattractant protein-1, transforming growth factor-β1, nerve growth factor, resistin and hyaluronic acid as serum markers:comparison between recurrent acute and chronic pancreatitis显示文摘BACKGROUND: Diagnostic parameters that can predict the presence of chronic pancreatitis(CP) in patients with recurrent pain due to pancreatitis would help to direct appropriate therapy. This study aimed to compare the serum levels of monocyte chemoattractant protein-1(MCP-1), transforming growth factor-β1(TGF-β1), nerve growth factor(NGF), resistin and hyaluronic acid(HA) in patients with recurrent acute pancreatitis(RAP) and CP to assess their ability to differentiate the two conditions.METHODS: Levels of serum markers assessed by enzymelinked immunosorbent assay(ELISA) were prospectively compared in consecutive patients with RAP, CP and in controls and stepwise discriminant analysis was performed to identify the markers differentiating RAP from CP.RESULTS: One hundred and thirteen consecutive patients(RAP=32, CP=81) and 78 healthy controls were prospectively enrolled. The mean(SD) age of the patients was 32.0(14.0)years; 89(78.8%) were male. All markers were significantly higher in CP patients than in the controls(P<0.001); MCP-1NGF and HA were significantly higher in RAP patients than in the controls(P<0.001). Stepwise discriminant analysis showed significant difference(P=0.002) between RAP and CP for resistin with an accuracy of 61.9%, discriminant scores of ≤-0.479 and ≥0.189 indicating RAP and CP, respectively. The other markers had no differential value between RAP and CP.CONCLUSION: Serum resistin is a promising marker to differentiate between RAP and CP and needs validation in future studies, especially in those with early CP. | M Ganesh Kamath C Ganesh Pai Asha Kamath Annamma Kurien | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，2： | 7 |
| 7 | Bernese periacetabular osteotomy for hip dysplasia: Surgical technique and indications显示文摘For young, active patients with healthy hip cartilage, pelvic osteotomy is a surgical option in to address hip pain and to improve mechanical loading conditions related to dysplasia. Hip dysplasia may lead to arthrosis at an early age due to poor coverage of the femoralhead and abnormal loading of the joint articulation. In patients with symptomatic dysplasia and closed triradiate cartilage(generally over age 10), including adolescents and young adults(generally up to around age 40), the Bernese periacetabular osteotomy(PAO) is a durable technique for addressing underlying structural deformity. The PAO involves a modified Smith-Petersen approach. Advantages of the Bernese osteotomy include preservation of the weight-bearing posterior column of the hemi-pelvis, preservation of the acetabular blood supply, maintenance of the hip abductor musculature, and the ability to effect powerful deformity correction about an ideal center of rotation. There is an increasing body of evidence that preservation of the native hip can be improved through pelvic osteotomy. In contrast to hip osteotomy and joint preservation, the role of total hip arthroplasty in young, active patients with correctable hip deformity remains controversial. Moreover, the durability of hip replacement in young patients is inherently limited. Pelvic osteotomy should be considered the preferred method to address correctable structural deformity of the hip in the young, active patient with developmental dysplasia. The Bernese PAO is technically demanding, yet offers reproducible results with good long-term survivorship in carefully selected patients with preserved cartilage and the ability to meet the demands of rehabilitation. | Atul F Kamath | 2016 | World Journal of Orthopedics2016，7，5： | 7 |
| 8 | The AO/ASIF proximal femoral nail antirotation (PFNA): A new design for the treatment of unstable proximal femoral fractures显示文摘 | Praveen Mereddy Sri Kamath Muthukrishnan Ramakrishnan Hamad Malik Nigel Donnachie | 2008 | Injury2008，，4： | 6 |
| 9 | Transjugular intrahepatic portosystemic stent shunt for medically refractory hepatic hydrothorax:A systematic review and cumulative meta-analysis显示文摘AIM:To assess the effectiveness of transjugular intrahepatic portosystemic stent shunt(TIPSS) in refractory hepatic hydrothorax(RHH) in a systematic review and cumulative meta-analysis.METHODS:A comprehensive literature search was conducted on MEDLINE,EMBASE,and Pub Med covering the period from January 1970 to August 2014.Two authors independently selected and abstracted data from eligible studies.Data were summarized using a random-effects model.Heterogeneity was assessed using the I2 test.RESULTS:Six studies involving a total of 198 patients were included in the analysis.The mean(SD) age of patients was 56(1.8) years.Most patients(56.9%) had Child-Turcott-Pugh class C disease.The mean duration of follow-up was 10 mo(range,5.7-16 mo).Response to TIPSS was complete in 55.8%(95%CI:44.7%-66.9%),partial in 17.6%(95%CI:10.9%-24.2%),and absent in 21.2%(95%CI:14.2%-28.3%).The mean change in hepatic venous pressure gradient post-TIPSS was 12.7 mm Hg.The incidence of TIPSS-related encephalopathy was 11.7%(95%CI:6.3%-17.2%),and the 45-d mortality was 17.7%(95%CI:11.34%-24.13%).CONCLUSION:TIPSS is associated with a clinically relevant response in RHH.TIPSS should be considered early in these patients,given its poor prognosis. | Ivo C Ditah Badr F Al Bawardy Behnam Saberi Chobufo Ditah Patrick S Kamath | 2015 | World Journal of Hepatology2015，7，13： | 5 |
| 10 | Gut microbiome in primary sclerosing cholangitis:A review显示文摘Primary sclerosing cholangitis(PSC)is a chronic cholestatic liver disease characterized by biliary inflammation and stricturing.Exploration of the pathogenesis of PSC in light of its association with inflammatory bowel disease(IBD)and the“gut-liver”axis is an emerging area of interest.A growing number of studies have begun to elucidate the role of the gut microbiota,its metabolites and its influence on host immune responses in the development of PSC and PSCIBD.Studies of the fecal microbiota have highlighted enriched levels of certain species,including Veillonella,Streptococcus and Enterococcus,among others.A heightened immune response to enteric dysbiosis and bacterial translocation have also been implicated.For example,Klebsiella pneumoniae strains derived from gnotobiotic mice transplanted with PSC-IBD microbiota were found to induce pore formation in human intestinal epithelial cells and enhanced Th17 responses.Gut microbes have additionally been hypothesized to be implicated in PSC pathogenesis through their role in the synthesis of various metabolites,including bile acids(BAs),which function as signaling molecules with important gut and hepatic effects.An expanded knowledge of the gut microbiome as it relates to PSC offers critical insight into the development of microbe-altering therapeutic interventions,such as antibiotics,nutritional interventions and fecal microbial transplantation.Some of these have already shown some preliminary evidence of benefit.Despite exciting progress in the field,much work remains to be done;areas that are particularly lacking include functional characterization of the microbiome and examination of pediatric populations.In this review,we summarize studies that have investigated the microbiome in PSC and PSC-IBD as well as putative mechanisms,including the potential role of metabolites,such as BAs.We then briefly review the evidence for interventions with microbe-altering properties for treating PSC. | Rebecca Little Eytan Wine Binita M Kamath Anne M Griffiths Amanda Ricciuto | 2020 | World Journal of Gastroenterology2020，26，21： | 5 |
| 11 | Hepatoprotective activity of Hepax-A polyherbal formulation显示文摘Objective:To evaluate the hepatoprotective potential of Hepax,a polyherbal formulation,against three experimentally induced hepatotoxicity models in rats.Methods:Hepatoprotective activity of Hepax was studied against three experimentally induced hepatotoxicity models,namely, carbon tetrachloride(CCl_4),paracetamol and thiocetamide induced hepatotoxicity in rats. Results:Administration of hepatotoxins(CCl_4,paracetamol and thiocetamide) showed significant morphological,biochemical and histological deteriorations in the liver of experimental animals. Pretreatment with Hepax had significant protection against hepatic damage by maintaining the morphological parameters(liver weight and liver weight to organ weight ratio) within normal range and normalizing the elevated levels of biochemical parameters(SGPT,SCOT,ALP and total bilirubin),which were evidently showed in histopathological study.Conclusions:The Hepax has highly significant hepatoprotective effect at 100 and 200 mg/kg,p.o.on the liver of all the three experimental animal models. | VC Devaraj B Gopala Krishna GL Viswanatha Jagadish V Kamath Sanjay Kumar | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，2： | 4 |
| 12 | Acute-on chronic liver failure显示文摘 | Rajiv Jalan Pere Gines Jody C Olson Rajeshwar P Mookerjee Richard Moreau Guadalupe Garcia-Tsao Vicente Arroyo Patrick S Kamath | 2012 | Journal of Hepatology2012，，6： | 4 |
| 13 | Evidence-Based Incorporation of Serum Sodium Concentration Into MELD显示文摘 | Scott W. Biggins W. Ray Kim Norah A. Terrault Sammy Saab Vijay Balan Thomas Schiano Joanne Benson Terry Therneau Walter Kremers Russell Wiesner Patrick Kamath Goran Klintmalm | 2006 | Gastroenterology2006，，6： | 3 |
| 14 | Alcoholic Hepatitis: Current challenges and future directions显示文摘 | Ashwani K. Singal Patrick S. Kamath Gregory J. Gores Vijay H. Shah | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 3 |
| 15 | Mesenteric Venous Thrombosis显示文摘 | Ashwani K. Singal Patrick S. Kamath Ayalew Tefferi | 2013 | Mayo Clinic Proceedings2013，，3： | 3 |
| 16 | MIPI将彻底改变移动产品设计方式显示文摘MIPI联盟定义了一套接口标准,把移动设备内部的接口如摄像头、显示屏、基带、射频接口等标准化,从而增加设计灵活性,同时降低成本、设计复杂度、功耗和EMI。 | Prakash Kamath | 2012 | 集成电路应用2012，，2： | 3 |
| 17 | The prevalence of isolated otolith dysfunction in a local tertiary hospital显示文摘Objective:Patients with dizziness may present with symptoms of tilting,swaying,rocking,floating or with disequilibrium.This may be suggestive of an isolated otolithic dysfunction yet,there is little emphasis on this emerging clinical entity.To characterize and describe the prevalence of isolated otolith dysfunction in a local tertiary hospital and correlate them with clinical diagnosis.Methodology:Retrospective medical chart review of patients who presented with dizziness to the specialist outpatient Otolaryngology clinic,who required vestibular laboratory investigation.Results:Of the 206 patients,more than half of them(52.4%)fulfilled the criteria for either probable or definite isolated otolith dysfunction.When there are clinical symptoms of otolith dysfunction reported,there is a 1.62 odds of a remarkable laboratory otolith finding.The most common clinical finding was“no clear diagnosis”(65.5%)followed by Vestibular Migraine(13.6%).Conclusion:The prevalence of isolated otolith dysfunction is quite high.Laboratory tests of otolith function should be performed more routinely.This can be done in a sequential way to optimize cost effectiveness in countries with no insurance reimbursement.Prospective cohort studies on isolated otolith dysfunction,will lay the groundwork for achieving diagnostic consensus and formulating rehabilitation plans to aid this group of patients。 | Kenneth Wei De Chua Heng Wai Yuen David Yong Ming Low Savitha Hosangadi Kamath | 2022 | Journal of Otology2022，17，1： | 3 |
| 18 | Model for end-stage liver disease (MELD) and allocation of donor livers显示文摘 | Russell Wiesner Erick Edwards Richard Freeman Ann Harper Ray Kim Patrick Kamath Walter Kremers John Lake Todd Howard Robert M. Merion Robert A. Wolfe Ruud Krom | 2003 | Gastroenterology2003，，1： | 2 |
| 19 | Hepatic resection of hepatocellular carcinoma in patients with cirrhosis: Model of end-stage liver disease (MELD) score predicts perioperative mortality显示文摘 | Swee H. Teh John Christein John Donohue Florencia Que Michael Kendrick Michael Farnell Stephen Cha Patrick Kamath Raymond Kim David M. Nagorney | 2005 | Journal of Gastrointestinal Surgery2005，，9： | 2 |
| 20 | Natural History of Cirrhosis显示文摘 | Sumeet K. Asrani Patrick S. Kamath | 2013 | Current Gastroenterology Reports2013，，2： | 2 |
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