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| 1 | Oxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin显示文摘瞄准:Microcirculatory 机能障碍和免费的氧激进分子是在严重尖锐胰腺炎的致病的重要因素。另外的氧交货可能每氧化提高类脂化合物,但是可以也改进胰腺的微循环。这研究在严重尖锐胰腺炎的一个啮齿类动物模型在氧激进分子和微循环的形成上估计免费细胞的牛的血红素的效果。方法:在尖锐胰腺炎 Wistar 老鼠的正式就职以后的十五分钟收到了任何一个 0.8 mL 牛的血红素(HBOC-200 ) , hydroxyethyl 淀粉(HES ) 或保证血量正常替换的生理盐水的 2.4 mL。在检查的 6 h 以后,胰每氧化产品 malondialdehyde (MDA ) 为类脂化合物的间接测量被切除并且很快处理了并且在胰腺的织物减少了谷胱甘肽(GSH ) 。结果:HBOC-200 的单个申请改进了胰腺的微循环并且显著地减少了组织病理学说的织物损坏。MDA 的织物集中没在这些组之间不同。另外,在 GSH 层次的差别都没被检测。结论:不过 HBOC-200 和 HES 的单个申请改进胰腺的微循环,在类脂化合物的没有差别每氧化,产品被检测。另外的氧供应(HBOC-200 ) 的有益的效果不每氧化导致提高的类脂化合物。 | Helge Kleinhans Oliver Mann Paulus G Schurr Jussuf T Kaifi Bente Hansen Jakob R Izbicki Tim Strate | 2006 | World Journal of Gastroenterology2006，12，18： | 6 |
| 2 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 3 | HER-2 amplification is highly homogenous in gastric cancer显示文摘 | Andreas H. Marx Lars Tharun Johanna Muth Ana-Maria Dancau Ronald Simon Emre Yekebas Jussuf T. Kaifi Martina Mirlacher Tim H. Brümmendorf Carsten Bokemeyer Jakob R. Izbicki Guido Sauter | 2009 | Human Pathology2009，，6： | 3 |
| 4 | Multidisciplinary management of malignant pleural effusion 显示文摘 | Kaifi JT Toth JW Gusani N J | 2012 | J Surg Oncol2012，105，7： | 1 |
| 5 | Multidisciplinary management of malignant pleural effusion 显示文摘 | Kaifi JT Toth JW Gusani NJ | 2012 | J Surg Oncol2012，105，7： | 1 |
| 6 | Absence of LI in pancre-atic masses distinguishes adenocarcinomas from poorlydifferentiat-ed neuroendocrine carcinomas 显示文摘 | Kaifi JT Heidtmann S Schurr PG | 2006 | Anticancer Res2006，26，2： | 1 |
| 7 | Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer显示文摘 | Jussuf T Kaifi Emre F | 2005 | J Nail Cancer Inst2005，97，24： | 1 |
| 8 | LI is a potential markerfor poorly - differentiated pancreatic neuroendocrine carcinoma显示文摘 | Kaifi JT Zinnkann U Yekebas EF | 2006 | World J Gastroenterol2006，12，1： | 1 |
| 9 | Distinct roles for PECAM-1,ICAM-1,and VCAM-1 in recruitment of neutrophils and eosinophils to the cornea in ocular onchocerciasis (river blindness)显示文摘 | Kaifi JT Diaconu E Pearlman E | 2001 | J Immunol2001，166，11： | 1 |
| 10 | Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer显示文摘 | Kaifi JT Yekehas EF Schorr P | | 0，，24： | 1 |
| 11 | Indications and approach to surgical resection of lung metastases显示文摘 | Kaifi JT Gusani NJ Deshaies I | | 0，，02： | 1 |
| 12 | Muhidisciplinary management of malignant pleural effusion 显示文摘 | Kaifi JT Toth JW Gusani N J | 2012 | J Surg Oncol2012，105，7： | 1 |
| 13 | Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal squamous cancer显示文摘 | Kaifi JT Yekebas EF Schur P | 2005 | J Natl Cancer Inst2005，97，24： | 1 |
| 14 | Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer 显示文摘 | Kaifi JT Yekebas EF Schurr P | 2005 | J Natl Cancer Inst2005，97，： | 1 |
| 15 | Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer 显示文摘 | Kaifi JT Yekebas EF Schurr P | 2005 | J Natl Cancer Inst2005，97，24： | 1 |
| 16 | Lymphatic spread and microinvolvement in adenocarcinoma of the esophago-gastric junction显示文摘 | SCHURR PG EKEBAS EF KAIFI JT | 2006 | J Surg Oncol2006，94，4： | 1 |
| 17 | Low levels of transforming growth factor-beta (TGF-beta) and reduced suppression of Th2- mediated inflammation in hyperreactive human onchocerciasis显示文摘 | Korten S Hoerauf A Kaifi JT | 2011 | Parasitology2011，138，1： | 1 |
| 18 | Postpancreatectomy Hemorrhage: Diagnosis and Treatment: An Analysis in 1669 Consecutive Pancreatic Resections显示文摘 | Emre F. Yekebas Lars Wolfram Guellue Cataldegirmen Christian R. Habermann Dean Bogoevski Alexandra M. Koenig Jussuf Kaifi Paulus G. Schurr Michael Bubenheim Claus Nolte-Ernsting Gerhard Adam Jakob R. Izbicki | 2007 | Annals of Surgery2007，，2： | 1 |
| 19 | Multidisciplinary management of malignant pleural effusion显示文摘 | Kaifi JT Toth JW Gusani NJ | 2012 | J Surg Oncol2012，105，7： | 1 |
| 20 | Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer显示文摘 | Kaifi JT Yekebas EF Schurr P | 2005 | Journal of the National Cancer Institute2005，97，24： | 1 |
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