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| 1 | 采用预喷射减少柴油机的NO_x排放显示文摘在一台涡轮增压直喷式柴油机上研究了预喷射对柴油机燃烧的影响。在改变预喷射油量和定时的情况下,测定了各种喷油条件下的发动机排放。结果表明,预喷射能减少低负荷时的NO_x和总HC排放,并能在一定程度上改善燃油耗。为了解这一现象,对柴油机的燃烧进行了分析,并用内窥镜观察了燃烧过程。发现预喷射之所以能降低燃气平均温度是由于限制了预混合燃烧以及延缓扩散燃烧的缘故。摄取了预喷射燃烧产生的燃气被喷入预喷射燃烧火焰中的主喷射油束卷吸而导致燃烧延缓的照片。 | Minami T Takeuchi K Shimazaki N 朱炳全 | 1998 | 国外内燃机1998，30，1： | 9 |
| 2 | Ellectrochemical deposition of SnS thin films显示文摘 | Ichimura M Takeuchi K Ono Y | 2000 | Thin Solid Films2000，98，： | 2 |
| 3 | Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components显示文摘 | Takeuchi O Hoshino K Kawai T | 1999 | Immunity1999，11，4： | 2 |
| 4 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 5 | Protective effect of Irsogladine on monochloramineinduced gastric mucosallesions in rats:a comparative study with rebamipide显示文摘AIM To examine the effect of irsogladine, a novel antiulcer drug, on the mucosal ulcerogenic response to monochloramine (NH 2Cl) in rat stomach, in comparison with rebamipide, another antiulcer drug with cytoprotective activity. METHODS AND RESULTS Oral administration of NH 2Cl (120*!mM) produced severe hemorrhagic lesions in unanesthetized rat stomachs. Both irsogladine ( 1*!mg/*!kg - 10*!mg/*!kg , po ) and rebamipide ( 30*!mg/*!kg - 100*!mg/*!kg , po ) dose dependently prevented the development of these lesions in response to NH 2Cl, the effect of irsogladine was significant at 3*!mg/*!kg or greater, and that of rebamipide only at 100*!mg/*!kg . The protective effect of irsogladine on NH 2Cl induced gastric lesions was significantly reduced by N G nitro L arginine methyl ester (L NAME) but not by indomethacin, while that of rebamipide was significantly mitigated by indomethacin but not by L NAME. Topical application of NH 2Cl (20*!mM) caused a marked reduction of potential difference (PD) in ex vivo stomachs. This PD reduction was not affected by mucosal application of irsogladine, but significantly prevented by rebamipide. The mucosal exposure to NH 4OH (120*!mM) also caused a marked PD reduction in the ischemic stomach (bleeding from the carotid artery), resulting in gastric lesions. These ulcerogenic and PD responses caused by NH 4OH plus ischemia were also significantly mitigated by rebamipide, in an indomethacin sensitive manner, while irsogladine potently prevented such lesions without affecting the PD response, in a L NAME sensitive manner. CONCLUSION These results suggest that ① NH 2Cl generated either exogenously or endogenously damages the gastric mucosa, ② both irsogladine and rebamipide protect the stomach against injury caused by NH 2Cl, and ③ the mechanism underlying the protective action of irsogladine is partly mediated by endogenous nitric oxide, while that of rebamipide is in part mediated by endogenous prostaglandins. | H Yamamoto, M Umeda, H Mizoguchi, S Kato and K Takeuchi | 1999 | World Journal of Gastroenterology1999，5，6： | 2 |
| 6 | Nitrile hydratase of Pseudomonas chlororaphis B23: Purification and characterization 显示文摘 | Nagasawa T Nanba H Ryuno K Takeuchi K Yamada H | 1987 | Eur J Biochem1987，162，： | 1 |
| 7 | Back analysis of measured displacement of tunnel显示文摘 | SAKURAI S TAKEUCHI K | 1983 | Rock Mech and Rock Eng1983，16，3： | 1 |
| 8 | Role of nitric oxide in mucosal blood flow response and the healing of HCl-induced lesions in the rat stomach显示文摘 | Takeuchi K Kato S Takehara K | 1997 | Digestion1997，58，1： | 1 |
| 9 | Potential therapeutic implication of nifedipine,a dihydropyridine-based calcium antagonist,in advanced glycation end product (AGE) -related disorders 显示文摘 | Yamagishi S Nakamura K Takeuchi M | 2005 | Med Hypotheses2005，65，2： | 1 |
| 10 | Characterization of a new cobalt-containing nitrile hydratase purified from urea-induced cells of Rhodococcus rhodochrous J1显示文摘 | Nagasawa T Takeuchi K Yamada H | 1991 | Eur J Biochem1991，196，： | 1 |
| 11 | For hydro- environmental simulation of a large ungauged basin- introduction of block-wise use of TOPMODEL and Muskingum-Cunge method 显示文摘 | Takeuchi K Ao Tianqi Ishidaira H | 1999 | Hydrological Sciences Journal1999，44，4： | 1 |
| 12 | Pigment epithelium-derived factor inhibits oxidative stress-induced apoptosis and dysfunction of cultured retinal pericytes显示文摘 | Amano S Yamagishi S Inagaki Y Nakamura K Takeuchi M Inoue H | 2005 | Microvasc Res2005，69，12： | 1 |
| 13 | Postprandial hypotension due to a lack of sympathetic compensation in patients with diabetes mellitus显示文摘 | Tanakaya M Takahashi N Takeuchi K | 2007 | Acta Med Okayama2007，61，4： | 1 |
| 14 | Biphasic vasodilatoraction of troglitazone on the renal microcirculation显示文摘 | Arima S Kohagura K Takeuchi K | 2002 | J Am SocNephrol2002，13，34： | 1 |
| 15 | Differential Effects of Am- rinone and Milrinone Upon Myocardial Inflammatory Signaling显示文摘 | Chanani N K Cowan D B Takeuchi K | 2002 | Cir- culation2002，106，： | 1 |
| 16 | Pyrolytic carbon nanotubes from vapor-grown carbon fibers 显示文摘 | ENDO M TAKEUCHI K KROTO H | 1995 | Carbon1995，33，7： | 1 |
| 17 | Piezoelectricity of c-axis orented PbTiO3 Thin-films显示文摘 | Kushida K Takeuchi H | 1987 | Appl Phys Lett1987，50，25： | 1 |
| 18 | Defferential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components 显示文摘 | Takeuchi OK Hoshino K Kawai T | 1999 | Immunity1999，11，： | 1 |
| 19 | Back analysis in measured displacements of tunnels显示文摘 | SAKURAI S TAKEUCHI K | 1983 | Rock Mechanics Rock Eng1983，16，： | 1 |
| 20 | Role of nitric oxtde in mucosalblood flow responns and the healing of HCL-induced lesions in the ratstomach 显示文摘 | Takeuchi K Kato S Takehara K | 1997 | Digestion1997，58，1： | 1 |
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