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| 1 | An HDR Imaging Method With DTDI Technology for Push-Broom Cameras显示文摘通常,高动态范围(HDR ) 成像基于拿二或有不同暴露的一样的景色的更多的图画。由于在照相机和景色之间的一个高速度的相对运动,然而,要用于推扫帚遥感照相机,为这种技术是难的。为在推扫帚遥感应用的 HDR 成像的缘故,现在的纸建议没有冗余的图象传感器或光部件,能产生 HDR 图象的一个创新方法。明确地,这份报纸与数字领域 time-delay-integration (DTDI ) 采用一个区域数组互补金属氧化物半导体(互补金属氧化物半导体) 为成像的技术而不是多于一个排图象传感器采用,从而与不同暴露拍摄超过一张照片。然后由与一个简单算法熔化二幅原来的图象的一幅新 HDR 图象能被完成。由进行实验,图象的动态范围(医生) 由 26.02 dB 增加。建议方法被证明有效并且在在照相机和场面之间有一个相对运动的另外的成像应用有潜力。 | Wu SUN Chengshan HAN Xucheng XUE Hengyi LV Junxia SHI Changhong HU Xiangzhi LI Yao FU Xiaonan JIANG Liang HUANG Hongyin HAN | 2018 | Photonic Sensors2018，8，1： | 4 |
| 2 | An online measurement method based on line laser scanning for large forgings 显示文摘 | Zhang Yucun Han Junxia Fu Xianbin | 2014 | The International Journal of Advanced Manufacturing Technology2014，70，14： | 1 |
| 3 | Distribution of metals and brominated flame retardants (BFRs) in sediments, soils and plants from an informal e-waste dismantling site, South China显示文摘 | Junxia Wang Lili Liu Jinfu Wang Bishu Pan Xiaoxu Fu Gang Zhang Long Zhang Kuangfei Lin | 2015 | Environmental Science and Pollution Research2015，，2： | 1 |
| 4 | hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells显示文摘 | Lei Shi Zihao Cheng Junxia Zhang Rui Li Peng Zhao Zhen Fu Yongping You | 2008 | Brain Research2008，，： | 1 |
| 5 | Mechanisms and regulation of defensins in host defense显示文摘As a family of cationic host defense peptides,defensins are mainly synthesized by Paneth cells,neutrophils,and epithelial cells,contributing to host defense.Their biological functions in innate immunity,as well as their structure and activity relationships,along with their mechanisms of action and therapeutic potential,have been of great interest in recent years.To highlight the key research into the role of defensins in human and animal health,we first describe their research history,structural features,evolution,and antimicrobial mechanisms.Next,we cover the role of defensins in immune homeostasis,chemotaxis,mucosal barrier function,gut microbiota regulation,intestinal development and regulation of cell death.Further,we discuss their clinical relevance and therapeutic potential in various diseases,including infectious disease,inflammatory bowel disease,diabetes and obesity,chronic inflammatory lung disease,periodontitis and cancer.Finally,we summarize the current knowledge regarding the nutrient-dependent regulation of defensins,including fatty acids,amino acids,microelements,plant extracts,and probiotics,while considering the clinical application of such regulation.Together,the review summarizes the various biological functions,mechanism of actions and potential clinical significance of defensins,along with the challenges in developing defensins-based therapy,thus providing crucial insights into their biology and potential clinical utility. | Jie Fu Xin Zong Mingliang Jin Junxia Min Fudi Wang Yizhen Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 1 |
| 6 | A comparative study of alteration in retinal layer segmentation alteration by SD-OCT in neuromyelitis optica spectrum disorders: A systematic review and meta-analysis显示文摘Background:To evaluate the feature of different retinal layer segmentation in neuromyelitis optica spectrum disorders(NMOSD)with spectral-domain optical coherence tomography(SD-OCT)and to compare it with that in multiple sclerosis(MS),healthy controls(HC),and idiopathic optic neuritis(ION).Methods:We retrieved four electronic databases,including Pubmed,Embase,Cochrane Library,and Web of Science from inception to September 1st,2021.A meta-analysis was performed to compare different retinal layer segmentation thicknesses between patients with or without a history of optic neuritis(ON)in NMOSD and the control group,including patients with MS,HC,and ION.Results:Forty-two studies were included and the interval between the last ON onset and examination was greater than 3 months.Compared with that in HC eyes,the loss of retinal nerve fiber layer(RNFL)and macular ganglion cell and inner plexiform layer(GC-IPL)was serious in NMOSD eye especially after ON.Moreover,compared with that in ION eyes or MS-related-ON eyes,the injury to the peripapillary retinal nerve fiber layer(pRNFL)was severe in NMOSD-related-ON eyes.In addition,the correlation coefficient between pRNFL and prognostic visual acuity was 0.43.However,the one-arm study revealed the inner nuclear layer(INL)was thickened in NMOSDrelated-ON eyes compared with HC eyes.Conclusions:Inclusion of the RNFL and macular GC-IPL is recommended for monitoring disease progression and attention should be paid to changes in the INL. | Junxia Fu Shaoying Tan Chunxia Peng Huanfen Zhou Shihui Wei | 2021 | Advances in Ophthalmology Practice and Research2021，1，1： | 1 |
| 7 | The clinical application of critical flicker fusion frequency in demyelinating optic neuritis显示文摘Purpose:To investigate the application of critical flicker fusion frequency(CFF)in demyelinating optic neuritis(DON).Methods:A cross-sectional study.A total of 127 eyes in 69 DON patients and 63 eyes in 33 healthy control(HC)groups were included between January 2021 to September 2021 from Department of Ophthalmology,PLA General Hospital.Patients underwent best-corrected visual acuity(BCVA),visual field,optical coherence tomography(OCT),flash visual evoked potential(F-VEP),and CFF examinations.The affected eyes were divided into aquaporins 4(AQP4-),myelin oligodendrocyte glycoprotein(MOG-),and double negative DON according to serum antibody;mild,moderate,severe degree visual impairment according to BCVA0.5,0.1-0.5,<0.1;and 4 groups:<1,1~<3,3~<6 and>6 months according to time interval from onset to CFF examination.One-way ANOVA was used to perform above subgroup analysis.The correlations between CFF and F-VEP peak time,peak value,BCVA and mean visual filed defect(MD)were analyzed in order via Pearson correlation analysis.Results:he trichromatic values of red,green,and yellow in DON affected eyes were 21.83±9.03,23.66±10.21,24.09±10.77 Hz,respectively,which was significantly reduced compared with the HC group(t=-14.82,-14.22,-14.00;P<0.001).The subgroup analysis showed no significant difference between different antibody subtypes(P=0.914<0.848<0.604),whereas,a significant decrease of CFF trichromatic value was found in severe visual acuity impairment group(P<0.001).There was a significant difference in CFF-trichromatic values at different time points(P<0.001),to be specific,CFF fluctuated under 20Hz within 3 months after onset and tended to be stable around 24-28Hz.Correlation analysis showed that the peak time of F-VEP(r=-0.486,-0.515,-0.526;P<0.001),BVCA(r=-0.640,-0.659,-0.642;P<0.001),were negatively correlated with CFF trichromatic values,MD and CFF were positively correlated(r=0.486,0.453,0.476;P=0.003,0.006,0.004).Conclusions:A significant decrease of CFF value was found in DON-affected eyes,and it has a good correlation with BCVA,MD and latency of F-VEP,and can better reflect the impairment of visual function. | Junxia Fu Yongping Wang Shaoying Tan Guangcan Xu Huanfen Zhou Quangang Xu Shihui Wei | 2021 | Advances in Ophthalmology Practice and Research2021，1，2： | 0 |
| 8 | Differences in the involved sites among different types of demyelinating optic neuritis in traditional MRI examination:A systematic review and meta-analysis显示文摘Background:Magnetic resonance imaging(MRI)plays a significant role in assessing optic neuropathy and providing more detailed information about the lesion of the visual pathway to help differentiate optic neuritis from other visual disorders.This study aims to systematically review the literature and verify if there is a real difference in lesion location among different demyelinating optic neuritis(DON)subtypes.Methods:A systematic search was conducted including 8 electronic databases and related resources from the establishment of the database to August 25th,2020.We classified DON into 5 subtypes and divided the visual pathways into five segments mainly comparing the differences in the involved visual pathway sites of different subtypes.Results:Fifty-five studies were included in the analysis,and the abnormal rate was as high as 92%during the acute phase(within 4 weeks of symptom onset).With respect to lesion location,the orbital segment of the optic nerve was the most frequently involved(87%),whereas optic tract involvement was very rare.Involvement of the orbital segment was more common in myelin oligodendrocyte glycoprotein antibody-related optic neuritis(MOGON)(78%)and chronic relapsing inflammatory optic neuropathy(CRION)(81%),while the lesion was found to be located more posteriorly in neuromyelitis optica spectrum disorder-related optic neuritis(NMOSD-ON).With respect to lesion length,approximately 77%of MOG-ON patients had lesions involving more than half of the optic nerve length.Conclusions:MRI examination is recommended for DON patients in the acute phase.In MOG-ON,anterior involvement is more common and the involved length is mostly more than 1/2 of the optic nerve length,whereas posterior involvement,intracranial segment,optic chiasm,or optic tract,is more common in NMOSD-ON. | Yongping Wang Junxia Fu Honglu Song Quangang Xu Huanfen Zhou Shihui Wei | 2021 | Advances in Ophthalmology Practice and Research2021，1，2： | 0 |
| 9 | The theory of critical flicker fusion frequency and its application in cataracts显示文摘Background:Due to media opacity,it is usually difficult to accurately evaluate the postoperative visual acuity in cataracts patients.As a small and portable tool,the critical flicker fusion frequency(CFF)device reflects the temporal resolution of visual function and has been widely used in clinical research.However,poor understanding of the technique and equipment limitations have restricted its clinical application in China.Main text:There was a decrease in the CFF value in various ophthalmic diseases,indicating that the CFF is sensitive to detect visual functional changes.A number of studies have shown that the CFF test can accurately distinguish patients with simple cataracts from those with cataracts combined with fundus disease,and,as a visual test,it can more accurately predict postoperative visual acuity without being affected by media opacity.This study comprehensive reviews the basic principles of CFF and its application in ophthalmology,especially in cataracts.Conclusions:As one of the tools for dynamic visual function detection,the CFF test could help doctors to assess the possible presence of fundus disease in cataracts patients,especially in eyes with dense cataracts,and more precisely provide a reasonable visual prognosis than other available visual tests. | Guangcan Xu Junxia Fu Haolan Qi Linyu Li Wenqian Chen Yi Gao Tianju Ma Zi Ye Zhaohui Li | 2023 | Advances in Ophthalmology Practice and Research2023，3，1： | 0 |
| 10 | A GAN-based deep enhancer for quality enhancement of retinal images photographed by a handheld fundus camera显示文摘Objective:Due to limited imaging conditions,the quality of fundus images is often unsatisfactory,especially for images photographed by handheld fundus cameras.Here,we have developed an automated method based on combining two mirror-symmetric generative adversarial networks(GANs)for image enhancement.Methods:A total of 1047 retinal images were included.The raw images were enhanced by a GAN-based deep enhancer and another methods based on luminosity and contrast adjustment.All raw images and enhanced images were anonymously assessed and classified into 6 levels of quality classification by three experienced ophthalmologists.The quality classification and quality change of images were compared.In addition,imagedetailed reading results for the number of dubiously pathological fundi were also compared.Results:After GAN enhancement,42.9% of images increased their quality,37.5%remained stable,and 19.6%decreased.After excluding the images at the highest level(level 0)before enhancement,a large number(75.6%)of images showed an increase in quality classification,and only a minority(9.3%)showed a decrease.The GANenhanced method was superior for quality improvement over a luminosity and contrast adjustment method(P<0.001).In terms of image reading results,the consistency rate fluctuated from 86.6%to 95.6%,and for the specific disease subtypes,both discrepancy number and discrepancy rate were less than 15 and 15%,for two ophthalmologists.Conclusions:Learning the style of high-quality retinal images based on the proposed deep enhancer may be an effective way to improve the quality of retinal images photographed by handheld fundus cameras. | Junxia Fu Lvchen Cao Shihui Wei Ming Xub Yali Song Huiqi Li Yuxia You | 2022 | Advances in Ophthalmology Practice and Research2022，2，3： | 0 |
| 11 | Clinical characteristics of radiation-induced optic neuropathy:A single-center retrospective study显示文摘Purpose:To observe the clinical and imaging characteristics of radiation-induced optic neuropathy(RION).Methods:We retrospectively reviewed the clinical data of 43 patients(69 eyes)who were diagnosed with RION at the Chinese PLA General Hospital from 2010 to 2021.Results:The latency from radiotherapy to onset of visual loss ranged from 1 to 132(36.33±30.48)months.Optic disc pallor and optic disc edema were found in 27.0%(10/37)and 8.1%(3/37)of the eyes,respectively,within 2 months.After treatment,the best corrected visual acuity(BCVA)was restored in 24.6%(17/69)of the eyes and the final BCVA improved in 13.0%(9/69)of the eyes.An 82.5%(33/40)of the eyes with magnetic resonance imaging(MRI)showed enhancement of the affected optic nerve,mostly(69.7%)in the intracranial segment,and 36.4%(12/33)of the eyes with expansion and T2-high signals also showed enhancement of the affected optic nerve.The superior retinal nerve fiber layer(RNFL)and the outer circle superior quadrant(OS)of the inner limiting membrane to retinal pigment epithelium(ILM-RPE)layer thinned significantly during the first month.The center of the ILM-RPE layer thickened significantly during the first two months and the inner circle temporal quadrant(IT)of the ILM-RPE layer thickened significantly from the third to sixth month.The RNFL thinned significantly after 6 months except for the temporal quadrant,and the average inner circle superior quadrant(IS)and outer circle of the ILM-RPE layer thinned significantly after 6 months.There was no significant difference between hyperbaric oxygen therapy(HBOT)and high-dose intravenous methylprednisolone(IVMP)therapy in improving BCVA recovery or final BCVA(P>0.05).Conclusions:The structural damage of the RNFL and ILM-RPE layer occurred during the first month,the RNFL showed progressive thinning during the follow-up period,while the ILM-RPE layer showed thinning during the first month,thickening from the third to sixth month,and thinning after 6 months.There was a discrete region of enhancement of the optic nerve,often with expansion and high-T2 signals on MRI.HBOT and high-dose IVMP therapy were hardly effective for treating RION in the non-acute stage. | Yongping Wang Junxia Fu Huanfen Zhou Hongen Li Quangang Xu Shihui Wei | 2023 | Advances in Ophthalmology Practice and Research2023，3，3： | 0 |
| 12 | First Beam Commissioning of SSC-Linac as an Injector of SSC显示文摘The construction of the SSC-Linac has made significant progress in 2019.The first beam commissioning of SSC-Linac as an injector of the Separated Sector Cyclotron(SSC)was performed succssfully with ^(40)Ar^(7+) beam and the particle energy of 5.98 MeV/u was obtained at the exit of SSC on December 17,2019. | Du Heng Yin Xuejun Yang Weiqing Li Zhongshan Kong Qiyu Li Xiaoni Yang Shengli Qian Cheng WangHaoning Cong Yan Jin Peng Zhang Ruifeng Han Xiaodong Fu Xin Wang Kai Jing Long Zhang Yong Li Lili Xie Wenjun Xu Xiaowei Wang Shaoming Chen Wenjun Liu Xiaojun Yue Min An Jingrui Zhang Xiang Yan Huaihai Feng Anhui Zhang Shuai Zhang Yongbo Sun Peng Zhu Tieming Sha Xiaoping Xu Jianye Sun Xiaolong Su Xuemin Li Anping Yan Tailai Meng Jun Zhang Wei Wu Junxia Yao Qinggao Yang Yaqing Xu Zhe Sun Liangting Gao Daqing Yuan Youjin Yang Jiancheng Xia Jiawen | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 13 | Effects of simvastatin on ion channel currents in ventricular myocytes from rabbit with acute myocardial infarction显示文摘Objective To investigate the effects of simvastatin on membrane ionic currents in left ventricular myocytes after acute myocardial infarction (AMI,so as to explore the ionic mechanism of statin treatment for antiarrhythmia.Methods Fourty-five New Zeland rabbits were randomly divided into three groups:AMI group,simvastatin intervention group (statin group) and sham-operated control group (CON).Rabbits were infarcted by ligation of the left anterior descending coronary artery after administration of oral simvastatin 5 mg·kg-1·d-1 (Statin group) or placebo (AMI group)for 3 days.Twenty-four hours later,single ventricular myocytes were isolated enzymatically from the epicardial zone of the infracted region.Whole cell patch clamp technique was used to record membrane ionic currents,including sodium current (INa),L-type calcium current (ICa-L) and transient outward potassium current (Ito).Results①There was no significant difference in serum cholesterol concentration among three groups.②The peak INa current density (at-30 mV) was significantly decreased in AMI group (-23.26±5.18) compared with CON (-42.78±5.48,P<0.05),while it was significantly increased in Statin group (-39.23±5.45) compared with AMI group (P<0.01);The peak ICa-L current density (at 0 mV) was significantly decreased in AMI group (-3.23±0.91) compared with CON (-4.56±1.01,P<0.05),while it was significantly increased in Statin group (- 4.18±0.95) compared with AMI group (P<0.05);The Ito current density(at +60 mV) was significantly decreased in AMI group(10.41±1.93)compared with CON (17.41±3.13,P<0.01),while it was significantly increased in Statin group(16.21±2.42)compared with AMI group (P<0.01).Conclusions AMI induces significant down-regulation of INa,ICa-L and Ito.Pretreatment with simvastatin could attenuate this change without lowering the serum cholesterol level,suggesting that simvastatin reverse this electrical remodeling,thus contributing to the ionic mechanism of statin treatment for antiarrhythmia. | Chao Ding~1 Xianghua Fu~2 Li Yang~1 Huixiao Chen~1 Junxia Li~1 Yuying Zhao~1 Jie Li~1 Jie Wang~1 1 Department of Cardiology, Bethune International Peace Hospital of Chinese PLA, Shijiazhuang Hebei 050082 China 2 Department of Cardiology, The Second Hospital, Hebei Medical University, Shijiazhuang Hebei 050000, China | 2008 | Journal of Geriatric Cardiology2008，5，3： | 0 |
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