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| 1 | Comparison of the effect and safety of Kuntai capsule and hormone replacement therapy in patients with perimenopausal syndrome:a systematic review and Meta-analysis显示文摘OBJECTIVE: To assess the effectiveness and safety of Kuntai capsule and hormone replacement therapy in treatment of perimenopausal syndrome.METHODS: Articles were retrieved from the databases Cochrane Database of Systematic Reviews,Pub Med, Chinese National Knowledge Infrastructure, China Science and Technology Journal Database, and Wanfang Database. Only randomized controlled trials were included; 15 trials involving1243 patients were identified from January 2005 to April 2015. A systemic review and Meta-analysis of publications was performed. The review was limit-ed to randomized controlled trials that compared Kuntai capsule and hormone replacement therapy to treat perimenopausal syndrome for at least 3months. The primary outcome assessed was the treatment efficacy at 3 months, including effective rate of Kupperman menopausal scores, Kupperman menopausal scores, and blood estradiol(E2) or blood follicle stimulating hormone(FSH) levels.Other outcomes assessed were safety or adverse events, such as gastrointestinal complaints, breast distending pain, or vaginal bleeding.RESULTS: Kupperman menopausal scores showed no significant difference in effective rate [odds ratio(OR): 1.05, 95% confidence intervals(CI): 0.71 to1.55] and changes in FSH level [mean difference(MD): 2.14, 95% CI:-2.36 to 6.65]. There was a significant statistical difference in Kupperman menopausal scores(MD:-1.14, 95% CI:-2.03 to-0.25)and changes in E2level(MD:-16.41, 95% CI:-18.83to-13.69). There were fewer adverse events in the Kuntai capsule group than in the hormone replacement therapy group(OR: = 0.35, 95% CI: 0.25 to0.48, P < 0.01).CONCLUSION: Compared with hormone replacement therapy, Kuntai capsule can improve perimenopausal symptoms and blood E2 levels, and reduce the incidence of adverse events. | Du Xiaoqin Xu Lin Wang Lijun Heng Mingli Bu Huaien Hao Yu Tian Jinhui | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 28 |
| 2 | Polyphenolic Compound and the Degree of Browning in Processing Apple Varieties显示文摘Polyphenolic compound in processing apple (Malus domestica Borkh.) varieties and the relationship between polyphenol content and enzymatic browning were studied to provide reference for raw material selection and processing method optimization. The content of polyphenol compound in 10 processing apple varieties (4 cider and 6 juice varieties) were analyzed using the Folin-Ciocalteu method and HPLC. The degree of browning and the activities of polyphenol oxidase were also studied. The content and proportion of the polyphenol varied depending on the variety. Bitter varieties globally showed a higher polyphenol concentration than sweet or acid varieties. Proanthocyanidins, chlorogenic acid, (+)-catechin, (-)-epicatechin were high-concentrated polyphenols in apple fruits. Phloridzin, the unique polyphenol of apple, was abundant in the bitter variety Frequin rouge fruit. Total polyphenols, proanthocyanidins, (+)-catechin, and phloridzin had higher correlations with browning. The correlation was low between chlorogenic acid and browning. The polyphenolic profiles were correlated with the apple types. Cider apples contained more polyphenol than juice apple varieties. The content of flavan-3-ol has a close relationship with fruit browning. | SONG Ye YAO Yu-xin ZHAI Heng DU Yuan-peng CHEN Feng WEI Shu-wei | 2007 | Agricultural Sciences in China2007，6，5： | 17 |
| 3 | Analysis of Genetic Diversity of Processing Apple Varieties显示文摘Genetic diversity of 18 processing apple varieties and two fresh varieties were evaluated using 12 simple sequence repeats (SSR) primer pairs previously identified in Malus domestica Borkh. A total of 87 alleles in 10 loci were detected using 10 polymorphic SSR markers selected within the range of 5-14 alleles per locus. All the 20 varieties could be distinguished using two primer pairs and they were divided into four groups using cluster analysis. The genetic similarity (GS) of groups analyzed using cluster analysis varied from 0.14 to 0.83. High acid variety Avrolles separated from other varieties with GS less than 0.42. The second group contained Longfeng and Dolgo from Northeast of China, the inherited genes of Chinese crab apple. The five cider varieties with high tannin contents, namely, Dabinette, Frequin rouge, Kermerrien, M.Menard, and D.Coetligne were clustered into the third group. The fourth group was mainly composed of 12 juice and fresh varieties. Principal coordinate analysis (PCO) also divided all the varieties into four groups. Juice and fresh apple varieties, Longfeng and Dolgo were clustered together, respectively, using both the analyses. Both the analyses showed there was much difference between cider and juice varieties, cider and fresh varieties, as well as Chinese crab apple and western European crab apple, whereas juice varieties and fresh varieties had a similar genetic background. The genetic diversity and differentiation could be sufficiently reflected by combining the two analytical methods. | SONG Ye ZHAI Heng YAO Yu-xin LI Ming DU Yuan-peng | 2006 | Agricultural Sciences in China2006，5，10： | 10 |
| 4 | Classification of microseismic events in high stress zone显示文摘For the purpose of having a better understanding of failure mechanisms of rock fracturing in mines, the equivalent point source models of tensile, shear and explosive seismic events were established, and the relationship between far-field seismic displacements of the waves and the corresponding equivalent forces were analyzed as well. Based on the results of a microseismic monitoring carried out in the mining progress of 9202 working face under the upper remnant coal pillar in Sanhejian Mine, the waveform features of the seismic events associated with different failure modes were further analyzed. The results show that the signals corresponding to different failure mechanisms have different radiation patterns of the seismic displacements, and different characteristics in waveform features, such as dominant frequency, energy released, the ratio of S- to P-wave energy, and so on. In addition, the rock burst happened in the high stress zone is mainly the result of the strong shear fracturing in the mining process. The results of this study have significantly improved the understanding of the characteristics of the failures associated with underground mining, and will greatly benefit the prevention and control of rock burst hazards in burst-prone mines. | CAO An-ye DOU Lin-ming YAN Ru-ling JIANG Heng LU Cai-ping DU Tao-tao LU Zhen-yu | 2009 | Mining Science and Technology2009，19，6： | 9 |
| 5 | The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families显示文摘We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes. | ZHAO Jinying WANG Heng XIONG Momiao HUANG Wei ZUO Jin CHEN Zhu QIANG Boqin SUN Qi LI Yuxiu LIU Qiuying DU Weinan CHEN Jialun DING Wei YUAN Wentao ZHAO Yang XU Hongyan JIN Li FANG Fude | 2000 | Chinese Science Bulletin2000，45，19： | 8 |
| 6 | Lung-protective Ventilation in Patients with Brain Injury: A Multicenter Cross-sectional Study and Questionnaire Survey in China显示文摘 | Xu-Ying Luo Ying-Hong Hu Xiang-Yuan Cao Yan Kang Li-Ping Liu Shou-Hong Wang Rong-Guo Yu Xiang-You Yu Xia Zhang Bao-Shan Li Zeng-Xiang Ma Yi-Bing Weng Heng Zhang De-Chang Chen Wei Chen Wen-Jin Chen Xiu-Mei Chen Bin Du Mei-Li Duan Jin Hu Yun-Feng Hoang Gui-Jun Jia Li-Hong Li Yu-Min Liang Bing-Yu Qin Xian-Dong Wang Jian Xiong Li-Mei Yan Zheng-Ping Yang Chen-Ming Dong Dong-Xin Wang Qing-Yuan Zhan Shuang-Lin FU Lin Zhao Qi-Bing Huang Ying-Guang Xie Xiao-Bo Huang Guo-Bin Zhang Wang-Bin Xu Yuan Xu YaLing Liu He-Ling Zhao Rong-Qing Sun Ming Sun Qing-Hong Cheng Xin Qu Xiao-Feng Yang Ming Xu Zhong-Hua Shi Han Chen Xuan He Yan-Lin Yang Guang-Qiang Chen Xiu-Mei Sun Jian-Xin Zhou | 2016 | Chinese Medical Journal2016，，14： | 6 |
| 7 | Modulation characteristics and microwave generation for AlGaInAs/InP microring lasers under four-wave mixing显示文摘The dynamic characteristics are investigated for a microring laser with an external radius of 12μm subject to external optical injection.Single-mode operation with a side mode suppression ratio of 33.4 dB is realized at a biasing current of 25 mA and a temperature of 290 K,and the corresponding small-signal modulation response is obtained with a resonance peak frequency of 7.5 GHz.Under the optical injection from a tunable laser,the improvements of the small-signal modulation response induced by four-wave mixing are observed for the microring laser,which shows an additional resonance peak around the frequency of the beat frequency between the lasing mode and the injecting light.Furthermore,optical generation of a microwave signal is realized by the light beating between the lasing mode and the injecting light measured by a high-speed photodetector and a spectrum analyzer. | Ling-Xiu Zou Yong-Zhen Huang Xiao-Meng Lv Bo-Wen Liu Heng Long Yue-De Yang Jin-Long Xiao Yun Du | 2014 | Photonics Research2014，2，6： | 6 |
| 8 | Functional characterization of WRKY46 in grape and its putative role in the interaction between grape and phylloxera (Daktulosphaira vitifoliae)显示文摘WRKY transcription factors are involved in defense responses caused by biotic stresses.Phylloxera(Daktulosphaira vitifoliae Fitch),a pest widespread in viticulture,elicits transcriptional reprogramming of plant defense-associated components,such as regulons related to WRKYs and salicylic acid(SA)signaling.In this study,we characterized WRKY46,a WRKY transcription factor responsible for phylloxera attack,and revealed the molecular mechanism for WRKY-mediated defense responses to phylloxera.qRT-PCR and GUS staining analyses revealed that WRKY46 is induced in response to phylloxera damage and mechanical wounding.VvWRKY46 is a nuclear-localized transcription factor that activates its downstream target VvCHIB by direct protein–DNA interaction.Regulons involved in the SA-mediated defense response were regulated during incompatible interactions between“1103 Paulsen”rootstock and phylloxera.In addition,WRKY46 exhibited a higher transcript abundance in“1103 Paulsen”than in“Crimson Seedless”,regardless of whether the plants were infected with phylloxera.Furthermore,the enhanced expression of VvWRKY46 significantly attenuated phylloxera attack and delayed nymph development of composite grape plants.In summary,we demonstrated that WRKY46 plays a role in the SA-mediated defense-regulatory network by directly binding to the downstream structural gene VvCHIB.The phylloxera-responsive gene WRKY46 was identified,which could improve the understanding of the basic mechanism of grapevine in response to phylloxera. | Feng-Pan Wang Pan-Pan Zhao Lei Zhang Heng Zhai Yuan-Peng Du | 2019 | Horticulture Research2019，6，1： | 6 |
| 9 | A new way to synthesize ZnS nanoparticles显示文摘ZnS nanoparticles were prepared with normal ZnO and Na2S by solid-liquid chemical reaction under ultrasonic condition andcharacterized by XRD,TEM,SEM,IR and TG-DTG.The results showed that these particles were good crystal cubic zinc blendedwith average size of 50 nm,possess good IR transmittance in the range of 400-4000 cm and good thermal stability. | Heng Zhi Zeng Ke Qiang Qiu Yuan Yuan Du Wen Zhang Li | 2007 | Chinese Chemical Letters2007，18，4： | 5 |
| 10 | Effectiveness of Using Mean Corpuscular Volume and Mean Corpuscular Hemoglobin for Beta-thalassemia Carrier Screening in the Guangdong Population of China显示文摘Beta(β)-thalassemia is one of the most common hemoglobinopathies worldwide,creating major public health problems and social burdens in many regions.Screening forβ-thalassemia carriers is crucial for controlling this condition.To investigate the?effectiveness?of?mean?corpuscular?volume?(MCV)and mean corpuscular hemoglobin(MCH)for screeningβ-thalassemia,retrospective data were analyzed for 6,779β-thalassemia carriers subjected to genetic testing following thalassemia screening in Guangdong province between January 2018 and December 2019. | GU Heng WANG Yong Xia DU Meng Xuan XU Shan Shan ZHOU Bing Yi LI Ming Zhen | 2021 | Biomedical and Environmental Sciences2021，34，8： | 4 |
| 11 | Novel hierarchical structure of MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) composites for dramatically enhanced electromagnetic absorbing properties显示文摘In order to prevent the microwave leakage and mutual interference,more and more microwave absorbing devices are added into the design of electronic products to ensure its routine operation.In this work,we have successfully prepared MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) hierarchical composites by one-pot hydrothermal method and focused on the relationship between structures and electromagnetic absorbing properties.Supported by comprehensive characterizations,M0S_(2) nanosheets were proved to be anchored on the surface and interlayer of Ti_(3)C_(2)T_(x) through a hydrothermal process.Additionally,TiO_(2) nanoparticles were obtained in situ.Due to these hierarchical structures,the MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) composites showed greatly enhanced microwave absorbing performance.The MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) composites exhibit a maximum reflection loss value of -33.5 dB at 10.24 GHz and the effective absorption bandwidth covers 3.1GHz(13.9-17 GHz)at the thickness of 1.0 mm,implying the features of wide frequency and light weight.This work in the hierarchical structure of MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) composites opens a promising door to the exploration of constructing extraordinary electromagnetic wave absorbents. | Heng DU Qipeng ZHANG Biao ZHAO Frank MARKEN Qiancheng GAO Hongxia LU Li GUAN Hailong WANG Gang SHAO Hongliang XU Rui ZHANG Bingbing FAN | 2021 | Journal of Advanced Ceramics2021，10，5： | 4 |
| 12 | Risk of Treatment Failure in Patients with Drug-susceptible Pulmonary Tuberculosis in China显示文摘The objective of this prospective study of the risks of treatment failure in patients with drug-susceptible pulmonary tuberculosis(PTB)was to provide reference data to help develop a disease control strategy.Participants were recruited in eight provinces of China from October 2008 to December2010.A total of 1447 patients with | WANG Ni MA Yan LIU YU Hong DU Jian ZHANG Hui XIE Shi Heng Zhu Kun LYU Xiao Ya SHU Wei WANG Hong Hong ZHU Guo Feng TAN Shou Yong FU Yan Yong MA Li Ping ZHANG Lian Ying LIU Fei Ying HU Dai Yu ZHANG Yan Ling LI Xiang Qun LI Liang | 2016 | Biomedical and Environmental Sciences2016，29，8： | 3 |
| 13 | Kongsheng Zhenzhong pill's effect on the learning and memory ability and its neuroprotective effects in vascular dementia rats显示文摘Clinical reports have demonstrated that the Kongsheng Zhenzhong pill (KSZZP),a classical prescription deriving from Valuable Prescription for Emergencies,has good therapeutic effects on vascular dementia.However,the mechanisms that mediate its effects remain unclear.In this study,the expression of N-methyl-D-aspartate receptor 1 mRNA,the content of nitric oxide,and the concentration of calcium in neurons was determined with in situ hybridization,spectrophotometry and flow cytometry,respectively.In addition,the expressions of N-methyl-D-aspartate receptor 1,nerve growth factor protein,and glial cell line-derived neurotrophic factor protein were detected with immunohistochemistry.We found that KSZZP could significantly decrease the expression of N-methyl-D-aspartate receptor 1 mRNA and protein,the content of nitric oxide,and the concentration of calcium in neurons.KSZZP also increased the expression of nerve growth factor and glial cell line-derived neurotrophic factor protein in the hippocampus CA1 region and in the cerebral cortex.Morris water maze and passive avoidance tests verified that KSZZP ameliorated the cognitive impairments of vascular dementia rats.Moreover,the KSZZP-induced improvements in the cognitive functions of vascular dementia rats were correlated with both inhibition of N-methyl-D-aspartate-induced excitable neurotoxicity and elevation of neurotrophic factor expression. | Xuming Ji Huayun Yu Bin Ouyang Guowei Liu Zhichun Wu Heng Liu Fang Du | 2011 | Neural Regeneration Research2011，6，30： | 3 |
| 14 | Role of Diabetes Mellitus on Treatment Effects in Drug-susceptible Initial Pulmonary Tuberculosis Patients in China显示文摘We assessed the role of diabetes mellitus(DM) on treatment effects in drug‐susceptible initial pulmonary tuberculosis(PTB) patients. A prospective study was conducted in eight provinces of China from October 2008 to December 2010. We enrolled 1,313 confirmed drug‐susceptible initial PTB patients, and all subjects received the treatment regimen(2 H3 R3 E3 Z3/4 H3 R3) as recommended by the national guidelines. Of the 1,313 PTB patients, 157(11.9%) had DM; these patients had more sputum smear‐positive rates at the end of the second month [adjusted odds ratios(aO R) 2.829, 95% confidence intervals(CI) 1.783‐4.490], and higher treatment failure(aO R 2.120, 95% CI 1.565‐3.477) and death rates(aO R 1.536, 95% CI 1.011‐2.628). DM was a contributing factor for culture‐positive rates at the end of the second month and treatment failure and death of PTB patients, thus playing an unfavorable role in treatment effects of PTB. | MA Yan HUANG Mai Ling LI Tao DU Jian SHU Wei XIE Shi Heng WANG Hong Hong ZHU Guo Feng TAN Shou Yong FU Yan Yong MA Li Ping ZHANG Lian Ying LIU Fei Ying HU Dai Yu ZHANG Yan Ling LI Xiang Qun LIU Yu Hong LI Liang | 2017 | Biomedical and Environmental Sciences2017，30，9： | 3 |
| 15 | Two-plane painting injection scheme for BRing of HIAF显示文摘The high-intensity heavy-ion accelerator facility(HIAF)is under design at the Institute of Modern Physics(IMP)and will provide an intense ion beam for nuclear physics,atomic mass measurement research,and other applications.As the main ring of HIAF,the BRing accumulates beams to high intensity and accelerates them to high energy.To achieve high intensities up to 1×10^(11)(^(238)U^(34+)),the injection gain of the BRing must be as high as 88.However,multiple multiturn injection supported by the electron cooling system takes a long time,causing substantial beam loss under a strong space charge effect.Hence,a two-plane painting injection scheme is proposed for beam accumulation in the BRing.This scheme uses a tilted injection septum and horizontal and vertical bump magnets to paint the beam into horizontal and vertical phase space simultaneously.In this paper,the two-plane painting injection parameters are optimized,and the resulting injection process is simulated using the Objective Ring Beam Injection and Tracking(ORBIT)code.An injection gain of up to 110.3 with a loss rate of 2:3%is achieved,meeting the requirements of BRing. | Guo-Feng Qu Wei-Ping Chai Jia-Wen Xia Jian-Cheng Yang Heng Du Zhong-Shan Li Wen-Wen Ge Wen-Heng Zheng Peng Shang | 2017 | Nuclear Science and Techniques2017，28，8： | 3 |
| 16 | Analysis of basic conditions of the power grid interconnection among Xinjiang, Pakistan, and five Central Asian countries显示文摘Inter-regional and transnational grid interconnection is necessary for energy development. Xinjiang, which is rich in renewable energy resources, is adjacent to countries in Central Asia and has great potential for interconnection with its neighbors. This paper outlines China's relevant policies for transnational power interconnection, and introduces the energy structure, load demand endowments, and power supply status of Xinjiang, Pakistan, and five Central Asian countries. Further, it analyzes the advantages of the multinational power interconnection from the aspects of power supply and load complementation. Finally, from the perspective of technical support and practical basis, the feasibility of interconnection between Xinjiang, Pakistan, and five Central Asian countries have been analyzed. This paper provides a theoretical basis for promoting and implementing China's 'Belt and Road' power transnational interconnected development strategy. | Chunyi Huang Chengmin Wang Heng Li Jing Luo Weiqing Sun Xizhou Du | 2019 | Global Energy Interconnection2019，2，1： | 2 |
| 17 | Dynamic Changes in the Calcium Content of Several Apple Cultivars During the Growing Season显示文摘Dynamic changes in calcium content were investigated in eight apple cultivars. The results showed that the calcium concentration in leaves and shoots increased with fruit development. The cultivars displayed only a small difference in the calcium concentration during the early stage of development, the difference became very significant at the late stage of development, especially in shoots. In shoots, for example, calcium content was highest in Starkrimson (19 638.6 mg kg-1) and lowest in Fuji (8 751.3 mg kg-1). Calcium concentration was highest in young fruits and was found to decrease with the growth of fruit, and was characterized by a dramatic drop at the rapid expansion stage. There was a significant difference among cultivars. Young Starkrimson fruits contained the highest calcium concentration of 506.52 mg kg-1 among cultivars tested, followed by Pink Lady and Fuji. The calcium concentration in mature fruits from high to low is as follows: Starkrimson, Sansa, Pink Lady, Senshu, Gala, Fuji, Red General and New Century. In this study, it was found that eight cultivars continuously assimilated calcium during the whole growing season, especially at the young stage when fruit took up 35-46% of total calcium. The calcium content in fruitlets was low in all cultivars; in the expansion stage, there was rapid absorption of about 30% of total calcium, whereas in the ripening fruit, content of calcium was reduced. The calcium accumulation increased with fruit growth in stalk, similar to that in fruit. | ZHENG Wei-wei YOU Chun-xiang DU Zhong-jun ZHAI Heng | 2006 | Agricultural Sciences in China2006，5，12： | 2 |
| 18 | Mechanical Behavior and Failure Mechanism of 2.5D(Shallow Bend-joint, Deep Straight-joint) and 3D Orthogonal UHWMPE Fiber/Epoxy Composites by Vacuum-assistant-resin-infused显示文摘Ultra-high molecular weight polyethylene(UHMWPE) fiber/epoxy composites were fabricated by a vacuum assisted resin infused(VARI) processing technology. The curing condition of composites was at a cure temperature of 80 ℃ for 3h in a drying oven. The characteristics of 2.5D(shallow bend-joint and deep straight-joint) structure and 3D orthogonal structure were compared. The failure behavior, flexural strength, and microstructures of both composites were investigated. It was found that the flexural property was closely related to undulation angle θ. The flexural strength of 3D orthogonal structure composite was superior to the other two structures composites with the same weave parameters and resin. | 赵晓琳 DU Jianhua YANG Hongwei JIA Chengchang GAO Heng WANG Dafeng Lü Yingying | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，6： | 2 |
| 19 | Effects of Partial Rootzone Drying on the Growth of Vitis vinifera cv.Malvasia Grafted on Different Rootstocks显示文摘To lay a biological foundation for rootstocks and alternate irrigation (AI) popularization, the effects of partial rootzone drying (PRD) on the growth of the grapevine Malvasia grafted on different rootstocks were investigated. Biological effects of 1/2 divided root irrigation on three combinations, i.e., Malvasia/420A, Malvasia/3309C, and Malvasia/110R, were studied by wood-boxed plants. All the plants were separated into three groups for different irrigation strategies. Mass growth of new root in alternate-irrigated plants was remarkably promoted by about 7.8-22.2% higher than the well- watered ones. However, new shoot growth, especially the internode was reduced by alternate irrigation. The average root-shoot ratio of all the three combinations was increased from 1.1 to 1.46. New root growth and internode length were decreased by fixed partial rootzone irrigation (FI) at different amount, M/3309C at 37.9 and 36.9%, M/110R at 18.4 and 22.5%, respectively. Total biomass of all the three combinations under FI decreased at the rate of 19.2-34.3% compared with well-watered ones. Water stress adaptation of grapevine mainly depends on rootstock. 110R is more efficient than 3309C and 420A in water stress adaptation. PRD-AI benefited root growth, thus improved the drought-resistant ability of grapevine. | QI Wei GUAN Xue-qiang LI En-mao ZHAI Heng WANG Xiao-fang DU Yuan-peng | 2007 | Agricultural Sciences in China2007，6，5： | 2 |
| 20 | Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury显示文摘Compelling evidence has revealed that biased activation of G protein-coupled receptor(GPCR)signaling,including angiotensin II(AngII)receptor type 1(AT1)signaling,plays pivotal roles in vascular homeostasis and injury,but whether a clinically relevant endogenous biased antagonism of AT1 signaling exists under physiological and pathophysiological conditions has not been clearly elucidated.Here,we show that an extracellular matrix protein,cartilage oligomeric matrix protein(COMP),acts as an endogenous allosteric biased modulator of the AT1 receptor and its deficiency is clinically associated with abdominal aortic aneurysm(AAA)development.COMP directly interacts with the extracellular N-terminus of the AT1 via its EGF domain and inhibits AT1-β-arrestin-2 signaling,but not Gq or Gi signaling,in a selective manner through allosteric regulation of AT1 intracellular conformational states.COMP deficiency results in activation of AT1a-β-arrestin-2 signaling and subsequent exclusive AAA formation in response to AngII infusion.AAAs in COMP–/–or ApoE–/–mice are rescued by AT1a orβ-arrestin-2 deficiency,or the application of a peptidomimetic mimicking the AT1-binding motif of COMP.Explorations of the endogenous biased antagonism of AT1 receptor or other GPCRs may reveal novel therapeutic strategies for cardiovascular diseases. | Yi Fu Yaqian Huang Zhao Yang Yufei Chen Jingang Zheng Chenfeng Mao Zhiqing Li Zhixin Liu Bing Yu Tuoyi Li Meili Wang Chanjuan Xu Yiwei Zhou Guizhen Zhao Yiting Jia Wei Guo Xin Jia Tao Zhang Li Li Ziyi Liu Shengchao Guo Mingliang Ma Heng Zhang Bo Liu Junbao Du Wengong Wang Chaoshu Tang Pei Gao Qingbo Xu Xian Wang Jianfeng Liu Jinpeng Sun Wei Kong | 2021 | Cell Research2021，31，7： | 2 |
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