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| 1 | Nidus vespae protein inhibiting proliferation of HepG2 hepatoma cells through extracellular signal-regulated kinase signaling pathways and inducing G1 cell cycle arrest显示文摘蛋白质说出 NVP (1 ) 从巢 vespae 被孤立。T 他现在的学习的目的是阐明 NVP (1 ) 是否并且怎么调制 HepG2 房间的增长。在 6.6 μg/ml 的集中的 NVP (1 ) 能在阶段 G 1 逮捕房间周期并且禁止 cyclinB, cyclinD1 和 cyclinE 的 mRNA 表示。NVP (1 ) 压制了 cdk2 蛋白质表示,但是增加了 p27 和 p21 蛋白质表示。然而, NVP (1 ) 没改变 p16 蛋白质表示层次。NVP (1 ) 在由原子染色质冷凝作用显示了的 HepG2 房间支持了 apoptosis,并且另外,表明小径的细胞外的调整信号的 kinase (英皇家空军之阶级最低之兵) 被激活。而且,当 HepG2 房间是有英皇家空军之阶级最低之兵禁止者 PD98059 的 pretreated 时,津贴蛋白质表示水平被稀释。这些结果证明 NVP (1 ) 通过表明小径的英皇家空军之阶级最低之兵禁止 HepG2 的增长。NVP (1 ) 能是为肝癌症的潜在的药。 | Changdong Wang Peng Chen Hongjuan Jin Xu Yan Lu Gan Yi Li Shiyi Zhou Junli Chang Yuesheng Wang Guangxiao Yang Guangyuan He | 2008 | Acta Biochimica et Biophysica Sinica2008，40，11： | 11 |
| 2 | The role of RIP3 in cardiomyocyte necrosis induced by mitochondrial damage of myocardial ischemia-reperfusion显示文摘Myocardial damage caused by myocardial ischemia-reperfusion injury (MIRI)is difficult to be alleviated because cardiomyocyte necrosis is an irreversible and unregulated death form.Recently, necroptosis,a necrosis form caused by tumor necrosis factor-α (TNF-α)and Fas ligand (FasL),was found to be regulated by receptor interacting protein 3 (RIP3)and RIP3-receptor interacting protein 1 (RIP1)-mixed lineage kinase domain like protein (MLKL)pathway.But it is unclear whether they also play a regulatory role in MIRI-induced necroptosis.Our previous results showed that in rat MIRI,RIP3 could translocate and express highly in mitochondria.Therefore,it is important to explore proteins that interact with RIP3 which was translocated to mitochondria.The aim of this study was to explore the role of RIP3 in cardiomyocyte necrosis induced by mitochondrial damage of hypoxia/reoxygenation (H/R).Our results showed that H/R could cause RIP3-depended mitochondrial fragmentation and necrosis-based death;and RIP3-promoted H/R-induced necroptosis in H9c2 cells through increasing lactate dehydrogenase release and inhibiting cell viability.This process did not require RIP1 or MLKL but dynamin-related protein 1 (Drp1),which was related to Drpl activation,reactive oxygen species elevation,and △Ψm decline.This study provides novel insights into the role of RIP3 in cardiomyocyte injury during H/R.RIP3 may serve as a potential target for the treatment of MIRI. | Huifang Hou Yongling Wang Qiong Li Zaibing Li Yan Teng Jingyu Li Xiaoying Wang Junli Chen Ning Huang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，11： | 10 |
| 3 | Developing a bacteriophage cocktail for biocontrol of potato bacterial wilt显示文摘Bacterial wilt is a devastating disease of potato and can cause an 80% production loss. To control wilt using bacteriophage therapy, we isolated and characterized twelve lytic bacteriophages from different water sources in Kenya and China. Based on the lytic curves of the phages with the pathogen Ralstonia solanacearum, one optimal bacteriophage cocktail, P1, containing six phage isolations was formulated and used for studying wilt prevention and treatment efficiency in potato plants growing in pots. The preliminary tests showed that the phage cocktail was very effective in preventing potato bacterial wilt by injection of the phages into the plants or decontamination of sterilized soil spiked with R. solanacearum. Eighty percent of potato plants could be protected from the bacterial wilt(caused by R. solanacearum reference strain GIM1.74 and field isolates), and the P1 cocktail could kill 98% of live bacteria spiked in the sterilized soil at one week after spraying.However, the treatment efficiencies of P1 depended on the timing of application of the phages, the susceptibility of the plants to the bacterial wilt, as well as the virulence of the bacteria infected,suggesting that it is important to apply the phage therapy as soon as possible once there are early signs of the bacterial wilt. These results provide the basis for the development of bacteriophagebased biocontrol of potato bacterial wilt as an alternative to the use of antibiotics. | Cuihua Wei Junli Liu Alice Nyarnbura Maina Francis B Mwaura Junping Yu Chenghui Yan Ruofang Zhang Hongping Wei | 2017 | Virologica Sinica2017，32，6： | 8 |
| 4 | Big data resource service platform for the internet financial industry显示文摘It is now the era of big data.Massive volumes of complex and dynamic data exist in a variety of industries,including internet finance.This paper briefly describes the current big data situation and its significance,discusses the big data resource service platform architecture that includes three levels:data resource identification and access,data resources storage and analysis,and network information service platform,and then introduces some work undertaken by our project team on big data analysis research and application of trusted transactions for internet finance. | Changjun Jiang Zhijun Ding Junli Wang Chungang Yan | 2014 | Chinese Science Bulletin2014，59，35： | 8 |
| 5 | Recent Progress on Al_(2)O_(3)-C Refractories with Low/ultra-low Carbon Content:A Review显示文摘This work intends to provide a comprehensive review on the development of Al_(2)O_(3)-C refractories with low/ultra-low carbon content.It covers three parts:carbon materials,microstructure optimization of the refractory matrix by ceramic phases,and application of metal Al as raw material.Carbon black,expanded graphite,and ultrafine microcrystalline graphite,as price-competitive carbon materials,can be chosen to prepare the low-carbon Al_(2)O_(3)-C refractories after some special treatment.Ni/Co/Fe-catalyzed phenolic resin contributes to improving the properties of the low-carbon Al_(2)O_(3)-C refractories.The performance deterioration of the low-carbon Al_(2)O_(3)-C refractories can also be improved by in-situ formed or pre-synthesized ceramic phases.Metal Al,characterized by plasticity forming,acceleration of sintering,oxidation resistance,and high reactivity,can be used as raw materials to completely replace graphite,and the prepared resin bonded Al-Al_(2)O_(3)based refractories are one novel development direction of the ultra-low carbon Al_(2)O_(3)-C refractories. | ZHAO Chenrui YAN Mingwei LI Hongyu NIU Zhiwang LIANG Baoqing SHANG Junli | 2022 | China's Refractories2022，31，1： | 4 |
| 6 | Poly IC pretreatment suppresses B cell-mediated lupus-like autoimmunity through induction of Peli1显示文摘 | Yan Wang Jia Yuan Dongfang Dai Junli Liu Jing Xu Xiang Miao Huan Wang Chaoming Mao Yichuan Xiao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 3 |
| 7 | Trp_(548)Met mutation of acetolactate synthase in rice confers resistance to a broad spectrum of ALS-inhibiting herbicides显示文摘Herbicide resistance in crop plants is valuable for integrated weed management in agriculture. Herbicide resistant rice, in particular, is important to management of weedy rice, a close relative of cultivated rice and a noxious weed prevalent in rice fields that remains challenging to farmers worldwide. Herbicide resistant plants can be obtained through transgenic approach or by mutagenesis of regular plant and screening of mutants with elevated resistance to herbicide. In this study, we conducted ethyl methyl sulfonate mutagenesis(EMS) to elite indica cultivar Huanghuazhan(HHZ) and screened for mutants resistant to imazapic, a herbicide that can inhibit the acetolactate synthase(ALS) in plants. We obtained three mutants of Os ALS gene that have not been reported previously in rice. One of the mutants, with Trp_(548) changed to Met(W_(548)M), was analyzed in more details in this study. This mutation had no negative effect on the plant physiology and morphology as well as rice yield. Compared with the imidazolinone-resistant mutant S_(627)N(Ser_(627) changed to Asn) that has been deployed for Clearfield rice development, W_(548)M mutant showed high levels of resistance to a broad spectrum of five families of ALSinhibiting herbicides, in addition to a higher level of resistance to herbicides of the imidazolinone family.The herbicide-resistance was stably inherited by crossing into other rice lines. Thus, the W_(548)M mutation provides a valuable resource for breeding of herbicide resistant rice and weed management. | Lei Chen Gang Gu Chengxu Wang Zhufeng Chen Wei Yan Man Jin Gang Xie Junli Zhou Xing Wang Deng Xiaoyan Tang | 2021 | The Crop Journal2021，9，4： | 3 |
| 8 | Correlation between radiologic features on contrastenhanced CT and pathological tumor grades in pancreatic neuroendocrine neoplasms显示文摘Contrast-enhanced computed tomography(CT)contributes to the increasing detection of pancreatic neuroendocrine neoplasms(PNENs).Nevertheless,its value for differentiating pathological tumor grades is not well recognized.In this report,we have conducted a retrospective study on the relationship between the 2017 World Health Organization(WHO)classification and CT imaging features in 94 patients.Most of the investigated features eventually provided statistically significant indicators for discerning PNENs G3 from PNENs G1/G2,including tumor size,shape,margin,heterogeneity,intratumoral blood vessels,vascular invasion,enhancement pattern in both contrast phases,enhancement degree in both phases,tumor-to-pancreas contrast ratio in both phases,common bile duct dilatation,lymph node metastases,and liver metastases.Ill-defined tumor margin was an independent predictor for PNENs G3 with the highest area under the curve(AUC)of 0.906 in the multivariable logistic regression and receiver operating characteristic curve analysis.The portal enhancement ratio(PER)was shown the highest AUC of 0.855 in terms of quantitative features.Our data suggest that the traditional contrastenhanced CT still plays a vital role in differentiation of tumor grades and heterogeneity analysis prior to treatment. | Wenbin Xu Han Yan Lulu Xu Mingna Li Wentao Gao Kuirong Jiang Junli Wu Yi Miao | 2021 | The Journal of Biomedical Research2021，35，3： | 2 |
| 9 | AP-2α expression and cell apoptosis of the lung tissue of rats with COPD and ECV304 cells stimulated by cigarette smoke extract显示文摘An increasing body of evidence suggests that apoptosis of structural cells in the lung might be an important upstream event in the pathogenesis of chronic obstructive pulmonary disease (COPD).AP-2α is one of the important transcription factors involved in the modulation of apoptosis in carcinogenesis and idiopathic-dilated cardiomyopathy.The relationship between AP-2α and apoptosis in COPD remains to be elucidated.The aim of the present study was to investigate the expression of AP-2α in the lung tissues of rats with COPD induced by smoking and its possible protective effect on cigarette smoke extract (CSE) induced endothelial cell apoptosis.Sprague-Dawley rats (n=24) were randomly assigned to normal and COPD groups.The COPD group was exposed to smoke from 20 commercial unfiltered cigarettes for 80 d before morphological assessment of the lung tissue was performed.The expression of AP-2α in lung tissues was measured by Western blotting.To demonstrate the relationship between apoptosis and AP-2α,in vitro cell experiments were carried out.Cells were treated with different concentrations of CSE before proliferation was measured by MTT.Apoptosis was then determined by Hoechst staining and the expression of cleaved caspase-3 and AP-2α by Western blotting over time following treatment with 5% CSE.Cells were then infected with an AP-2α adenovirus vector and the expression of cleaved caspase-3 and AP-2α was compared to the control groups by Western blotting.The COPD group showed larger air spaces and significant decrease of FEV 0.3/FVC compared with the rats in the control group (P<0.05).The expression of AP-2α was significantly higher in the lung tissue of rats with COPD compared with those of controls (P<0.05).In the ECV304 cells,CSE induced apoptosis (P<0.01) and caspase-3 activation in a time-dependent manner and reduced the cell proliferation rate in a dose-dependent manner (P<0.005).Moreover,5% CSE treatment increased endogenous AP-2α protein expression.AP-2α overexpression inhibited 5% CSE-induced cell apoptosis and activated caspase-3 expression (P<0.05) AP-2α protects ECV304 cells against CSE-induced apoptosis and may play an important role in smoking induced-apoptosis in COPD. | LI JunLi CHEN Yan CHEN Ping CAI Shan PENG Hong ZHOU Rui XIANG XuDong LONG Hong LIU ShaoKun | 2011 | Chinese Science Bulletin2011，56，15： | 2 |
| 10 | Biochar-based Solid Acids as Catalysts for Carbohydrate Hydrolysis: A Critical Review显示文摘Recently, increasing interest has been focused on the hydrolysis of carbohydrates to monosaccharides, among which, glucose and xylose as typical platform sugars can be used to produce chemicals and biofuels. As heterogeneous catalysts, solid acids have gained extensive attention for biomass biorefinery and could replace the conventional process owing to their excellent properties, including acceptable acidity and easy separation. In particular, biochar-based solid acids derived from biomass are promising for biomass conversion owing to the low-cost of feedstocks and the simple preparation procedure. Herein, we attempt to provide a critical overview of biochar-based solid acids for hydrolysis of carbohydrates into glucose and xylose. The preparation methods and properties of biochar-based catalysts as well as the influence of their properties on catalytic performance were discussed in detail. We also highlight the major challenges facing the use of biochar-based solid acids for carbohydrate hydrolysis. | XiaoHui Wang QiXuan Lin YuHuan Yan BangGui Cheng Tao Song JunLi Ren | 2018 | Paper And Biomaterials2018，3，2： | 2 |
| 11 | Nutrient value of wild fodder species and the implications for improving the diet of mithun (Bos frontalis) in Dulongjiang area, Yunnan Province, China显示文摘Wild fodder plants are valuable because they provide an important livestock feed resource globally,especially for smallholder farmers,and have important roles in natural resource management.In-depth knowledge of wild forage plants can motivate local people for feed resource and habitat conservation of threatened herbivores such as Mithun(Bos frontalis).Mithun occur in small patches in the mountains of Dulongjiang,nearby villagers domesticated this animal but left animal to freely graze in the mountains.Many fodder plants occur in these mountains,however,little is known about their nutritional value.We conducted an ethnobotanical survey to document important wild fodder plants consumed by mithun in the Dulongjiang Township.The nutritional content of 21 highly mentioned wild fodder plants in an ethnobotanical survey was examined.Laboratory analysis showed that Fagopyrum dibotrys were the fodder species with the highest crude protein(CP)content(26.89%),followed by Polygonum molle(21.88%)and Hydrangea longipes(21.12%).Synthesis of relative feed value index and grey relational grade,P.molle,H.longipes and Tetrastigma obtectum were ranked the top three nutritional fodders.There was a significant difference between 21 species on their in vitro digestibility and the most highly digestible fodder species was Elatostema hookerianum.Linear model analysis on relationship between frequency of citation of 21 wild forage plants by local farmers and their nutrient composition showed that the frequency was significantly positively correlated with the nutritional value of the feed(R2?0.28,P<0.05).We concluded that these species have high nutritional values to improve mithun production in integrated crop-livestock systems.Fodder species or mixtures of species with useful nutritional characters could be cultivated to improve livestock productivity,habitat conservation including that of mithun and wild forage resource management. | Yanfei Geng Sailesh Ranjitkar Qiaoshun Yan Zhijun He Baqi Su Shengtao Gao Junli Niu Dengpan Bu Jianchu Xu | 2020 | Plant Diversity2020，42，6： | 2 |
| 12 | Solubility determination and thermodynamic modeling of bis-2-hydroxyethyl terephthalate(BHET)in different solvents显示文摘Studies on the degradation process of waste polyethylene terephthalate(PET)have become increasingly mature,but there are relatively few studies on the separation of degradation products.The products contain many components and the separation of which is difficult.Therefore,the study on phase equilibrium thermodynamics of bis-2-hydroxyethyl terephthalate(BHET)is of great theoretical significance and practical value to provide basic data for the BHET crystallization separation.In this work,the degraded products were purified and characterized.The solubility of BHET in methanol,ethanol,ethylene glycol,water and the mixture of ethylene glycol+water were determined by static method.The experimental results were correlated with different models,such as ideal solution(IS)model,λh equation,Apelblat equation and NRTL model.Based on the van’t Hoff equation,the mixing Gibbs energy,enthalpy and entropy were calculated.From this work,the basic data which can be used to guide the crystallization process of BHET were obtained,including solubility data,correlation model and thermodynamic properties. | Haoyu Yao Dongxia Yan Xingmei Lu Qing Zhou Yinan Bao Junli Xu | 2022 | Chinese Journal of Chemical Engineering2022，35，5： | 1 |
| 13 | Chaos synchronization of semiconductor lasers over 1040-km fiber relay transmission with hybrid amplification显示文摘Optical chaos communication and key distribution have been extensively demonstrated with high-speed advantage but only within the metropolitan-area network range of which the transmission distance is restricted to around 300 km.For secure-transmission requirement of the backbone fiber link,the critical threshold is to realize long-reach chaos synchronization.Here,we propose and demonstrate a scheme of long-reach chaos synchronization using fiber relay transmission with hybrid amplification of an erbium-doped fiber amplifier(EDFA)and a distributed fiber Raman amplifier(DFRA).Experiments and simulations show that the hybrid amplification extends the chaos-fidelity transmission distance thanks to that the low-noise DFRA suppresses the amplified spontaneous emission noise and self-phase modulation.Optimizations of the hybrid-relay conditions are studied,including launching power,gain ratio of DFRA to EDFA,single-span fiber length,and number of fiber span.A 1040-km chaos synchronization with a synchronization coefficient beyond 0.90 is experimentally achieved,which underlies the backbone network-oriented optical chaos communication and key distribution. | LONGSHENG WANG JUNLI WANG YUSHAN WU YUEHUI SUN SONGSUI LI LIANSHAN YAN YUNCAI WANG ANBANG WANG | 2023 | Photonics Research2023，11，6： | 1 |
| 14 | Effect of Purple Sweet Potato Anthocyanins on β-Amyloid-Mediated PC-12 Cells Death by Inhibition of Oxidative Stress显示文摘 | Junli Ye Xiangjun Meng Chunling Yan Chunbo Wang | 2010 | Neurochemical Research2010，，3： | 1 |
| 15 | Preparation and magnetic properties of NdsFe95_xB, nanowire arrays显示文摘 | Gao Daqiang Fu Junli Xu Yan | 2008 | Materials Letters2008，107，： | 1 |
| 16 | The ubiquitin ligase Pelil inhibits ICOS and thereby Tfh-mediated immunity显示文摘T follicular helper(Tfh)cells are crucial for regulating autoimmune inflammation and protective immunity against viral infection.However,the molecular mechanism controlling Tfh cell differentiation is poorly understood.Here,through two mixed bone marrow chimeric experiments,we identified Peli1,a T cell-enriched E3 ubiquitin ligase,as an intrinsic regulator that inhibits Tfh cell differentiation.Peli1 deficiency significantly promoted c-Rel-mediated inducible T-cell costimulator(ICOS)expression,and PELI1 mRNA expression was negatively associated with ICOS expression on human CD4^(+)T cells.Mechanistically,increased ICOS expression on Peli1-KO CD4^(+)T cells enhanced the activation of PI3K-AKT signaling and thus suppressed the expression of Klf2,a transcription factor that inhibits Tfh differentiation.Therefore,reconstitution of Klf2 abolished the differences in Tfh differentiation and germinal center reaction between WT and Peli1-KO cells.As a consequence,Peli1-deficient CD4^(+)T cells promoted lupus-like autoimmunity but protected against H1N1 influenza virus infection in mouse models.Collectively,our findings established Peli1 as a critical negative regulator of Tfh differentiation and indicated that targeting Peli1 may have beneficial therapeutic effects in Tfhrelated autoimmunity or infectious diseases. | Xinfang Huang Shumeng Hao Junli Liu Yuanyuan Huang Manman Liu Chunyuan Xiao Yan Wang Siyu Pei Tao Yu Jing Xu Haikun Wang Dongfang Dai Xiao Su Yichuan Xiao | 2021 | Cellular & Molecular Immunology2021，18，4： | 1 |
| 17 | Ultraprecision surface finishing of nano-ZrO2 ceramics using two-dimensional ultrasonic assisted grinding显示文摘 | Yan Yanyan Zhao Bo Liu Junli | 2009 | The International Journal of Advanced Manufacturing Technology2009，43，56： | 1 |
| 18 | Deregulated MIR 335 that targets MAPK 1 is implicated in poor outcome of paediatric acute lymphoblastic leukaemia显示文摘 | Junli Yan Nan Jiang Gaofeng Huang Jim L.‐S. Tay Baohong Lin Chonglei Bi Grace S. Koh Zhenhua Li Joy Tan Tae‐Hoon Chung Yi Lu Hany Ariffin Shirley K. Y. Kham Allen E. J. Yeoh Wee‐Joo Chng | 2013 | Br J Haematol2013，，1： | 1 |
| 19 | Ultraprecision surface finishing of nano-ZrO2 ceramic using two-dimensional ultrasonic assisted grinding显示文摘 | Yan Yanyan Zhao Bo Liu Junli | 2009 | Manuf Technol2009，43，： | 1 |
| 20 | Liquid chromatography tandem mass spectrometry method for determination of bisoprolol in human plasma using d5‐bisoprolol as the internal standard显示文摘 | Gang‐yiLiu WeiWang Jing‐yingJia ChuanLu Yan‐meiLiu Meng‐qiZhang YunLiu Shui‐junLi ChenYu | 2010 | Biomed Chromatogr2010，，6： | 1 |
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